Molecular anatomy of a trafficking organelle
Open accessAbstract
Membrane traffic in eukaryotic cells involves transport of vesicles that bud from a donor compartment and fuse with an acceptor compartment. Common principles of budding and fusion have emerged, and many of the proteins involved in these events are now known. However, a detailed picture of an entire trafficking organelle is not yet available. Using synaptic vesicles as a model, we have now determined the protein and lipid composition; measured vesicle size, density, and mass; calculated the average protein and lipid mass per vesicle; and determined the copy number of more than a dozen major constituents. A model has been constructed that integrates all quantitative data and includes structural models of abundant proteins. Synaptic vesicles are dominated by proteins, possess a surprising diversity of trafficking proteins, and, with the exception of the V-ATPase that is present in only one to two copies, contain numerous copies of proteins essential for membrane traffic and neurotransmitter uptake.
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Competition for Rab6A on the vesicle will be high as the absolute number of Rab GTPases on an individual transport vesicle is likely to be small (~10 per vesicle) and many effectors, including two domains of KIF1C, will be vying to bind to Rabs.
“Competition for Rab6A on the vesicle will be high as the absolute number of Rab GTPases on an individual transport vesicle is likely to be small (∼10 per vesicle; Takamori et al., 2006) and many effectors, including two domains of KIF1C, will be vying to bind to Rabs.”
From The Rab6-regulated KIF1C kinesin motor domain contributes to Golgi organization (2015) · cites this paper as Takamori et al., 2006
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Experimental — accuracy not yet measuredDendritic membranes on which these receptors reside are highly crowded structures.
“The dendritic membranes on which these receptors reside are, similar to other biological membranes, highly crowded structures (Takamori et al., 2006).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Takamori et al., 2006
The Summary (p. 1) identifies synaptic vesicles as the paper’s model. Implications for Membrane Structure (p. 13) reports that their membranes have unexpectedly high protein density and describes the proteins as crowded. The paper does not establish that the dendritic membranes bearing the cited receptors are highly crowded. (LLM, conf=0.86)
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- Authors
- Takamori, S., Holt, M., Stenius, K., Lemke, E. A., Grønborg, M., Riedel, D., Urlaub, H., Schenck, S., Brügger, B., Ringler, P., Müller, S. A., Rammner, B., Gräter, F., Hub, J. S., De Groot, B. L., Mieskes, G., Moriyama, Y., Klingauf, J., Grubmüller, H., Heuser, J., Wieland, F., & Jahn, R.
- Affiliations
- Max Planck Institute for Biophysical Chemistry (DE)
- Yale University (US)
- Heidelberg University (DE)
- University of Basel (CH)
- Okayama University (JP)
- Washington University in St. Louis (US)
- Corresponding author
- Jahn, Reinhard
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2006-11
- Volume
- 127
- Issue
- 4
- Pages
- 831-846
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2144447780
- Cited by
- 2,373
- References
- 65
- Citations by year
- 2026: 65 · 2025: 94 · 2024: 124 · 2023: 103 · 2022: 136 · 2021: 131 · 2020: 132 · 2019: 106 · 2018: 134 · 2017: 126 · 2016: 121 · 2015: 127 · 2014: 131 · 2013: 119 · 2012: 124
- FWCI
- 47.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion, other-oa)
- Max Planck Institute for Plasma Physics (submittedVersion)
- GRO (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Funders
- University of Cambridge
- Deutsche Forschungsgemeinschaft
- Forsknings- og Innovationsstyrelsen
- Leibniz-Gemeinschaft
- Japan Society for the Promotion of Science
- Danish Agency for Science and Higher Education
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- synaptic vesicles, membrane trafficking, vesicle budding, vesicle fusion, protein composition, lipid composition, protein copy number, V-ATPase, neurotransmitter uptake
- MeSH terms
- Animals, Lipids, Models, Molecular, Proteins, Spectrometry, Fluorescence, Synaptic Vesicles, Protein Transport, Rats
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