Cited by 88

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Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice

Allard, Joanne S., Perez, Evelyn J., Fukui, Koji, Carpenter, Priscilla, Ingram, Donald K., Cabo, Rafael de·2016·Behavioural Brain Research

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  1. Whiting, 2011, IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030, Diabetes Res. Clin. Pract., 94, 311, 10.1016/j.diabres.2011.10.029 · DOI
  2. Moses, 2010, Repaglinide/metformin fixed-dose combination to improve glycemic control in patients with type 2 diabetes: an update, Diabetes Metab. Syndr. Obes., 3, 145, 10.2147/DMSO.S6621 · DOI
  3. Mooradian, 1988, Cortical function in elderly non-insulin dependent diabetic patients. Behavioral and electrophysiologic studies, Arch. Intern. Med., 148, 2369, 10.1001/archinte.1988.00380110035007 · DOI
  4. Perlmuter, 1984, Decreased cognitive function in aging non-insulin-dependent diabetic patients, Am. J. Med., 77, 1043, 10.1016/0002-9343(84)90186-4 · DOI
  5. Hassenstab, 2010, Metabolic syndrome is associated with learning and recall impairment in middle age, Dement. Geriatr. Cogn. Disord., 29, 356, 10.1159/000296071 · DOI
  6. Akter, 2011, Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?, Br. J. Clin. Pharmacol., 71, 365, 10.1111/j.1365-2125.2010.03830.x · DOI · Paper page
  7. Strachan, 2010, The brain as a target organ in Type 2 diabetes: exploring the links with cognitive impairment and dementia, Diabet. Med., 28, 141, 10.1111/j.1464-5491.2010.03199.x · DOI
  8. Xu, 2009, Uncontrolled diabetes increases the risk of Alzheimer's disease: a population-based cohort study, Diabetologia, 52, 1031, 10.1007/s00125-009-1323-x · DOI · Paper page
  9. Ryan, 2006, Improving metabolic control leads to better working memory in adults with type 2 diabetes, Diabetes Care, 29, 345, 10.2337/diacare.29.02.06.dc05-1626 · DOI
  10. Zhou, 2001, Role of AMP-activated protein kinase in mechanism of metformin action, J. Clin. Investig., 108, 1167, 10.1172/JCI13505 · DOI · Paper page
  11. Bailey, 1995, Metformin and intestinal glucose handling, Diabetes. Metab. Rev., 11, S23, 10.1002/dmr.5610110505 · DOI
  12. Ikeda, 2000, Inhibitory effect of metformin on intestinal glucose absorption in the perfused rat intestine, Biochem. Pharmacol., 59, 887, 10.1016/S0006-2952(99)00396-2 · DOI
  13. Hettich, 2014, The anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complex, PloS One, 9, e102420, 10.1371/journal.pone.0102420 · DOI · Paper page
  14. Wang, 2012, Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation, Cell Stem Cell, 11, 23, 10.1016/j.stem.2012.03.016 · DOI · Paper page
  15. Imfeld, 2012, Metformin, other antidiabetic drugs, and risk of Alzheimer's disease: a population-based case-control study, J. Am. Geriatr. Soc., 60, 916, 10.1111/j.1532-5415.2012.03916.x · DOI
  16. Chen, 2009, Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription, Proc. Natl. Acad. Sci. U. S. A., 106, 3907, 10.1073/pnas.0807991106 · DOI · Paper page
  17. Palomba, 2014, Metformin and gonadotropins for ovulation induction in patients with polycystic ovary syndrome: a systematic review with meta-analysis of randomized controlled trials, Reprod. Biol. Endocrinol., 12, 3, 10.1186/1477-7827-12-3 · DOI
  18. Pernicova, 2014, Metformin?mode of action and clinical implications for diabetes and cancer, Nat. Rev. Endocrinol., 10, 143, 10.1038/nrendo.2013.256 · DOI
  19. Rosilio, 2014, Metformin: a metabolic disruptor and anti-diabetic drug to target human leukemia, Cancer Lett., 346, 188, 10.1016/j.canlet.2014.01.006 · DOI
  20. Beckmann, 1969, Absorption, distribution in the organism and elimination of metformin, Diabetologia, 5, 318, 10.1007/BF00452906 · DOI
  21. Lv, 2012, The effect of metformin on food intake and its potential role in hypothalamic regulation in obese diabetic rats, Brain Res., 1444, 11, 10.1016/j.brainres.2012.01.028 · DOI
  22. Labuzek, 2010, Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide, Pharmacol. Rep., 62, 956, 10.1016/S1734-1140(10)70357-1 · DOI
  23. Ashabi, 2014, Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: interference of AMPK/PGC-1alpha pathway, Metab. Brain Dis., 29, 47, 10.1007/s11011-013-9475-2 · DOI
  24. Jin, 2014, Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke, Brain Behav. Immun., 40, 131, 10.1016/j.bbi.2014.03.003 · DOI
  25. Patil, 2014, Neuroprotective effect of metformin in MPTP-induced Parkinson's disease in mice, Neuroscience, 277, 747, 10.1016/j.neuroscience.2014.07.046 · DOI
  26. Zhu, 2015, Chronic metformin preconditioning provides neuroprotection via suppression of nf-κb-mediated inflammatory pathway in rats with permanent cerebral ischemia, Mol. Neurobiol., 52, 375, 10.1007/s12035-014-8866-7 · DOI
  27. Aghili, 2014, Body composition in adults with newly diagnosed type 2 diabetes: effects of metformin, J. Diabetes Metab. Disord., 13, 88, 10.1186/s40200-014-0088-z · DOI
  28. Aubert, 2011, The anorexigenic effects of metformin involve increases in hypothalamic leptin receptor expression, Metabolism, 60, 327, 10.1016/j.metabol.2010.02.007 · DOI
  29. Duan, 2013, Metformin inhibits food intake and neuropeptide Y gene expression in the hypothalamus, Neural Regen. Res., 8, 2379
  30. Kim, 2013, Central administration of metformin into the third ventricle of C57BL/6 mice decreases meal size and number and activates hypothalamic S6 kinase, Am. J. Physiol. Regul. Integr. Comp. Physiol., 305, R499, 10.1152/ajpregu.00099.2013 · DOI
  31. Lee, 2012, Intracerebroventricular injection of metformin induces anorexia in rats, Diabetes Metab. J., 36, 293, 10.4093/dmj.2012.36.4.293 · DOI
  32. Collier, 2006, Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle, Am. J. Physiol. Endocrinol. Metab., 291, E182, 10.1152/ajpendo.00272.2005 · DOI
  33. Wang, 2014, Metformin suppresses lipid accumulation in skeletal muscle by promoting fatty acid oxidation, Clin. Lab., 60, 887, 10.7754/Clin.Lab.2013.130531 · DOI
  34. Ratzmann, 1979, Relationship between body fat mass, carbohydrate tolerance and IRI response during glucose infusion in subjects with early diabetes, Acta Diabetol. Lat., 16, 67, 10.1007/BF02590765 · DOI
  35. Kwankaew, 2014, Lean mass inversely predicts plasma glucose levels after oral glucose load independent of insulin secretion or insulin sensitivity in glucose intolerance subjects, Endocr. J., 61, 77, 10.1507/endocrj.EJ13-0241 · DOI
  36. Kahn, 2001, Obesity, body fat distribution, insulin sensitivity and Islet beta-cell function as explanations for metabolic diversity, J. Nutr., 131, 354S, 10.1093/jn/131.2.354S · DOI
  37. Rebuffe-Scrive, 1993, Regional fat distribution and metabolism in a new mouse model (C57BL/6J) of non-insulin-dependent diabetes mellitus, Metab. Clin. Exp., 42, 1405, 10.1016/0026-0495(93)90190-Y · DOI
  38. Kane, 2010, Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats, Free Radic. Biol. Med., 49, 1082, 10.1016/j.freeradbiomed.2010.06.022 · DOI · Paper page
  39. Andrzejewski, 2014, Metformin directly acts on mitochondria to alter cellular bioenergetics, Cancer Metab., 2, 12, 10.1186/2049-3002-2-12 · DOI
  40. Wessels, 2014, Metformin impairs mitochondrial function in skeletal muscle of both lean and diabetic rats in a dose-dependent manner, PloS One, 9, e100525, 10.1371/journal.pone.0100525 · DOI
  41. Alzoubi, 2014, Metformin Eased Cognitive Impairment Induced by Chronic l-methionine Administration: Potential Role of Oxidative Stress, Curr. Neuropharmacol., 12, 186, 10.2174/1570159X11666131120223201 · DOI
  42. Zhao, 2014, Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice, Biochem. Biophys. Res. Commun., 448, 414, 10.1016/j.bbrc.2014.04.130 · DOI
  43. Moore, 2013, Increased risk of cognitive impairment in patients with diabetes is associated with metformin, Diabetes Care, 36, 2981, 10.2337/dc13-0229 · DOI · Paper page
  44. DiTacchio, 2015, Metformin treatment alters memory function in a mouse model of Alzheimer's disease, J. Alzheimer's Dis., 44, 43, 10.3233/JAD-141332 · DOI
  45. Berry, 2012, Social deprivation stress is a triggering factor for the emergence of anxiety- and depression-like behaviours and leads to reduced brain BDNF levels in C57BL/6 J mice, Psychoneuroendocrinology, 37, 762, 10.1016/j.psyneuen.2011.09.007 · DOI
  46. Bothwell, 2014, NGF, BDNF, NT3, and NT4, Handb. Exp. Pharmacol., 220, 3, 10.1007/978-3-642-45106-5_1 · DOI
  47. Maier, 2009, Correlation of mRNA and protein in complex biological samples, FEBS Lett., 583, 3966, 10.1016/j.febslet.2009.10.036 · DOI · Paper page
  48. Srividhya, 2002, Metformin improves liver antioxidant potential in rats fed a high-fructose diet, Asia Pac. J. Clin. Nutr., 11, 319, 10.1046/j.1440-6047.2002.00306.x · DOI
  49. Esteghamati, 2013, Effects of metformin on markers of oxidative stress and antioxidant reserve in patients with newly diagnosed type 2 diabetes: a randomized clinical trial, Clin. Nutr., 32, 179, 10.1016/j.clnu.2012.08.006 · DOI
  50. Formoso, 2008, Decreased in vivo oxidative stress and decreased platelet activation following metformin treatment in newly diagnosed type 2 diabetic subjects, Diabetes Metab. Res. Rev., 24, 231, 10.1002/dmrr.794 · DOI
  51. Huang, 2002, Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription, J. Biol. Chem., 277, 42769, 10.1074/jbc.M206911200 · DOI
  52. Lewis, 2015, Regulation of Nrf2 signaling and longevity in naturally long-lived rodents, Proc. Natl. Acad. Sci. U. S. A., 112, 3722, 10.1073/pnas.1417566112 · DOI
  53. Picone, 2015, Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation: use of insulin to attenuate metformin’s effect, Biochim. Biophys. Acta., 1853, 1046, 10.1016/j.bbamcr.2015.01.017 · DOI
  54. McNeilly, 2012, A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin, Diabetologia, 55, 3061, 10.1007/s00125-012-2686-y · DOI

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Metadata

Authors
Allard, J. S., Perez, E. J., Fukui, K., Carpenter, P., Ingram, D. K., & Cabo, R. D.
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2016-03
Volume
301
Pages
1-9
ISSN
0166-4328
Cited by
88
References
8
Language
en
Funders
  • National Institute on Aging
  • National Institutes of Health (1R25AG047843-01)

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