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Adoptive Transfer of Umbilical Cord Blood-Derived Regulatory T Cells and Early Viral Reactivation
Open accessAbstract
We previously reported that the infusion of ex vivo expanded umbilical cord blood (UCB)-derived natural regulatory T cells (nTregs) infused immediately after UCB transplantation was associated with a reduced incidence of acute graft-versus-host disease (GVHD) relative to historical control subjects [1]. We did not observe an increased incidence of opportunistic infections or relapse, suggesting the transient nature of nTreg provided sufficient immune suppression to control GVHD without long-term deleterious effects.
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The number of cells needed for infusion of polyclonal Tregs is quite large, and the risk of nonspecific immunosuppression should be considered.
“However, studies show the number of cells needed for infusion of polyclonal Tregs is quite large, and the risk of nonspecific immunosuppression should be considered.85”
From Modulating immune responses to AAV by expanded polyclonal T-regs and capsid specific chimeric antigen receptor T-regulatory cells (2021) · cites this paper as [85]
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References 5 · Cited by 96
Metadata
- Authors
- Brunstein, C. G., Blazar, B. R., Miller, J. S., Cao, Q., Hippen, K. L., McKenna, D. H., Curtsinger, J., McGlave, P. B., & Wagner, J. E.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Brunstein, Claudio G.
- ORCID
- Venue
- Biology of Blood and Marrow Transplantation
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 19
- Issue
- 8
- Pages
- 1271-1273
- ISSN
- 1083-8791 (ISSN-L)
- PMC
- PMC3870093
- OpenAlex
- W2103020736
- Cited by
- 96
- References
- 5
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 12 · 2020: 11 · 2019: 9 · 2018: 12 · 2017: 14 · 2016: 10 · 2015: 10 · 2014: 3 · 2013: 1
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Transplantation and Cellular Therapy (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P01 CA65493)
- Leukemia and Lymphoma Society Scholar in Clinical Research Award
- Children's Cancer Research Fund (R01 CA105216)
- National Heart, Lung and Blood Institute (N01 HB037164, HHSN268201000008C)
- Leukemia and Lymphoma Translational Research (R6029-07)
- National Marrow Donor Program (13396 AM#2)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
- Keywords
- cord blood transplantation, regulatory T cells, adoptive cell transfer, natural regulatory T cells, viral reactivation, acute graft-versus-host disease, ex vivo Treg expansion, opportunistic infections, relapse
- MeSH terms
- Fetal Blood, Graft vs Host Disease, Humans, Virus Activation, Immunotherapy, Adoptive, T-Lymphocytes, Regulatory
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