Effects of azole treatments on the physical properties of Candida albicans plasma membrane: A spin probe EPR study
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EPR spectroscopy was applied to investigate the effects of the treatment of Candida albicans cells with fluconazole (FLC) and two newly synthesized azoles (CPA18 and CPA109), in a concentration not altering yeast morphology, on the lipid organization and dynamics of the plasma membrane. Measurements were performed in the temperature range between 0°C and 40°C using 5-doxyl- (5-DSA) and 16-doxyl- (16-DSA) stearic acids as spin probes. 5-DSA spectra were typical of lipids in a highly ordered environment, whereas 16-DSA spectra consisted of two comparable components, one corresponding to a fluid bulk lipid domain in the membrane and the other to highly ordered and motionally restricted lipids interacting with integral membrane proteins. A line shape analysis allowed the relative proportion and the orientational order and dynamic parameters of the spin probes in the different environments to be determined. Smaller order parameters, corresponding to a looser lipid packing, were found for the treated samples with respect to the control one in the region close to the membrane surface probed by 5-DSA. On the other hand, data on 16-DSA indicated that azole treatments hamper the formation of ordered lipid domains hosting integral proteins and/or lead to a decrease in integral protein content in the membrane. The observed effects are mainly ascribable to the inhibition of ergosterol biosynthesis by the antifungal agents, although a direct interaction of the CPA compounds with the membrane bilayer in the region close to the lipid polar head groups cannot be excluded.
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In a spin probe electron paramagnetic resonance study, azole treatment disrupted the formation of the ordered lipid bilayer and/or decreased the content of integral membrane proteins.
“In a spin probe electron paramagnetic resonance (EPR) study, Sgherri et al. detected that azole treatment disrupted the formation of the ordered lipid bilayer and/or decreased the content of integral membrane proteins.”
From The synthesis, regulation, and functions of sterols in<i>Candida albicans</i>: Well-known but still lots to learn (2016) · cites this paper as [18]
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- Authors
- Sgherri, C., Porta, A., Castellano, S., Pinzino, C., Quartacci, M. F., & Calucci, L.
- Affiliations
- University of Pisa (IT)
- University of Salerno (IT)
- Institute for the Chemistry of OrganoMetallic Compounds (IT)
- Corresponding author
- Calucci, Lucia
- ORCID
- Venue
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 1838
- Issue
- 1
- Pages
- 465-473
- ISSN
- 0005-2736 (ISSN-L)
- OpenAlex
- W2077218057
- Cited by
- 16
- References
- 79
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 1
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Biomembranes (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Funders
- Ministero dell'Università e della Ricerca
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electron Spin Resonance Studies
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- Candida albicans, plasma membrane, azole antifungals, fluconazole, spin probes, 5-doxylstearic acid, lipid order parameter, lipid dynamics, ordered lipid domains, integral membrane proteins, ergosterol biosynthesis inhibition, membrane lipid packing
- MeSH terms
- Antifungal Agents, Azoles, Candida albicans, Cell Fractionation, Cell Membrane, Cyclic N-Oxides, Electron Spin Resonance Spectroscopy, Membrane Fluidity, Membrane Lipids, Membrane Proteins, Spin Labels, Temperature, Fluconazole
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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