The DOI matches its Crossref record; 440 of the 440 references it cites were found in a registry or an index.
Counter-regulatory renin-angiotensin system in hypertension: Review and update in the era of COVID-19 pandemic
Open accessAbstract
Cardiovascular disease is the major cause of mortality and disability, with hypertension being the most prevalent risk factor. Excessive activation of the renin-angiotensin system (RAS) under pathological conditions, leading to vascular remodeling and inflammation, is closely related to cardiovascular dysfunction. The counter-regulatory axis of the RAS consists of angiotensin-converting enzyme 2 (ACE2), angiotensin (1-7), angiotensin (1-9), alamandine, proto-oncogene Mas receptor, angiotensin II type-2 receptor and Mas-related G protein-coupled receptor member D. Each of these components has been shown to counteract the effects of the overactivated RAS. In this review, we summarize the latest insights into the complexity and interplay of the counter-regulatory RAS axis in hypertension, highlight the pathophysiological functions of ACE2, a multifunctional molecule linking hypertension and COVID-19, and discuss the function and therapeutic potential of targeting this counter-regulatory RAS axis to prevent and treat hypertension in the context of the current COVID-19 pandemic.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Our results, and those of other clinical studies, suggests that the role of the RAS in COVID-19 pathophysiology may be more complex than previously thought.9,28”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Items 401–440 of 440
Gao, S., Park, B. M., Cha, S. A., et al. (2013) · Peptides · doi:10.1016/j.peptides.2013.06.008 · Cited by 24
Li, M., Wang, Y., Ndiwane, N., Orner, M. B., Palacios, N., Mittler, B. S., Berlowitz, D. R., Kazis, L. E., & Xia, W. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248652 · Cited by 24
Almutlaq, M., Alamro, A. A., Alroqi, F. J., & Barhoumi, T. (2021) · CJC Open · doi:10.1016/j.cjco.2021.04.004 · Cited by 24
Angiotensin II Promotes SARS-CoV-2 Infection via Upregulation of ACE2 in Human Bronchial Cells
Caputo, I., Caroccia, B., Frasson, I., Poggio, E., Zamberlan, S., Morpurgo, M., Seccia, T. M., Calí, T., Brini, M., Richter, S. N., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095125 · Cited by 24
Li, P., Zhang, F., Sun, H., et al. (2015) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2015.08.005 · Cited by 23
Shao, Z., Shrestha, K. L., Borowski, A. G., Kennedy, D. J., Epelman, S., Thomas, J. D., & Tang, W. H. W. (2013) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2013.06.296 · Cited by 23
Alamandine alleviates hypertension and renal damage via oxidative-stress attenuation in Dahl rats
Gong, J., Luo, M., Yong, Y., Zhong, S., & Li, P. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-00822-y · Cited by 21
He, J., Chen, S., Huang, Y., Chen, Y., Dong, Y., & Ma, H. (2010) · Heart and Vessels · doi:10.1007/s00380-009-1213-7 · Cited by 20
Self-citationDillon, G. A., Wolf, S. T., & Alexander, L. M. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00602.2021 · Cited by 20
Angiotensin-(1-7)-induced renal vasodilation is reduced in human kidneys with renal artery stenosis
van Twist, D. J. L., Houben, A. J. H. M., de Haan, M. W., et al. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000351 · Cited by 19
Zhu, P., Verma, A., Prasad, T., & Li, Q. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01716-4 · Cited by 19
Pulmonary arterial hypertension post COVID-19: A sequala of SARS-CoV-2 infection?
Khan, A. W., Ullah, I., Khan, K. S., Tahir, M. J., Masyeni, S., & Harapan, H. (2021) · Respiratory Medicine Case Reports · doi:10.1016/j.rmcr.2021.101429 · Cited by 19
Blood pressure increase during hospitalization for COVID-19
Angeli, F., Zappa, M., Oliva, F. M., Spanevello, A., & Verdecchia, P. (2022) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2022.06.010 · Cited by 19
van Twist, D. J. L., Houben, A. J. H. M., de Haan, M. W., et al. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000000917 · Cited by 18
Triposkiadis, F. K., Starling, R. C., Xanthopoulos, A. V., Butler, J., & Boudoulas, H. K. (2020) · Heart Lung and Circulation · doi:10.1016/j.hlc.2020.11.008 · Cited by 18
Assessment of Alamandine in Pulmonary Fibrosis and Respiratory Mechanics in Rodents
Fernandes, R. S., Dias, H. B., Jaques, W. A. D. S., Becker, T., & Rigatto, K. (2021) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1155/2021/9975315 · Cited by 18
ACE2, the Counter-Regulatory Renin–Angiotensin System Axis and COVID-19 Severity
Triposkiadis, F. K., Xanthopoulos, A. V., Giamouzis, G., Boudoulas, K. D., Starling, R. C., Skoularigis, J. S., Boudoulas, H. K., & Iliodromitis, E. K. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10173885 · Cited by 18
Norambuena‐Soto, I., Ocaranza, M. P., Cancino-Arenas, N., et al. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114190 · Cited by 17
Nandadeva, D., Skow, R. J., Grotle, A., Stephens, B. Y., Young, B. E., & Fadel, P. J. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00216.2022 · Cited by 17
Vascular wall ACE is not required for atherogenesis in ApoE−/− mice
Weiss, D., Bernstein, K. E., Fuchs, S., et al. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.09.069 · Cited by 16
Clinical characteristics and fatal outcomes of hypertension in patients with severe COVID-19
Cheng, X., Cai, G., Wen, X., Gao, L., Jiang, D., Sun, M., Qin, S., Zhou, J., & Zhang, D. (2020) · Aging · doi:10.18632/aging.104019 · Cited by 16
Purification and characterization of angiotensin II AT2 receptors from neonatal rat kidney.
Ciuffo, G. M., Heemskerk, F. M. J., & Saavedra, J. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11009 · Cited by 15
Excessive eating and weight gain:A rare post-acute COVID-19 syndrome
Kaggwa, M. M., Favina, A., Najjuka, S. M., et al. (2021) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2021.102252 · Cited by 15
Safety of ACEi and ARB in COVID‐19 management: A retrospective analysis
Kumar, S., Nikravesh, M., Umeh, C. A., Randazzo, M., Flores, P., Choday, P., Raja, A., Aseri, M., Shah, S., Chaudhuri, S., et al. (2022) · Clinical Cardiology · doi:10.1002/clc.23836 · Cited by 15
Emerging Therapy in Hypertension
Stewart, M. H., Lavie, C. J., & Ventura, H. O. (2019) · Current Hypertension Reports · doi:10.1007/s11906-019-0923-1 · Cited by 14
Bejarano, J., Rojas, A., Ramírez‐Sagredo, A., Riveros, A. L., Morales-Zavala, F., Flores, Y., Riquelme, J. A., Guzmán, F., Araya, E., Chiong, M., et al. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.11.002 · Cited by 14
Bergrath, S., Müller, M. P., Rossaint, R., et al. (2018) · Health Informatics Journal · doi:10.1177/1460458218775157 · Cited by 13
Nami, B., Ghanaeian, A., Ghanaeian, K., Houri, R., Nami, N., Ghasemi-Dizgah, A., & Caluseriu, O. (2021) · Journal of Hypertension · doi:10.1097/hjh.0000000000002829 · Cited by 13
Renal AT 2 Receptors Mediate Natriuresis via Protein Phosphatase PP2A
Kemp, B. A., Howell, N. L., Gildea, J. J., Keller, S. R., Brautigan, D. L., & Carey, R. M. (2021) · Circulation Research · doi:10.1161/circresaha.121.319519 · Cited by 13
Profiling Levels of Serum microRNAs and Soluble ACE2 in COVID-19 Patients
Elemam, N. M., Hasswan, H., Aljaibeji, H., Sharif‐Askari, N. S., Halwani, R., Taneera, J., & Sulaiman, N. D. (2022) · Life · doi:10.3390/life12040575 · Cited by 13
Early blood pressure-independent cardiac changes in diabetic rats
Landau, D., Chayat, C. B., Zucker, N., et al. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0040 · Cited by 11
Metabolic Syndrome “Interacts” With COVID-19
Guo, Z., Jiang, S., Li, Z., & Chen, S. (2020) · BIO Integration · doi:10.15212/bioi-2020-0035 · Cited by 10
Self-citationLerner, R. K., Stein, M., Hemi, R., Zada, N., Asraf, K., Doolman, R., Benoit, S. W., de Oliveira, M. H. S., Lippi, G., Henry, B. M., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12040622 · Cited by 9
Gunarathne, L. S., Rajapaksha, I. G., Casey, S., et al. (2022) · Hepatology Communications · doi:10.1002/hep4.1987 · Cited by 9
Nanoparticle-Mediated Angiotensin-(1-9) Drug Delivery for the Treatment of Cardiac Hypertrophy
Sepúlveda-Rivas, S., Leal, M. S., Pedrozo, Z., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13060822 · Cited by 8
Bądzyńska, B., Lipkowski, A. W., Sadowski, J., et al. (2014) · Pharmacological Reports · doi:10.1016/j.pharep.2014.04.013 · Cited by 7
Mutlu, E., İlhan, S., Onat, E., et al. (2016) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1502-18 · Cited by 6
Chen, L., Chen, J., Wu, Y., Zhong, J., Zhou, F.-Z., Liu, Y., Xu, A., Li, J., & Cai, H. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s324077 · Cited by 4
Alabsi, W., Jaynes, T., Alqahtani, T., et al. (2022) · Medicinal Chemistry Research · doi:10.1007/s00044-022-02881-3 · Cited by 3
Zinoune, L., Bourouis, I., Assamti, M., et al. (2022) · Radiology Case Reports · doi:10.1016/j.radcr.2022.04.057 · Cited by 3
Research works printed but not linked: 1
- G. Wirnsberger, V. Monteil, B. Eaton, E. Postnikova, M. Murphy, B. Braunsfeld, I. Crozier, F. Kricek, J. Niederhofer, A. Schwarzbock, H. Breid, A.S. Jimenez, A. Bugajska-Schretter, A. Dohnal, C. Ruf, R. Gugenberger, A. Hagelkruys, N. Montserrat, M.R. Holbrook, C. Oostenbrink, R.H. Shoemaker, A. Mirazimi, J.M. Penninger, Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants, bioRxiv (2021) 459744. · DOI
Cited by
Sorted by citations
Lobo, S. M., Plantefève, G., Nair, G., Joaquim Cavalcante, A., Franzin de Moraes, N., Nunes, E., Barnum, O., Berdun Stadnik, C. M., Lima, M. P., Lins, M., et al. (2024) · eClinicalMedicine · doi:10.1016/j.eclinm.2023.102383 · Cited by 27
Metadata
- Authors
- Chen, H., Peng, J., Wang, T., Wen, J., Chen, S., Huang, Y., & Zhang, Y.
- Affiliations
- Sun Yat-sen University (CN)
- Corresponding author
- Zhang, Yang
- Venue
- Biochemical Pharmacology
- Publisher
- Elsevier BV
- Published
- 2023-02
- Volume
- 208
- Pages
- 115370
- ISSN
- 0006-2952 (ISSN-L)
- PMC
- PMC9721294
- OpenAlex
- W4310726093
- Cited by
- 19
- References
- 440
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 6
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Biochemical Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CityU Scholars (submittedVersion, cc-by-nc-nd)
- Funders
- Basic and Applied Basic Research Foundation of Guangdong Province (2021B1515020005)
- National Natural Science Foundation of China (82000462)
- Research Grants Council, University Grants Committee (SRFS2021-4S04)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Hematology › Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- hypertension, angiotensin-converting enzyme 2, angiotensin-(1-7), angiotensin-(1-9), alamandine, Mas receptor, angiotensin II type 2 receptor, COVID-19 pandemic, vascular remodeling, cardiovascular inflammation, antihypertensive therapy
- MeSH terms
- Angiotensin-Converting Enzyme 2, COVID-19, Angiotensin I, Humans, Hypertension, Peptide Fragments, Renin-Angiotensin System, Receptors, G-Protein-Coupled, Pandemics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
