Neonatal lesions of the rat ventral hippocampus result in hyperlocomotion and deficits in social behaviour in adulthood
Abstract
The neonatal ibotenic acid lesion of the ventral hippocampus in the rat is an animal model of several aspects of schizophrenia. This lesion produces a number of behavioural abnormalities, such as hyperlocomotion and deficits in prepulse inhibition of startle, that present themselves relatively late in development, i.e. after puberty. Some of these abnormalities, which are thought to model the positive symptoms of schizophrenia, can be normalized by chronic treatment with neuroleptics. In the present study, we examined the effects of the neonatal hippocampal lesion on social behaviour. Social withdrawal and isolation are key components of the negative symptoms of schizophrenia that have not been previously addressed in this model. Rats were lesioned on postnatal day 7 (PD7) and tested for social interaction on PD35 and PD65. They were then treated with clozapine (1.9 and 7.4 micromol/kg or 0.63 and 2.5 mg/kg) for 21 days and retested. The results show that although, as previously reported, spontaneous hyperlocomotion emerged in the lesioned rats only after puberty (PD65), social interaction deficits and behaviors that may reflect anxiety were present at both PD35 and PD65. Clozapine normalized locomotion, but did not ameliorate putative anxiety or social interaction deficits in the neonatally lesioned rats. Our results indicate that the neonatal hippocampal lesion in the rat models some aspects of both positive and negative symptoms of schizophrenia. The effects of clozapine appear inconsistent with its putative benefit for negative symptoms.
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Adult rats with a NVHL show hyperlocomotion, increased response to novelty, abnormal social behaviors, exaggerated responses to stress, stimulants and NMDA antagonists, and increased liability for addictive behaviors.
“Behaviorally, adult rats with a NVHL show hyperlocomotion, 39,40 increased response to novelty, 41 abnormal social behaviors, 41 exaggerated responses to stress, stimulants and NMDA antagonists, 39,42 and increased liability for addictive behaviors.43,44”
From Adolescent Onset of Cortical Disinhibition in Schizophrenia: Insights From Animal Models (2011) · cites this paper as [41]
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Behavioral changes in rats with early ventral hippocampal damage vary with age at damage
Wood, G. K., Lipska, B. K., & Weinberger, D. R. (1997) · Developmental Brain Research · doi:10.1016/s0165-3806(97)00050-3 · Cited by 69 · see citing works
Self-citationThe lateral septum mediates kinship behavior in the rat
Clemens, A. M., Wang, H., & Brecht, M. (2020) · Nature Communications · doi:10.1038/s41467-020-16489-x · Cited by 64 · see citing works
Al-Amin, H. A., Weickert, C. S., Weinberger, D. R., & Lipska, B. K. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00968-9 · Cited by 67 · see citing works
Self-citationA Specific Test of Hippocampal Deficit in Schizophrenia.
Hanlon, F. M., Weisend, M. P., Yeo, R. A., Huang, M., Lee, R. R., Thoma, R. J., Moses, S. N., Paulson, K. M., Miller, G. A., & Cañive, J. M. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.4.863 · Cited by 66 · see citing works
Neurodevelopmental Animal Models of Schizophrenia: Role in Novel Drug Discovery and Development
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Review of animal models for autism: implication of thyroid hormone
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Effects of antipsychotics and amphetamine on social behaviors in spontaneously hypertensive rats
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Sex differences in animal models of schizophrenia shed light on the underlying pathophysiology
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- Authors
- Sams-Dodd, F., Lipska, B. K., & Weinberger, D. R.
- Affiliations
- National Institutes of Health (US)
- Venue
- Psychopharmacology
- Published
- 1997-08-05
- Volume
- 132
- Issue
- 3
- Pages
- 303-310
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2036180008
- Cited by
- 346
- References
- 17
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 10 · 2018: 10 · 2017: 8 · 2016: 14 · 2015: 15 · 2014: 21 · 2013: 14 · 2012: 17
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- ventral hippocampus, ibotenic acid, animal models of schizophrenia, social behavior, social withdrawal, negative symptoms of schizophrenia, positive symptoms, hyperlocomotion, clozapine, antipsychotic drugs, anxiety, social interaction deficits
- MeSH terms
- Animals, Animals, Newborn, Behavior, Animal, Clozapine, Female, Hippocampus, Male, Motor Activity, Social Behavior, Antipsychotic Agents, Rats, Sprague-Dawley, Rats
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