Influence of extraction methods and solvent system on the chemical composition and antioxidant activity of Centella asiatica L. leaves

Antioxidant and cytoprotective benefits from C. asiatica are mediated through direct ROS scavenging and upregulation of endogenous antioxidant enzymes such as SOD and catalase.

“Antioxidant and cytoprotective benefits from C. asiatica are mediated through direct ROS scavenging and upregulation of endogenous antioxidant enzymes such as superoxide dismutase (SOD) and catalase (Zhao et al. 2020; Mohapatra et al. 2021; Jiang et al. 2022).”

Flavonoids and phenolics in C. asiatica, such as quercetin and kaempferol, offer ROS scavenging capacity and selective modulation of inflammatory pathways such as JAK/STAT3, which are particularly relevant in conditions like psoriasis.

“Flavonoids and phenolics further augment these effects, with compounds like quercetin and kaempferol offering reactive oxygen species (ROS) scavenging capacity and selective modulation of inflammatory pathways such as JAK/STAT3, which are particularly relevant in conditions like psoriasis (Vasavi et al. 2016; Mohapatra et al. 2021; Soun-udom et al. 2024).”