Lipids on the move: Simulations of membrane pores, domains, stalks and curves
Open accessAbstract
In this review we describe the state-of-the-art of computer simulation studies of lipid membranes. We focus on collective lipid-lipid and lipid-protein interactions that trigger deformations of the natural lamellar membrane state, showing that many important biological processes including self-aggregation of membrane components into domains, the formation of non-lamellar phases, and membrane poration and curving, are now amenable to detailed simulation studies.
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Molecular dynamics studies provide detailed information on bilayer entry and exit of individual lipid molecules, including inference on thermodynamic and kinetic parameters.
“Of particular relevance to GARD are molecular dynamics studies that provide detailed information on bilayer entry and exit of individual lipid molecules, including inference on thermodynamic and kinetic parameters [140,255,256].”
From Systems protobiology: origin of life in lipid catalytic networks (2018) · cites this paper as [256]
Cites
Molecular anatomy of a trafficking organelle
Takamori, S., Holt, M., Stenius, K., Lemke, E. A., Grønborg, M., Riedel, D., Urlaub, H., Schenck, S., Brügger, B., Ringler, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.10.030 · Cited by 2,373 · see citing works
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Systems protobiology: origin of life in lipid catalytic networks
Lancet, D., Zidovetzki, R., & Markovitch, O. (2018) · Journal of The Royal Society Interface · doi:10.1098/rsif.2018.0159 · Cited by 182 · see citing works
MagiC: software package for multiscale modeling
Mirzoev, A., & Lyubartsev, A. P. (2013) · Journal of Chemical Theory and Computation · doi:10.1021/ct301019v · Cited by 62 · see citing works
- Authors
- Marrink, S. J., de Vries, A. H., & Tieleman, D. P.
- Affiliations
- University of Groningen (NL)
- University of Calgary (CA)
- Corresponding author
- Marrink, Siewert J.
- Venue
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 1788
- Issue
- 1
- Pages
- 149-168
- ISSN
- 0005-2736 (ISSN-L)
- OpenAlex
- W2061417691
- Cited by
- 440
- References
- 1
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 10 · 2023: 13 · 2022: 11 · 2021: 16 · 2020: 15 · 2019: 21 · 2018: 28 · 2017: 22 · 2016: 29 · 2015: 28 · 2014: 45 · 2013: 37 · 2012: 45
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Biomembranes (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Funders
- Fondation pour la Recherche Médicale
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Keywords
- lipid membranes, membrane curvature, membrane poration, lipid domains, protein-lipid interactions, lipid-lipid interactions, membrane deformation
- MeSH terms
- Animals, Computer Simulation, Energy Metabolism, Humans, Membrane Fluidity, Membrane Lipids, Models, Biological, Models, Molecular, Membrane Microdomains, Cellular Structures
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