Cited by 677Hypothalamic control of reproductive hormonesGenetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesSexual Differentiation and Disorders

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The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system

Funes, Sandrine, Hedrick, Joseph A, Vassileva, Galya, Markowitz, Lisa, Abbondanzo, Susan, Golovko, Andrei, Yang, Shijun, Monsma, Frederick J, Gustafson, Eric L·2003·Biochemical and Biophysical Research Communications

DOI 10.1016/j.bbrc.2003.11.066

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Abstract

GPR54 is a G-protein-coupled receptor that displays a high percentage of identity in the transmembrane domains with the galanin receptors. The ligand for GPR54 has been identified as a peptide derived from the KiSS-1 gene. KiSS-1 has been shown to have anti-metastatic effects, suggesting that KiSS-1 or its receptor represents a potential therapeutic target. To further our understanding of the physiological function of this receptor, we have generated a mutant mouse line with a targeted disruption of the GPR54 receptor (GPR54 -/-). The analysis of the GPR54 mutant mice revealed developmental abnormalities of both male and female genitalia and histopathological changes in tissues which normally contain sexually dimorphic features. These data suggest a role for GPR54/KiSS-1 in normal sexual development, and indicate that study of the GPR54 mutant mice may provide valuable insights into human reproductive syndromes.

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Authors: Funes, S., Hedrick, J. A., Vassileva, G., Markowitz, L., Abbondanzo, S., Golovko, A., Yang, S., Monsma, F. J., & Gustafson, E. L.
Corresponding author: Gustafson, Eric L
ORCID: Hedrick, Joseph A
Golovko, Andrei
Monsma, Frederick J
Venue: Biochemical and Biophysical Research Communications
Publisher: Elsevier BV
Published: 2003-12
Volume: 312
Issue: 4
Pages: 1357-1363
ISSN: 0006-291X (ISSN-L)
DOI: 10.1016/j.bbrc.2003.11.066
OpenAlex: W1964782601
Cited by: 675
References: 26
Citations by year: 2026: 4 · 2025: 9 · 2024: 22 · 2023: 15 · 2022: 17 · 2021: 25 · 2020: 29 · 2019: 35 · 2018: 28 · 2017: 26 · 2016: 37 · 2015: 40 · 2014: 38 · 2013: 38 · 2012: 51
FWCI: 20.89
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochemical and Biophysical Research Communications (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords: GPR54, KISS1, galanin receptors, G protein-coupled receptors, reproductive system development, sexual differentiation, genitalia development, mouse mutants, sexual dimorphism
MeSH terms: Receptors, Kisspeptin-1, Animals, Female, Genitalia, Hypogonadism, Male, Mutation, Organ Specificity, Phenotype, Proteins, Reproduction, Sexual Maturation, Tissue Distribution, Receptors, Neuropeptide, Mice, Knockout, Receptors, G-Protein-Coupled, Mice, Kisspeptins

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The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system

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