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Cited by 30Neurogenesis and neuroplasticity mechanismsUbiquitin and proteasome pathwaysDevelopmental Biology and Gene Regulation

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The Sumo protease Senp7 is required for proper neuronal differentiation

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Juarez-Vicente, Francisco, Luna-Pelaez, Noelia, Garcia-Dominguez, Mario·2016·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
DOI 10.1016/j.bbamcr.2016.03.028
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Abstract

Covalent attachment of the Small ubiquitin-like modifier (Sumo) polypeptide to proteins regulates many processes in the eukaryotic cell. In the nervous system, Sumo has been associated with the synapsis and with neurodegenerative diseases. However, its involvement in regulating neuronal differentiation remains largely unknown. Here we show that net Sumo deconjugation is observed during neurogenesis and that Sumo overexpression impairs this process. In an attempt to shed light on the underlying mechanisms, we have analyzed the expression profile of genes coding for components of the sumoylation pathway following induction of neuronal differentiation. Interestingly, we observed strong upregulation of the Senp7 protease at both mRNA and protein levels under differentiation conditions. Sumo proteases, by removing Sumo from targets, are key regulators of sumoylation. Strikingly, loss-of-function analysis demonstrated that Senp7 is required for neuronal differentiation not only in a model cell line, but also in the developing neural tube. Finally, reporter-based analysis of the Senp7 promoter indicated that Senp7 was transiently activated at early stages of neuronal differentiation. Thus, the Sumo protease Senp7 adds to the list of factors involved in vertebrate neurogenesis.

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Metadata

Authors
Juarez-Vicente, F., Luna-Pelaez, N., & Garcia-Dominguez, M.
Venue
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Publisher
Elsevier BV
Published
2016-07
Volume
1863
Issue
7
Pages
1490-1498
ISSN
0167-4889 (ISSN-L)
DOI
10.1016/j.bbamcr.2016.03.028
OpenAlex
W2327684284
Cited by
30
References
0
Citations by year
2026: 3 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 8 · 2021: 5 · 2020: 3 · 2018: 2 · 2017: 3
FWCI
0.85
Type
journal article
Language
en
Open access
Licence
Locations
  • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
  • RISalud Institutional Health Repository of Andalucía (submittedVersion, other-oa)
Funders
  • Ministerio de Economía y Competitividad (BFU2012-37304/BFI)
  • Consejo Superior de Investigaciones Científicas
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
SENP7, SUMO protease, SUMOylation, SUMO deconjugation, neuronal differentiation, neurogenesis, neural tube development, gene expression profiling, promoter activation, brain development
MeSH terms
Animals, Chick Embryo, Endopeptidases, Promoter Regions, Genetic, RNA, Messenger, Time Factors, Transfection, Tretinoin, Signal Transduction, Transcriptional Activation, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Developmental, Gene Expression Profiling, RNA Interference, Cell Line, Tumor, Mice, Neural Tube, Neurogenesis, Sumoylation, Neural Stem Cells

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CoChat. (2026). Citation check: The Sumo protease Senp7 is required for proper neuronal differentiation. https://app.cochat.ai/papers/10.1016/j.bbamcr.2016.03.028
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Juarez-Vicente, F., Luna-Pelaez, N., & Garcia-Dominguez, M. (2016). The Sumo protease Senp7 is required for proper neuronal differentiation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. https://doi.org/10.1016/j.bbamcr.2016.03.028