Cited by 151Tryptophan and brain disordersStress Responses and CortisolVagus Nerve Stimulation Research

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Depressive symptoms enhance stress-induced inflammatory responses.

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Fagundes, Christopher P., Glaser, Ronald, Hwang, Beom Seuk, Malarkey, William B., Kiecolt-Glaser, Janice K.·2013·Brain, Behavior, and Immunity

DOI 10.1016/j.bbi.2012.05.006PMC PMC3518610

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Abstract

Depression is a risk factor for morbidity and mortality, and immune dysregulation may be partially responsible for this link. Proinflammatory cytokines such as interleukin 6 (IL-6) are reliable predictors of quality of life, morbidity, and many causes of mortality. The current study evaluated relationships between depressive symptoms, as assessed by the CES-D, and stress-induced inflammation. The participants, 138 healthy adults, were evaluated at rest, and after a standardized laboratory speech and mental arithmetic stressor. Compared with individuals with fewer depressive symptoms, those with more depressive symptoms produced more IL-6 in response to the stressor, as well as significantly higher levels of IL-6 both 45 min and 2 h after the stressor. These findings add to our emerging understanding of the complex interactions among stress, depression, and immune dysregulation, and provide one potential pathway to explain relationships between depressive symptoms and disease.

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Authors: Fagundes, C. P., Glaser, R., Hwang, B. S., Malarkey, W. B., & Kiecolt-Glaser, J. K.
Affiliations: The Ohio State University Wexner Medical Center (US)
The Ohio State University (US)
ORCID: Fagundes, Christopher P.
Hwang, Beom Seuk
Malarkey, William B.
Venue: Brain, Behavior, and Immunity
Publisher: Elsevier BV
Published: 2013-07
Volume: 31
Pages: 172-176
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2012.05.006
PMC: PMC3518610
OpenAlex: W2145636091
Cited by: 151
References: 49
Citations by year: 2026: 6 · 2025: 6 · 2024: 3 · 2023: 10 · 2022: 13 · 2021: 12 · 2020: 7 · 2019: 14 · 2018: 14 · 2017: 16 · 2016: 9 · 2015: 8 · 2014: 19 · 2013: 11
FWCI: 3.94
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG029562)
National Cancer Institute (CA016058, CA126857, R01CA126857, CA131029, R01CA131029, P30CA016058)
National Institute of Dental and Craniofacial Research (DE-014320, T32DE014320)
National Center for Research Resources (UL1RR025755)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords: depressive symptoms, stress-induced inflammation, interleukin-6, inflammatory cytokines, immune dysregulation, psychological stress, speech stressor, mental arithmetic stressor, CES-D
MeSH terms: Adult, Depression, Female, Humans, Inflammation, Male, Middle Aged, Stress, Physiological, Stress, Psychological, Interleukin-6

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Depressive symptoms enhance stress-induced inflammatory responses.

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