The p53 response: Emerging levels of co-factor complexity
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p53 activators JMY, TOPORS, TP53BP2, DAXX, and HNRPK can stabilize p53 protein levels by interfering with MDM2 and/or act as p53 transcriptional cofactors, assisting p53 in transactivating genes that induce apoptosis and growth arrest.
“The miR-21 targets we identified included p53 homologue, p63, p53 activators JMY, TOPORS, TP53BP2, DAXX, and HNRPK, which can stabilize p53 protein levels by interfering with MDM2 and/or act as p53 transcriptional cofactors, assisting p53 in transactivating genes that can induce apoptosis and growth arrest (21)(22)(23)(24)(25)(26).”
From MicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells (2008) · cites this paper as [21]
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References 100 · Cited by 72
- Authors
- Coutts, A. S., & La Thangue, N. B.
- Affiliations
- University of Glasgow (GB)
- ORCID
- Coutts, Amanda S.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 331
- Issue
- 3
- Pages
- 778-785
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2066570761
- Cited by
- 72
- References
- 100
- Citations by year
- 2026: 1 · 2023: 2 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 5 · 2013: 2 · 2012: 5
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancer Research UK (13058)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Keywords
- miR-21, glioma, microRNA, treatment resistance, chemoresistance, radiotherapy resistance, tumor grade, prognosis, post-transcriptional regulation, p53, tumor cell survival, tumor invasion
- MeSH terms
- Promyelocytic Leukemia Protein, Tumor Suppressor p53-Binding Protein 1, Nucleophosmin, p300-CBP-Associated Factor, Acetyltransferases, Animals, Carrier Proteins, Chromatin, Chromosomal Proteins, Non-Histone, DNA-Binding Proteins, Humans, Neoplasm Proteins, Nuclear Proteins, Phosphoproteins, Proto-Oncogene Proteins, Transcription Factors, Transcriptional Activation, Trans-Activators, Tumor Suppressor Protein p53, Cell Cycle Proteins, Tumor Suppressor Proteins, Intracellular Signaling Peptides and Proteins, Adaptor Proteins, Signal Transducing, p300-CBP Transcription Factors, CREB-Binding Protein, Apoptosis Regulatory Proteins, Mice, Histone Acetyltransferases, Proto-Oncogene Proteins c-mdm2
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