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Cited by 23

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

ST6GAL1 negatively regulates monocyte transendothelial migration and atherosclerosis development

Zhang, Jun, Liu, Yan, Deng, Xiao, Chen, Linmu, Yang, Xi, Yu, Chao·2018·Biochemical and Biophysical Research Communications
DOI 10.1016/j.bbrc.2018.04.053
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Abstract

Monocyte transendothelial migration is a critical step in the initial stage of atherosclerosis, in which the involvement of α-2,6 sialyltransferase 1 (ST6GAL1) has been confirmed by increasing evidence. But the direct relationship between ST6GAL1 and atherosclerosis remains incompletely uncertain. In this study, we demonstrated that the expression level of ST6GAL1 in vascular endothelium was significantly decreased in atherosclerosis development process, while obviously recovered after atherosclerosis regression. Further analysis showed that knockdown of ST6GAL1 by RNA interference in vascular endothelial cells EA. hy926 obviously promoted TNFα-triggered monocyte-transendothelial migration, whereas overexpression of ST6GAL1 strongly inhibited monocyte-transendothelial migration. Moreover, we firstly found β-catenin is a sialylated protein and its sialylation level is decreased in TNFα-treated EA. hy926 cells, suggesting that the function of ST6GAL1 in preventing both atherosclerosis development and monocyte transendothelial migration might result from the sialylation of β-catenin of endothelium. Our results suggested ST6GAL1 might be a potential target for atherosclerosis prevention and treatment.

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  • BACE1 cleavage of ST6Gal-1 contributes to preventing monocyte transendothelial migration, a pivotal mechanism in initial stages of atherosclerosis.

    “BACE1 cleavage of ST6Gal‐1, a protein involved in the terminal step of N‐glycan biosynthesis of glycoproteins, contributes to preventing monocyte transendothelial migration, a pivotal mechanism in the initial stages of atherosclerosis.”

    From BACE1: More than just a β‐secretase (2022) · cites this paper as [142]

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Metadata

Authors
Zhang, J., Liu, Y., Deng, X., Chen, L., Yang, X., & Yu, C.
ORCID
Zhang, Jun
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2018-06
Volume
500
Issue
2
Pages
249-255
ISSN
0006-291X
DOI
10.1016/j.bbrc.2018.04.053
Cited by
23
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • National Natural Science Foundation of China (81370403, 81500343)
  • Chongqing Research Program of Basic Research and Frontier Technology (cstc2015jcyjA10002, cstc2015jcyjBX0053)
  • Chongqing Medical University Scientific Research Cultivating Fund (201414)

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