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Cited by 39Sleep and Wakefulness ResearchSleep and related disordersNeurotransmitter Receptor Influence on Behavior

Effects of eszopiclone and zolpidem on sleep–wake behavior, anxiety-like behavior and contextual memory in rats

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Huang, Max P., Radadia, Kushan, Macone, Brian W., Auerbach, Sanford H., Datta, Subimal·2010·Behavioural Brain Research
DOI 10.1016/j.bbr.2010.02.018PMC PMC2844486
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Abstract

At present, eszopiclone and zolpidem are the most commonly prescribed drugs for treating insomnia. Despite the established relationship between sleep disturbance and anxiety, it remains unknown whether targeted treatment for insomnia may affect acute anxiety. Therefore, the objective of this study was to examine the effects of three different doses (1, 3, and 10mg/kg) of eszopiclone and zolpidem on the states of sleep and wakefulness, levels of anxiety-like behavior, and long-term contextual memory in footshock-induced anxious rats. The results of this study demonstrated that the administration of eszopiclone and zolpidem both were equally effective in attenuating footshock stressor-induced suppression of slow-wave sleep (SWS). The administration of eszopiclone at 1mg/kg or zolpidem at 1 and 3mg/kg doses showed a tendency for attenuating stressor-induced suppression of REM sleep. However, the REM sleep attenuating effects of these drugs disappeared when they were administered at higher doses. The administration of eszopiclone at 3 and 10mg/kg doses and zolpidem at all three doses reduced the power of electroencephalographic theta band frequencies during wakefulness. In addition, the administration of eszopiclone at 1 and 3mg/kg doses suppressed stressor-induced anxiety-like behavior. The administration of zolpidem at 1, 3, or 10mg/kg doses was not effective in attenuating stressor-induced anxiety-like behavior. Contextual memory after administration of eszopiclone at 1mg/kg dose had no effects, but was reduced significantly with increased dosage. Contextual memory after administration of zolpidem, at all three doses, was severely disrupted. The results of this study suggest that eszopiclone at a low dose could be used effectively to control anxiety and anxiety-induced insomnia.

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  • In rats, eszopiclone and zolpidem after learning before sleep impaired contextual memory tested 24 h later.

    “In rats, administration of the GABA A agonists eszopiclone and zolipem after learning before sleep impaired contextual memory tested 24 h later (577).”

    From About Sleep's Role in Memory (2013) · cites this paper as [577]

    The Discussion (§4.4) reports that zolpidem and higher doses of eszopiclone impaired contextual memory when rats were tested 24 hours after conditioning. The claim omits a dose qualification: the same passage says 1 mg/kg eszopiclone did not impair memory. The Methods (§2.5) place the injections after conditioning, followed by sleep–wake recording. (LLM, conf=0.86)

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Authors
Huang, M. P., Radadia, K., Macone, B. W., Auerbach, S. H., & Datta, S.
Affiliations
Boston University (US)
Corresponding author
Datta, Subimal
ORCID
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2010-06
Volume
210
Issue
1
Pages
54-66
ISSN
0166-4328 (ISSN-L)
DOI
10.1016/j.bbr.2010.02.018
PMC
PMC2844486
OpenAlex
W2015314195
Cited by
39
References
6
Citations by year
2026: 4 · 2025: 3 · 2024: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 6 · 2013: 2 · 2012: 4
FWCI
1.55
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Sepracor, Inc. (ESRC961)
  • National Institutes of Health (MH 59839)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
eszopiclone, zolpidem, insomnia, anxiety-like behavior, contextual memory, sleep-wake behavior, slow-wave sleep, REM sleep, footshock stress, theta power, dose-dependent effects, anxiolytics
MeSH terms
Eszopiclone, Zolpidem, Animals, Anxiety, Brain, Dose-Response Relationship, Drug, Electroshock, Hypnotics and Sedatives, Male, Memory, Memory Disorders, Piperazines, Pyridines, Sleep, Sleep, REM, Stress, Psychological, Theta Rhythm, Wakefulness, Rats, Wistar, Rats, Azabicyclo Compounds

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