Integrating cell-signalling pathways with NF-κB and IKK function

Signaling to NF-κB

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Activators and target genes of Rel/NF-κB transcription factors

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Activators and Target Genes of Rel/NF-кB Transcription Factors

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Live or let die: the cell's response to p53

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The two NF-κB activation pathways and their role in innate and adaptive immunity

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Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

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TLR signaling

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Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

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Molecular targets of dietary agents for prevention and therapy of cancer

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Role of Transcriptional Activation of IκBα in Mediation of Immunosuppression by Glucocorticoids

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The IKK NF-κB system: a treasure trove for drug development

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Shaping the nuclear action of NF-κB

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Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300

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Ubiquitin signalling in the NF-κB pathway

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A physical and functional map of the human TNF-α/NF-κB signal transduction pathway

Bouwmeester, T., Bauch, A., Ruffner, H., Angrand, P., Bergamini, G., Croughton, K., Cruciat, C., Eberhard, D., Gagneur, J., Ghidelli, S., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1086 · Cited by 1,030 · see citing works

The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination

Kovalenko, A., Chable-Bessia, C., Cantarella, G., Israël, A., Wallach, D., & Courtois, G. (2003) · Nature · doi:10.1038/nature01802 · Cited by 1,018 · see citing works

Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome

Thanos, D., & Maniatis, T. (1995) · Cell · doi:10.1016/0092-8674(95)90136-1 · Cited by 1,014 · see citing works

CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members

Trompouki, E., Hatzivassiliou, E., Tsichritzis, T., Farmer, H., Ashworth, A., & Mosialos, G. (2003) · Nature · doi:10.1038/nature01803 · Cited by 964 · see citing works

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

Brummelkamp, T. R., Nijman, S. M. B., Dirac, A. M. G., & Bernards, R. (2003) · Nature · doi:10.1038/nature01811 · Cited by 947 · see citing works

Nuclear factor-?B: its role in health and disease

Kumar, A., Takada, Y., Boriek, A., & Aggarwal, B. (2004) · Journal of Molecular Medicine · doi:10.1007/s00109-004-0555-y · Cited by 933 · see citing works

The Interplay between the Glucocorticoid Receptor and Nuclear Factor-κB or Activator Protein-1: Molecular Mechanisms for Gene Repression

De Bosscher, K., Vanden Berghe, W., & Haegeman, G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0006 · Cited by 898 · see citing works

IKK/NF- B signaling: balancing life and death - a new approach to cancer therapy

Luo, J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26322 · Cited by 879 · see citing works

IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a

Hu, M. C.-T., Lee, D.-F., Xia, W., Golfman, L. S., Ou-Yang, F., Yang, J.-Y., Zou, Y., Bao, S., Hanada, N., Saso, H., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00302-2 · Cited by 868 · see citing works

Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex

Gao, Z., Hwang, D. H., Bataille, F., Lefevre, M., York, D. A., Quon, M. J., & Ye, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209459200 · Cited by 777 · see citing works

Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38

Madrid, L. V., Mayo, M. W., Reuther, J. Y., & Baldwin, A. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101103200 · Cited by 777 · see citing works

To be, or not to be: NF-κB is the answer – role of Rel/NF-κB in the regulation of apoptosis

Kucharczak, J., Simmons, M. J., Fan, Y., & Gélinas, C. (2003) · Oncogene · doi:10.1038/sj.onc.1207230 · Cited by 761 · see citing works

Role of NF-κB in p53-mediated programmed cell death

Ryan, K. M., Ernst, M. K., Rice, N. R., & Vousden, K. H. (2000) · Nature · doi:10.1038/35009130 · Cited by 735 · see citing works

Glucocorticoid Receptor Recruitment of Histone Deacetylase 2 Inhibits Interleukin-1β-Induced Histone H4 Acetylation on Lysines 8 and 12

Ito, K., Barnes, P. J., & Adcock, I. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6891-6903.2000 · Cited by 723 · see citing works

p38-dependent marking of inflammatory genes for increased NF-κB recruitment

Saccani, S., Pantano, S., & Natoli, G. (2001) · Nature Immunology · doi:10.1038/ni748 · Cited by 694 · see citing works

Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway

Perkins, N. D. (2006) · Oncogene · doi:10.1038/sj.onc.1209937 · Cited by 674 · see citing works

Molecular determinants of crosstalk between nuclear receptors and toll-like receptors

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IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

Lawrence, T., Bébien, M., Liu, G. Y., Nizet, V., & Karin, M. (2005) · Nature · doi:10.1038/nature03491 · Cited by 625 · see citing works

Achieving Stability of Lipopolysaccharide-Induced NF-κB Activation

Covert, M. W., Leung, T., Gaston, J. E., & Baltimore, D. (2005) · Science · doi:10.1126/science.1112304 · Cited by 603 · see citing works

Transcriptional Cross Talk between NF-κB and p53

Webster, G. A., & Perkins, N. D. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3485 · Cited by 598 · see citing works

Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression

Yamamoto, Y., Verma, U. N., Prajapati, S., Kwak, Y.-T., & Gaynor, R. B. (2003) · Nature · doi:10.1038/nature01576 · Cited by 577 · see citing works

A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression

Anest, V., Ostrander, J. H., Cogswell, P. C., Steinbrecher, K. A., Strahl, B. D., & Baldwin, A. S. (2003) · Nature · doi:10.1038/nature01648 · Cited by 522 · see citing works

Molecular Linkage Between the Kinase ATM and NF-κB Signaling in Response to Genotoxic Stimuli

Wu, Z., Shi, Y., Tibbetts, R. S., & Miyamoto, S. (2006) · Science · doi:10.1126/science.1121513 · Cited by 515 · see citing works

MSK2 and MSK1 mediate the mitogen‐ and stress‐induced phosphorylation of histone H3 and HMG‐14

Soloaga, A., Thomson, S., Wiggin, G. R., Rampersaud, N., Dyson, M. H., Hazzalin, C. A., Mahadevan, L. C., & Arthur, J. S. C. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg273 · Cited by 508 · see citing works

Stimulus Specificity of Gene Expression Programs Determined by Temporal Control of IKK Activity

Werner, S. L., Barken, D. M., & Hoffmann, A. (2005) · Science · doi:10.1126/science.1113319 · Cited by 506 · see citing works

Good cop, bad cop: the different faces of NF-κB

Perkins, N. D., & Gilmore, T. D. (2006) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401838 · Cited by 489 · see citing works

Cyld Inhibits Tumor Cell Proliferation by Blocking Bcl-3-Dependent NF-κB Signaling

Massoumi, R., Masoumi, K. C., Hennecke, K., Pfeifer, A., & Fässler, R. (2006) · Cell · doi:10.1016/j.cell.2006.03.041 · Cited by 480 · see citing works

Recruitment of CBP/p300 by the IFNβ Enhanceosome Is Required for Synergistic Activation of Transcription

Merika, M., Williams, A. J., Chen, G., Collins, T., & Thanos, D. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80028-3 · Cited by 435 · see citing works

The IKK/NF-κB activation pathway—a target for prevention and treatment of cancer

Greten, F. R. (2003) · Cancer Letters · doi:10.1016/j.canlet.2003.08.029 · Cited by 410 · see citing works

Update on glucocorticoid action and resistance

Ito, K., Chung, K. F., & Adcock, I. M. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.01.032 · Cited by 401 · see citing works

NF-κB and IKK as therapeutic targets in cancer

Kim, H. J., Hawke, N. A., & Baldwin, A. S. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401877 · Cited by 390 · see citing works

Active Repression of Antiapoptotic Gene Expression by RelA(p65) NF-κB

Campbell, K. J., Rocha, S., & Perkins, N. D. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00131-5 · Cited by 386 · see citing works

β-catenin interacts with and inhibits NF-κB in human colon and breast cancer

Deng, J., Miller, S. A., Wang, H.-Y., Xia, W., Wen, Y., Zhou, B. P., Li, Y., Lin, S., & Hung, M. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00154-x · Cited by 372 · see citing works

Reactive oxygen species mediate crosstalk between NF-κB and JNK

Nakano, H., Nakajima, A., Sakon-Komazawa, S., Piao, J.-H., Xue, X., & Okumura, K. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401830 · Cited by 367 · see citing works

IKKα controls formation of the epidermis independently of NF-κB

Hu, Y., Baud, V., Oga, T., Kim, K. I., Yoshida, K., & Karin, M. (2001) · Nature · doi:10.1038/35070605 · Cited by 358 · see citing works

Enhanceosomes

Merika, M., & Thanos, D. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00180-5 · Cited by 353 · see citing works

IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9

Hoshino, K., Sugiyama, T., Matsumoto, M., Tanaka, T., Saito, M., Hemmi, H., Ohara, O., Akira, S., & Kaisho, T. (2006) · Nature · doi:10.1038/nature04641 · Cited by 352 · see citing works

Genetic analysis of NF‐κB/Rel transcription factors defines functional specificities

Hoffmann, A., Leung, T., & Baltimore, D. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg534 · Cited by 329 · see citing works

Genetic approaches in mice to understand Rel/NF-κB and IκB function: transgenics and knockouts

Gerondakis, S., Grossmann, M., Nakamura, Y., Pohl, T., & Grumont, R. J. (1999) · Oncogene · doi:10.1038/sj.onc.1203236 · Cited by 329 · see citing works

Signals from within: the DNA-damage-induced NF-κB response

Janssens, S., & Tschopp, J. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401843 · Cited by 321 · see citing works

p53 stabilization is decreased upon NFκB activation

Tergaonkar, V., Pando, M. P., Vafa, O., Wahl, G. M., & Verma, I. M. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00068-5 · Cited by 312 · see citing works

Cotranslational Biogenesis of NF-κB p50 by the 26S Proteasome

Li, L., Demartino, G., & Greene, W. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81409-9 · Cited by 312 · see citing works

Nuclear Integration of Glucocorticoid Receptor and Nuclear Factor-κB Signaling by CREB-binding Protein and Steroid Receptor Coactivator-1

Sheppard, K.-A., Phelps, K. M., Williams, A. J., Thanos, D., Glass, C. K., Rosenfeld, M. G., Gerritsen, M. E., & Collins, T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29291 · Cited by 305 · see citing works

Transcriptional regulation of a metastasis suppressor gene by Tip60 and β-catenin complexes

Kim, J. H., Kim, B., Cai, L., Choi, H. J., Ohgi, K. A., Tran, C., Chen, C., Chung, C. H., Huber, O., Rose, D. W., et al. (2005) · Nature · doi:10.1038/nature03452 · Cited by 291 · see citing works

Reversal of intrinsic DNA bends in the IFNβ gene enhancer by transcription factors and the architectural protein HMG I(Y)

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Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

Yamamoto, M., Okamoto, T., Takeda, K., Sato, S., Sanjo, H., Uematsu, S., Saitoh, T., Yamamoto, N., Sakurai, H., Ishii, K. J., et al. (2006) · Nature Immunology · doi:10.1038/ni1367 · Cited by 265 · see citing works

IKK mediates ischemia-induced neuronal death

Herrmann, O., Baumann, B., Lorenzi, R. D., Muhammad, S., Zhang, W., Kleesiek, J., Malfertheiner, M. V., Köhrmann, M., Potrovita, I., Maegele, I., et al. (2005) · Nature Medicine · doi:10.1038/nm1323 · Cited by 259 · see citing works

Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator Activity by IκB Kinase

Wu, R., Qin, J., Hashimoto, Y., Wong, J., Xu, J., Tsai, S. Y., Tsai, M., & O’Malley, B. W. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.10.3549-3561.2002 · Cited by 257 · see citing works

p53 Induces NF-κB Activation by an IκB Kinase-independent Mechanism Involving Phosphorylation of p65 by Ribosomal S6 Kinase 1

Bohuslav, J., Chen, L., Kwon, H., Mu, Y., & Greene, W. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313509200 · Cited by 256 · see citing works

Interactions of NF-κB with chromatin: the art of being at the right place at the right time

Natoli, G., Saccani, S., Bosisio, D., & Marazzi, I. (2005) · Nature Immunology · doi:10.1038/ni1196 · Cited by 250 · see citing works

p53 Represses Cyclin D1 Transcription through Down Regulation of Bcl-3 and Inducing Increased Association of the p52 NF-κB Subunit with Histone Deacetylase 1

Rocha, S., Martin, A. M., Meek, D. W., & Perkins, N. D. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.13.4713-4727.2003 · Cited by 237 · see citing works

The NF-κB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease

Papa, S., Bubici, C., Zazzeroni, F., Pham, C. G., Kuntzen, C., Knabb, J. R., Dean, K., & Franzoso, G. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401865 · Cited by 236 · see citing works

Transient and Selective NF-κB p65 Serine 536 Phosphorylation Induced by T Cell Costimulation Is Mediated by IκB Kinase β and Controls the Kinetics of p65 Nuclear Import

Mattioli, I., Sebald, A., Bucher, C., Charles, R., Nakano, H., Doi, T., Kracht, M., & Schmitz, M. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.10.6336 · Cited by 230 · see citing works

Nuclear receptors versus inflammation: mechanisms of transrepression

Pascual, G., & Glass, C. K. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.08.005 · Cited by 228 · see citing works

Acetylation of Stat1 modulates NF-κB activityPreprint

Krämer, O. H., Baus, D., Knauer, S. K., Stein, S., Jäger, E., Stauber, R. H., Grez, M., Pfitzner, E., & Heinzel, T. (2006) · Genes & Development · doi:10.1101/gad.364306 · Cited by 220 · see citing works

SMRT Derepression by the IκB Kinase α

Hoberg, J. E., Yeung, F., & Mayo, M. W. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.10.010 · Cited by 220 · see citing works

The glucocorticoid receptor blocks P-TEFb recruitment by NFκB to effect promoter-specific transcriptional repressionPreprint

Luecke, H. F., & Yamamoto, K. R. (2005) · Genes & Development · doi:10.1101/gad.1297105 · Cited by 217 · see citing works

Putting the Rap on Akt

Thompson, J. E., & Thompson, C. B. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.01.103 · Cited by 206 · see citing works

Lipopolysaccharide Activation of the TPL-2/MEK/Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Cascade Is Regulated by IκB Kinase-Induced Proteolysis of NF-κB1 p105

Beinke, S., Robinson, M. J., Hugunin, M., & Ley, S. C. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9658-9667.2004 · Cited by 205 · see citing works

A hyper‐dynamic equilibrium between promoter‐bound and nucleoplasmic dimers controls NF‐κB‐dependent gene activity

Bosisio, D., Marazzi, I., Agresti, A., Shimizu, N., Bianchi, M. E., & Natoli, G. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600977 · Cited by 201 · see citing works

Dorsal gradient networks in the Drosophila embryo.

Stathopoulos, A., & Levine, M. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0652 · Cited by 197 · see citing works

Formation of an IKKα-Dependent Transcription Complex Is Required for Estrogen Receptor-Mediated Gene Activation

Park, K.-J., Krishnan, V., O’Malley, B. W., Yamamoto, Y., & Gaynor, R. B. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.006 · Cited by 193 · see citing works

p53- and Mdm2-Independent Repression of NF-κB Transactivation by the ARF Tumor Suppressor

Rocha, S., Campbell, K. J., & Perkins, N. D. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00223-5 · Cited by 189 · see citing works

Activated AKT regulates NF-κB activation, p53 inhibition and cell survival in HTLV-1-transformed cells

Jeong, S., Pise-Masison, C. A., Radonovich, M. F., Park, H. U., & Brady, J. N. (2005) · Oncogene · doi:10.1038/sj.onc.1208825 · Cited by 185 · see citing works

Achieving transcriptional specificity with nf-κb

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The Putative Oncoprotein Bcl-3 Induces Cyclin D1 To Stimulate G1 Transition

Westerheide, S. D., Mayo, M. W., Anest, V., Ostrander, J. H., & Baldwin, A. S. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.24.8428-8436.2001 · Cited by 183 · see citing works

IκB Kinase α-Mediated Derepression of SMRT Potentiates Acetylation of RelA/p65 by p300

Hoberg, J. E., Popko, A. E., Ramsey, C. S., & Mayo, M. W. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.26.2.457-471.2006 · Cited by 181 · see citing works

NF-κB Is Essential for Induction of CYLD, the Negative Regulator of NF-κB

Jono, H., Lim, J. H., Chen, L. F., Xu, H., Trompouki, E., Pan, Z. K., Mosialos, G., & Li, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406638200 · Cited by 180 · see citing works

Dissection of the NF-κB signalling cascade in transgenic and knockout mice

Pasparakis, M., Luedde, T., & Schmidt-Supprian, M. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401870 · Cited by 172 · see citing works

IKKβ and Phosphatidylinositol 3-Kinase/Akt Participate in Non-pathogenic Gram-negative Enteric Bacteria-induced RelA Phosphorylation and NF-κB Activation in Both Primary and Intestinal Epithelial Cell Lines

Haller, D., Russo, M. P., Sartor, R. B., & Jobin, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205737200 · Cited by 165 · see citing works

Tumor Necrosis Factor Alpha-Mediated Reduction of KLF2 Is Due to Inhibition of MEF2 by NF-κB and Histone Deacetylases

Kumar, A., Lin, Z., SenBanerjee, S., & Jain, M. K. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.14.5893-5903.2005 · Cited by 165 · see citing works

Regulation of NF‐κB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor

Rocha, S., Garrett, M. D., Campbell, K. J., Schumm, K., & Perkins, N. D. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600608 · Cited by 161 · see citing works

The IκB Kinase Complex and NF-κB Actas Master Regulators of Lipopolysaccharide-Induced Gene Expressionand Control Subordinate Activation ofAP-1

Krappmann, D., Wegener, E., Sunami, Y., Esen, M., Thiel, A., Mordmüller, B. G., & Scheidereit, C. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.14.6488-6500.2004 · Cited by 151 · see citing works

Regulation of β-Catenin Function by the IκB Kinases

Lamberti, C., Lin, K., Yamamoto, Y., Verma, U. N., Verma, I. M., Byers, S., & Gaynor, R. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104227200 · Cited by 147 · see citing works

IKKα Regulates Mitogenic Signaling through Transcriptional Induction of Cyclin D1 via Tcf

Albanese, C., Wu, K., D’Amico, M., Jarrett, C. R., Joyce, D. A., Hughes, J. R., Hulit, J., Sakamaki, T., Fu, M., Ben‐Ze'ev, A., et al. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.02-06-0101 · Cited by 145 · see citing works

The 20S proteasome processes NF‐κB1 p105 into p50 in a translation‐independent manner

Moorthy, A. K., Savinova, O. V., Ho, J. Q., Wang, V. Y., Vu, D., & Ghosh, G. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601081 · Cited by 140 · see citing works

Stabilization of p53 Is a Novel Mechanism for Proapoptotic Function of NF-κB

Fujioka, S., Schmidt, C., Sclabas, G. M., Li, Z., Pelicano, H., Peng, B., Yao, A., Niu, J., Zhang, W., Evans, D. B., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313435200 · Cited by 139 · see citing works

Stat3 activation of NF-κB p100 processing involves CBP/p300-mediated acetylation

Nadiminty, N., Lou, W., Lee, S. O., Lin, X., Trump, D. L., & Gao, A. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509808103 · Cited by 138 · see citing works

Essential Role for IκB Kinase β in Remodeling Carma1-Bcl10-Malt1 Complexes upon T Cell Activation

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