The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
No effects of PCSK9-inhibitor treatment on spatial learning, locomotor activity, and novel object recognition in mice
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“in animal models of cognitive impairment induced by a high-fat diet, the administration of a PCSK9 inhibitor was associated with a reduction in Aβ1-42-formation, microglial activation, hippocampal apoptosis, and lower cognitive decline, although the results were not consistent across the studies [73,74,75,76]”
From PCSK9 affects astrocyte cholesterol metabolism and reduces neuron cholesterol supplying in vitro: potential implications in Alzheimer’s disease (2022) · cites this paper as [76]
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Cites
Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease
Sabatine, M. S., Giugliano, R. P., Keech, A. C., Honarpour, N., Wiviott, S. D., Murphy, S. A., Kuder, J. F., Wang, H., Liu, T., Wasserman, S. M., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1615664 · Cited by 6,138
Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome
Schwartz, G. G., Steg, P. G., Szarek, M., Bhatt, D. L., Bittner, V. A., Diaz, R., Edelberg, J. M., Goodman, S. G., Hanotin, C., Harrington, R. A., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1801174 · Cited by 3,634
Efficacy and Safety of Evolocumab in Reducing Lipids and Cardiovascular Events
Sabatine, M. S., Giugliano, R. P., Wiviott, S. D., Raal, F. J., Blom, D. J., Robinson, J., Ballantyne, C. M., Somaratne, R., Legg, J., Wasserman, S. M., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1500858 · Cited by 1,509
Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol
Ray, K. K., Landmesser, U., Leiter, L. A., Kallend, D., Dufour, R., Karakas, M., Hall, T., Troquay, R. P. T., Turner, T., Visseren, F. L. J., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1615758 · Cited by 992
Webster, S. J., Bachstetter, A. D., Nelson, P. T., Schmitt, F. A., & Van Eldik, L. J. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00088 · Cited by 755
Cognitive function in a randomized trial of evolocumab
Giugliano, R. P., Mach, F., Zavitz, K., Kurtz, C., Im, K., Kanevsky, E., Schneider, J., Wang, H., Keech, A., Pedersen, T. R., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1701131 · Cited by 492
Guedeney, P., Giustino, G., Sorrentino, S., Claessen, B. E., Camaj, A., Kalkman, D. N., Vogel, B., Sartori, S., De Rosa, S., Baber, U., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehz430 · Cited by 208
Kühnast, S., van der Hoorn, J. W. A., Pieterman, E. J., van den Hoek, A. M., Sasiela, W. J., Gusarova, V., Peyman, A., Schäfer, H.-L., Schwahn, U., Jukema, J. W., et al. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m051326 · Cited by 204
Self-citationMefford, M. T., Rosenson, R. S., Cushman, M., Farkouh, M. E., McClure, L. A., Wadley, V. G., Irvin, M. R., Bittner, V., Safford, M. M., Somaratne, R., et al. (2018) · Circulation · doi:10.1161/circulationaha.117.029785 · Cited by 44
Flagged first, then by citations
Research works printed but not linked: 14
- Sabatine, 2015, Pcsk9 inhibitors and cardiovascular events, N Engl J Med, 373, 774
- Robinson, 2015, Efficacy and safety of alirocumab in reducing lipids and cardiovascular events, N Engl J Med, 372, 1489, 10.1056/NEJMoa1501031 · DOI · Paper page
- Ason, 2014, Pcsk9 inhibition fails to alter hepatic ldlr, circulating cholesterol, and atherosclerosis in the absence of apoe, J Lipid Res, 55, 2370, 10.1194/jlr.M053207 · DOI
- Tanila, 2018, Testing cognitive functions in rodent disease models: Present pitfalls and future perspectives, Behav Brain Res, 352, 23, 10.1016/j.bbr.2017.05.040 · DOI
- Antunes, 2012, The novel object recognition memory: Neurobiology, test procedure, and its modifications, Cogn Process, 13, 93, 10.1007/s10339-011-0430-z · DOI · Paper page
- Winter, 2004, Dysexecutive syndrome after mild cerebral ischemia? Mice learn normally but have deficits in strategy switching, Stroke, 35, 191, 10.1161/01.STR.0000107188.29688.2C · DOI
- Winter, 2005, Anxious and hyperactive phenotype following brief ischemic episodes in mice, Biol Psychiatry, 57, 1166, 10.1016/j.biopsych.2005.02.010 · DOI
- Kronenberg, 2008, Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase, J Neurosci, 28, 7219, 10.1523/JNEUROSCI.0940-08.2008 · DOI
- Seidah, 2003, The secretory proprotein convertase neural apoptosis-regulated convertase 1 (narc-1): Liver regeneration and neuronal differentiation, Proc Natl Acad Sci U S A, 100, 928, 10.1073/pnas.0335507100 · DOI · Paper page
- McCormack, 2016, Very low ldl-c levels may safely provide additional clinical cardiovascular benefit: The evidence to date, Int J Clin Pract, 70, 886, 10.1111/ijcp.12881 · DOI · Paper page
- Koren, 2017, Long-term low-density lipoprotein cholesterol-lowering efficacy, persistence, and safety of evolocumab in treatment of hypercholesterolemia: Results up to 4 years from the open-label osler-1 extension study, JAMA Cardiol, 2, 598, 10.1001/jamacardio.2017.0747 · DOI
- Harvey, 2018, No evidence of neurocognitive adverse events associated with alirocumab treatment in 3340 patients from 14 randomized phase 2 and 3 controlled trials: A meta-analysis of individual patient data, Eur Heart J., 39, 374, 10.1093/eurheartj/ehx661 · DOI
- van Vlijmen, 1996, Modulation of very low density lipoprotein production and clearance contributes to age- and gender- dependent hyperlipoproteinemia in apolipoprotein e3-leiden transgenic mice, J Clin Invest, 97, 1184, 10.1172/JCI118532 · DOI
- Schuster, 2019, Anti-pcsk9 antibodies inhibit pro-atherogenic mechanisms in apoe*3leiden.Cetp mice, Sci Rep., 9, 11079, 10.1038/s41598-019-47242-0 · DOI
Cited by
Sorted by citations
Papotti, B., Adorni, M. P., Marchi, C., Zimetti, F., Ronda, N., Panighel, G., Lupo, M. G., Vilella, A., Giuliani, D., Ferri, N., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012192 · Cited by 41
PCSK9 deficiency alters brain lipid composition without affecting brain development and function
Pärn, A., Olsen, D., Tuvikene, J., Kaas, M., Borisova, E., Bilgin, M., Elhauge, M., Vilstrup, J., Madsen, P., Ambrozkiewicz, M. C., et al. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1084633 · Cited by 16
Metadata
- Authors
- Schlunk, F., Fischer, P., Princen, H. M. G., Rex, A., Prinz, V., Foddis, M., Lütjohann, D., Laufs, U., & Endres, M.
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 396
- Pages
- 112875
- ISSN
- 0166-4328
- Cited by
- 10
- References
- 9
- Language
- en
- Licence
- Funders
- Charité –Universitätsmedizin Berlin and the Berlin Institute of Health
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