Angiotensin-Converting Enzyme 2 (ACE2) Is a Key Modulator of the Renin Angiotensin System in Health and Disease
Open accessAbstract
Angiotensin-converting enzyme 2 (ACE2) shares some homology with angiotensin-converting enzyme (ACE) but is not inhibited by ACE inhibitors. The main role of ACE2 is the degradation of Ang II resulting in the formation of angiotensin 1–7 (Ang 1–7) which opposes the actions of Ang II. Increased Ang II levels are thought to upregulate ACE2 activity, and in ACE2 deficient mice Ang II levels are approximately double that of wild-type mice, whilst Ang 1–7 levels are almost undetectable. Thus, ACE2 plays a crucial role in the RAS because it opposes the actions of Ang II. Consequently, it has a beneficial role in many diseases such as hypertension, diabetes, and cardiovascular disease where its expression is decreased. Not surprisingly, current therapeutic strategies for ACE2 involve augmenting its expression using ACE2 adenoviruses, recombinant ACE2 or compounds in these diseases thereby affording some organ protection.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Lower ACE2 may reduce the potential for SARS-CoV-2 invasion, while further ACE2 reduction caused by viral entry may worsen a proinflammatory response that mediates cytokine storm, acute lung injury and ARDS.
“Decreased expression of ACE2 could mean less potential for SARS-CoV-2 invasion of host cells, and further ACE2 reduction caused by viral entry may exacerbate a heightened proinflammatory response that helps mediate cytokine storm, acute lung injury, and ARDS.”
From SARS-CoV-2, COVID-19 and the aging immune system (2021) · cites this paper as [65]
ACE2 is downregulated in people with cardiovascular disease and diabetes, conditions that also correlate with severe COVID-19.
“ACE2 is also downregulated in humans with cardiovascular disease and diabetes, which also correlate with severe COVID-1965.”
From SARS-CoV-2, COVID-19 and the aging immune system (2021) · cites this paper as [65]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
Li, W., Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., et al. (2003) · Nature · doi:10.1038/nature02145 · Cited by 5,923 · see citing works
Pfeffer, M. A., Braunwald, E., Moyé, L. A., Basta, L., Brown, E. J., Cuddy, T. E., Davis, B. R., Geltman, E. M., Goldman, S., Flaker, G. C., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271001 · Cited by 5,911 · see citing works
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
Kuba, K., Imai, Y., Rao, S., Gao, H., Guo, F., Guan, B., Huan, Y., Yang, P., Zhang, Y., Deng, W., et al. (2005) · Nature Medicine · doi:10.1038/nm1267 · Cited by 3,445 · see citing works
Donoghue, M., Hsieh, F., Baronas, E., Godbout, K., Gosselin, M. L., Stagliano, N. E., Donovan, M. J., Woolf, B., Robison, K. E., Jeyaseelan, R., et al. (2000) · Circulation Research · doi:10.1161/01.res.87.5.e1 · Cited by 3,084 · see citing works
Angiotensin-converting enzyme 2 protects from severe acute lung failure
Imai, Y., Kuba, K., Rao, S., Huan, Y., Guo, F., Guan, B., Yang, P., Sarao, R., Wada, T., Leong-Poi, H., et al. (2005) · Nature · doi:10.1038/nature03712 · Cited by 2,453 · see citing works
A Human Homolog of Angiotensin-converting Enzyme
Tipnis, S. R., Hooper, N. M., Hyde, R., Karran, E. H., Christie, G., & Turner, A. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002615200 · Cited by 2,032 · see citing works
Angiotensin-converting enzyme 2 is an essential regulator of heart function
Crackower, M. A., Sarao, R., Oudit, G. Y., Yagil, C., Kozieradzki, I., Scanga, S. E., Oliveira-dos-Santos, A. J., da Costa, J., Zhang, L., Pei, Y., et al. (2002) · Nature · doi:10.1038/nature00786 · Cited by 1,733 · see citing works
Hydrolysis of Biological Peptides by Human Angiotensin-converting Enzyme-related Carboxypeptidase
Vickers, C., Hales, P., Kaushik, V. K., Dick, L. R., Gavin, J. M., Tang, J., Godbout, K., Parsons, T. F., Baronas, E., Hsieh, F., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200581200 · Cited by 1,406 · see citing works
Sadoshima, J.-I., Xu, Y., Slayter, H. S., & Izumo, S. (1993) · Cell · doi:10.1016/0092-8674(93)90541-w · Cited by 1,348 · see citing works
Angiotensin II induces smooth muscle cell proliferation in the normal and injured rat arterial wall.
Daemen, M. J. A. P., Lombardi, D. M., Bosman, F. T., & Schwartz, S. M. (1991) · Circulation Research · doi:10.1161/01.res.68.2.450 · Cited by 738 · see citing works
Rice, G., Thomas, D. A., Grant, P. J., Turner, A. J., & Hooper, N. M. (2004) · Biochemical Journal · doi:10.1042/bj20040634 · Cited by 619 · see citing works
Tissue-specific activation of cardiac angiotensin converting enzyme in experimental heart failure.
Hirsch, A. T., Talsness, C. E., Schunkert, H., Paul, M., & Dzau, V. J. (1991) · Circulation Research · doi:10.1161/01.res.69.2.475 · Cited by 458 · see citing works
Zhong, J., Basu, R., Guo, D., Chow, F. L., Byrns, S., Schuster, M., Loibner, H., Wang, X., Penninger, J. M., Kassiri, Z., et al. (2010) · Circulation · doi:10.1161/circulationaha.110.955369 · Cited by 457 · see citing works
The angiotensin–converting enzyme gene family: genomics and pharmacology
Turner, A. J., & Hooper, N. M. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01994-5 · Cited by 407 · see citing works
Ferrario, C. M., Trask, A. J., & Jessup, J. A. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00618.2005 · Cited by 385 · see citing works
Chen, X.-L., Tummala, P. E., Olbrych, M. T., Alexander, R. W., & Medford, R. M. (1998) · Circulation Research · doi:10.1161/01.res.83.9.952 · Cited by 384 · see citing works
Characterization of Renal Angiotensin-Converting Enzyme 2 in Diabetic Nephropathy
Tikellis, C., Johnston, C. I., Forbes, J. M., Burns, W. C., Burrell, L. M., Risvanis, J., & Cooper, M. E. (2003) · Hypertension · doi:10.1161/01.hyp.0000060689.38912.cb · Cited by 349 · see citing works
Self-citationCrowley, S. D., Gurley, S. B., Oliverio, M. I., Pazmino, A. K., Griffiths, R., Flannery, P. J., Spurney, R. F., Kim, H., Smithies, O., Le, T. H., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23378 · Cited by 349 · see citing works
Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice
Gurley, S. B., Allred, A. J., Le, T. H., Griffiths, R., Mao, L., Philip, N., Haystead, T., Donoghue, M., Breitbart, R. E., Acton, S. L., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci16980 · Cited by 330 · see citing works
Yamamoto, K. I., Ohishi, M., Katsuya, T., Ito, N., Ikushima, M., Kaibe, M., Tatara, Y., Shiota, A., Sugano, S., Takeda, S., et al. (2006) · Hypertension · doi:10.1161/01.hyp.0000205833.89478.5b · Cited by 323 · see citing works
Kuba, K., Zhang, L., Imai, Y., Arab, S., Chen, M., Maekawa, Y., Leschnik, M. W., Leibbrandt, A., Markovic, M., Schwaighofer, J., et al. (2007) · Circulation Research · doi:10.1161/circresaha.107.158659 · Cited by 309 · see citing works
Increased Angiotensin-(1-7)–Forming Activity in Failing Human Heart Ventricles
Zisman, L. S., Keller, R. S., Weaver, B. A., Lin, Q., Speth, R. C., Bristow, M. R., & Canver, C. C. (2003) · Circulation · doi:10.1161/01.cir.0000094734.67990.99 · Cited by 308 · see citing works
Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis
Lovren, F., Pan, Y., Quan, A., Teoh, H., Wang, G., Shukla, P. C., Levitt, K., Oudit, G. Y., Al-Omran, M. A., Stewart, D. J., et al. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00331.2008 · Cited by 307 · see citing works
Targeting the Degradation of Angiotensin II With Recombinant Angiotensin-Converting Enzyme 2
Wysocki, J. A., Ye, M., Rodríguez, E., González‐Pacheco, F. R., Barrios, C., Evora, K., Schuster, M., Loibner, H., Brosnihan, K. B., Ferrario, C. M., et al. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.138420 · Cited by 300 · see citing works
Human Recombinant ACE2 Reduces the Progression of Diabetic Nephropathy
Oudit, G. Y., Liu, G. C., Zhong, J., Basu, R., Chow, F. L., Zhou, J., Loibner, H., Janzek, E., Schuster, M., Penninger, J. M., et al. (2009) · Diabetes · doi:10.2337/db09-1218 · Cited by 298 · see citing works
Prada, J. A. H., Ferreira, A. J., Katovich, M. J., Shenoy, V., Qi, Y., Santos, R. A. S., Castellano, R. K., Lampkins, A. J., Gubala, V., Ostrov, D. A., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.108944 · Cited by 273 · see citing works
Loss of Angiotensin-Converting Enzyme-2 (Ace2) Accelerates Diabetic Kidney Injury
Wong, D., Oudit, G. Y., Reich, H. N., Kassiri, Z., Zhou, J., Liu, Q. C., Backx, P. H., Penninger, J. M., Herzenberg, A. M., & Scholey, J. W. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060977 · Cited by 267 · see citing works
Candido, R., Jandeleit-Dahm, K. A. M., Cao, Z., Nesteroff, S. P., Burns, W. C., Twigg, S. M., Dilley, R. J., Cooper, M. E., & Allen, T. J. (2002) · Circulation · doi:10.1161/01.cir.0000021122.63813.32 · Cited by 261 · see citing works
Oudit, G. Y., Kassiri, Z., PATEL, M., Chappell, M. C., BUTANY, J. W., Backx, P. H., Tsushima, R. G., Scholey, J. W., Khokha, R., & Penninger, J. M. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.04.007 · Cited by 247 · see citing works
Ferreira, A. J., Shenoy, V., Yamazato, Y., Sriramula, S., Francis, J., Yuan, L., Castellano, R. K., Ostrov, D. A., Oh, S. P., Katovich, M. J., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200811-1678oc · Cited by 245 · see citing works
Zhang, H., Wada, J., Hida, K., Tsuchiyama, Y., Hiragushi, K., Shikata, K., Wang, H., Lin, S., Kanwar, Y. S., & Makino, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006723200 · Cited by 239 · see citing works
Renal ACE2 expression in human kidney disease
Lely, A. T., Hamming, I., van Goor, H., & Navis, G. (2004) · The Journal of Pathology · doi:10.1002/path.1670 · Cited by 239 · see citing works
Zhong, J., Guo, D., Chen, C. B., Wang, W., Schuster, M., Loibner, H., Penninger, J. M., Scholey, J. W., Kassiri, Z., & Oudit, G. Y. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.164244 · Cited by 234 · see citing works
Structural remodeling in hypertensive heart disease and the role of hormones.
Weber, K. T., Sun, Y., & Guarda, E. (1994) · Hypertension · doi:10.1161/01.hyp.23.6.869 · Cited by 231 · see citing works
Oudit, G. Y., Herzenberg, A. M., Kassiri, Z., Wong, D., Reich, H. N., Khokha, R., Crackower, M. A., Backx, P. H., Penninger, J. M., & Scholey, J. W. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051091 · Cited by 231 · see citing works
Thomas, M. C., Pickering, R. J., Tsorotes, D., Koı̈tka, A., Sheehy, K., Bernardi, S., Toffoli, B., Nguyen‐Huu, T., Head, G. A., Fu, Y., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.219279 · Cited by 230 · see citing works
Self-citationCassis, L. A., Gupte, M., Thayer, S., Zhang, X., Charnigo, R. J., Howatt, D. A., Rateri, D. L., & Daugherty, A. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00028.2009 · Cited by 226 · see citing works
Kassiri, Z., Zhong, J., Guo, D., Basu, R., Wang, X., Liu, P. P., Scholey, J. W., Penninger, J. M., & Oudit, G. Y. (2009) · Circulation Heart Failure · doi:10.1161/circheartfailure.108.840124 · Cited by 226 · see citing works
A protein complex in the brush‐border membrane explains a Hartnup disorder allele
Kowalczuk, S., Bröer, A., Tietze, N., Vanslambrouck, J. M., Rasko, J. E. J., & Bröer, S. (2008) · The FASEB Journal · doi:10.1096/fj.08-107300 · Cited by 222 · see citing works
Soler, M. J., Wysocki, J. A., Ye, M., Lloveras, J., Kanwar, Y. S., & BATLLE, D. C. (2007) · Kidney International · doi:10.1038/sj.ki.5002373 · Cited by 217 · see citing works
Donoghue, M. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00177-9 · Cited by 214 · see citing works
ACE2 gene transfer attenuates hypertension-linked pathophysiological changes in the SHR
Díez-Freire, C., Vázquez, J., de Adjounian, M. F. C., Ferrari, M., Yuan, L., Silver, X., Torres, R., & Raizada, M. K. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00312.2005 · Cited by 200 · see citing works
Irbesartan but Not Amlodipine Suppresses Diabetes-Associated Atherosclerosis
Candido, R., Allen, T. J., Lassila, M., Cao, Z., Thallas, V., Cooper, M. E., & Jandeleit-Dahm, K. A. M. (2004) · Circulation · doi:10.1161/01.cir.0000124061.78478.94 · Cited by 194 · see citing works
Feng, Y., Xia, H., Cai, Y., Halabi, C. M., Becker, L. K., Santos, R. A. S., Speth, R. C., Sigmund, C. D., & Lazartigues, E. D. (2009) · Circulation Research · doi:10.1161/circresaha.109.208645 · Cited by 190 · see citing works
Rentzsch, B., Todiraş, M., Iliescu, R., Popova, E., Campos, L. A., Oliveira, M. L., Baltatu, O. C., Santos, R. A. S., & Bäder, M. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.114322 · Cited by 187 · see citing works
Studer, R., Reinecke, H., Müller, B., Holtz, J., Just, H., & Drexler, H. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117322 · Cited by 186 · see citing works
ACE2 Deficiency Modifies Renoprotection Afforded by ACE Inhibition in Experimental Diabetes
Tikellis, C., Bialkowski, K., Pete, J., Sheehy, K., Qui, S., Johnston, C. I., Cooper, M. E., & Thomas, M. C. (2008) · Diabetes · doi:10.2337/db07-1212 · Cited by 182 · see citing works
Self-citationYamazato, M., Yamazato, Y., Sun, C., Díez-Freire, C., & Raizada, M. K. (2007) · Hypertension · doi:10.1161/01.hyp.0000259942.38108.20 · Cited by 180 · see citing works
Tissue angiotensin converting enzyme in cardiac and vascular hypertrophy, repair, and remodeling.
Johnston, C. I. (1994) · Hypertension · doi:10.1161/01.hyp.23.2.258 · Cited by 167 · see citing works
Pieruzzi, F., Abassi, Z. A., & Keiser, H. R. (1995) · Circulation · doi:10.1161/01.cir.92.10.3105 · Cited by 154 · see citing works
Vasoprotective and Atheroprotective Effects of Angiotensin (1-7) in Apolipoprotein E–Deficient Mice
Tesanovic, S., Vinh, A., Gaspari, T. A., CASLEY, D. J., & Widdop, R. E. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.204453 · Cited by 151 · see citing works
Sarkissian, S. D., Grobe, J. L., Yuan, L., Narielwala, D. R., Walter, G. A., Katovich, M. J., & Raizada, M. K. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.100693 · Cited by 144 · see citing works
Loot, A. E., Schreiber, J. G., Fißlthaler, B., & Fleming, I. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090449 · Cited by 144 · see citing works
Li, N., Zimpelmann, J., Cheng, K., Wilkins, J. A., & Burns, K. D. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00144.2004 · Cited by 143 · see citing works
Feng, Y., Yue, X., Xia, H., Bindom, S. M., Hickman, P. J., Filipeanu, C. M., Wu, G., & Lazartigues, E. D. (2008) · Circulation Research · doi:10.1161/circresaha.107.169110 · Cited by 141 · see citing works
ACE2 Activation Promotes Antithrombotic Activity
Fraga-Silva, R. A., Sorg, B. S., Wankhede, M., deDeugd, C. M., Jun, J. Y., Baker, M. B., Li, Y., Castellano, R. K., Katovich, M. J., Raizada, M. K., et al. (2010) · Molecular Medicine · doi:10.2119/molmed.2009.00160 · Cited by 133 · see citing works
Lambert, D., Clarke, N. E., Hooper, N. M., & Turner, A. J. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.085 · Cited by 131 · see citing works
Overexpression of ACE2 Enhances Plaque Stability in a Rabbit Model of Atherosclerosis
Dong, B., Zhang, C., Feng, J. B., Zhao, Y. X., Li, S. Y., Yang, Y. P., Dong, Q. L., Deng, B. P., Zhu, L., Yu, Q. T., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.164715 · Cited by 131 · see citing works
Zhong, J., Huang, D., Yang, Y., Li, Y., Liu, G., Song, X., & Du, K. (2004) · Hypertension · doi:10.1161/01.hyp.0000146400.57221.74 · Cited by 129 · see citing works
Sluimer, J. C., Gasc, J., Hamming, I., van Goor, H., Michaud, A., van den Akker, L., Jutten, B., Cleutjens, J. P. M., Bijnens, A. P., Corvol, P. L., et al. (2008) · The Journal of Pathology · doi:10.1002/path.2357 · Cited by 126 · see citing works
Liu, C. X., Hu, Q., Wang, Y., Zhang, W., Ma, Z. Y., Feng, J. B., Wang, R., Wang, X. P., Dong, B., Gao, F., et al. (2010) · Molecular Medicine · doi:10.2119/molmed.2010.00111 · Cited by 126 · see citing works
Tissue renin-angiotensin systems. Their role in cardiovascular disease.
Lee, M. A., Böhm, M., Paul, M., & Ganten, D. (1993) · PubMed · Cited by 121 · see citing works
Renin-angiotensin system and atherothrombotic disease: from genes to treatment.
Jacoby, D. S., & Rader, D. J. (2003) · PubMed · doi:10.1001/archinte.163.10.1155 · Cited by 116 · see citing works
Ferreira, A. J., Shenoy, V., Qi, Y., Fraga-Silva, R. A., Santos, R. A. S., Katovich, M. J., & Raizada, M. K. (2010) · Experimental Physiology · doi:10.1113/expphysiol.2010.055277 · Cited by 112 · see citing works
Hokimoto, S., Yasue, H., Fujimoto, K., Yamamoto, H., Nakao, K., Kaikita, K., Sakata, R., & Miyamoto, E. (1996) · Circulation · doi:10.1161/01.cir.94.7.1513 · Cited by 104 · see citing works
Progression of Cardiovascular Damage: The Role of Renin–Angiotensin System Blockade
Probstfield, J. L., & O’Brien, K. D. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.10.006 · Cited by 90 · see citing works
Bodiga, S., Zhong, J. C., Wang, W., Basu, R., Lo, J., Liu, G. C., Guo, D., Holland, S. M., Scholey, J. W., Penninger, J. M., et al. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr036 · Cited by 83 · see citing works
Wei, C., Tian, B., Perry, G. J., Meng, Q. C., Chen, Y.-F., Oparil, S., & Dell’Italia, L. J. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00191.2001 · Cited by 82 · see citing works
Kiely, D. G. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(96)00180-0 · Cited by 76 · see citing works
Diz, D. I., Garcia-Espinosa, M. A., Gegick, S., Tommasi, E. N., Ferrario, C. M., Tallant, E. A., Chappell, M. C., & Gallagher, P. E. (2008) · Experimental Physiology · doi:10.1113/expphysiol.2007.040261 · Cited by 75 · see citing works
Crowley, S. D., Gurley, S. B., Oliverio, M. I., Pazmino, A. K., Griffiths, R., Flannery, P. J., Spurney, R. F., Kim, H., Smithies, O., Le, T. H., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200523378 · Cited by 75 · see citing works
The renin-angiotensin system and volume overload-induced changes in cardiac collagen and elastin.
Ruzicka, M., KEELEY, F. W., & Leenen, F. H. H. (1994) · Circulation · doi:10.1161/01.cir.90.4.1989 · Cited by 71 · see citing works
Angiotensin‐converting enzyme 2 gene targeting studies in mice: mixed messages
Gurley, S. B., & Coffman, T. M. (2008) · Experimental Physiology · doi:10.1113/expphysiol.2007.040014 · Cited by 69 · see citing works
Raffai, G., Durand, M. J., & Lombard, J. H. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00202.2011 · Cited by 68 · see citing works
Garabelli, P. J., Modrall, J. G., Penninger, J. M., Ferrario, C. M., & Chappell, M. C. (2008) · Experimental Physiology · doi:10.1113/expphysiol.2007.040246 · Cited by 66 · see citing works
Hayashi, N., Yamamoto, K. I., Ohishi, M., Tatara, Y., Takeya, Y., Shiota, A., Oguro, R., Iwamoto, Y., Takeda, M., & Rakugi, H. (2010) · Hypertension Research · doi:10.1038/hr.2010.147 · Cited by 55 · see citing works
Benter, I. F., Yousif, M. H. M., Al-Saleh, F. M., Raghupathy, R., Chappell, M. C., & Diz, D. I. (2011) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31821324b6 · Cited by 53 · see citing works
Communal, C., Singh, M., Menon, B., Xie, Z., Colucci, W. S., & Singh, K. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10520 · Cited by 51 · see citing works
Masson, R., Nicklin, S. A., Craig, M. A., McBride, M., Gilday, K., Gregorevic, P., Allen, J. M., Chamberlain, J. S., Smith, G. L., Graham, D., et al. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.122333 · Cited by 43 · see citing works
Stanziola, L. (1999) · American Journal of Hypertension · doi:10.1016/s0895-7061(99)00090-4 · Cited by 39 · see citing works
Nakamura, K., Koibuchi, N., Nishimatsu, H., Higashikuni, Y., Hirata, Y., Kugiyama, K., Nagai, R., & Sata, M. (2008) · Hypertension Research · doi:10.1291/hypres.31.1953 · Cited by 38 · see citing works
Kakishita, M., Nakamura, K., Asanuma, M., Morita, H., Saito, H., KUSANO, K. F., Nakamura, Y., Emori, T., Matsubara, H., Sugaya, T., et al. (2003) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200312001-00015 · Cited by 33 · see citing works
The Angiotensin Converting Enzyme 2/Ang-(1-7) Axis in the Heart
Stewart, J. A., Lazartigues, E. D., & Lucchesi, P. A. (2008) · Circulation Research · doi:10.1161/circresaha.108.189068 · Cited by 29 · see citing works
Genetic manipulation of the renin-angiotensin system
Doan, T. N., Gletsu-Miller, N. A., Cole, J. M., & Bernstein, K. E. (2001) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200107000-00002 · Cited by 26 · see citing works
Goulter, A. B., Avella, M., Botham, K. M., & Elliott, J. (2003) · Clinical Science · doi:10.1042/cs20030039 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
COVID-19 and cardiovascular disease
Clerkin, K. J., Fried, J. A., Raikhelkar, J., Sayer, G., Griffin, J. M., Masoumi, A., Jain, S. S., Burkhoff, D., Kumaraiah, D., Rabbani, L., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.046941 · Cited by 1,738 · see citing works
The pivotal link between ACE2 deficiency and SARS-CoV-2 infection
Verdecchia, P., Cavallini, C., Spanevello, A., & Angeli, F. (2020) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2020.04.037 · Cited by 1,237 · see citing works
“[61-63] Several experimental and clinical studies indicate that ACE2 deficiency obtained through deletion or inhibition may be a causative factor for hypertension.”
Bourgonje, A. R., Abdulle, A. E., Timens, W., Hillebrands, J., Navis, G. J., Gordijn, S. J., Bolling, M. C., Dijkstra, G. D. H., Voors, A. A., Osterhaus, A. D. M. E., et al. (2020) · The Journal of Pathology · doi:10.1002/path.5471 · Cited by 1,119 · see citing works
Health benefits of polyphenols: A concise review
Rana, A., Samtiya, M., Dhewa, T., Mishra, V., & Aluko, R. E. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14264 · Cited by 800 · see citing works
The hypercoagulable state in COVID-19: Incidence, pathophysiology, and management
Abou-Ismail, M. Y., Diamond, A., Kapoor, S., Arafah, Y., & Nayak, L. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.06.029 · Cited by 694 · see citing works
Age-Related Morbidity and Mortality among Patients with COVID-19
Kang, S., & Jung, S. (2020) · Infection and Chemotherapy · doi:10.3947/ic.2020.52.2.154 · Cited by 516 · see citing works
A comprehensive review of COVID-19 characteristics
Esakandari, H., Nabi‐Afjadi, M., Afjadi, J. F., Farahmandian, N., Miresmaeili, S. M., & Bahreini, E. (2020) · Biological Procedures Online · doi:10.1186/s12575-020-00128-2 · Cited by 511 · see citing works
da Silveira, M. P., da Silva Fagundes, K. K., Bizuti, M. R., Starck, É., Rossi, R. C., & de Resende e Silva, D. T. (2021) · Clinical and Experimental Medicine · doi:10.1007/s10238-020-00650-3 · Cited by 475 · see citing works
Clinical Characteristics of Covid-19 in China
Chen, A. T. C., Coura-Filho, G. B., & Rehder, M. H. H. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2005203 · Cited by 475 · see citing works
Gemmati, D., Bramanti, B., Serino, M. L., Secchiero, P., Zauli, G., & Tisato, V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103474 · Cited by 401 · see citing works
Henry, B. M., Vikse, J., Benoit, S. W., Favaloro, E. J., & Lippi, G. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.04.027 · Cited by 381 · see citing works
ACE2, Much More Than Just a Receptor for SARS-COV-2
Samavati, L., & Uhal, B. D. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00317 · Cited by 366 · see citing works
COVID-19: breaking down a global health crisis
Mallah, S. I., Ghorab, O. K. H. A., Al-Salmi, S., Abdellatif, O. S., Tharmaratnam, T., Iskandar, M. M. A., Sefen, J. A. N., Sidhu, P., Atallah, B., El-Lababidi, R. M., et al. (2021) · Annals of Clinical Microbiology and Antimicrobials · doi:10.1186/s12941-021-00438-7 · Cited by 375 · see citing works
SARS-CoV-2, COVID-19 and the aging immune system
Bartleson, J. M., Radenkovic, D., Covarrubias, A. J., Furman, D., Winer, D. A., & Verdin, E. (2021) · Nature Aging · doi:10.1038/s43587-021-00114-7 · Cited by 359 · see citing works
COVID-19, diabetes mellitus and ACE2: The conundrum
Pal, R., & Bhansali, A. K. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108132 · Cited by 359 · see citing works
Gastrointestinal symptoms associated with COVID-19: impact on the gut microbiome
Villapol, S. (2020) · Translational research · doi:10.1016/j.trsl.2020.08.004 · Cited by 344 · see citing works
Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy
Zhang, Q., Xiang, R., Huo, S., Zhou, Y., Jiang, S., Wang, Q., & Yu, F. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00653-w · Cited by 341 · see citing works
Racial Disparities-Associated COVID-19 Mortality among Minority Populations in the US
Alcendor, D. J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082442 · Cited by 334 · see citing works
Atri, D. S., Siddiqi, H. K., Lang, J. P., Nauffal, V. D., Morrow, D. A., & Bohula, E. A. (2020) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2020.04.002 · Cited by 331 · see citing works
Investigation into SARS-CoV-2 Resistance of Compounds in Garlic Essential Oil
Thuý, B. T. P., My, T. T. A., Hải, N. T. T., Hiếu, L. T., Hòa, T. T., Loan, H. T. P., Triet, N. T., Anh, T. T. V., Quý, P. T., Tất, P. V., et al. (2020) · ACS Omega · doi:10.1021/acsomega.0c00772 · Cited by 315 · see citing works
Racial and Gender-Based Differences in COVID-19
Kopel, J. J., Perisetti, A., Roghani, A., Aziz, M., Gajendran, M., & Goyal, H. (2020) · Frontiers in Public Health · doi:10.3389/fpubh.2020.00418 · Cited by 314 · see citing works
COVID-19 and diabetes mellitus: An unholy interaction of two pandemics
Pal, R., & Bhadada, S. K. (2020) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2020.04.049 · Cited by 311 · see citing works
Meftahi, G. H., Jangravi, Z., Sahraei, H., & Bahari, Z. (2020) · Inflammation Research · doi:10.1007/s00011-020-01372-8 · Cited by 289 · see citing works
COVID-19 and comorbidities: a systematic review and meta-analysis
Gold, M. S., Sehayek, D., Gabrielli, S., Zhang, X., McCusker, C. T., & Ben‐Shoshan, M. (2020) · Postgraduate Medicine · doi:10.1080/00325481.2020.1786964 · Cited by 289 · see citing works
Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2
Salamanna, F., Maglio, M., Landini, M. P., & Fini, M. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.594495 · Cited by 283 · see citing works
COVID-19, Renin-Angiotensin System and Endothelial Dysfunction
Amraei, R., & Rahimi, N. (2020) · Cells · doi:10.3390/cells9071652 · Cited by 275 · see citing works
Bader, F. M., Manla, Y., Atallah, B., & Starling, R. C. (2020) · Heart Failure Reviews · doi:10.1007/s10741-020-10008-2 · Cited by 259 · see citing works
Datta, P., Liu, F.-M., Fischer, T., Rappaport, J., & Qin, X. (2020) · Theranostics · doi:10.7150/thno.48076 · Cited by 227 · see citing works
Izquierdo-Lara, R. W., Elsinga, G., Heijnen, L., Munnink, B. B. O., Schapendonk, C. M. E., Nieuwenhuijse, D. F., Kon, M., Lu, L., Aarestrup, F. M., Lycett, S., et al. (2021) · Emerging infectious diseases · doi:10.3201/eid2705.204410 · Cited by 216 · see citing works
The Immune Response and Immunopathology of COVID-19
Mortaz, E., Tabarsi, P., Varahram, M., Folkerts, G., & Adcock, I. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02037 · Cited by 206 · see citing works
Will children reveal their secret? The coronavirus dilemma
Cristiani, L., Mancino, E., Matera, L., Nenna, R., Pierangeli, A., Scagnolari, C., & Midulla, F. (2020) · European Respiratory Journal · doi:10.1183/13993003.00749-2020 · Cited by 204 · see citing works
A hypothesis for pathobiology and treatment of COVID‐19 : The centrality of ACE1 / ACE2 imbalance
Sriram, K., & Insel, P. A. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15082 · Cited by 195 · see citing works
Factors leading to high morbidity and mortality of COVID ‐19 in patients with type 2 diabetes
Rajpal, A., Rahimi, L., & Ismail‐Beigi, F. (2020) · Journal of Diabetes · doi:10.1111/1753-0407.13085 · Cited by 165 · see citing works
SARS-CoV-2, ACE2 expression, and systemic organ invasion
Ashraf, U., Abokor, A. A., Edwards, J. M., Waigi, E. W., Royfman, R., Hasan, S. A., Smedlund, K., Grégio, A. M. T., Chakravarti, R., & Koch, L. G. (2020) · Physiological Genomics · doi:10.1152/physiolgenomics.00087.2020 · Cited by 173 · see citing works
Nasiri, M. J., Haddadi, S., Tahvildari, A., Farsi, Y., Arbabi, M., Hasanzadeh, S., Jamshidi, P. K., Murthi, M., & Mirsaeidi, M. S. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00459 · Cited by 170 · see citing works
Sanchis‐Gomar, F., Lavie, C. J., Pérez-Quilis, C., Henry, B. M., & Lippi, G. (2020) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.03.026 · Cited by 167 · see citing works
Cen, Y., Chen, X., Shen, Y., Zhang, X.-H., Lei, Y., Xu, C., Jiang, W.-R., Xu, H., Chen, Y., Zhu, J., et al. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.05.041 · Cited by 164 · see citing works
Bhowmick, G. D., Dhar, D., Nath, D., Ghangrekar, M. M., Banerjee, R., Das, S., & Chatterjee, J. (2020) · npj Clean Water · doi:10.1038/s41545-020-0079-1 · Cited by 163 · see citing works
COVID-19 and the Cardiovascular System
Veer, M., Kumar, A. M., & Ivanova, V. (2020) · Critical Care Nursing Quarterly · doi:10.1097/cnq.0000000000000323 · Cited by 164 · see citing works
Will children reveal their secret? The coronavirus dilemma
Midulla, F., Cristiani, L., & Mancino, E. (2020) · European Respiratory Journal · doi:10.1183/13993003.01617-2020 · Cited by 160 · see citing works
Understanding the renin–angiotensin–aldosterone–SARS-CoV axis: a comprehensive review
Ingraham, N. E., Barakat, A., Reilkoff, R. A., Bezdicek, T. L., Schacker, T. W., Chipman, J. G., Tignanelli, C. J., & Puskarich, M. A. (2020) · European Respiratory Journal · doi:10.1183/13993003.00912-2020 · Cited by 156 · see citing works
The ACE-2 in COVID-19: Foe or Friend?
Dalan, R., Bornstein, S. R., El‐Armouche, A., Rodionov, R. N., Markov, A. G., Wielockx, B., Beuschlein, F., & Boehm, B. O. (2020) · Hormone and Metabolic Research · doi:10.1055/a-1155-0501 · Cited by 155 · see citing works
ACE2 polymorphism and susceptibility for SARS-CoV-2 infection and severity of COVID-19
Möhlendick, B., Schönfelder, K., Breuckmann, K., Elsner, C., Babel, N., Balfanz, P., Dahl, E., Dreher, M., Fistera, D., Herbstreit, F., et al. (2021) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000436 · Cited by 131 · see citing works
Biomechanical characterization of SARS-CoV-2 spike RBD and human ACE2 protein-protein interaction
Cao, W., Dong, C., Kim, S., Hou, D., Tai, W., Du, L., Im, W., & Zhang, X. H. (2021) · Biophysical Journal · doi:10.1016/j.bpj.2021.02.007 · Cited by 127 · see citing works
Surgery in times of COVID-19—recommendations for hospital and patient management
Flemming, S., Hankir, M. K., Ernestus, R.-I., Seyfried, F., Germer, C.-T., Meybohm, P., Wurmb, T. E., Vogel, U. F., & Wiegering, A. (2020) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-020-01888-x · Cited by 126 · see citing works
Clinical Insights into the Gastrointestinal Manifestations of COVID-19
Kopel, J. J., Perisetti, A., Gajendran, M., Boregowda, U. N., & Goyal, H. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06362-8 · Cited by 123 · see citing works
Infections and Autoimmunity—The Immune System and Vitamin D: A Systematic Review
Wimalawansa, S. J. (2023) · Nutrients · doi:10.3390/nu15173842 · Cited by 123 · see citing works
Carcaterra, M., & Caruso, C. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110412 · Cited by 121 · see citing works
Vitamin D can prevent COVID-19 infection-induced multiple organ damage
Aygün, H. (2020) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-020-01911-4 · Cited by 117 · see citing works
Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2
Muchtaridi, M., Fauzi, M., Ikram, N. K. K., Gazzali, A. M., & Wahab, H. A. (2020) · Molecules · doi:10.3390/molecules25173980 · Cited by 113 · see citing works
Smoking and COVID-19: What we know so far
Shastri, M. D., Shukla, S. D., Chong, W. C., Rajendra, K. C., Dua, K., Patel, R. P., Peterson, G. M., & O’Toole, R. (2020) · Respiratory Medicine · doi:10.1016/j.rmed.2020.106237 · Cited by 110 · see citing works
Pathogenesis, Clinical Manifestations and Complications of COVID-19
Kordzadeh-Kermani, E., Khalili, H., & Karimzadeh, I. (2020) · Future Microbiology · doi:10.2217/fmb-2020-0110 · Cited by 116 · see citing works
Sex‐related differences in COVID‐19 lethality
Penna, C. R. R., Mercurio, V., Tocchetti, C. G., & Pagliaro, P. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15207 · Cited by 100 · see citing works
COVID-19 and diabetes: Association intensify risk factors for morbidity and mortality
Sharma, P., Behl, T., Sharma, N., Singh, S., Grewal, A. S., Albarrati, A., Albratty, M., Meraya, A. M., & BUNGAU, S. G. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113089 · Cited by 100 · see citing works
COVID-19 and non-communicable diseases
Pal, R., & Bhadada, S. K. (2020) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2020-137742 · Cited by 94 · see citing works
Vasculopathy and Coagulopathy Associated with SARS-CoV-2 Infection
Labò, N., Ohnuki, H., & Tosato, G. (2020) · Cells · doi:10.3390/cells9071583 · Cited by 89 · see citing works
SARS-CoV-2 entry in host cells-multiple targets for treatment and prevention
Mahmoud, I. S., Jarrar, Y. B., Alshaer, W., & Ismail, S. I. (2020) · Biochimie · doi:10.1016/j.biochi.2020.05.012 · Cited by 83 · see citing works
Immunological Aspects of SARS-CoV-2 Infection and the Putative Beneficial Role of Vitamin-D
Peng, M.-Y., Liu, W.-C., Zheng, J.-Q., Lu, C., Hou, Y., Zheng, C., Song, J.-Y., Lu, K., & Chao, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105251 · Cited by 84 · see citing works
Simon, H., Sakano, T. M. S., Rodrigues, R. M., Eisencraft, A. P., Carvalho, V. E. D. L., Schvartsman, C., & Reis, A. G. (2020) · Jornal de Pediatria · doi:10.1016/j.jped.2020.08.004 · Cited by 82 · see citing works
COVID-19: Yet another coronavirus challenge in transplantation
Aslam, S., & Mehra, M. R. (2020) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2020.03.007 · Cited by 82 · see citing works
Hung, Y.-H., Hsieh, W., Hsieh, J. S., Liu, F.-C., Tsai, C.-H., Lu, L.-C., Huang, C.-Y., Wu, C.-L., & Lin, C. (2016) · International Journal of Biological Sciences · doi:10.7150/ijbs.13379 · Cited by 81 · see citing works
Hassanein, M., Radhakrishnan, Y., Sedor, J. R., Vachharajani, T. J., Vachharajani, V., Augustine, J. J., Demirjian, S. G., & Thomas, G. (2020) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.87a.20072 · Cited by 81 · see citing works
Angelidi, A. M., Belanger, M. J., & Mantzoros, C. S. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154245 · Cited by 83 · see citing works
Dalan, R., Ang, L. W., Tan, W. Y. T., Fong, S., Tay, W. C., Chan, Y., Rénia, L., Ng, L. F. P., Lye, D. C., Chew, D. E. K., et al. (2020) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvaa098 · Cited by 79 · see citing works
O Efeito da Doença de Coronavírus 2019 nas Doenças Cardiovasculares
Aşkın, L., Tanrıverdi, O., & Aşkın, H. Ş. (2020) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20200273 · Cited by 77 · see citing works
Moran, C. S., Biroš, E., Krishna, S. M., Wang, Y., Tikellis, C., Morton, S. K., Moxon, J. V., Cooper, M. E., Norman, P. E., Burrell, L. M., et al. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.310129 · Cited by 76 · see citing works
Self-citationDiabetes and COVID-19: Global and regional perspectives
Jeong, I., Yoon, K., & Lee, M. K. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108303 · Cited by 76 · see citing works
The renin-angiotensin-aldosterone system (RAAS) signaling pathways and cancer: foes versus allies
Hassani, B., Attar, Z., & Firouzabadi, N. (2023) · Cancer Cell International · doi:10.1186/s12935-023-03080-9 · Cited by 76 · see citing works
MIN, F., GAO, F., Li, Q., & Liu, Z. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.3025 · Cited by 76 · see citing works
The relationship of stress and blood pressure effectors.
Ayada, C., Toru, Ü., & Korkut, Y. (2015) · Europe PMC (PubMed Central) · Cited by 75 · see citing works
Cardiovascular disease and <scp>COVID</scp> ‐19: Australian and New Zealand consensus statement
Zaman, S., MacIsaac, A. I., Jennings, G. L., Schlaich, M. P., Inglis, S. C., Arnold, R., Kumar, S., Thomas, L., Wahi, S., Lo, S., et al. (2020) · Medical Journal of Australia · doi:10.5694/mja2.50714 · Cited by 73 · see citing works
The value of ECG changes in risk stratification of COVID‐19 patients
Bergamaschi, L., D’Angelo, E. C., Paolisso, P., Toniolo, S., Fabrizio, M., Angeli, F., Donati, F., Magnani, I., Rinaldi, A., Bartoli, L., et al. (2021) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12815 · Cited by 72 · see citing works
Goru, S. K., Kadakol, A., Malek, V., Pandey, A., Sharma, N., & Gaikwad, A. B. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13946 · Cited by 72 · see citing works
Wang, Y., Chen, B., Li, Y., Zhang, L., Wang, Y., Yang, S., Xiao, X., & Qin, Q. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26625 · Cited by 72 · see citing works
An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2
Tada, T., Fan, C., Chen, J., Kaur, R., Stapleford, K. A., Gristick, H. B., Dcosta, B. M., Wilen, C. B., Nimigean, C. M., & Landau, N. R. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108528 · Cited by 71 · see citing works
The Perfect Storm: COVID-19 Health Disparities in US Blacks
Phillips, N., Park, I.-W., Robinson, J. R., & Jones, H. P. (2020) · Journal of Racial and Ethnic Health Disparities · doi:10.1007/s40615-020-00871-y · Cited by 71 · see citing works
Aktaş, G. (2020) · Experimental Biomedical Research · doi:10.30714/j-ebr.2020463629 · Cited by 71 · see citing works
Angiotensin-Converting-Enzyme 2 and Renin-Angiotensin System Inhibitors in COVID-19: An Update
Shukla, A. K., & Banerjee, M. (2021) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-021-00439-9 · Cited by 72 · see citing works
COVID-19 cardiovascular epidemiology, cellular pathogenesis, clinical manifestations and management
Sattar, Y., Ullah, W., Rauf, H., Virk, H. U. H., Yadav, S. K., Chowdhury, M., Connerney, M. A., Mamtani, S. S., Pahuja, M., Patel, R., et al. (2020) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2020.100589 · Cited by 70 · see citing works
COVID ‐19, microthromboses, inflammation, and platelet activating factor
Demopoulos, C. A., Antonopoulou, S., & Theoharides, T. C. (2020) · BioFactors · doi:10.1002/biof.1696 · Cited by 70 · see citing works
Gowrishankar, S., Muthumanickam, S., Kamaladevi, A., Karthika, C., Jothi, R., Boomi, P., Maniazhagu, D., & Pandian, S. K. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111966 · Cited by 70 · see citing works
Cooper, S. L., Boyle, E., Jefferson, S. R., Heslop, C., Mohan, P., Mohanraj, G. G. J., Sidow, H. A., Tan, R. C. P., Hill, S. J., & Woolard, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158255 · Cited by 67 · see citing works
Role of comorbidities like diabetes on severe acute respiratory syndrome coronavirus-2: A review
Das, S., Anu, K. R., Birangal, S., Nikam, A. N., Pandey, A. P., Mutalik, S., & Joseph, A. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118202 · Cited by 67 · see citing works
Vitamin A in resistance to and recovery from infection: relevance to SARS-CoV2
Stephensen, C. B., & Lietz, G. (2021) · British Journal Of Nutrition · doi:10.1017/s0007114521000246 · Cited by 66 · see citing works
Epithelial and Endothelial Expressions of ACE2: SARS-CoV-2 Entry Routes
Güney, C., & Akar, F. (2021) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/jpps31455 · Cited by 65 · see citing works
Sellegounder, D., Zafari, P., Rajabinejad, M., Taghadosi, M., & Kapahi, P. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107806 · Cited by 68 · see citing works
Molecular Pathogenesis, Immunopathogenesis and Novel Therapeutic Strategy Against COVID-19
Chatterjee, S. K., Saha, S., & Muñoz, M. N. M. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00196 · Cited by 65 · see citing works
Association of vitamin D with the modulation of the disease severity in COVID-19
Mardani, R., Alamdary, A., Nasab, S. D. M., Gholami, R., Ahmadi, N., & Gholami, A. (2020) · Virus Research · doi:10.1016/j.virusres.2020.198148 · Cited by 65 · see citing works
Ambient PM2.5 exposure and rapid spread of COVID-19 in the United States
Chakrabarty, R. K., Beeler, P., Liu, P., Goswami, S., Harvey, R. D., Pervez, S., van Donkelaar, A., & Martin, R. V. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.143391 · Cited by 65 · see citing works
Pasini, A. M. F., Stranieri, C., Cominacini, L., & Mozzini, C. (2021) · Antioxidants · doi:10.3390/antiox10020272 · Cited by 66 · see citing works
Immunosenescence and inflamm-ageing in COVID-19
Zinatizadeh, M. R., Zarandi, P. K., Ghiasi, M., Kooshki, H., Mohammadi, M., Amani, J., & Rezaei, N. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101818 · Cited by 62 · see citing works
Arterial Hypertension as a Risk Comorbidity Associated with COVID‐19 Pathology
Kamyshnyi, O., Krynytska, І., Matskevych, V. M., Марущак, М. І., & Lushchak, O. V. (2020) · International Journal of Hypertension · doi:10.1155/2020/8019360 · Cited by 63 · see citing works
COVID‐19 and immunothrombosis: emerging understanding and clinical management
Shaw, R., Bradbury, C. A., Abrams, S. T., Wang, G., & Toh, C. (2021) · British Journal of Haematology · doi:10.1111/bjh.17664 · Cited by 59 · see citing works
Mechanisms of COVID-19-induced kidney injury and current pharmacotherapies
Faour, W. H., Choaib, A., Issa, E., Choueiry, F. E., Shbaklo, K., Alhajj, M., Sawaya, R. T., Harhous, Z., Alefishat, E. A., & Nader, M. (2021) · Inflammation Research · doi:10.1007/s00011-021-01520-8 · Cited by 59 · see citing works
Bos, J. M., Hebl, V. B., Oberg, A. L., Sun, Z., Herman, D. S., Teekakirikul, P., Seidman, J. G., Seidman, C. E., dos Remedios, C. G., Maleszewski, J. J., et al. (2020) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.04.028 · Cited by 62 · see citing works
Classical and alternative receptors for SARS‐CoV‐2 therapeutic strategy
Masre, S. F., Jufri, N. F., Ibrahim, F. W., & Raub, S. H. A. (2020) · Reviews in Medical Virology · doi:10.1002/rmv.2207 · Cited by 59 · see citing works
Supervised molecular dynamics for exploring the druggability of the SARS-CoV-2 spike protein
Deganutti, G., Prischi, F., & Reynolds, C. A. (2020) · Journal of Computer-Aided Molecular Design · doi:10.1007/s10822-020-00356-4 · Cited by 58 · see citing works
A Review on the Neurological Manifestations of COVID-19 Infection: a Mechanistic View
Zangbar, H. S., Gorji, A., & Ghadiri, T. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02149-0 · Cited by 57 · see citing works
Holly, J. M. P., Biernacka, K. M., Maskell, N. A., & Perks, C. M. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.582870 · Cited by 56 · see citing works
Chowdhury, R., Boorla, V. S., & Maranas, C. D. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.09.019 · Cited by 56 · see citing works
- Authors
- Tikellis, C., & Thomas, M. C.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- Corresponding author
- Tikellis, Chris
- ORCID
- Thomas, M. C.
- Venue
- International Journal of Peptides
- Publisher
- Hindawi Limited
- Published
- 2012-03-20
- Volume
- 2012
- Pages
- 1-8
- ISSN
- 1687-9767 (ISSN-L)
- 1687-9775
- PMC
- PMC3321295
- OpenAlex
- W2082133861
- Cited by
- 624
- References
- 85
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 31 · 2023: 57 · 2022: 87 · 2021: 164 · 2020: 244 · 2019: 7 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 3
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- International Journal of Peptides (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Funders
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Genetics › Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- angiotensin-converting enzyme 2, renin-angiotensin system, angiotensin II, angiotensin-(1-7), hypertension, diabetes mellitus, cardiovascular disease, organ protection
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
