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Cited by 171Ion channel regulation and functionIon Transport and Channel RegulationIon Channels and Receptors

Involvement of a novel fast inward sodium current in the invasion capacity of a breast cancer cell line

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Roger, Sébastien, Besson, Pierre, Le Guennec, Jean-Yves·2003·Biochimica et Biophysica Acta (BBA) - Biomembranes
DOI 10.1016/j.bbamem.2003.07.001
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Abstract

This work reports the finding of a unique fast inward sodium current (I(Na)) in MDA-MB-231 cells which is missing in MDA-MB-468 cells and in MCF-7 cells. This current is high-voltage-activated and displays a window current at the membrane potential of MDA-MB-231 cells. This current is blocked by high concentrations of tetrodotoxin (TTX). In MDA-MB-231 cells, which are the most invasive cells among the three cell lines tested, proliferation and migration were not sensitive to TTX while invasion was reduced by approximately 30%. These experiments suggest that I(Na) is involved in the invasion process, probably through its participation to the regulation of the intracellular sodium homeostasis.

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  • Functional VGSCs have been found in a number of cancer types, and suppressing VGSCs with siRNA or pharmacological agents inhibits migration and invasion.

    “For example, functional VGSCs have been found in a number of cancer types [reviewed in Brackenbury (2012)], and suppressing VGSCs with siRNA or pharmacological agents inhibits migration and invasion (Roger et al., 2003; Fraser et al., 2005; Brackenbury et al., 2007; House et al., 2010; Yang et al., 2012).”

    From Membrane potential and cancer progression (2013) · cites this paper as Roger et al., 2003

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Authors
Roger, S., Besson, P., & Le Guennec, J.-Y.
Affiliations
Inserm (FR)
ORCID
Venue
Biochimica et Biophysica Acta (BBA) - Biomembranes
Publisher
Elsevier BV
Published
2003-10
Volume
1616
Issue
2
Pages
107-111
ISSN
0005-2736 (ISSN-L)
DOI
10.1016/j.bbamem.2003.07.001
OpenAlex
W1988505019
Cited by
171
References
0
Citations by year
2026: 1 · 2025: 14 · 2024: 7 · 2023: 11 · 2022: 13 · 2021: 7 · 2020: 12 · 2019: 12 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 13 · 2014: 8 · 2013: 7 · 2012: 10
FWCI
1.61
Type
journal article
Language
en
Open access
Licence
Locations
  • Biochimica et Biophysica Acta (BBA) - Biomembranes (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
breast cancer cell invasion, MDA-MB-231 cells, tetrodotoxin, window current, cell migration, cell proliferation, voltage-gated sodium channels
MeSH terms
Breast Neoplasms, Female, Humans, Neoplasm Invasiveness, Sodium, Tetrodotoxin, Tumor Cells, Cultured, Sodium Channels

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