Role of RhoA/ROCK signaling in Alzheimer’s disease
Abstract
Rho-associated coiled-coil kinase (ROCK), a serine/threonine kinase regulated by the small GTPase RhoA, is involved in regulating cell migration, proliferation, and survival. Numerous studies have shown that the RhoA/ROCK signaling pathway can promote Alzheimer's disease (AD) occurrence. ROCK activation increases β-secretase activity and promotes amyloid-beta (Aβ) production; moreover, Aβ further activates ROCK. This is suggestive of a possible positive feedback role for Aβ and ROCK. Moreover, ROCK activation promotes the formation of neurofibrillary tangles and abnormal synaptic contraction. Additionally, ROCK activation can promote the neuroinflammatory response by activating microglia and astrocytes to release inflammatory cytokines. Therefore, ROCK is a promising drug target in AD; further, there is a need to elucidate the specific mechanism of action.
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Accumulating evidence supports a role for RhoA signaling in Aβ aggregation, tau phosphorylation, neuroinflammation, and synaptic damage in AD.
“Accumulating evidence supports a role for RhoA signaling in Aβ aggregation, tau phosphorylation, neuroinflammation, and synaptic damage in AD [223].”
From RhoA Signaling in Neurodegenerative Diseases (2022) · cites this paper as [223]
Cites
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RhoA Signaling in Neurodegenerative Diseases
Schmidt, S. I., Blaabjerg, M., Freude, K., & Meyer, M. (2022) · Cells · doi:10.3390/cells11091520 · Cited by 110 · see citing works
- Authors
- Cai, R., Wang, Y., Huang, Z., Zou, Q., Pu, Y., Yu, C., & Cai, Z.
- Affiliations
- University of Chinese Academy of Sciences (CN)
- Zunyi Medical University (CN)
- Corresponding author
- Yu, Changyin
- Cai, Zhiyou
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2021-09
- Volume
- 414
- Pages
- 113481
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W3183200082
- Cited by
- 96
- References
- 6
- Citations by year
- 2026: 14 · 2025: 27 · 2024: 30 · 2023: 11 · 2022: 11 · 2021: 3
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chongqing Natural Science Foundation
- Department of Health of Guizhou Province
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- RhoA/ROCK signaling, Alzheimer's disease, Rho kinase, beta-secretase, amyloid-beta, neurofibrillary tangles, synaptic dysfunction, neuroinflammation, microglia, astrocytes, inflammatory cytokines, positive feedback loop, therapeutic target
- MeSH terms
- Neuroinflammatory Diseases, Alzheimer Disease, Animals, Humans, Amyloid beta-Peptides, tau Proteins, rhoA GTP-Binding Protein, rho-Associated Kinases
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