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NAP1L1 regulates NF-κB signaling pathway acting on anti-apoptotic Mcl-1 gene expression

Tanaka, Toshiaki, Hozumi, Yasukazu, Iino, Mitsuyoshi, Goto, Kaoru·2017·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
DOI 10.1016/j.bbamcr.2017.06.021
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Abstract

Nuclear factor-κB (NF-κB) participates in apoptosis signaling pathway under various pathophysiological conditions. It exerts transcriptional control on the anti-apoptotic Bcl-2 family, such as Bcl-2, Bcl-xl, and Mcl-1, which act on the mitochondrial outer membrane. Previously, we described that NF-κB is negatively regulated by diacylglycerol kinase ζ (DGKζ), an enzyme that phosphorylates a lipid second messenger diacylglycerol. DGKζ downregulation enhances inhibitors of NF-κB α (IκBα) degradation and p65 subunit phosphorylation, leading to enhanced NF-κB transcriptional activity. Transcriptional machinery is tightly regulated by assembly/disassembly and modification of nucleosomal components. Of those, the human NAP1-like protein (NAP1L) family functions in the transport, assembly/disassembly of nucleosome core particles. We previously identified NAP1L1 and NAP1L4 as novel DGKζ binding partners, but the mechanism by which NAP1Ls are involved in NF-κB signaling pathway remains unclear. Here we show that knockdown of NAP1L1 suppresses IκBα degradation and nuclear transport of p65 subunit after treatment with TNF-α stimulation, leading to attenuation of the NF-κB transcriptional activity, whereas NAP1L4 knockdown remains silent. Moreover, ChIP assay reveals that NAP1L1 knockdown attenuates p65 binding to the Mcl-1 promoter after TNF-α stimulation. This attenuation leads to reduced expression of anti-apoptotic Mcl-1, thereby decreasing the mitochondrial membrane potential and sub…

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Metadata

Authors
Tanaka, T., Hozumi, Y., Iino, M., & Goto, K.
Venue
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Publisher
Elsevier BV
Published
2017-10
Volume
1864
Issue
10
Pages
1759-1768
ISSN
0167-4889
DOI
10.1016/j.bbamcr.2017.06.021
Cited by
24
References
3
Language
en
Licence
Funders
Ministry of Education, Culture, Sports, Science and Technology (24390044)

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CoChat. (2026). Citation check: NAP1L1 regulates NF-κB signaling pathway acting on anti-apoptotic Mcl-1 gene expression. https://app.cochat.ai/papers/10.1016/j.bbamcr.2017.06.021
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Tanaka, T., Hozumi, Y., Iino, M., & Goto, K. (2017). NAP1L1 regulates NF-κB signaling pathway acting on anti-apoptotic Mcl-1 gene expression. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. https://doi.org/10.1016/j.bbamcr.2017.06.021