Ultraviolet radiation-induced apoptosis in keratinocytes: On the role of cytosolic factors
Abstract
Epidemiological and experimental evidences have established solar ultraviolet (UV) radiation as the leading cause of skin cancers. Specifically, the frequency of non-melanoma skin cancer, one of the malignancies with the most rapidly increasing incidence, is directly related to the total exposure to solar UV light. As part of a general effort to elucidate the components of cellular signal transduction pathways, the mechanisms of cellular responses to UV radiation have received considerable attention over the last few years. These efforts were driven mainly by the conviction that understanding how normal cells respond to extracellular stimuli such as exposure to UV radiation will undoubtedly help in deciphering what goes wrong in a variety of clinical disorders including skin cancers and will assist in the development of novel therapeutic strategies. Studies over the last decade have established that UV radiation induces a bewildering array of signal transduction pathways, some of which could lead to apoptotic cell death. UV-induced cell death by apoptosis is considered to be a natural protective mechanism that removes damaged keratinocytes and circumvents the risk of malignant transformation. In this review, we summarize some of the most important findings regarding the response and role of mitogen-activated protein kinases in UVA and UVB radiation-induced signaling to apoptosis in keratinocytes. We will also briefly discuss what is known about the role of the BCL-2 family of…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
p53 mediates mitochondria-dependent apoptosis through direct interaction with the mitochondrion itself and/or with members of the BCL-2 family of apoptosis-regulating proteins.
“Current understanding holds that p53 mediates mitochondria-dependent apoptosis through direct interaction with the mitochondrion itself and/or with members of the BCL-2 family of apoptosis-regulating proteins [23].”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [23]
Cites
Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis
Chipuk, J. E., Kuwana, T., Bouchier-Hayes, L., Droin, N. M., Newmeyer, D. D., Schuler, M., & Green, D. R. (2004) · Science · doi:10.1126/science.1092734 · Cited by 2,066 · see citing works
BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.
Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M., & Korsmeyer, S. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.6961 · Cited by 1,252 · see citing works
Changes in biologically active ultraviolet radiation reaching the Earth's surface
Madronich, S., McKenzie, R. L., Björn, L. O., & Caldwell, M. M. (1998) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(98)00182-1 · Cited by 1,086 · see citing works
Marsden, V. S., O'Connor, L., O'Reilly, L. A., Silke, J., Metcalf, D., Ekert, P. G., Huang, D. C. S., Cecconi, F., Kuida, K., Tomaselli, K. J., et al. (2002) · Nature · doi:10.1038/nature01101 · Cited by 578 · see citing works
Boya, P., Gonzalez-Polo, R.-A., Poncet, D., Andreau, K., Vieira, H. L., Roumier, T., Perfettini, J.-L., & Kroemer, G. (2003) · Oncogene · doi:10.1038/sj.onc.1206622 · Cited by 385 · see citing works
UVB-induced activation and internalization of keratinocyte growth factor receptor
Marchese, C., Maresca, V., Cardinali, G., Belleudi, F., Ceccarelli, S., Bellocci, M., Frati, L., Torrisi, M. R., & Picardo, M. (2003) · Oncogene · doi:10.1038/sj.onc.1206301 · Cited by 61 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Kregel, K. C., & Zhang, H. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00327.2006 · Cited by 883 · see citing works
Environmental toxicity, oxidative stress and apoptosis: Ménage à Trois
Franco, R., Sánchez-Olea, R., Reyes-Reyes, E. M., & Panayiotidis, M. I. (2009) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2008.11.012 · Cited by 541 · see citing works
Lee, C.-H., Wu, S.-B., Hong, C.-H., Yu, H.-S., & Wei, Y.-H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14036414 · Cited by 271 · see citing works
Cutaneous responses to environmental stressors
Valacchi, G., Sticozzi, C., Pecorelli, A., Cervellati, F., Cervellati, C., & Maioli, E. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06724.x · Cited by 243 · see citing works
Nanocosmetics and Nanomedicines
(2011) · doi:10.1007/978-3-642-19792-5 · Cited by 116 · see citing works
Cell type and DNA damage specific response of human skin cells to environmental agents
D’Errico, M., Lemma, T., Calcagnile, A., Santis, L. P. D., & Dogliotti, E. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.06.009 · Cited by 98 · see citing works
Zbytek, B., Wortsman, J., & Slominski, A. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0116 · Cited by 60 · see citing works
Nys, K., Maes, H., Andrei, G., Snoeck, R., Garmyn, M., & Agostinis, P. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.12.017 · Cited by 22 · see citing works
Self-citationFull-component extract of <i>Crithmum maritimum</i> and its effect on epidermal regeneration
Huang, H., Qian, J., Zeng, L., Zhang, J., Peng, X., Tang, X., Tang, Y., Fu, M., Liu, Q., Song, F., et al. (2025) · RSC Advances · doi:10.1039/d4ra04301d · Cited by 4 · see citing works
- Authors
- Assefa, Z., Van Laethem, A., Garmyn, M., & Agostinis, P.
- Affiliations
- KU Leuven (BE)
- Corresponding author
- Assefa, Zerihun
- Venue
- Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Publisher
- Elsevier BV
- Published
- 2005-07
- Volume
- 1755
- Issue
- 2
- Pages
- 90-106
- ISSN
- 0304-419X (ISSN-L)
- OpenAlex
- W2147290034
- Cited by
- 212
- References
- 6
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 11 · 2020: 7 · 2019: 4 · 2018: 17 · 2017: 10 · 2016: 11 · 2015: 17 · 2014: 6 · 2013: 11 · 2012: 19
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Reviews on Cancer (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion)
- Funders
- Australian Government
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- ultraviolet radiation, apoptosis, keratinocytes, non-melanoma skin cancer, mitogen-activated protein kinase, UVA, UV-B radiation, Bcl-2 family proteins, lysosomal proteases, signal transduction, skin cancer prevention
- MeSH terms
- Animals, Cell Survival, Cytosol, Humans, Ultraviolet Rays, Keratinocytes, Apoptosis, Extracellular Signal-Regulated MAP Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
