The DOI matches its Crossref record; 180 of the 180 references it cites were found in a registry or an index.
Tocotrienols, the vitamin E of the 21st century: Its potential against cancer and other chronic diseases
Open accessAbstract
Initially discovered in 1938 as a “fertility factor,” vitamin E now refers to eight different isoforms that belong to two categories, four saturated analogues (α, β, γ, and δ) called tocopherols and four unsaturated analogues referred to as tocotrienols. While the tocopherols have been investigated extensively, little is known about the tocotrienols. Very limited studies suggest that both the molecular and therapeutic targets of the tocotrienols are distinct from those of the tocopherols. For instance, suppression of inflammatory transcription factor NF-κB, which is closely linked to tumorigenesis and inhibition of HMG-CoA reductase, mammalian DNA polymerases and certain protein tyrosine kinases, is unique to the tocotrienols. This review examines in detail the molecular targets of the tocotrienols and their roles in cancer, bone resorption, diabetes, and cardiovascular and neurological diseases at both preclinical and clinical levels. As disappointment with the therapeutic value of the tocopherols grows, the potential of these novel vitamin E analogues awaits further investigation.
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Cited by
Zeng, Z., Han, N., Liu, C., Buerte, B., Zhou, C., Chen, J., Wang, M., Zhang, Y., Tang, Y., Zhu, M., et al. (2020) · Annals of Botany · doi:10.1093/aob/mcaa115 · Cited by 86
Metadata
- Authors
- Aggarwal, B. B., Sundaram, C., Prasad, S., & Kannappan, R.
- Venue
- Biochemical Pharmacology
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 80
- Issue
- 11
- Pages
- 1613-1631
- ISSN
- 0006-2952 (ISSN-L)
- OpenAlex
- W2068560722
- Cited by
- 566
- References
- 180
- FWCI
- 17.50
- Type
- journal article
- Language
- en
- Open access
- green
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- Aggarwal, B. B., Sundaram, C., Prasad, S., & Kannappan, R. (2010). Tocotrienols, the vitamin E of the 21st century: Its potential against cancer and other chronic diseases. Biochemical Pharmacology. https://doi.org/10.1016/j.bcp.2010.07.043
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
