Maternal deprivation in the middle of a stress hyporesponsive period decreases hippocampal calcineurin expression and causes abnormal social and cognitive behaviours in adult male Wistar rats: relevance to negative symptoms of schizophrenia.
Abstract
Adverse experiences in early life profoundly influence the developing nervous, endocrine, and immune systems, and also affect human behaviour during adult life and are considered in the pathogenesis of psychiatric disorders. Numerous studies have provided evidence that maternal deprivation in the middle of a stress hyporesponsive period (SHRP) causes multiple behavioural and physiological abnormalities that mimic positive symptoms of schizophrenia in humans. To investigate the neurochemical characteristics of maternal deprivation in the middle of the SHRP in the context of a possible animal model of the symptoms of schizophrenia, we examined calcineurin expression in the hippocampus of maternally deprived rats. To investigate other behavioural characteristics, we behaviourally phenotyped the rats by applying a comprehensive behavioural test battery. The results indicate that maternal deprivation in the middle of the SHRP has no effects on general health, neurological reflexes, sensory function, or motor function, but does have sex-specific effects on a type of anxiety-related behaviour in the open field test and male-specific effects on hippocampal calcineurin expression, social behaviour, and objective memory function. An interpretation of our results and previous studies in the context of the neurodevelopmental hypothesis of schizophrenia suggests that maternal deprivation in the middle of the SHRP in rats models some positive and negative aspects of schizophrenia. The find…
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In rats, social interest was reduced in males but not females after 12 h maternal deprivation on PND 9 and 11.
“In rats, social interest was reduced in males – but not females – after 12 h MD on PND 9 and 11 (Takase et al., 2012)”
From Effects of Maternal Deprivation and Complex Housing on Rat Social Behavior in Adolescence and Adulthood (2018) · cites this paper as Takase et al., 2012
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Effects of early-life stress on cognitive function and hippocampal structure in female rodents.
Loi, M., Mossink, J. C. L., Meerhoff, G. F., Den Blaauwen, J. L., Lucassen, P. J., & Joëls, M. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.024 · Cited by 109 · see citing works
Monoaminergic and Neuropeptidergic Neurons Have Distinct Expression Profiles of Histone Deacetylases
Takase, K., Oda, S., Kuroda, M., & Funato, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058473 · Cited by 47 · see citing works
Self-citationKentrop, J., Smid, C. R., Achterberg, E. J. M., van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., Joëls, M., & van der Veen, R. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00193 · Cited by 41 · see citing works
“In rats, social interest was reduced in males – but not females – after 12 h MD on PND 9 and 11 (Takase et al., 2012), while 24 h MD on PND 9 did not affect male or female social exploration (Zamberletti et al.”
- Authors
- Takase, K., Yamamoto, Y., & Yagami, T.
- Affiliations
- Toho University (JP)
- Himeji Dokkyo University (JP)
- Corresponding author
- Takase, Kenkichi
- Yagami, Tatsurou
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 232
- Issue
- 1
- Pages
- 306-315
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2116067623
- Cited by
- 40
- References
- 4
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 1
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (23790279)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- maternal deprivation, stress hyporesponsive period, schizophrenia, negative symptoms, social behavior, anxiety-like behavior, memory function, sex differences, neurodevelopmental hypothesis, childhood adversity, animal models of schizophrenia
- MeSH terms
- Analysis of Variance, Animals, Cognition, Exploratory Behavior, Factor Analysis, Statistical, Female, Hippocampus, Male, Maternal Deprivation, Motor Activity, Schizophrenic Psychology, Sex Characteristics, Social Behavior, Stress, Psychological, Blotting, Western, Rats, Wistar, Calcineurin, Recognition, Psychology, Rats
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