Design, engineering, and characterization of zinc finger nucleases

Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain.

Kim, Y. G., Cha, J., & Chandrasegaran, S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1156 · Cited by 2,099 · see citing works

Zinc Finger-DNA Recognition: Crystal Structure of a Zif268-DNA Complex at 2.1 Å

Pavletich, N. P., & Pabo, C. O. (1991) · Science · doi:10.1126/science.2028256 · Cited by 2,081 · see citing works

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

Urnov, F. D., Miller, J. C., Lee, Y.-L., Beausejour, C. M., Rock, J. M., Augustus, S., Jamieson, A. C., Porteus, M. H., Gregory, P. D., & Holmes, M. C. (2005) · Nature · doi:10.1038/nature03556 · Cited by 1,642 · see citing works

Targeted Chromosomal Cleavage and Mutagenesis in Drosophila Using Zinc-Finger Nucleases

Bibikova, M., Golic, M., Golic, K. G., & Carroll, D. (2002) · Genetics · doi:10.1093/genetics/161.3.1169 · Cited by 860 · see citing works

Enhancing Gene Targeting with Designed Zinc Finger Nucleases

Bibikova, M. V., Beumer, K. J., Trautman, J. K., & Carroll, D. (2003) · Science · doi:10.1126/science.1079512 · Cited by 824 · see citing works

Nucleic Acids and Molecular Biology

Eckstein, F., & Lilley, D. M. J. (1994) · Nucleic acids and molecular biology · doi:10.1007/978-3-642-78666-2 · Cited by 769 · see citing works

Chimeric nucleases stimulate gene targeting in human cells

Porteus, M. H., & Baltimore, D. (2003) · Science · doi:10.1126/science.1078395 · Cited by 741 · see citing works

Stimulation of Homologous Recombination through Targeted Cleavage by Chimeric Nucleases

Bibikova, M. V., Carroll, D., Segal, D. J., Trautman, J. K., Smith, J., Kim, Y., & Chandrasegaran, S. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.289-297.2001 · Cited by 614 · see citing works

Toward controlling gene expression at will: Specific regulation of the erbB - 2 / HER - 2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks

Beerli, R. R., Segal, D. J., Dreier, B., & Barbas, C. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14628 · Cited by 539 · see citing works

Engineering polydactyl zinc-finger transcription factors

Beerli, R. R., & Barbas, C. F. (2002) · Nature Biotechnology · doi:10.1038/nbt0202-135 · Cited by 495 · see citing works

Fok I dimerization is required for DNA cleavage

Bitinaite, J., Wah, D. A., Aggarwal, A. K., & Schildkraut, I. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10570 · Cited by 490 · see citing works

Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains

Smith, J. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.17.3361 · Cited by 425 · see citing works

Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5′-GNN-3′ DNA target sequences

Segal, D. J., Dreier, B., Beerli, R. R., & Barbas, C. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.2758 · Cited by 420 · see citing works

Targeted mutagenesis using zinc-finger nucleases in Arabidopsis

Lloyd, A., Plaisier, C. L., Carroll, D., & Drews, G. N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409339102 · Cited by 418 · see citing works

A General Strategy for Selecting High-Affinity Zinc Finger Proteins for Diverse DNA Target Sites

Greisman, H. A., & Pabo, C. O. (1997) · Science · doi:10.1126/science.275.5300.657 · Cited by 331 · see citing works

Development of Zinc Finger Domains for Recognition of the 5′-ANN-3′ Family of DNA Sequences and Their Use in the Construction of Artificial Transcription Factors

Dreier, B., Beerli, R. R., Segal, D. J., Flippin, J. D., & Barbas, C. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102604200 · Cited by 329 · see citing works

Design of polydactyl zinc-finger proteins for unique addressing within complex genomes

Liu, Q., Segal, D. J., Ghiara, J. B., & Barbas, C. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.11.5525 · Cited by 327 · see citing works

Structure of the multimodular endonuclease FokI bound to DNA

Wah, D. A., Hirsch, J. A., Dorner, L. F., Schildkraut, I., & Aggarwal, A. K. (1997) · Nature · doi:10.1038/40446 · Cited by 266 · see citing works

Drug discovery with engineered zinc-finger proteins

Jamieson, A., Miller, J. C., & Pabo, C. (2003) · Nature reviews. Drug discovery · doi:10.1038/nrd1087 · Cited by 263 · see citing works

Functional domains in Fok I restriction endonuclease.

Li, L., Wu, L. P., & Chandrasegaran, S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4275 · Cited by 239 · see citing works

Regulation of an Endogenous Locus Using a Panel of Designed Zinc Finger Proteins Targeted to Accessible Chromatin Regions

Liu, P., Rebar, E. J., Zhang, L., Liu, Q., Jamieson, A. C., Liang, Y., Qi, H., Li, P.-X., Chen, B., Mendel, M. C., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011172200 · Cited by 239 · see citing works

Use of a zinc-finger consensus sequence framework and specificity rules to design specific DNA binding proteins.

Desjarlais, J. R., & Berg, J. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2256 · Cited by 227 · see citing works

Getting a handhold on DNA: Design of poly-zinc finger proteins with femtomolar dissociation constants

Kim, J., & Pabo, C. O. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2812 · Cited by 221 · see citing works

Structure of Fok I has implications for DNA cleavage

Wah, D. A., Bitinaite, J., Schildkraut, I., & Aggarwal, A. K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10564 · Cited by 202 · see citing works

Synthetic Zinc Finger Transcription Factor Action at an Endogenous Chromosomal Site

Zhang, L., Spratt, S. K., Liu, Q., Johnstone, B. H., Qi, H., Raschke, E. E., Jamieson, A. C., Rebar, E. J., Wolffe, A. P., & Case, C. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005341200 · Cited by 180 · see citing works

A 2.2 Å resolution crystal structure of a designed zinc finger protein bound to DNA

Kim, C. A., & Berg, J. M. (1996) · Nature Structural Biology · doi:10.1038/nsb1196-940 · Cited by 178 · see citing works

Validated Zinc Finger Protein Designs for All 16 GNN DNA Triplet Targets

Liu, Q., Xia, Z., & Case, C. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110669200 · Cited by 164 · see citing works

Improved DNA binding specificity from polyzinc finger peptides by using strings of two-finger units

Moore, M. J. B., Klug, A., & Choo, Y. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1437 · Cited by 162 · see citing works

Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection

Hurt, J. A., Thibodeau, S. A., Hirsh, A. S., Pabo, C. O., & Joung, J. K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2135381100 · Cited by 146 · see citing works

A detailed study of the substrate specificity of a chimeric restriction enzyme

Smith, J., Berg, J. M., & Chandrasegaran, S. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.2.674 · Cited by 107 · see citing works

Chimeric Restriction Enzymes: What Is Next?

Chandrasegaran, S., & Smith, J. (1999) · Biological Chemistry · doi:10.1515/bc.1999.103 · Cited by 85 · see citing works

A direct comparison of the properties of natural and designed zinc-finger proteins

Shi, Y., & Berg, J. M. (1995) · Chemistry & Biology · doi:10.1016/1074-5521(95)90280-5 · Cited by 61 · see citing works

[8] Phage display methods for selecting zinc finger proteins with novel DNA-binding specificities

Rebar, E. J., Greisman, H. A., & Pabo, C. O. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)67010-4 · Cited by 53 · see citing works

'Magic' scissors for genome surgery

Kandavelou, K., Mani, M., Sundar, D., & Chandrasegaran, S. (2005) · Nature Biotechnology · doi:10.1038/nbt0605-686 · Cited by 33 · see citing works

A Bacterial One-Hybrid Selection System for Interrogating Zinc Finger- DNA Interactions

Sundar, D., Bosley, A. D., Abulencia, A., Chandrasegaran, S., & Ostermeier, M. (2006) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/138620706776843147 · Cited by 33 · see citing works

Long-range identification of hepatocyte nuclear factor-3 (FoxA) high and low-affinity binding sites with a chimeric nuclease 1 1Edited by M. Yaniv

Ruminy, P., Derambure, C., Chandrasegaran, S., & Salier, J. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4788 · Cited by 14 · see citing works

Engineering and Applications of Chimeric Nucleases

Kandavelou, K., Mani, M., Durai, S., & Chandrasegaran, S. (2004) · Nucleic acids and molecular biology · doi:10.1007/978-3-642-18851-0_16 · Cited by 8 · see citing works

Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells

Durai, S. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki912 · Cited by 522 · see citing works

Recombinant Probes for Visualizing Endogenous Synaptic Proteins in Living Neurons

Gross, G. G., Junge, J. A., Mora, R. J., Kwon, H., Olson, C. A., Takahashi, T. T., Liman, E. R., Ellis‐Davies, G. C. R., McGee, A. W., Sabatini, B. L., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.017 · Cited by 357 · see citing works

Zinc-finger Nucleases: The Next Generation Emerges.

Cathomen, T., & Joung, J. (2008) · Molecular Therapy · doi:10.1038/mt.2008.114 · Cited by 361 · see citing works

CRISPR/Cas9-mediated targeted mutagenesis in Nicotiana tabacum

Gao, J., Wang, G., Ma, S., Xie, X., Wu, X., Zhang, X., Wu, Y., Zhao, P., & Xia, Q. (2014) · Plant Molecular Biology · doi:10.1007/s11103-014-0263-0 · Cited by 340 · see citing works

Origins of Programmable Nucleases for Genome Engineering

Chandrasegaran, S., & Carroll, D. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.10.014 · Cited by 327 · see citing works

Genetic therapies against HIV

Rossi, J. J., June, C. H., & Kohn, D. B. (2007) · Nature Biotechnology · doi:10.1038/nbt1367 · Cited by 233 · see citing works

Oligomerized pool engineering (OPEN): an 'open-source' protocol for making customized zinc-finger arrays

Maeder, M. L., Thibodeau-Beganny, S., Sander, J. D., Voytas, D. F., & Joung, J. K. (2009) · Nature Protocols · doi:10.1038/nprot.2009.98 · Cited by 207 · see citing works

Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly

Wright, D. A., Thibodeau-Beganny, S., Sander, J. D., Winfrey, R. J., Hirsh, A. S., Eichtinger, M., Fu, F., Porteus, M. H., Dobbs, D. L., Voytas, D. F., et al. (2006) · Nature Protocols · doi:10.1038/nprot.2006.259 · Cited by 206 · see citing works

Inhibition of hepatitis B virus by the CRISPR/Cas9 system via targeting the conserved regions of the viral genome

Liu, X., Hao, R., Chen, S., Guo, D., & Chen, Y. Z. (2015) · Journal of General Virology · doi:10.1099/vir.0.000159 · Cited by 151 · see citing works

Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases

Wilen, C. B., Wang, J., Tilton, J. C., Miller, J. C., Kim, K. A., Rebar, E. J., Sherrill-Mix, S. A., Patro, S. C., Secreto, A. J., Jordan, A. P. O., et al. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002020 · Cited by 142 · see citing works

Delivery of Multiple Transgenes to Plant Cells

Dafny-Yelin, M., & Tzfira, T. (2007) · Plant Physiology · doi:10.1104/pp.107.106104 · Cited by 136 · see citing works

Mutation Breeding in Tomato: Advances, Applicability and Challenges

Chaudhary, J., Alisha, A., Bhatt, V. D., Chandanshive, S., Kumar, N., Mir, Z. A., Kumar, A., Yadav, S. K., Shivaraj, S. M., Sonah, H., et al. (2019) · Plants · doi:10.3390/plants8050128 · Cited by 134 · see citing works

Genome Engineering at the Dawn of the Golden Age

Segal, D. J., & Meckler, J. F. (2013) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-091212-153435 · Cited by 125 · see citing works

Genome editing in plant cells by zinc finger nucleases

Weinthal, D., Tovkach, A., Zeevi, V., & Tzfira, T. (2010) · Trends in Plant Science · doi:10.1016/j.tplants.2010.03.001 · Cited by 121 · see citing works

Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling

Beckers, J., Wurst, W., & de Angelis, M. H. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2578 · Cited by 112 · see citing works

Genome Editing Tools in Plants

Mohanta, T. K., Bashir, T., Hashem, A., Allah, E. F. A., & Bae, H. (2017) · Genes · doi:10.3390/genes8120399 · Cited by 105 · see citing works

Efficient Generation of Myostatin (MSTN) Biallelic Mutations in Cattle Using Zinc Finger Nucleases

Luo, J., Song, Z., Yu, S., Cui, D., Wang, B., Ding, F., Song, L., Dai, Y., & Li, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095225 · Cited by 104 · see citing works

CRISPR/Cas9: an advanced tool for editing plant genomes

Samanta, M. K., Dey, A., & Gayen, S. (2016) · Transgenic Research · doi:10.1007/s11248-016-9953-5 · Cited by 104 · see citing works

Direct detection of double-stranded DNA: molecular methods and applications for DNA diagnostics

Ghosh, I., Stains, C. I., Ooi, A. T., & Segal, D. J. (2006) · Molecular BioSystems · doi:10.1039/b611169f · Cited by 101 · see citing works

Zinc finger nuclease technology heralds a new era in mammalian transgenesis

Provost, F. L., Lillico, S. G., Passet, B., Young, R. A., Whitelaw, B., & Vilotte, J.-L. (2009) · Trends in biotechnology · doi:10.1016/j.tibtech.2009.11.007 · Cited by 88 · see citing works

Correction of the ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Gene by Zinc-Finger Nuclease Homology-Directed Repair

Lee, C. M., Flynn, R., Hollywood, J. A., Scallan, M. F., & Harrison, P. T. (2012) · BioResearch open access · doi:10.1089/biores.2012.0218 · Cited by 84 · see citing works

Custom-designed zinc finger nucleases: What is next?

Wu, J. S., Kandavelou, K., & Chandrasegaran, S. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7206-8 · Cited by 87 · see citing works

Newer Gene Editing Technologies toward HIV Gene Therapy

Manjunath, N., Yi, G., Dang, Y., & Shankar, P. (2013) · Viruses · doi:10.3390/v5112748 · Cited by 77 · see citing works

Creating Designed Zinc-Finger Nucleases with Minimal Cytotoxicity

Ramalingam, S., Kandavelou, K., Rajenderan, R., & Chandrasegaran, S. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.10.043 · Cited by 77 · see citing works

Enhancement of specialized metabolites using CRISPR/Cas gene editing technology in medicinal plants

Das, S., Kwon, M., & Kim, J. (2024) · Frontiers in Plant Science · doi:10.3389/fpls.2024.1279738 · Cited by 81 · see citing works

A toolbox and procedural notes for characterizing novel zinc finger nucleases for genome editing in plant cells

Tovkach, A., Zeevi, V., & Tzfira, T. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03718.x · Cited by 76 · see citing works

The Generation of Zinc Finger Proteins by Modular Assembly

Bhakta, M. S., & Segal, D. J. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-753-2_1 · Cited by 75 · see citing works

Genome modifications in plant cells by custom‐made restriction enzymes

Tzfira, T., Weinthal, D., Marton, I., Zeevi, V., Zuker, A., & Vainstein, A. (2012) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2011.00672.x · Cited by 68 · see citing works

A novel arrangement of zinc finger nuclease system for in vivo targeted genome engineering: the tomato LEC1-LIKE4 gene case

Hilioti, Z., Ganopoulos, I. V., Ajith, S., Bossis, I., & Tsaftaris, A. S. (2016) · Plant Cell Reports · doi:10.1007/s00299-016-2031-x · Cited by 68 · see citing works

Targeted DNA excision in Arabidopsis by a re-engineered homing endonuclease

Antunes, M. S., Smith, J., Jantz, D., & Medford, J. I. (2012) · BMC Biotechnology · doi:10.1186/1472-6750-12-86 · Cited by 60 · see citing works

Application of ZFN for Site Directed Mutagenesis of Rice SSIVa Gene

Jung, Y., Nogoy, F. M., Lee, S., Cho, Y., & Kang, K.-K. (2018) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-017-0420-9 · Cited by 59 · see citing works

Novel Approaches to Inhibit HIV Entry

Didigu, C. A., & Doms, R. W. (2012) · Viruses · doi:10.3390/v4020309 · Cited by 52 · see citing works

Genome editing strategies: potential tools for eradicating HIV-1/AIDS

Khalili, K., Kaminski, R., Gordon, J., Cosentino, L., & Hu, W. (2015) · Journal of NeuroVirology · doi:10.1007/s13365-014-0308-9 · Cited by 48 · see citing works

Towards targeted mutagenesis and gene replacement in plants

Tzfira, T., & White, C. I. (2005) · Trends in biotechnology · doi:10.1016/j.tibtech.2005.10.002 · Cited by 46 · see citing works

Strategies for mitochondrial gene editing

Yang, X., Jiang, J., Li, Z., Liang, J., & Xiang, Y. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.06.003 · Cited by 44 · see citing works

Endonucleases: tools to correct the dystrophin gene

Rousseau, J., Chapdelaine, P., Boisvert, S., de Almeida, L. P., Corbeil, J., Montpetit, A., & Tremblay, J. P. (2011) · The Journal of Gene Medicine · doi:10.1002/jgm.1611 · Cited by 42 · see citing works

Stem cell-based therapies for HIV/AIDS

Pernet, O., Yadav, S. S., & An, D. S. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.027 · Cited by 42 · see citing works

Zinc Finger Nuclease and Homing Endonuclease-Mediated Assembly of Multigene Plant Transformation Vectors

Zeevi, V., Liang, Z., Arieli, U., & Tzfira, T. (2011) · PLANT PHYSIOLOGY · doi:10.1104/pp.111.184374 · Cited by 39 · see citing works

Targeted manipulation of mammalian genomes using designed zinc finger nucleases

Kandavelou, K., Ramalingam, S., London, V., Mani, M., Wu, J., Alexeev, V. Y., Civin, C. I., & Chandrasegaran, S. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.07.112 · Cited by 38 · see citing works

Gene targeting in plants: fingers on the move

Kumar, S., Allen, G. C., & Thompson, W. F. (2006) · Trends in Plant Science · doi:10.1016/j.tplants.2006.02.002 · Cited by 36 · see citing works

Heterodimeric DNA methyltransferases as a platform for creating designer zinc finger methyltransferases for targeted DNA methylation in cells

Meister, G. E., Chandrasegaran, S., & Ostermeier, M. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1126 · Cited by 35 · see citing works

A novel strategy to visualize vesicle‐bound kinesins reveals the diversity of kinesin‐mediated transport

Yang, R., Bostick, Z., Garbouchian, A., Luisi, J., Banker, G. A., & Bentley, M. (2019) · Traffic · doi:10.1111/tra.12692 · Cited by 35 · see citing works

Recent developments and clinical studies utilizing engineered zinc finger nuclease technology

Jo, Y.-I., Kim, S., & Ramakrishna, S. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1956-5 · Cited by 36 · see citing works

Maraviroc in the treatment of HIV infection

Ray, N. (2008) · Drug Design Development and Therapy · doi:10.2147/dddt.s3474 · Cited by 34 · see citing works

Increasing cloning possibilities using artificial zinc finger nucleases

Zeevi, V., Tovkach, A., & Tzfira, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803618105 · Cited by 33 · see citing works

The chemokine system and CCR5 antagonists: potential in HIV treatment and other novel therapies

Dhami, H., Fritz, C. E., Gankin, B., Pak, S. H., Yi, W., Seya, M.-J., Raffa, R. B., & Nagar, S. (2008) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/j.1365-2710.2008.00978.x · Cited by 31 · see citing works

Engineered Zinc Finger Nuclease–Mediated Homologous Recombination of the Human Rhodopsin Gene

Greenwald, D. L., Cashman, S. M., & Kumar‐Singh, R. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5781 · Cited by 25 · see citing works

Catalytic domain of restriction endonuclease BmrI as a cleavage module for engineering endonucleases with novel substrate specificities

Chan, S., Bao, Y., Ciszak, E. M., Laget, S., & Xu, S.-Y. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm665 · Cited by 25 · see citing works

Emerging gene editing strategies for Duchenne muscular dystrophy targeting stem cells

Bertoni, C. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00148 · Cited by 24 · see citing works

CCR5 as Target for HIV-1 Gene Therapy

Nazari, R., & Joshi, S. (2008) · Current Gene Therapy · doi:10.2174/156652308785160674 · Cited by 22 · see citing works

Genome Editing Approaches with CRISPR/Cas9 for Cancer Treatment: Critical Appraisal of Preclinical and Clinical Utility, Challenges, and Future Research

Chira, S., Nutu, A. M., Isachesku, E., Bica, C., Pop, L., Ciocan, C. A., & Berindan‐Neagoe, I. (2022) · Cells · doi:10.3390/cells11182781 · Cited by 23 · see citing works

HER2+ Breast Cancer Therapy: By CPP-ZFN Mediated Targeting of mTOR?

Puria, R., Sahi, S., & Nain, V. (2012) · Technology in Cancer Research & Treatment · doi:10.7785/tcrt.2012.500247 · Cited by 19 · see citing works

The development of genome editing tools as powerful techniques with versatile applications in biotechnology and medicine: CRISPR/Cas9, ZnF and TALE nucleases, RNA interference, and Cre/loxP

Schulze, S., & Lammers, M. (2020) · ChemTexts · doi:10.1007/s40828-020-00126-7 · Cited by 22 · see citing works

Custom-Designed Molecular Scissors for Site-Specific Manipulation of the Plant and Mammalian Genomes

Kandavelou, K., & Chandrasegaran, S. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-483-4_40 · Cited by 18 · see citing works

Methods of crop improvement and applications towards fortifying food security

Patel, A., Miles, A., Strackhouse, T., Cook, L., Leng, S., Patel, S., Klinger, K., Rudrabhatla, S. V., & Potlakayala, S. D. (2023) · Frontiers in Genome Editing · doi:10.3389/fgeed.2023.1171969 · Cited by 17 · see citing works

Genome editing and its role in vaccine, diagnosis, and therapeutic advancement

Bisht, D., Salave, S., Desai, N., Gogoi, P., Rana, D., Biswal, P., Sarma, G., Benival, D. M., Kommineni, N., & Desai, D. N. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131802 · Cited by 16 · see citing works

Classical Cys2His2Zinc Finger Peptides Are Rapidly Oxidized by Either H2O2or O2Irrespective of Metal Coordination

Lee, S. J., Michalek, J. L., Besold, A. N., Rokita, S. E., & Michel, S. L. J. (2011) · Inorganic Chemistry · doi:10.1021/ic102252a · Cited by 16 · see citing works

New approaches in the treatment of HIV/AIDS – focus on maraviroc and other CCR5 antagonists

Dezube, B. J. (2008) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s1997 · Cited by 16 · see citing works

Mitochondrial Diseases: Molecular Pathogenesis and Therapeutic Advances

Mei, J., Ding, P., Gao, C., Zhou, J., Li, Z., Zhang, C., & Gao, J. (2025) · MedComm · doi:10.1002/mco2.70385 · Cited by 15 · see citing works

Validation and Expression of Zinc Finger Nucleases in Plant Cells

Tovkach, A., Zeevi, V., & Tzfira, T. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-753-2_20 · Cited by 15 · see citing works

High-Throughput Cellular Screening of Engineered Nuclease Activity Using the Single-Strand Annealing Assay and Luciferase Reporter

Cradick, T. J., Antico, C. J., & Bao, G. (2014) · Methods in molecular biology · doi:10.1007/978-1-62703-761-7_22 · Cited by 13 · see citing works

Expression, purification and characterization of cloning-grade zinc finger nuclease

Tovkach, A., Zeevi, V., & Tzfira, T. (2010) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2010.10.071 · Cited by 13 · see citing works

Rapid Transcriptional Activity in Vivo and Slow DNA Binding in Vitro by an Artificial Multi-Zinc Finger Protein

Morisaki, T., Imanishi, M., Futaki, S., & Sugiura, Y. (2008) · Biochemistry · doi:10.1021/bi801124b · Cited by 13 · see citing works

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Gene Therapy Targeting HIV Entry

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Targeting the human genome

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Gene Editing in Ganoderma lucidum: Development, Challenges, and Future Prospects

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Stem Cell Gene Therapy for HIV: Strategies to Inhibit Viral Entry and Replication

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Retroviral Vector Technology for Gene Therapy: History, Current Landscape, and Future Prospects

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An EM View of the FokI Synaptic Complex by Single Particle Analysis

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Modulating Mitochondrial DNA Heteroplasmy with Mitochondrially Targeted Endonucleases

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From Agrobacterium to viral vectors: genome modification of plant cells by rare cutting restriction enzymes

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Transgenesis and Genome Engineering: A Historical Review

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Artificial Zinc Finger Nucleases for DNA Cloning

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Genome Editing Approaches Using Zinc Finger Nucleases (ZFNs) for the Treatment of Motor Neuron Diseases

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Evaluating the Mutagenic Activity of Targeted Endonucleases Containing a Sharkey FokI Cleavage Domain Variant in Zebrafish

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Non-transgenic Approach to Deliver ZFNs in Seeds for Targeted Genome Engineering

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Understanding Enzyme Mechanism through Protein Chimeragenesis

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Assessing Accumulation of Organic Material on Rodent Cage Accessories

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In vitro gene manipulation of spinal muscular atrophy fibroblast cell line using gene-targeting fragment for restoration of SMN protein expression

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Targeting DNA 5mCpG sites with chimeric endonucleases

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Genome Editing Technologies for Resistance Against Phytopathogens: Principles, Applications and Future Prospects

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Plant Genome Engineering Using Zinc Finger Nucleases

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Research development and the prospect of animal models of mitochondrial DNA-related mitochondrial diseases

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Mutation Breeding on Medicinal Solanum Species: Advances, Applicability and Challenges

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CRISPR/Cas9 Editing in Induced Pluripotent Stem Cells: A Way Forward for Treating Cystic Fibrosis?

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Custom-designed zinc finger nucleases: What is next?

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Custom-Designed Molecular Scissors for Site-Specific Manipulation of the Plant and Mammalian Genomes

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Zinc Finger Nucleases and Targeted Genome Engineering in Plants

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Gene knockout and knockin by zinc-finger nucleases: current status and perspectives

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