Ion channel expression as promising cancer biomarker

Cancer statistics, 2014

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Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

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Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012

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The Consensus Coding Sequences of Human Breast and Colorectal Cancers

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Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

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Bile salt transporters: molecular characterization, function, and regulation

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Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins.

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The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME–Tox)

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Bile Acid Transporters: Structure, Function, Regulation and Pathophysiological Implications

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Voltage-Gated Sodium Channel Expression and Potentiation of Human Breast Cancer Metastasis

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Pancreatic Cancer hENT1 Expression and Survival From Gemcitabine in Patients From the ESPAC-3 Trial

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Rab25 and CLIC3 Collaborate to Promote Integrin Recycling from Late Endosomes/Lysosomes and Drive Cancer Progression

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Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling

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Calcium-Selective Ion Channel, CaT1, Is Apically Localized in Gastrointestinal Tract Epithelia and Is Aberrantly Expressed in Human Malignancies

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Immunohistochemical Profile of the Sodium/Iodide Symporter in Thyroid, Breast, and Other Carcinomas Using High Density Tissue Microarrays and Conventional Sections

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Targeting Ion Channels in Cancer: A Novel Frontier in Antineoplastic Therapy

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Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis

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Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene

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Overexpression of Eag1 potassium channels in clinical tumours

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Expression of the Ca2+-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression

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Voltage-Gated Na+ Channel SCN5A Is a Key Regulator of a Gene Transcriptional Network That Controls Colon Cancer Invasion

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High Expression of Transient Receptor Potential Channels in Human Breast Cancer Epithelial Cells and Tissues: Correlation with Pathological Parameters

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The SERCA pump as a therapeutic target: Making a “smart bomb” for prostate cancer

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Evidence that TRPM7 is required for breast cancer cell proliferation

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An Unexpected Role for Ion Channels in Brain Tumor Metastasis

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Expression of Nicotinic Acetylcholine Receptor Subunit Genes in Non–Small-Cell Lung Cancer Reveals Differences between Smokers and Nonsmokers

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Voltage-gated Sodium Channel Activity Promotes Cysteine Cathepsin-dependent Invasiveness and Colony Growth of Human Cancer Cells

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herg1 Gene and HERG1 Protein Are Overexpressed in Colorectal Cancers and Regulate Cell Invasion of Tumor Cells

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TRPM7 Is Required for Breast Tumor Cell Metastasis

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ORAI1-Mediated Calcium Influx in Lactation and in Breast Cancer

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Down‐regulation of Orai3 arrests cell‐cycle progression and induces apoptosis in breast cancer cells but not in normal breast epithelial cells

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Blockage of Intermediate-Conductance Ca2+-Activated K+ Channels Inhibit Human Pancreatic Cancer Cell Growth in Vitro

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The role of TRPV6 in breast carcinogenesis

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Involvement of aquaporins in colorectal carcinogenesis

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Orai3 is an estrogen receptor α‐regulated Ca 2+ channel that promotes tumorigenesis

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Monocarboxylate transporter 1 is up‐regulated in basal‐like breast carcinoma

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TRPV4 mediates tumor-derived endothelial cell migration via arachidonic acid-activated actin remodeling

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Prognostic significance of L-type amino-acid transporter 1 expression in surgically resected pancreatic cancer

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The neonatal splice variant of Nav1.5 potentiates in vitro invasive behaviour of MDA-MB-231 human breast cancer cells

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Involvement of a novel fast inward sodium current in the invasion capacity of a breast cancer cell line

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Aquaporin-5: A Marker Protein for Proliferation and Migration of Human Breast Cancer Cells

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Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype

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Vanilloids in pancreatic cancer: potential for chemotherapy and pain management

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Calcium signaling and T-type calcium channels in cancer cell cycling

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Regulation of the Na+/H+ Exchanger (NHE1) in Breast Cancer Metastasis

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A potential novel marker for human prostate cancer: voltage-gated sodium channel expression in vivo

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Expression of Voltage-Gated Potassium Channels in Human and Mouse Colonic Carcinoma

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Role of Human Aquaporin 5 In Colorectal Carcinogenesis

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Transient receptor potential melastatin‐related 7 channel is overexpressed in human pancreatic ductal adenocarcinomas and regulates human pancreatic cancer cell migration

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Calcium influx pathways in breast cancer: opportunities for pharmacological intervention

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Potent inhibition by ropivacaine of metastatic colon cancer SW620 cell invasion and NaV1.5 channel function

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Intermediate-conductance Ca2+-activated K+ channels (IKCa1) regulate human prostate cancer cell proliferation through a close control of calcium entry

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KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer

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Calcium Channel TRPV6 as a Potential Therapeutic Target in Estrogen Receptor–Negative Breast Cancer

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PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer

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Role of KCNMA1gene in breast cancer invasion and metastasis to brain

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Overexpression of Cellular Iron Import Proteins Is Associated with Malignant Progression of Esophageal Adenocarcinoma

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Orai1 and STIM1 mediate SOCE and contribute to apoptotic resistance of pancreatic adenocarcinoma

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K+ Channel Expression in Human Breast Cancer Cells: Involvement in Cell Cycle Regulation and Carcinogenesis

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Ca2+-independent Phospholipase A2-dependent Gating of TRPM8 by Lysophospholipids

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Voltage-gated Na+ channels: multiplicity of expression, plasticity, functional implications and pathophysiological aspects

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Clinicopathological and Biological Significance of Human Voltage-gated Proton Channel Hv1 Protein Overexpression in Breast Cancer

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Abnormal expression, localization and interaction of canonical transient receptor potential ion channels in human breast cancer cell lines and tissues: a potential target for breast cancer diagnosis and therapy

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Overexpression of CLIC1 in human gastric carcinoma and its clinicopathological significance

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Critical role of aquaporin 3 on growth of human esophageal and oral squamous cell carcinoma

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Expression profiling of ion channel genes predicts clinical outcome in breast cancer

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Differences in Transcript Levels of ABC Transporters Between Pancreatic Adenocarcinoma and Nonneoplastic Tissues

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Voltage‐gated sodium channel polymorphisms play a pivotal role in the development of oxaliplatin‐induced peripheral neurotoxicity: Results from a prospective multicenter study

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Role of KCNMA1 in Breast Cancer

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Systematic review of immunohistochemical biomarkers to identify prognostic subgroups of patients with pancreatic cancer

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The mRNA of L-Type Calcium Channel Elevated in Colon Cancer

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Expression of L-type amino acid transporter 1 (LAT1) in esophageal carcinoma

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TREK-1 Is a Novel Molecular Target in Prostate Cancer

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Estrogen regulation of TRPM8 expression in breast cancer cells

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Differential expression of Aquaporin 8 in human colonic epithelial cells and colorectal tumors

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Voltage‐gated K channels support proliferation of colonic carcinoma cells

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Functional expression of the voltage-gated sodium channel, Nav1.7, underlies epidermal growth factor-mediated invasion in human [R1.S1] non-small cell lung cancer cells

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The Transition from Proliferation to Differentiation in Colorectal Cancer Is Regulated by the Calcium Activated Chloride Channel A1

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Expressions of putative cancer stem cell markers ABCB1, ABCG2, and CD133 are correlated with the degree of differentiation of gastric cancer

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A novel polyclonal antibody specific for the Nav1.5 voltage-gated Na+ channel ‘neonatal’ splice form

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The prognostic value of CD147/EMMPRIN is associated with monocarboxylate transporter 1 co-expression in gastric cancer

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Expression of the Ca 2+ -Activated Chloride Channel Genes CLCA1 and CLCA2 Is Downregulated in Human Colorectal Cancer

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Methylation of the Calcium Channel-Related Gene, CACNA2D3, Is Frequent and a Poor Prognostic Factor in Gastric Cancer

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Article on Sodium Channels and Breast Cancer Metastasis

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