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Depressive symptoms enhance stress-induced inflammatory responses.
Open accessAbstract
Depression is a risk factor for morbidity and mortality, and immune dysregulation may be partially responsible for this link. Proinflammatory cytokines such as interleukin 6 (IL-6) are reliable predictors of quality of life, morbidity, and many causes of mortality. The current study evaluated relationships between depressive symptoms, as assessed by the CES-D, and stress-induced inflammation. The participants, 138 healthy adults, were evaluated at rest, and after a standardized laboratory speech and mental arithmetic stressor. Compared with individuals with fewer depressive symptoms, those with more depressive symptoms produced more IL-6 in response to the stressor, as well as significantly higher levels of IL-6 both 45 min and 2 h after the stressor. These findings add to our emerging understanding of the complex interactions among stress, depression, and immune dysregulation, and provide one potential pathway to explain relationships between depressive symptoms and disease.
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“Individuals with diagnosed depression have demonstrated stronger increases in proinflammatory cytokines in response to laboratory stress than non-depressed individuals (Weinstein et al., 2010; Fagundes et al., 2013)”
From The interplay between stress, inflammation, and emotional attention: relevance for depression (2019) · cites this paper as Fagundes et al., 2013
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Metadata
- Authors
- Fagundes, C. P., Glaser, R., Hwang, B. S., Malarkey, W. B., & Kiecolt-Glaser, J. K.
- Affiliations
- The Ohio State University Wexner Medical Center (US)
- The Ohio State University (US)
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 31
- Pages
- 172-176
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC3518610
- OpenAlex
- W2145636091
- Cited by
- 151
- References
- 49
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 3 · 2023: 10 · 2022: 13 · 2021: 12 · 2020: 7 · 2019: 14 · 2018: 14 · 2017: 16 · 2016: 9 · 2015: 8 · 2014: 19 · 2013: 11
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG029562)
- National Cancer Institute (CA016058, CA126857, R01CA126857, CA131029, R01CA131029, P30CA016058)
- National Institute of Dental and Craniofacial Research (DE-014320, T32DE014320)
- National Center for Research Resources (UL1RR025755)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- depressive symptoms, stress-induced inflammation, interleukin-6, inflammatory cytokines, immune dysregulation, psychological stress, speech stressor, mental arithmetic stressor, CES-D
- MeSH terms
- Adult, Depression, Female, Humans, Inflammation, Male, Middle Aged, Stress, Physiological, Stress, Psychological, Interleukin-6
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