Molecular and cellular aspects of age-related cognitive decline and Alzheimer’s disease
Open accessAbstract
As the population of people aged 60 or older continues to rise, it has become increasingly important to understand the molecular basis underlying age-related cognitive decline. In fact, a better understanding of aging biology will help us identify ways to maintain high levels of cognitive functioning throughout the aging process. Many cellular and molecular aspects of brain aging are shared with other organ systems; however, certain age-related changes are unique to the nervous system due to its structural, cellular and molecular complexity. Importantly, the brain appears to show differential changes throughout the aging process, with certain regions (e.g. frontal and temporal regions) being more vulnerable than others (e.g. brain stem). Within the medial temporal lobe, the hippocampus is especially susceptible to age-related changes. The important role of the hippocampus in age-related cognitive decline and in vulnerability to disease processes such as Alzheimer's disease has prompted this review, which will focus on the complexity of changes that characterize aging, and on the molecular connections that exist between normal aging and Alzheimer's disease. Finally, it will discuss behavioral interventions and emerging insights for promoting healthy cognitive aging.
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Diffusion MRI indicates age-related changes in white matter connectivity between prefrontal and posterior cortical regions and within posterior sensory cortices.
“Diffusion MRI methods have shown age-related changes in white matter connectivity between prefrontal and posterior cortical regions, and within posterior sensory cortices.25–27”
From Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing (2018) · cites this paper as [26]
The Introduction and §5.1 discuss age-related brain and synaptic changes, but not diffusion MRI findings about the specified cortical connections. Searches for diffusion MRI, white matter, and prefrontal-to-posterior or posterior sensory connectivity found no passage addressing the claim. Page numbers are not available in our copy. (LLM, conf=0.76)
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References 272 · Cited by 68
- Authors
- Hullinger, R., & Puglielli, L.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Puglielli, Luigi
- ORCID
- Puglielli, Luigi
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 322
- Issue
- Pt B
- Pages
- 191-205
- ISSN
- 0166-4328 (ISSN-L)
- PMC
- PMC5099115
- OpenAlex
- W2365882656
- Cited by
- 68
- References
- 272
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 11 · 2023: 6 · 2022: 12 · 2021: 7 · 2020: 7 · 2019: 4 · 2018: 7 · 2017: 5 · 2016: 2
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- VA Merit Award (BX001638)
- NIH (NS094154, AG033514)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- brain aging, age-related cognitive decline, Alzheimer's disease, synaptic plasticity, hippocampus, medial temporal lobe, aging pathways, healthy cognitive aging, behavioral interventions
- MeSH terms
- Aging, Alzheimer Disease, Animals, Humans, Cognitive Dysfunction
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