The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system

The GPR54 Gene as a Regulator of Puberty

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Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54

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The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54

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Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor

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KiSS-1, a Novel Human Malignant Melanoma Metastasis-Suppressor Gene

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AXOR12, a Novel Human G Protein-coupled Receptor, Activated by the Peptide KiSS-1

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Discovery of a receptor related to the galanin receptors

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Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis

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Male-specific cell migration into the developing gonad

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Dramatic Elevation of Plasma Metastin Concentrations in Human Pregnancy: Metastin as a Novel Placenta-Derived Hormone in Humans

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Kisspeptin Induces Dynamic Chromatin Modifications to Control GnRH Gene Expression

Novaira, H. J., Sonko, M. L., & Radovick, S. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9269-0 · Cited by 17

Photoperiod regulates the differential expression of KiSS-1 and GPR54 in various tissues and sexes of striped hamster

Li, S. N., Xue, H. L., Zhang, Q., Xu, J. H., Wang, S., Chen, L., & Xu, L. (2015) · Genetics and Molecular Research · doi:10.4238/2015.october.29.10 · Cited by 16

The Role of the FSH System in the Development and Progression of Prostate Cancer

Crawford, E. D., Rove, K. O., Schally, A. V., Rick, F. G., Block, N. L., Beveridge, T. J. R., Dahdal, D. N., & Marshall, D. C. (2014) · American Journal of Hematology / Oncology® · Cited by 17

KISS1 Suppresses Apoptosis and Stimulates the Synthesis of E2 in Porcine Ovarian Granulosa Cells

Xin, X., Li, Z., Zhong, Y., Li, Q., Wang, J., Zhang, H., Yuan, X., Li, J., & Zhang, Z. (2019) · Animals · doi:10.3390/ani9020054 · Cited by 17

Kisspeptin and attributes of infertile males and females: A cross‐sectional study in a subset of Pakistani population

Rehman, R., Fatima, S. S., Alam, F., Ashraf, M., & Zafar, S. (2019) · Andrologia · doi:10.1111/and.13370 · Cited by 17

Neuroendocrinology of Reproduction

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Gene Targeting in Neuroendocrinology

Candlish, M., Angelis, R. D., Götz, V., & Boehm, U. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140079 · Cited by 20

CRISPR/Cas9-editing of KISS1 to generate pigs with hypogonadotropic hypogonadism as a castration free trait

Flórez, J. M., Martins, K. V., Solin, S. L., Bostrom, J. R., Rodríguez-Villamil, P., Ongaratto, F. L., Larson, S. A., Ganbaatar, U., Coutts, A. W., Kern, D., et al. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2022.1078991 · Cited by 16

G Protein-coupled receptors as targets for drug design

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Response to exogenous kisspeptin varies according to sex and reproductive condition in Siberian hamsters (Phodopus sungorus)

Greives, T. J., Long, K. L. P., Burns, C. M. B., & Demas, G. E. (2010) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2010.10.001 · Cited by 16

Phylogenetic aspects of gonadotropin‐inhibitory hormone and its homologs in vertebrates

Tsutsui, K. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05510.x · Cited by 16

Reproductive responses of male Brandt’s voles (Lasiopodomys brandtii) to 6-methoxybenzoxazolinone (6-MBOA) under short photoperiod

Dai, X., Jiang, L. Y., Han, M., Ye, M. H., Wang, A. Q., Wei, W. H., & Yang, S. M. (2016) · Die Naturwissenschaften · doi:10.1007/s00114-016-1347-2 · Cited by 16

Kisspeptin stimulates LH secretion but not ovulation in mares during vernal transition

McGrath, B., Scott, C., WYNN, P. C., Loy, J., & Norman, S. T. (2016) · Theriogenology · doi:10.1016/j.theriogenology.2016.05.016 · Cited by 16

Tachykinins and Kisspeptins in the Regulation of Human Male Fertility

Blasco, V., Pinto, F. M., González-Ravina, C., Santamaría‐López, E., Candenas, L., & Sánchez, M. F. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm9010113 · Cited by 16

The role of kisspeptin/GPR54 in the reproductive system.

Papaoiconomou, E., Msaouel, P., Makri, A., Diamanti‐Kandarakis, E., & Koutsilieris, M. (2011) · PubMed · Cited by 16

Neuroendocrine Control of Reproduction in Amphibians

Tsai, P. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-374931-4.10002-1 · Cited by 16

Kiss1 and its receptor: molecular characterization and immunolocalization in the hypothalamus and corpus luteum of the buffalo

Mishra, G. K., Patra, M. K., Singh, L. K., Upmanyu, V., Chakravarti, S., Karikalan, M., Singh, S. K., Das, G. K., Kumar, H., & Krishnaswamy, N. (2018) · Animal Biotechnology · doi:10.1080/10495398.2018.1520715 · Cited by 16

Genetic dissection of puberty in mice

Kumar, D., & Boehm, U. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2013.071928 · Cited by 16

Investigation the mRNA expression of KISS1 and localization of kisspeptin in the testes of Shiba goats and its relationship with the puberty and steriodogenic enzymes

Samir, H., Nagaoka, K., Karen, A., Ahmed, E., Sayed, M. E. E., & Watanabe, G. (2015) · Small Ruminant Research · doi:10.1016/j.smallrumres.2015.10.024 · Cited by 15

Role of Kisspeptin in Regulation of Reproductive and Immune Reactions

Gorbunova, O. L., & Ширшев, С. В. (2020) · Biochemistry (Moscow) · doi:10.1134/s0006297920080015 · Cited by 15

Neuropeptidergic and Neuroendocrine Systems Underlying Eusociality and the Concomitant Social Regulation of Reproduction in Naked Mole-Rats: A Comparative Approach

Coen, C. W., Bennett, N. C., Holmes, M. M., & Faulkes, C. G. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-65943-1_3 · Cited by 16

Feedback regulation of 17β-estradiol on two kisspeptin genes in the Dabry's sturgeon (Acipenser dabryanus)

Yue, H., Ye, H., Ruan, R., Du, H., Li, C., & Wei, Q. (2019) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2019.01.006 · Cited by 14

Evaluation of candidate point mutation of Kisspeptin 1 gene associated with litter size in Indian Goat breeds and its effect on transcription factor binding sites

Jeet, V., Magotra, A., Bangar, Y. C., Kumar, S., Garg, A. R., Yadav, A. S., & Bahurupi, P. (2021) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2021.106676 · Cited by 14

Conditional Deletion of KOR (Oprk1) in Kisspeptin Cells Does Not Alter LH Pulses, Puberty, or Fertility in Mice

Coutinho, E. A., Esparza, L. A., Hudson, A. D., Rizo, N., Steffen, P., & Kauffman, A. S. (2022) · Endocrinology · doi:10.1210/endocr/bqac175 · Cited by 14

Effect of Peripheral Administration of Kisspeptin-10 on Dynamic LH Secretion in Prepubertal Ewes

Wang, J., Sun, L., Zhang, T., Zhou, H., & Lou, Y. (2012) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2011.11390 · Cited by 14

Applying Gene Silencing Technology to Contraception

Dissen, G. A., Lomniczi, A., Boudreau, R. L., Chen, Y., Davidson, B. L., & Ojeda, S. (2012) · Reproduction in Domestic Animals · doi:10.1111/rda.12016 · Cited by 15

Impact of fetal and neonatal malnutrition on the onset of puberty and associated noncommunicable disease risks

Connor, N. E. (2011) · Adolescent Health Medicine and Therapeutics · doi:10.2147/ahmt.s10147 · Cited by 15

Neuroendocrine Mechanism of Puberty

Terasawa, E., & Kurian, J. R. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-375097-6.10019-8 · Cited by 15

Molecular Biology of the Kisspeptin Receptor: Signaling, Function, and Mutations

Bianco, S. D. C., & Kaiser, U. B. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6199-9_7 · Cited by 13

Quantification of Rat Kisspeptin Using a Novel Radioimmunoassay

Kinsey‐Jones, J. S., Beale, K., Cuenco, J., Li, X. F., Bloom, S. R., O’Byrne, K. T., & Murphy, K. G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097611 · Cited by 13

Identification and Profiling of Pituitary microRNAs of Sheep during Anestrus and Estrus Stages

Ullah, Y., Li, C., Li, X., Ni, W., Yao, R., Xu, Y., Quan, R., Li, H., Zhang, M., Liu, L., et al. (2020) · Animals · doi:10.3390/ani10030402 · Cited by 13

Increased high molecular weight adiponectin, but decreased total adiponectin and kisspeptin, in central precocious puberty compared with aged-matched prepubertal girls

Sitticharoon, C., Sukharomana, M., Likitmaskul, S., Churintaraphan, M., & Maikaew, P. (2017) · Reproduction Fertility and Development · doi:10.1071/rd16282 · Cited by 13

Use of genetic models of idiopathic hypogonadotrophic hypogonadism in mice and men to understand the mechanisms of disease

Lippincott, M. F., True, C. A., & Seminara, S. B. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2013.071910 · Cited by 17

Animal models for aberrations of gonadotropin action

Peltoketo, H., Zhang, F., & Rulli, S. B. (2011) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-011-9174-4 · Cited by 13

Engineering a gene silencing viral construct that targets the cat hypothalamus to induce permanent sterility: An update

Dissen, G. A., Adachi, K., Lomniczi, A., Chatkupt, T. T., Davidson, B. L., Nakai, H., & Ojeda, S. (2016) · Reproduction in Domestic Animals · doi:10.1111/rda.12834 · Cited by 13

Ectopic over expression of kiss1 may compensate for the loss of kiss2

Etzion, T., Zmora, N., Zohar, Y., Levavi‐Sivan, B., Golan, M., & Gothilf, Y. (2020) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2020.113523 · Cited by 13

Seasonal expression of KiSS-1 and the pituitary gonadotropins LHβ and FSHβ in adult male Libyan jird (Meriones libycus)

Boufermes, R., Richard, N., Moguen, K. L., Amirat, Z., Khammar, F., & Kottler, M. (2014) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2014.04.001 · Cited by 13

Expression profile of the Kisspeptin/Kiss1r system and angiogenic and immunological mediators in the ovary of cyclic and pregnant cats

Santos, L. C., Cordeiro, J. M. D. A., Santana, L. D. S., Barbosa, E. M., Santos, B. R., da Silva, T. Q. M., de Souza, S. S., Corrêa, J. M. X., de Lavor, M. S. L., da Silva, E. B., et al. (2021) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2021.106650 · Cited by 12

Role of the Kisspeptin/KISS1 Receptor System in the Testicular Development of Mice

Chiang, C.-M., Chiu, H.-Y., Jong, D., Wu, L., Lee, Y., & Chiu, C. (2020) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000000443f · Cited by 15

Effects of the Hormone Kisspeptin on Reproductive Hormone Release in Humans

Calley, J. L., & Dhillo, W. S. (2014) · Advances in Biology · doi:10.1155/2014/512650 · Cited by 12

Expression of GnRH receptor in the canine corpus luteum, and luteal function following deslorelin acetate‐induced puberty delay

Kaya, D., Gram, A., Kowalewski, M. P., Schäfer–Somi, S., Kuru, M., Boos, A., & Aslan, S. (2017) · Reproduction in Domestic Animals · doi:10.1111/rda.13038 · Cited by 12

Expression and functional role of kisspeptin and its receptor in the cyclic corpus luteum of buffalo (Bubalus bubalis)

Mishra, G. K., Patra, M. K., Singh, L. K., Upmanyu, V., Chakravarti, S., Karikalan, M., Bag, S., Singh, S. K., Das, G. K., Kumar, H., et al. (2019) · Theriogenology · doi:10.1016/j.theriogenology.2019.02.037 · Cited by 13

Endocrine Events Involved in Puberty: A Revisit to Existing Knowledge

Aslam, S. (2020) · Life and Science · doi:10.37185/lns.1.1.43 · Cited by 13

Corrigendum to : Increased high molecular weight adiponectin, but decreased total adiponectin and kisspeptin, in central precocious puberty compared with aged-matched prepubertal girls

Sitticharoon, C., Sukharomana, M., Likitmaskul, S., Churintaraphan, M., & Maikaew, P. (2017) · Reproduction Fertility and Development · doi:10.1071/rd16282_co · Cited by 12

Serum kisspeptin: New possible biomarker for sexual behaviour and sperm concentration in buffalo bulls

Bhardwaj, S., Kumar, P., Jerome, A., Ravesh, S., Patil, C., Singh, P., & Lailer, P. C. (2020) · Reproduction in Domestic Animals · doi:10.1111/rda.13761 · Cited by 11

Expression of GnRH and Kisspeptin in Primary Cultures of Fetal Rat Brain

Sukhbaatar, U., Kanasaki, H., Mijiddorj, T., Oride, A., Hara, T., Yamada, T., & Kyo, S. (2016) · Reproductive Sciences · doi:10.1177/1933719116653679 · Cited by 11

Endocannabinoids and Kisspeptins: Two Modulators in Fight for the Regulation of GnRH Activity

Meccariello, R., Chianese, R., Fasano, S., & Pierantoni, R. (2013) · InTech eBooks · doi:10.5772/48443 · Cited by 11

Effects of various photoperiods on Kisspeptin and reproductive hormones in the goldfish,Carassius auratus

Shin, H. S., Song, J. A., Choi, J. Y., Kim, N. N., Choi, Y. J., Sung, S. N., Park, M. S., Min, B. H., & Choi, C. Y. (2014) · Animal Cells and Systems · doi:10.1080/19768354.2014.902863 · Cited by 11

GnRH and Cognition

Kacimi, L., & Prévot, V. (2025) · Endocrinology · doi:10.1210/endocr/bqaf033 · Cited by 10

Initiation of active immunization against testosterone during early puberty alters negative feedback regulation of the hypothalamic-pituitary-testicular axis in rabbits

Han, X., Cheng, W., Chen, Z. Y., Du, X., Cao, X., & Zeng, X. Y. (2014) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2014.04.001 · Cited by 10

Association of the KiSS1 gene with litter size in Cyprus and Iraqi black goats

Rahawy, M. A., & Al-Mutar, H. A.-K. (2021) · Veterinary World · doi:10.14202/vetworld.2021.1995-2001 · Cited by 10

Can the kisspeptin help us in the understanding of pathology of some neurodegenerative brain diseases?

Melka, N., Pszczolińska, A., Klejbor, I., Ludkiewicz, B., Kowiański, P., & Moryś, J. (2021) · Folia Morphologica · doi:10.5603/fm.a2021.0090 · Cited by 10

Aspectos clínicos e moleculares do hipogonadismo hipogonadotrófico isolado congênito

Tusset, C., Trarbach, E. B., Silveira, L. F. G., Beneduzzi, D., Montenegro, L. R., & Latronico, A. C. (2011) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302011000800002 · Cited by 10

The Influence of Gonadal Steroid Hormones on Immunoreactive Kisspeptin in the Preoptic Area and Arcuate Nucleus of Developing Agonadal Mice with a Genetic Disruption of Steroidogenic Factor 1

Büdefeld, T., Tobet, S. A., & Majdič, G. (2015) · Neuroendocrinology · doi:10.1159/000437166 · Cited by 10

Characterization of the receptor binding residues of kisspeptins by positional scanning using peptide photoaffinity probes

Misu, R., Oishi, S., Setsuda, S., Noguchi, T., Kaneda, M., Ohno, H., Evans, B. J., Navenot, J.-M., Peiper, S. C., & Fujii, N. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.02.098 · Cited by 11

Association between polymorphism of GPR54 gene and litter size in Small Tail Han sheep

Tang, Q. Q., Chu, M., Cao, G., Li, F., Di, R., Feng, T., Huang, D., & Li, N. (2011) · Livestock Science · doi:10.1016/j.livsci.2011.09.005 · Cited by 10

Kisspeptide in the estrous mare: Is it an appropriate ovulation-inducing agent?

Magee, C., Bruemmer, J. E., Nett, T. M., Squires, E. L., & Clay, C. M. (2012) · Theriogenology · doi:10.1016/j.theriogenology.2012.07.012 · Cited by 10

Variety of functions and effects of kisspeptin

Matvienko, M. G., Pustovalov, A. S., & Dzerzhinskii, N. E. (2013) · Biopolymers and Cell · doi:10.7124/bc.000801 · Cited by 10

Temporal expression of the KISS1/GPR54 system in goats’ testes and epididymides and its spatial expression in pubertal goats

Han, Y., Zhao, Y., Si, W., Jiang, X., Wu, J., Na, R., Han, Y., Li, K., Yang, L., Guangxin, E., et al. (2020) · Theriogenology · doi:10.1016/j.theriogenology.2020.04.022 · Cited by 10

Knockout of tac3 genes in zebrafish shows no impairment of reproduction

Li, Y., Zhao, T., Liu, Y., Lin, H., Li, S., & Zhang, Y. (2021) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2021.113839 · Cited by 10

Differential regulation of GPR54 transcription by specificity protein-1 and partial estrogen response element in mouse pituitary cells

DeFino, M. C., Wacker, J. L., Lyssand, J. S., Wang, E. H., & Hague, C. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.026 · Cited by 11

Gonadotropin-Releasing Hormones

Millar, R. P., & Tello, J. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00115-3 · Cited by 11

Three Siblings with Idiopathic Hypogonadotropic Hypogonadism in a Nonconsanguineous Family: A Novel KISS1R/GPR54 Loss-of-Function Mutation

Nalbantoğlu, Ö., Arslan, G., Köprülü, Ö., Hazan, F., Gürsoy, S., & Özkan, B. (2019) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.galenos.2019.2018.0230 · Cited by 10

Gonadotropin-inhibitory Hormone (GnIH): Biosynthesis, Mode of Action and Functional Significance in Birds

Tsutsui, K., & Bentley, G. E. (2009) · Avian Biology Research · doi:10.3184/175815508x402473 · Cited by 10

Kisspeptin and lactational anestrus: Current understanding and future prospects

Uenoyama, Y., Inoue, N., & Tsukamura, H. (2023) · Peptides · doi:10.1016/j.peptides.2023.171026 · Cited by 9

Targeted Gene Silencing to Induce Permanent Sterility

Dissen, G. A., Lomniczi, A., Boudreau, R. L., Chen, Y., Davidson, B. L., & Ojeda, S. (2012) · Reproduction in Domestic Animals · doi:10.1111/j.1439-0531.2012.02080.x · Cited by 9

Correlation of plasma kisspeptin with total testosterone levels in smokeless tobacco and smoking tobacco users in a healthy cohort: a cross-sectional study

Shah, S. S., Shah, M., Habib, S. H., Shah, F. A., & Malik, M. O. (2019) · Andrologia · doi:10.1111/and.13409 · Cited by 9

Model Systems for Studying Kisspeptin Signalling: Mice and Cells

Colledge, W. H., Doran, J., & Mei, H. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6199-9_22 · Cited by 9

Effects of repeated injection of kisspeptin-10 on the initiation of egg-laying in juvenile quail

Ni, Y., Huang, Y., Xiao, Y., Wu, J., Qian, F., Großmann, R., & Zhao, R. (2012) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2012.08.022 · Cited by 9

The role of kisspeptin signalling in the regulation of the GnRH-gonadotrophin ovarian axis in mice

Colledge, W. H., & de Tassigny, X. D. (2010) · Annales d Endocrinologie · doi:10.1016/j.ando.2010.02.011 · Cited by 9

Effects of Kisspeptin-10 on Lipid Metabolism in Cultured Chicken Hepatocytes

Wu, J., Fu, W., Huang, Y., & Ni, Y. (2012) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2012.12189 · Cited by 9

The role of kisspeptin signalling in control of reproduction in genetically similar species.

Babiker, A. M. I., & Shaikh, A. M. A. (2016) · PubMed Central · Cited by 9

The Kiss2/GPR54 system stimulates the reproductive axis in male black porgy, Acanthopagrus schlegelii

Ma, X., Yuan, B., & Zhou, L.-B. (2019) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2019.04.024 · Cited by 9

Orphan neuropeptides

Chung, S., & Civelli, O. (2006) · Neuropeptides · doi:10.1016/j.npep.2006.04.002 · Cited by 9

New insights on the neuroendocrine control of puberty and seasonal breeding in female sheep

Decourt, C., & Beltramo, M. (2018) · Animal Reproduction · doi:10.21451/1984-3143-ar2018-0047 · Cited by 9

Estrogen-Regulated Lateral Septal Kisspeptin Neurons Abundantly Project to GnRH Neurons and the Hypothalamic Supramammillary Nucleus

Szentkirályi-Tóth, S., Göcz, B., Takács, S., Sárvári, M., Farkas, I., Skrapits, K., Rumpler, É., Póliska, S., Rácz, G., Matolcsy, A., et al. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1307-24.2024 · Cited by 9

The testobolome in microbial testosterone metabolism and human health

Veerus, L., Subrahmanian, A., & Blaser, M. J. (2026) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00861-0 · Cited by 9

Kisspeptins in physiology and pathology of sex development - new diagnostic and therapeutic approaches

Nikitina, I. L., Азизович, Б. А., Николаевна, Х. Ю., & Shabanov, P. D. (2014) · Reviews on Clinical Pharmacology and Drug Therapy · doi:10.17816/rcf1243-12 · Cited by 8

Contrôle de l’axe gonadotrope : nouveaux aspects physiologiques et thérapeutiques

Maione, L., Christin‐Maître, S., Chanson, P., & Young, J. (2017) · Annales d Endocrinologie · doi:10.1016/s0003-4266(17)30923-x · Cited by 9

Hypothalamic Kisspeptin Expression in Hyperandrogenic Female Rats and Aging Rats

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Direct effect of RFRP‑3 microinjection into the lateral ventricle on the hypothalamic kisspeptin neurons in ovariectomized estrogen‑primed rats

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