Blazar, Bruce R.

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine

HIV Research and TreatmentHIV-related health complications and treatments

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Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

Sakuishi, K., Apetoh, L., Sullivan, J. M., Blazar, B. R., Kuchroo, V. K., & Anderson, A. C. (2010) · Journal of Experimental Medicine

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

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Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

Kamphorst, A. O., Wieland, A., Nasti, T., Yang, S., Zhang, R., Barber, D. L., Konieczny, B. T., Daugherty, C. Z., Koenig, L., Yu, K., et al. (2017) · Science

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

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Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

Wang, Z., Aguilar, E. G., Luna, J. I., Dunai, C., Khuat, L. T., Le, C. T., Mirsoian, A., Minnar, C. M., Stoffel, K. M., Sturgill, I. R., et al. (2019) · Nature Medicine

Cancer Immunotherapy and BiomarkersImmune cells in cancer

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Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

Zhou, Q., Munger, M. E., Veenstra, R. G., Weigel, B. J., Hirashima, M., Munn, D. H., Murphy, W. J., Azuma, M., Anderson, A. C., Kuchroo, V. K., et al. (2011) · Blood

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

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Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation

Jenq, R. R., Ubeda, C., Taur, Y., Menezes, C. C., Khanin, R., Dudakov, J. A., Liu, C., West, M. L., Singer, N. V., Equinda, M. J., et al. (2012) · Journal of Experimental Medicine

Gut microbiota and healthHematopoietic Stem Cell Transplantation

Cited by 626

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

Paczulla, A. M., Rothfelder, K., Raffel, S., Konantz, M., Steinbacher, J., Wang, H., Tandler, C., Mbarga, M., Schaefer, T., Falcone, M., et al. (2019) · Nature

Immune Cell Function and InteractionAcute Myeloid Leukemia Research

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Bone Marrow Transplantation for Recessive Dystrophic Epidermolysis Bullosa

Wagner, J. E., Ishida-Yamamoto, A., McGrath, J. A., Hordinsky, M., Keene, D. R., Woodley, D. T., Chen, M., Riddle, M. J., Osborn, M. J., Lund, T., et al. (2010) · New England Journal of Medicine

Skin and Cellular Biology ResearchHematopoietic Stem Cell Transplantation

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Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy

Rosato, P. C., Wijeyesinghe, S., Stolley, J. M., Nelson, C. E., Davis, R. L., Manlove, L. S., Pennell, C. A., Blazar, B. R., Chen, C. C., Geller, M. A., et al. (2019) · Nature Communications

Immunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

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Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism

Zanin-Zhorov, A., Weiss, J. M., Nyuydzefe, M. S., Chen, W., Scher, J. U., Mo, R., Depoil, D., Rao, N., Liu, B., Wei, J., et al. (2014) · Proceedings of the National Academy of Sciences

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

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TALEN-based Gene Correction for Epidermolysis Bullosa

Osborn, M. J., Starker, C. G., McElroy, A. N., Webber, B. R., Riddle, M. J., Xia, L., DeFeo, A. P., Gabriel, R., Schmidt, M., Von Kalle, C., et al. (2013) · Molecular Therapy

CRISPR and Genetic EngineeringVirus-based gene therapy research

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Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells

Rossi, S. W., Jeker, L. T., Ueno, T., Kuse, S., Keller, M. P., Zuklys, S., Gudkov, A. V., Takahama, Y., Krenger, W., Blazar, B. R., et al. (2007) · Blood

Hematopoietic Stem Cell TransplantationT-cell and B-cell Immunology

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Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging

Min, D., Panoskaltsis-Mortari, A., Kuro-o, M., Holländer, G. A., Blazar, B. R., & Weinberg, K. I. (2007) · Blood

T-cell and B-cell ImmunologyHematopoietic Stem Cell Transplantation

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Evaluation of TCR Gene Editing Achieved by TALENs, CRISPR/Cas9, and megaTAL Nucleases

Osborn, M. J., Webber, B. R., Knipping, F., Lonetree, C.-L., Tennis, N., DeFeo, A. P., McElroy, A. N., Starker, C. G., Lee, C., Merkel, S., et al. (2016) · Molecular Therapy

CRISPR and Genetic EngineeringCAR-T cell therapy research

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ROCK2 inhibition with belumosudil (KD025) for the treatment of chronic graft-versus-host disease

Jagasia, M., Lazaryan, A., Bachier, C. R., Salhotra, A., Weisdorf, D. J., Zoghi, B., Essell, J., Green, L., Schueller, O., Patel, J., et al. (2021) · Journal of Clinical Oncology

Hematopoietic Stem Cell TransplantationImmunodeficiency and Autoimmune Disorders

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Induced Pluripotent Stem Cells from Individuals with Recessive Dystrophic Epidermolysis Bullosa

Tolar, J., Xia, L., Riddle, M. J., Lees, C. J., Eide, C. R., McElmurry, R. T., Titeux, M., Osborn, M. J., Lund, T. C., Hovnanian, A., et al. (2011) · Journal of Investigative Dermatology

Pluripotent Stem Cells ResearchSkin and Cellular Biology Research

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Adoptive transfer of umbilical cord blood-derived regulatory T cells and early viral reactivation

Brunstein, C. G., Blazar, B. R., Miller, J. S., Cao, Q., Hippen, K. L., McKenna, D. H., Curtsinger, J., McGlave, P. B., & Wagner, J. E. (2013) · Biology of Blood and Marrow Transplantation

Hematopoietic Stem Cell TransplantationT-cell and B-cell Immunology

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Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration

Brinkman, C. C., Iwami, D., Hritzo, M. K., Xiong, Y., Ahmad, S., Simon, T., Hippen, K. L., Blazar, B. R., & Bromberg, J. S. (2016) · Nature Communications

T-cell and B-cell ImmunologyLymphatic System and Diseases

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ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis

Nalkurthi, C., Schroder, W. A., Melino, M., Irvine, K. M., Nyuydzefe, M., Chen, W., Liu, J., Teng, M. W. L., Hill, G. R., Bertolino, P., et al. (2022) · JHEP Reports

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

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ROCK2, a critical regulator of immune modulation and fibrosis has emerged as a therapeutic target in chronic graft-versus-host disease

Zanin-Zhorov, A., & Blazar, B. R. (2021) · Clinical Immunology

Hematopoietic Stem Cell TransplantationT-cell and B-cell Immunology

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Cryopreservation timing is a critical process parameter in a thymic regulatory T-cell therapy manufacturing protocol

MacDonald, K. N., Ivison, S., Hippen, K. L., Hoeppli, R. E., Hall, M., Zheng, G., Dijke, I. E., Aklabi, M. A., Freed, D. H., Rebeyka, I., et al. (2019) · Cytotherapy

T-cell and B-cell ImmunologyMesenchymal stem cell research

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