New hepatic targets for glycaemic control in diabetes

Agius, Loranne

doi:10.1016/j.beem.2007.09.001

Cited by 171Diabetes Treatment and ManagementMetabolism, Diabetes, and CancerPancreatic function and diabetes

New hepatic targets for glycaemic control in diabetes

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Agius, Loranne·2007·Best Practice & Research Clinical Endocrinology & Metabolism

DOI 10.1016/j.beem.2007.09.001

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Abstract

Type-2 diabetes is associated with impaired glucose clearance by the liver in the postprandial state, and with elevated glucose production in the post-absorptive state. New targets within the liver are currently being investigated for development of antihyperglycaemic drugs for type-2 diabetes. They include glucokinase, which catalyses the first step in glucose metabolism, the glucagon receptor, and enzymes of gluconeogenesis and/or glycogenolysis such as glucose 6-phosphatase, fructose 1,6-bisphosphatase and glycogen phosphorylase. Preclinical studies with candidate drugs on animal models or cell-based assays suggest that these targets have the potential for pharmacological glycaemic control. Data from clinical studies is awaited. Further work is required for better understanding of the implications of targeting these sites in terms of possible side-effects or tachyphylaxis. The advantage of combined targeting of two or more sites within the liver for minimizing side-effects and tachyphylaxis caused by single-site targeting is discussed.

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In type 2 diabetic patients, serum after glargine treatment activates insulin receptors A and B to a similar extent as NPH insulin and does not enhance IGF-1 receptor signalling.
“serum from type 2 diabetic patients treated with glargine activates insulin receptors A and B similarly to NPH insulin and does not increase signalling through the IGF-1 receptor128.”
From Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future (2014) · cites this paper as [128]

Lower blood glucose, hyperglucagonemia, and pancreatic α cell hyperplasia in glucagon receptor knockout mice
Gelling, R. W., Du, X. Q., Dichmann, D. S., Rømer, J., Huang, H., Cui, L., Obici, S., Tang, B., Holst, J. J., Fledelius, C., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0237106100 · Cited by 563 · see citing works
Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy
Grimsby, J. S., Sarabu, R., Corbett, W. L., Haynes, N.-E., Bizzarro, F. T., Coffey, J. W., Guertin, K. R., Hilliard, D. W., Kester, R. F., Mahaney, P. E., et al. (2003) · Science · doi:10.1126/science.1084073 · Cited by 526 · see citing works
Structural Basis for Allosteric Regulation of the Monomeric Allosteric Enzyme Human Glucokinase
Kamata, K., Mitsuya, M., Nishimura, T., Eiki, J., & Nagata, Y. (2004) · Structure · doi:10.1016/j.str.2004.02.005 · Cited by 502 · see citing works
Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo.
Cherrington, A. D. (1999) · Diabetes · doi:10.2337/diabetes.48.5.1198 · Cited by 500 · see citing works
Specific features of glycogen metabolism in the liver
Bollen, M., Keppens, S., & Stalmans, W. (1998) · Biochemical Journal · doi:10.1042/bj3360019 · Cited by 409 · see citing works
The Family of Glycogen Phosphorylases: Structure and Functio
Newgard, C. B., Hwang, P. K., & Fletterick, R. J. (1989) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238909082552 · Cited by 392 · see citing works
The role of α-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications
Dunning, B. E., & Gerich, J. E. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0026 · Cited by 369 · see citing works
The Network of Glucokinase-Expressing Cells in Glucose Homeostasis and the Potential of Glucokinase Activators for Diabetes Therapy
Matschinsky, F. M., Magnuson, M. A., Zelent, D., Jetton, T. L., Doliba, N. M., Han, Y., Taub, R. A., & Grimsby, J. S. (2006) · Diabetes · doi:10.2337/diabetes.55.01.06.db05-0926 · Cited by 300 · see citing works
Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange
DeFronzo, R. A., Ferrannini, E., Hendler, R., Wahren, J., & Felig, P. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.10.5173 · Cited by 296 · see citing works
Glycogen phosphorylase inhibitors for treatment of type 2 diabetes mellitus
Treadway, J. L., Mendys, P., & Hoover, D. J. (2001) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.10.3.439 · Cited by 260 · see citing works
Taxonomy, Fermentation, Isolation and Biological Activities.
Mori, H., Urano, Y., Abe, F., Furukawa, S., Furukawa, S., TSURUMI, Y., Sakamoto, K., Hashimoto, M., Takase, S., Hino, M., et al. (2003) · The Journal of Antibiotics · doi:10.7164/antibiotics.56.72 · Cited by 238 · see citing works
Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo
Martin, W. H., Hoover, D. J., Armento, S. J., Stock, I. A., McPherson, R. K., Danley, D. E., Stevenson, R. W., Barrett, E. J., & Treadway, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1776 · Cited by 232 · see citing works
Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans
Petersen, K. F., & Sullivan, J. T. (2001) · Diabetologia · doi:10.1007/s001250100006 · Cited by 209 · see citing works
Reduction in Glucagon Receptor Expression by an Antisense Oligonucleotide Ameliorates Diabetic Syndrome in db/db Mice
Liang, Y. T., Osborne, M. C., Monia, B. P., Bhanot, S., Gaarde, W. A., Reed, C. A., She, P., Jetton, T. L., & Demarest, K. T. (2004) · Diabetes · doi:10.2337/diabetes.53.2.410 · Cited by 203 · see citing works
Perturbation of Fuel Homeostasis Caused by Overexpression of the Glucose-6-phosphatase Catalytic Subunit in Liver of Normal Rats
Trinh, K. Y., O'Doherty, R. M., Anderson, P., Lange, A. J., & Newgard, C. B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.31615 · Cited by 191 · see citing works
Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia.
O'Doherty, R. M., Lehman, D. L., Télémaque, S., & Newgard, C. B. (1999) · Diabetes · doi:10.2337/diabetes.48.10.2022 · Cited by 187 · see citing works
Glucose Regulates in Vivo Glucose-6-phosphatase Gene Expression in the Liver of Diabetic Rats
Massillon, D., Barzilai, N., Chen, W., Hu, M., & Rossetti, L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.17.9871 · Cited by 168 · see citing works
Glycogen Phosphorylase as a Molecular Target for Type 2 Diabetes Therapy
Oikonomakos, N. G. (2002) · Current Protein and Peptide Science · doi:10.2174/1389203023380422 · Cited by 166 · see citing works
MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes
Erion, M. D., van Poelje, P. D., Dang, Q., Kasibhatla, S. R., Potter, S. C., Reddy, M. R., Reddy, K. R., Jiang, T., & Lipscomb, W. N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502983102 · Cited by 162 · see citing works
Glycemic Control in Mice with Targeted Disruption of the Glucagon Receptor Gene
Parker, J. C., Andrews, K. M., Allen, M. R., Stock, J. L., & McNeish, J. D. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6265 · Cited by 160 · see citing works
Evidence for a Role of Glucose-induced Translocation of Glucokinase in the Control of Hepatic Glycogen Synthesis
Agius, L., Peak, M., Newgard, C. B., Gómèz‐Foix, A. M., & Guinovart, J. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.48.30479 · Cited by 149 · see citing works
Self-citation
Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes.
Clore, J. N., Stillman, J., & Sugerman, H. J. (2000) · Diabetes · doi:10.2337/diabetes.49.6.969 · Cited by 146 · see citing works
Regulation of endogenous glucose production by glucose per se is impaired in type 2 diabetes mellitus.
Mevorach, M., Giacca, A., Aharon, Y., Hawkins, M. A., Shamoon, H., & Rossetti, L. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2720 · Cited by 142 · see citing works
Liver Glucokinase: Decreased Activity in Patients with Type II Diabetes
Caro, J., Triester, S. L., Patel, V., Tapscott, E. B., Leggett-Frazier, N., & Dohm, G. L. (1995) · Hormone and Metabolic Research · doi:10.1055/s-2007-979899 · Cited by 135 · see citing works
A new allosteric site in glycogen phosphorylase b as a target for drug interactions
Oikonomakos, N. G., Skamnaki, V. T., Tsitsanou, K. E., Gavalas, N. G., & Johnson, L. N. (2000) · Structure · doi:10.1016/s0969-2126(00)00144-1 · Cited by 132 · see citing works
A Novel Glucokinase Activator Modulates Pancreatic Islet and Hepatocyte Function
Efanov, A. M., Barrett, D. G., Brenner, M. B., Briggs, S., Delaunois, A. G., Durbin, J. D., Giese, U., Guo, H., Radloff, M., Gil, G. S., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0377 · Cited by 131 · see citing works
Stimulation of Hepatocyte Glucose Metabolism by Novel Small Molecule Glucokinase Activators
Brocklehurst, K. J., Payne, V. A., Davies, R. A., Carroll, D., Vertigan, H. L., Wightman, H. J., Aiston, S., Waddell, I. D., Leighton, B., Coghlan, M. P., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.3.535 · Cited by 130 · see citing works
Self-citation
Human liver glycogen phosphorylase inhibitors bind at a new allosteric site
Rath, V. L., Ammirati, M. J., Danley, D. E., Ekstrom, J. L., Gibbs, E. M., Hynes, T. R., Mathiowetz, A. M., McPherson, R. K., Olson, T. V., Treadway, J. L., et al. (2000) · Chemistry & Biology · doi:10.1016/s1074-5521(00)00004-1 · Cited by 129 · see citing works
Quantitative contributions of gluconeogenesis to glucose production during fasting in type 2 diabetes mellitus
Wajngot, A., Chandramouli, V., Schumann, W. C., Ekberg, K., Jones, P. K., Efendic, S., & Landau, B. R. (2001) · Metabolism · doi:10.1053/meta.2001.19422 · Cited by 128 · see citing works
Small Increases in Insulin Inhibit Hepatic Glucose Production Solely Caused by an Effect on Glycogen Metabolism
Edgerton, D. S., Cardin, S., Emshwiller, M., Neal, D. W., Chandramouli, V., Schumann, W. C., Landau, B. R., Rossetti, L., & Cherrington, A. D. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1872 · Cited by 127 · see citing works
Flavopiridol Inhibits Glycogen Phosphorylase by Binding at the Inhibitor Site
Oikonomakos, N. G., Schnier, J. B., Zographos, S. E., Skamnaki, V. T., Tsitsanou, K. E., & Johnson, L. N. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004485200 · Cited by 124 · see citing works
Inhibition of glycogenolysis in primary rat hepatocytes by 1,4-dideoxy-1,4-imino-D-arabinitol
ANDERSEN, B., RASSOV, A., Westergaard, N., & Lundgren, K. (1999) · Biochemical Journal · doi:10.1042/bj3420545 · Cited by 115 · see citing works
Glycogen Phosphorylase Inhibitors
Henke, B. R., & Sparks, S. M. (2006) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955706777934991 · Cited by 114 · see citing works
Pentacyclic triterpenes. Part 1: The first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases
Wen, X., Sun, H., Liu, J., Wu, G., Zhang, L., Wu, X., & Ni, P. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.08.026 · Cited by 112 · see citing works
Long-term overexpression of glucokinase in the liver of transgenic mice leads to insulin resistance
Ferré, T., Riu, E., Franckhauser, S., Agudo, J., & Bosch, F. (2003) · Diabetologia · doi:10.1007/s00125-003-1244-z · Cited by 109 · see citing works
A Novel Glucagon Receptor Antagonist Inhibits Glucagon-Mediated Biological Effects
Qureshi, S. A., Candelore, M. R., Xie, D., Yang, X., Tota, L. M., Ding, V. D. H., Li, Z., Bansal, A., Miller, C. O., Cohen, S. M., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3267 · Cited by 109 · see citing works
Activation of Human Liver Glycogen Phosphorylase by Alteration of the Secondary Structure and Packing of the Catalytic Core
Rath, V. L., Ammirati, M., LeMotte, P. K., Fennell, K. F., Mansour, M. N., Danley, D. E., Hynes, T. R., Schulte, G. K., Wasilko, D. J., & Pandit, J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00006-7 · Cited by 107 · see citing works
Expression of Human Hepatic Glucokinase in Transgenic Mice Liver Results in Decreased Glucose Levels and Reduced Body Weight
Hariharan, N., Farrelly, D., Hagan, D. L., Hillyer, D. E., ARBEENY, C. M., Sabrah, T., Treloar, A., Brown, K. S., Kalinowski, S. S., & Mookhtiar, K. A. (1997) · Diabetes · doi:10.2337/diab.46.1.11 · Cited by 107 · see citing works
Indole-2-carboxamide Inhibitors of Human Liver Glycogen Phosphorylase
Hoover, D. J., Snow, S. L., Burgess‐Henry, J., Martin, W. H., Armento, S. J., Stock, I. A., McPherson, R. K., Genereux, P. E., Gibbs, E. M., & Treadway, J. L. (1998) · Journal of Medicinal Chemistry · doi:10.1021/jm980264k · Cited by 100 · see citing works
An Allosteric Activator of Glucokinase Impairs the Interaction of Glucokinase and Glucokinase Regulatory Protein and Regulates Glucose Metabolism
Futamura, M., Hosaka, H., Kadotani, A., Shimazaki, H., Sasaki, K., Ohyama, S., Nishimura, T., Eiki, J., & Nagata, Y. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605186200 · Cited by 100 · see citing works
Pharmacological Approaches to Inhibit Endogenous Glucose Production as a Means of Anti-diabetic Therapy
McCormack, J., Westergaard, N., Kristiansen, M., Brand, C. L., & Lau, J. F. (2001) · Current Pharmaceutical Design · doi:10.2174/1381612013397393 · Cited by 97 · see citing works
Insulin dose-response curves for stimulation of splanchnic glucose uptake and suppression of endogenous glucose production differ in nondiabetic humans and are abnormal in people with type 2 diabetes
Basu, R., Basu, A., Johnson, C. M., Schwenk, W. F., & Rizza, R. A. (2004) · Diabetes · doi:10.2337/diabetes.53.8.2042 · Cited by 97 · see citing works
Hypoglycaemic effect of AICAriboside in mice
Vincent, M. F., Erion, M. D., Gruber, H. E., & den Berghe, G. V. (1996) · Diabetologia · doi:10.1007/bf02658500 · Cited by 93 · see citing works
Kinetic and Functional Characterization of 1,4-Dideoxy-1,4-imino--arabinitol: A Potent Inhibitor of Glycogen Phosphorylase with Anti-hyperglyceamic Effect in ob/ob Mice
Fosgerau, K., Westergaard, N., Quistorff, B., Grunnet, N., Kristiansen, M., & Lundgren, K. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1930 · Cited by 91 · see citing works
Acute Inhibition of Hepatic Glucose-6-phosphatase Does Not Affect Gluconeogenesis but Directs Gluconeogenic Flux toward Glycogen in Fasted Rats
Dijk, V. T., van der Sluijs, Wiegman, C., Baller, J. F. W., GUSTAFSON, L. A., Burger, H.-J., Herling, A., Kuipers, F., Meijer, A. J., & Reijngoud, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101223200 · Cited by 90 · see citing works
Glucokinase and glucose homeostasis: proven concepts and new ideas
Zelent, D., Najafi, H., Odili, S., Buettger, C. W., Weik-Collins, H., Li, Z., Doliba, N. M., Grimsby, J. S., & Matschinsky, F. M. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330306 · Cited by 88 · see citing works
Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions
Fyfe, M. C. T., White, J. R., Taylor, A., Chatfield, R., Wargent, E. T., Printz, R. L., Sulpice, T., McCormack, J. G., Procter, M. J., Reynet, C., et al. (2007) · Diabetologia · doi:10.1007/s00125-007-0646-8 · Cited by 87 · see citing works
Inhibition of Fructose 1,6-Bisphosphatase Reduces Excessive Endogenous Glucose Production and Attenuates Hyperglycemia in Zucker Diabetic Fatty Rats
van Poelje, P. D., Potter, S. C., Chandramouli, V. C., Landau, B. R., Dang, Q., & Erion, M. D. (2006) · Diabetes · doi:10.2337/db05-1443 · Cited by 87 · see citing works
Iminosugars: potential inhibitors of liver glycogen phosphorylase
Jakobsen, P., Lundbeck, J. M., Kristiansen, M., Breinholt, J., Demuth, H., Pawlas, J., Candela, M. P. T., Andersen, B., Westergaard, N., Lundgren, K., et al. (2001) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(00)00291-1 · Cited by 85 · see citing works
Anilinoquinazoline Inhibitors of Fructose 1,6-Bisphosphatase Bind at a Novel Allosteric Site: Synthesis, In Vitro Characterization, and X-ray Crystallography
Wright, S. W., Carlo, A. A., Carty, M. D., Danley, D. E., Hageman, D. L., Karam, G. A., Levy, C. B., Mansour, M. N., Mathiowetz, A. M., McClure, L. D., et al. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm010496a · Cited by 83 · see citing works
Immunoneutralization of Endogenous Glucagon Reduces Hepatic Glucose Output and Improves Long-Term Glycemic Control in Diabetic ob/ob Mice
Sørensen, H., Brand, C. L., Neschen, S., Holst, J. J., Fosgerau, K., Nishimura, E., & Shulman, G. I. (2006) · Diabetes · doi:10.2337/db06-0222 · Cited by 80 · see citing works
Glucose-6-phosphatase Overexpression Lowers Glucose 6-Phosphate and Inhibits Glycogen Synthesis and Glycolysis in Hepatocytes without Affecting Glucokinase Translocation
Aiston, S., Trinh, K. Y., Lange, A. J., Newgard, C. B., & Agius, L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.24559 · Cited by 79 · see citing works
Self-citation
Acyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes
Klabunde, T., Wendt, K. U., Kadereit, D., Brachvogel, V., Burger, H.-J., Herling, A. W., Oikonomakos, N. G., Kosmopoulou, M. N., Schmoll, D., Sarubbi, E., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm049034y · Cited by 77 · see citing works
Hepatic Glycogen Synthesis Is Highly Sensitive to Phosphorylase Activity
Aiston, S., Hampson, L. J., Gómèz‐Foix, A. M., Guinovart, J. J., & Agius, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101454200 · Cited by 74 · see citing works
Self-citation
Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats
Coope, G., Atkinson, A. M., Allott, C. P., McKerrecher, D., Johnstone, C., Pike, K. G., Holme, P. C., Vertigan, H. L., Gill, D., Coghlan, M. P., et al. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706848 · Cited by 73 · see citing works
Small Molecule Glucokinase Activators as Glucose Lowering Agents: A New Paradigm for Diabetes Therapy
Guertin, K. R., & Grimsby, J. S. (2006) · Current Medicinal Chemistry · doi:10.2174/092986706777452551 · Cited by 72 · see citing works
Acute Inhibition of Glucose-6-Phosphate Translocator Activity Leads to Increased De Novo Lipogenesis and Development of Hepatic Steatosis Without Affecting VLDL Production in Rats
Bandsma, R., Wiegman, C., Herling, A. W., Burger, H.-J., ter Harmsel, A., Meijer, A. J., Romijn, J. A., Reijngoud, D., & Kuipers, F. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2591 · Cited by 70 · see citing works
The physiological role of glucokinase binding and translocation in hepatocytes
Agius, L. (1998) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(97)00001-0 · Cited by 68 · see citing works
Self-citation
Iminosugars as Potential Inhibitors of Glycogenolysis: Structural Insights into the Molecular Basis of Glycogen Phosphorylase Inhibition
Oikonomakos, N. G., Tiraidis, C., Leonidas, D. D., Zographos, S. E., Kristiansen, M., Jessen, C. U., Nørskov‐Lauritsen, L., & Agius, L. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm060496g · Cited by 65 · see citing works
Self-citation
Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes.
Parker, J. C., McPherson, R. K., Andrews, K. M., Levy, C. B., Dubins, J. S., Chin, J. E., Perry, P., Hulin, B., Perry, D. A., Inagaki, T., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2079 · Cited by 65 · see citing works
Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors
Ogawa, A. K., Willoughby, C. A., Bergeron, R., Ellsworth, K. P., Geissler, W. M., Myers, R. W., Yao, J., Harris, G., & Chapman, K. T. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(03)00798-4 · Cited by 65 · see citing works
Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis
Aiston, S., Coghlan, M. P., & Agius, L. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03648.x · Cited by 62 · see citing works
Self-citation
Alterations of carbohydrate and lipid intermediary metabolism during inhibition of glucose-6-phosphatase in rats
Herling, A. W., Burger, H.-J., Schubert, G., Hemmerle, H., Schaefer, H.-L., & Kramer, W. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00748-7 · Cited by 62 · see citing works
Dual Role of Phosphofructokinase-2/Fructose Bisphosphatase-2 in Regulating the Compartmentation and Expression of Glucokinase in Hepatocytes
Payne, V. A., Arden, C., Wu, C., Lange, A. J., & Agius, L. (2005) · Diabetes · doi:10.2337/diabetes.54.7.1949 · Cited by 60 · see citing works
Self-citation
Natural flavonoids are potent inhibitors of glycogen phosphorylase
Jakobs, S., Fridrich, D., Hofem, S., Pahlke, G., & Eisenbrand, G. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500163 · Cited by 60 · see citing works
Plasma glucose levels are reduced in rats and mice treated with an inhibitor of glucose-6-phosphate translocase.
Parker, J. C., VanVolkenburg, M. A., Levy, C. B., Martin, W. H., Burk, S. H., Kwon, Y., Giragossian, C., Gant, T. G., Carpino, P. A., McPherson, R. K., et al. (1998) · Diabetes · doi:10.2337/diabetes.47.10.1630 · Cited by 58 · see citing works
The Cyclin-Dependent Kinase (CDK) Inhibitor Flavopiridol Inhibits Glycogen Phosphorylase
Kaiser, A., Nishi, K., Gorin, F. A., Walsh, D. A., Bradbury, E. M., & Schnier, J. B. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2220 · Cited by 57 · see citing works
Discovery, synthesis and biological evaluation of novel glucokinase activators
McKerrecher, D., Allen, J. V., Bowker, S. S., Boyd, S., Caulkett, P. W. R., Currie, G. S., Davies, C. D., Fenwick, M. L., Gaskin, H., Grange, E., et al. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.01.087 · Cited by 55 · see citing works
Phlorizin treatment of diabetic rats partially reverses the abnormal expression of genes involved in hepatic glucose metabolism
Brichard, S. M., Henquin, J., & Girard, J. R. (1993) · Diabetologia · doi:10.1007/bf00400230 · Cited by 54 · see citing works
Hepatic Enzyme Activities of Glycolysis and Gluconeogenesis in Diabetes of Man and Laboratory Animals
Willms, B., Ben-Ami, P., & Söling, H. (1970) · Hormone and Metabolic Research · doi:10.1055/s-0028-1095102 · Cited by 53 · see citing works
Glucose regulation of gene expression
Foufelle, F., Girard, J. R., & Ferré, P. (1998) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-199807000-00002 · Cited by 53 · see citing works
Diverse effects of two allosteric inhibitors on the phosphorylation state of glycogen phosphorylase in hepatocytes
LATSIS, T., ANDERSEN, B., & Agius, L. (2002) · Biochemical Journal · doi:10.1042/bj20021070 · Cited by 52 · see citing works
Self-citation
Structure-Activity Analysis of the Purine Binding Site of Human Liver Glycogen Phosphorylase
Ekstrom, J. L., Pauly, T. A., Carty, M. D., Soeller, W. C., Culp, J., Danley, D. E., Hoover, D. J., Treadway, J. L., Gibbs, E. M., Fletterick, R. J., et al. (2002) · Chemistry & Biology · doi:10.1016/s1074-5521(02)00186-2 · Cited by 50 · see citing works
3-(2-Carboxy-ethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site
Wright, S. W., Carlo, A. A., Danley, D. E., Hageman, D. L., Karam, G. A., Mansour, M. N., McClure, L. D., Pandit, J., Schulte, G. K., Treadway, J. L., et al. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(03)00310-x · Cited by 50 · see citing works
Molecular mode of inhibition of glycogenolysis in rat liver by the dihydropyridine derivative, BAY R3401: inhibition and inactivation of glycogen phosphorylase by an activated metabolite.
Bergans, N., Stalmans, W., Goldmann, S., & Vanstapel, F. J. L. A. (2000) · Diabetes · doi:10.2337/diabetes.49.9.1419 · Cited by 49 · see citing works
Dual-acting peptide with prolonged glucagon-like peptide-1 receptor agonist and glucagon receptor antagonist activity for the treatment of type 2 diabetes
Claus, T. H., Pan, C. Q., Buxton, J. M., Yang, L., Reynolds, J. C., Barucci, N., Burns, M. G., Ortiz, A. A., Roczniak, S., Livingston, J. N., et al. (2007) · Journal of Endocrinology · doi:10.1677/joe-06-0018 · Cited by 46 · see citing works
Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3‐isopropyl 4‐(2‐chlorophenyl)‐1,4‐dihydro‐1‐ethyl‐2‐methyl‐pyridine‐3,5,6‐tricarboxylate
Oikonomakos, N. G., Tsitsanou, K. E., Zographos, S. E., Skamnaki, V. T., Goldmann, S., & Bischoff, H. (1999) · Protein Science · doi:10.1110/ps.8.10.1930 · Cited by 43 · see citing works
Glucokinase-activating ureas
Castelhano, A. L., Dong, H., Fyfe, M. C. T., Gardner, L. S., Kamikozawa, Y., Kurabayashi, S., Nawano, M., Ohashi, R., Procter, M. J., Li, Q., et al. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2004.12.083 · Cited by 43 · see citing works
A Novel Glucagon Receptor Antagonist, NNC 25-0926, Blunts Hepatic Glucose Production in the Conscious Dog
Rivera, N., Grueter, C. A., Edgerton, D. S., Rodewald, T., Neal, D. W., Nishimura, E., Larsen, M. O., Jacobsen, L. O., Kristensen, K., Brand, C. L., et al. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.115717 · Cited by 43 · see citing works
Inhibition of Fructose-1,6-bisphosphatase by a New Class of Allosteric Effectors
Choe, J.-Y., Nelson, S. W., Arienti, K. L., Axe, F. U., Collins, T. L., Jones, T. K., Kimmich, R. D. A., Newman, M. J., Norvell, K., Ripka, W. C., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308396200 · Cited by 41 · see citing works
Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors
Birch, A. M., Kenny, P. W., Oikonomakos, N. G., Otterbein, L. R., Schofield, P. N., Whittamore, P. R. O., & Whalley, D. P. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.10.037 · Cited by 40 · see citing works
Identification, Synthesis, and Characterization of New Glycogen Phosphorylase Inhibitors Binding to the Allosteric AMP Site
Kristiansen, M., Andersen, B., Iversen, L. F., & Westergaard, N. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm031121n · Cited by 40 · see citing works
Glucose 6-phosphate causes translocation of phosphorylase in hepatocytes and inactivates the enzyme synergistically with glucose
Aiston, S., GREEN, A., Mukhtar, M. H., & Agius, L. (2004) · Biochemical Journal · doi:10.1042/bj20031191 · Cited by 39 · see citing works
Self-citation
Quantitation of glycogen synthase and phosphorylase protein in mouse liver: Correlation between enzymatic protein and enzyme activity
Roesler, W. J., & Khandelwal, R. L. (1986) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(86)90130-x · Cited by 35 · see citing works
Novel 3,4-Dihydroquinolin-2(1 H )-one inhibitors of human glycogen phosphorylase a
Rosauer, K. G., Ogawa, A. K., Willoughby, C. A., Ellsworth, K. P., Geissler, W. M., Myers, R. W., Deng, Q., Chapman, K. T., Harris, G., & Moller, D. E. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2003.09.022 · Cited by 35 · see citing works
A new class of glycogen phosphorylase inhibitors
Lu, Z., Bohn, J., Bergeron, R., Deng, Q., Ellsworth, K. P., Geissler, W. M., Harris, G., McCann, P. E., McKeever, B. M., Myers, R. W., et al. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2003.08.046 · Cited by 35 · see citing works
The role of glucose 6‐phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism
Härndahl, L., Schmoll, D., Herling, A. W., & Agius, L. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.05067.x · Cited by 33 · see citing works
Self-citation
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Andersen, B. B., & Westergaard, N. (2002) · Biochemical Journal · doi:10.1042/bj20020153 · Cited by 33 · see citing works
Effects of C-1-substituted glucose analogue on the activation states of glycogen synthase and glycogen phosphorylase in rat hepatocytes
M Board, Bollen, M., Stalmans, W., Kim, Y., Fleet, G. W. J., & Johnson, L. N. (1995) · Biochemical Journal · doi:10.1042/bj3110845 · Cited by 31 · see citing works
Effects of Novel Analogues of D-Glucose on Glycogen Phosphorylase Activities in Crude Extracts of Liver and Skeletal Muscle
Mary Board, Hadwen, M., & Johnson, L. N. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.0753m.x · Cited by 30 · see citing works
Novel thienopyrrole glycogen phosphorylase inhibitors: Synthesis, in vitro SAR and crystallographic studies
Whittamore, P. R. O., Addie, M. S., Bennett, S. N. L., Birch, A. M., Butters, M., Godfrey, L., Kenny, P. W., Morley, A., Murray, P. M., Oikonomakos, N. G., et al. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.08.047 · Cited by 30 · see citing works
The Experimental Type 2 Diabetes Therapy Glycogen Phosphorylase Inhibition Can Impair Aerobic Muscle Function During Prolonged Contraction
Baker, D. J., Greenhaff, P. L., MacInnes, A., & Timmons, J. A. (2006) · Diabetes · doi:10.2337/db05-1687 · Cited by 30 · see citing works
Expression of human hepatic glucokinase in transgenic mice liver results in decreased glucose levels and reduced body weight
Hariharan, N., Farrelly, D., Hagan, D., et al. (1997) · Diabetes · doi:10.2337/diabetes.46.1.11 · Cited by 30 · see citing works
Discovery and Actions of Glucokinase Activators
Grimsby, J. S., Matschinsky, F. M., & Grippo, J. F. (2004) · KARGER eBooks · doi:10.1159/000079030 · Cited by 29 · see citing works
Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site
Hampson, L. J., Arden, C., Agius, L., Ganotidis, M., Kosmopoulou, M. N., Tiraidis, C., Elemes, Y., Sakarellos, C., Leonidas, D. D., & Oikonomakos, N. G. (2006) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2006.07.060 · Cited by 27 · see citing works
Self-citation
Sensitivity of glycogen phosphorylase isoforms to indole site inhibitors is markedly dependent on the activation state of the enzyme
Freeman, S., Bartlett, J. B., Convey, G., Hardern, I. M., Teague, J., Loxham, S. J. G., Allen, J. M., Poucher, S. M., & Charles, A. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706925 · Cited by 27 · see citing works
Peroxyvanadium Compounds Inhibit Glucose-6-phosphatase Activity and Glucagon-Stimulated Hepatic Glucose Output in the Ratin Vivo
Westergaard, N., Brand, C. L., Lewinsky, R., Andersen, H. S., Carr, R. D., Burchell, A. N., & Lundgren, K. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1181 · Cited by 26 · see citing works
Impaired glycogen synthesis in hepatocytes from Zucker fatty fa/fa rats: the role of increased phosphorylase activity
Aiston, S., Peak, M., & Agius, L. (2000) · Diabetologia · doi:10.1007/s001250051348 · Cited by 25 · see citing works
Self-citation
Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs
Oikonomakos, N. G., Kosmopoulou, M. N., Chrysina, E. D., Leonidas, D. D., Kostas, I. D., Wendt, K. U., Klabunde, T., & Defoßa, E. (2005) · Protein Science · doi:10.1110/ps.051432405 · Cited by 25 · see citing works
Inhibition of glycogenolysis enhances gluconeogenic precursor uptake by the liver of conscious dogs
Shiota, M., Jackson, P. A., Bischoff, H., McCaleb, M. L., Scott, M. F., Monohan, M., Neal, D. W., & Cherrington, A. D. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.5.e868 · Cited by 24 · see citing works
FR258900, a Novel Glycogen Phosphorylase Inhibitor Isolated from Fungus No. 138354
Furukawa, S., Murakami, K., NISHIKAWA, M., Nakayama, O., & Hino, M. (2005) · The Journal of Antibiotics · doi:10.1038/ja.2005.67 · Cited by 20 · see citing works
Evidence against Glycogen Cycling of Gluconeogenic Substrates in Various Liver Preparations
Fosgerau, K., Breinholt, J., McCormack, J. G., & Westergaard, N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201565200 · Cited by 17 · see citing works
Increased Potency and Efficacy of Combined Phosphorylase Inactivation and Glucokinase Activation in Control of Hepatocyte Glycogen Metabolism
Hampson, L. J., & Agius, L. (2005) · Diabetes · doi:10.2337/diabetes.54.3.617 · Cited by 14 · see citing works
Self-citation
FR258900, a Novel Glycogen Phosphorylase Inhibitor Isolated from Fungus No. 138354
Furukawa, S., TSURUMI, Y., Murakami, K., Nakanishi, T., Ohsumi, K., Hashimoto, M., NISHIKAWA, M., Takase, S., Nakayama, O., & Hino, M. (2005) · The Journal of Antibiotics · doi:10.1038/ja.2005.66 · Cited by 12 · see citing works
FR258900, a potential anti‐hyperglycemic drug, binds at the allosteric site of glycogen phosphorylase
Tiraidis, C., Alexacou, K.-M., Zographos, S. E., Leonidas, D. D., Gimisis, T., & Oikonomakos, N. G. (2007) · Protein Science · doi:10.1110/ps.072925607 · Cited by 11 · see citing works
GKRP/GK: Control of Metabolic Fluxes in Hepatocytes
Agius, L., Aiston, S., Mukhtar, M. H., & de la Iglesia, N. (2004) · KARGER eBooks · doi:10.1159/000079018 · Cited by 9 · see citing works
Self-citation
Identification of two novel and potent competitive inhibitors of the glucose‐6‐phosphatase catalytic protein
Westergaard, N., Madsen, P., Lundbeck, J. M., Jakobsen, P., Varming, A. R., & Andersen, B. (2002) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2002.00179.x · Cited by 9 · see citing works
Hepatic glucokinase activity in human diabetics and nondiabetics
Ferris, S. A. (1964) · Metabolism · doi:10.1016/0026-0495(64)90042-3 · Cited by 7 · see citing works

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Kahn, S. E., Cooper, M. E., & Del Prato, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62154-6 · Cited by 1,743 · see citing works
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Åhrén, B. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2782 · Cited by 417 · see citing works
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Agius, L. (2008) · Biochemical Journal · doi:10.1042/bj20080595 · Cited by 384 · see citing works
Self-citation
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Rines, A. K., Sharabi, K., Tavares, C. D. J., & Puigserver, P. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.151 · Cited by 380 · see citing works
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Kerru, N., Singh‐Pillay, A., Awolade, P., & Singh, P. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.04.061 · Cited by 370 · see citing works
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Ahmad, M. F. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.08.036 · Cited by 277 · see citing works
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Zois, C. E., & Harris, A. L. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1377-9 · Cited by 254 · see citing works
Mechanisms underlying the effect of polysaccharides in the treatment of type 2 diabetes: A review
Wu, J., Shi, S., Wang, H., & Wang, S. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.02.040 · Cited by 242 · see citing works
Characterization and hypoglycemic effect of a polysaccharide extracted from the fruit of Lycium barbarum L.
Zhu, J., Liu, W., Yu, J., Zou, S., Wang, J., Yao, W., & Gao, X. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.04.057 · Cited by 233 · see citing works
Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Glycogen Phosphorylase: Synthesis, Structure−Activity Relationships, and X-ray Crystallographic Studies
Wen, X., Sun, H., Liu, J., Cheng, K., Zhang, P., Zhang, L., Jia, H., Zhang, L., Ni, P., Zographos, S. E., et al. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm8000949 · Cited by 191 · see citing works
Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin
Wu, S., Wang, G., Liu, Z., Rao, J.-J., Xu, W., Xu, W., Wu, S., & Zhang, J. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2008.17 · Cited by 175 · see citing works
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Murali, R., & Saravanan, R. (2012) · Biomedicine & Preventive Nutrition · doi:10.1016/j.bionut.2012.08.008 · Cited by 163 · see citing works
GPR119 agonists for the treatment of type 2 diabetes
Jones, R. M., Leonard, J. N., Buzard, D. J., & Lehmann, J. (2009) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543770903153878 · Cited by 154 · see citing works
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Zheng, Y., Bai, L., Zhou, Y., Tong, R., Zeng, M., Li, X., & Shi, J. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.10.072 · Cited by 142 · see citing works
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Xiao, C., Wu, Q., Zhang, J., Xie, Y., Cai, W. F., & Tan, J. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.11.044 · Cited by 136 · see citing works
Overview of food products and dietary constituents with antidiabetic properties and their putative mechanisms of action: A natural approach to complement pharmacotherapy in the management of diabetes
Lacroix, I. M. E., & Li‐Chan, E. C. Y. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300223 · Cited by 125 · see citing works
New Drugs for Type 2 Diabetes Mellitus
Krentz, A. J., Patel, M., & Bailey, C. J. (2008) · Drugs · doi:10.2165/00003495-200868150-00005 · Cited by 121 · see citing works
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Zhou, J., Xu, G., Yan, J., Li, K., Bai, Z., Cheng, W., & Huang, K. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.02.026 · Cited by 120 · see citing works
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Hossain, M., Kitagaki, S., Nakano, D., Nishiyama, A., Funamoto, Y., Matsunaga, T., Tsukamoto, I., Yamaguchi, F., Kamitori, K., Dong, Y., et al. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.12.091 · Cited by 113 · see citing works
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Neyrinck, A. M., Cani, P. D., Dewulf, E. M., Backer, F. D., Bindels, L. B., & Delzenne, N. M. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.05.070 · Cited by 113 · see citing works
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Hiyoshi, T., Fujiwara, M., & Zemin, Y. (2018) · Journal of Biomedical Research · doi:10.7555/jbr.31.20160164 · Cited by 110 · see citing works
Glycogen metabolism in cancer
Zois, C. E., Favaro, E., & Harris, A. L. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.09.001 · Cited by 102 · see citing works
The Current Drug Treatment Landscape for Diabetes and Perspectives for the Future
Bailey, C. J. (2015) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.144 · Cited by 101 · see citing works
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Habtemariam, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms19010004 · Cited by 100 · see citing works
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Xiao, C., Wu, Q., Cai, W. F., Tan, J., Yang, X., & Zhang, J. (2012) · Archives of Pharmacal Research · doi:10.1007/s12272-012-1012-z · Cited by 96 · see citing works
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Lv, L. L., Wu, S., Wang, G., Zhang, J., Pang, J., Liu, Z., Xu, W. G., Wu, S., & Rao, J. (2009) · Phytotherapy Research · doi:10.1002/ptr.2915 · Cited by 91 · see citing works
Optimization of antioxidant, anti-diabetic, and anti-inflammatory activities and ganoderic acid content of differentially dried Ganoderma lucidum using response surface methodology
Ryu, D. H., Cho, J. Y., Sadiq, N. B., Kim, J., Lee, B., Hamayun, M., Lee, T. S., Kim, H. S., Park, S. H., Nho, C. W., et al. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.127645 · Cited by 90 · see citing works
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Kim, J., & Park, Y. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-106 · Cited by 90 · see citing works
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Liu, S., Chang, Y.-H., & Chiang, M. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf100662r · Cited by 87 · see citing works
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Goyard, D., Kónya, B., Chajistamatiou, A. S., Chrysina, E. D., Leroy, J., Balzarin, S., Tournier, M., Tousch, D., Petit, P., Duret, C., et al. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.12.004 · Cited by 86 · see citing works
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Bokor, É., Docsa, T., Gergely, P., & Somsák, L. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.12.043 · Cited by 85 · see citing works
Methanolic extract of Moringa oleifera leaves improves glucose tolerance, glycogen synthesis and lipid metabolism in alloxan-induced diabetic rats
Olayaki, L. A., Irekpita, J. E., Yakubu, M. T., & Ojo, O. O. (2015) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2014-0129 · Cited by 84 · see citing works
Profiling and Identification of Small rDNA-Derived RNAs and Their Potential Biological Functions
Wei, H., Zhou, B. Z., Zhang, F., Tu, Y., Hu, Y., Zhang, B., & Zhai, Q. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056842 · Cited by 84 · see citing works
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Liu, W., Zheng, Y., Zhang, Z., Yao, W., & Gao, X. (2014) · Food & Function · doi:10.1039/c4fo00430b · Cited by 81 · see citing works
Glucose derived inhibitors of glycogen phosphorylase
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Sorghum extract exerts an anti-diabetic effect by improving insulin sensitivity via PPAR-γ in mice fed a high-fat diet
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Liu, W., Lu, W., Chai, Y., Liu, Y., Yao, W., & Gao, X. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.08.071 · Cited by 74 · see citing works
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Wu, G., Liu, D., Wan, Y., Huang, X., & Nie, S. (2018) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2018.12.035 · Cited by 69 · see citing works
A DPP-IV-resistant triple-acting agonist of GIP, GLP-1 and glucagon receptors with potent glucose-lowering and insulinotropic actions in high-fat-fed mice
Bhat, V. K., Kerr, B. D., Vasu, S., Flatt, P. R., & Gault, V. A. (2013) · Diabetologia · doi:10.1007/s00125-013-2892-2 · Cited by 66 · see citing works
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Tóth, M., Kun, S., Bokor, É., Benltifa, M., Tallec, G., Vidal, S., Docsa, T., Gergely, P., Somsák, L., & Praly, J. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.04.036 · Cited by 65 · see citing works
Gene expression profiling and pathway analysis of hepatotoxicity induced by triptolide in Wistar rats
Wang, J., Jiang, Z., Ji, J., Wang, X., Wang, T., Zhang, Y., Tai, T., Chen, M., Sun, L., Li, X., et al. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.04.039 · Cited by 61 · see citing works
Synthesis of glucoconjugates of oleanolic acid as inhibitors of glycogen phosphorylase
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Targeting Hepatic Glucokinase in Type 2 Diabetes
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Self-citation
An untargeted metabolomics approach reveals further insights of Lycium barbarum polysaccharides in high fat diet and streptozotocin-induced diabetic rats
Xia, H., Tang, H., Wang, F., Yang, X., Wang, Z., Liu, H., Pan, D., Yang, C., Wang, S., & Sun, G. (2018) · Food Research International · doi:10.1016/j.foodres.2018.12.043 · Cited by 56 · see citing works
Glycogen phosphorylase inhibitors: a patent review (2013 - 2015)
Donnier‐Maréchal, M., & Vidal, S. (2015) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2016.1131268 · Cited by 55 · see citing works
Current strategies for the inhibition of hepatic glucose production in type 2 diabetes
Dale, S. E. (2009) · Frontiers in bioscience · doi:10.2741/3301 · Cited by 55 · see citing works
Hypothalamic Apelin/Reactive Oxygen Species Signaling Controls Hepatic Glucose Metabolism in the Onset of Diabetes
Drougard, A., Duparc, T., Brénachot, X., Carneiro, L., Gouazé, A., Fournel, A., Geurts, L., Cadoudal, T., Prats, A., Pénicaud, L., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5182 · Cited by 54 · see citing works
Phytochemical-Related Health-Promoting Attributes of Sorghum and Millets
Duodu, K. G., & Awika, J. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811527-5.00008-3 · Cited by 51 · see citing works
Multiple roles of glucose-6-phosphatases in pathophysiology
Marcolongo, P., Fulceri, R., Gamberucci, A., Czegle, I., Bánhegyi, G., & Benedetti, A. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.12.013 · Cited by 48 · see citing works
C-Glucopyranosyl-1,2,4-triazoles As New Potent Inhibitors of Glycogen Phosphorylase
Bokor, É., Docsa, T., Gergely, P., & Somsák, L. (2013) · ACS Medicinal Chemistry Letters · doi:10.1021/ml4001529 · Cited by 48 · see citing works
Treatment of type 2 diabetes: future approaches
Bailey, C. J., & Day, C. (2018) · British Medical Bulletin · doi:10.1093/brimed/ldy013 · Cited by 48 · see citing works
New synthesis of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazoles, nanomolar inhibitors of glycogen phosphorylase
Kun, S., Bokor, É., Varga, G., Szőcs, B., Páhi, A., Czifrák, K., Tóth, M., Juhász, L., Docsa, T., Gergely, P., et al. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.02.041 · Cited by 46 · see citing works
Hypoglycemic activity and potential mechanism of a polysaccharide from the loach in streptozotocin-induced diabetic mice
Zhou, J., Yan, J., Bai, Z., Li, K., & Huang, K. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.12.037 · Cited by 46 · see citing works
Aloe vera carbohydrates regulate glucose metabolism through improved glycogen synthesis and downregulation of hepatic gluconeogenesis in diabetic rats
Govindarajan, S., Babu, S. N., Vijayalakshmi, M. A., Manohar, P., & Noor, A. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114556 · Cited by 45 · see citing works
Selenite exacerbates hepatic insulin resistance in mouse model of type 2 diabetes through oxidative stress-mediated JNK pathway
Zhou, J., Xu, G., Bai, Z., Li, K., Yan, J., Li, F., Ma, S., Xu, H., & Huang, K. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.10.019 · Cited by 45 · see citing works
Glycogen Phosphorylase Inhibitor N-(3,5-Dimethyl-Benzoyl)-N’-(β-D-Glucopyranosyl)Urea Improves Glucose Tolerance under Normoglycemic and Diabetic Conditions and Rearranges Hepatic Metabolism
Nagy, L., Docsa, T., Szántó, M., Brunyánszki, A., Hegedűs, C., Márton, J., Kónya, B., Virág, L., Somsák, L., Gergely, P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069420 · Cited by 45 · see citing works
Biochemical and biological assessment of the inhibitory potency of extracts from vinification byproducts of Vitis vinifera extracts against glycogen phosphorylase
Kantsadi, A. L., Apostolou, A., Theofanous, S., Stravodimos, G. A., Kyriakis, E., Gorgogietas, V. A., Chatzileontiadou, D. S. M., Pegiou, K., Skamnaki, V. T., Stagos, D., et al. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.01.055 · Cited by 45 · see citing works
Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus
Vitak, T. Y., Yurkiv, B., Wasser, S. P., Nevo, E., & Sybirna, N. O. (2017) · World Journal of Diabetes · doi:10.4239/wjd.v8.i5.187 · Cited by 45 · see citing works
The σ‐Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b
Kantsadi, A. L., Hayes, J. M., Manta, S., Skamnaki, V. T., Kiritsis, C., Psarra, A. G., Koutsogiannis, Z., Dimopoulou, A., Theofanous, S., Nikoleousakos, N., et al. (2012) · ChemMedChem · doi:10.1002/cmdc.201100533 · Cited by 44 · see citing works
Glycogen phosphorylase inhibition improves beta cell function
Nagy, L., Márton, J., Vida, A., Kis, G. N., Bokor, É., Kun, S., Gönczi, M., Docsa, T., Tóth, A., Antal, M., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13819 · Cited by 44 · see citing works
Hypoglycemic and Hypolipidemic Effects of Phellinus Linteus Mycelial Extract from Solid-State Culture in A Rat Model of Type 2 Diabetes
Liu, Y., Wang, C., Li, J., Mei, Y., & Liang, Y. (2019) · Nutrients · doi:10.3390/nu11020296 · Cited by 44 · see citing works
Synthetic, enzyme kinetic, and protein crystallographic studies of C -β- d -glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase
Kantsadi, A. L., Bokor, É., Kun, S., Stravodimos, G. A., Chatzileontiadou, D. S. M., Leonidas, D. D., Juhász‐Tóth, É., Szakács, A., Batta, G., Docsa, T., et al. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.06.049 · Cited by 42 · see citing works
Glucagon and Cyclic AMP: Time to Turn the Page?
Rodgers, R. L. (2012) · Current Diabetes Reviews · doi:10.2174/157339912802083540 · Cited by 42 · see citing works
Efficient Atropodiastereoselective Access to 5,5′‐Bis‐1,2,3‐triazoles: Studies on 1‐Glucosylated 5‐Halogeno 1,2,3‐Triazoles and Their 5‐Substituted Derivatives as Glycogen Phosphorylase Inhibitors
Goyard, D., Chajistamatiou, A. S., Sotiropoulou, A. I., Chrysina, E. D., Praly, J., & Vidal, S. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201304989 · Cited by 39 · see citing works
Therapeutic potential of non-starch polysaccharides on type 2 diabetes: from hypoglycemic mechanism to clinical trials
Xiao, M., Jia, X., Wang, N., Kang, J., Hu, X., Goff, H. D., Cui, S. W., Ding, H. H., & Guo, Q. M. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2113366 · Cited by 38 · see citing works
4(5)-Aryl-2-C-glucopyranosyl-imidazoles as New Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase
Bokor, É., Kun, S., Docsa, T., Gergely, P., & Somsák, L. (2015) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.5b00361 · Cited by 37 · see citing works
Hypoglycemic mechanisms of Ganoderma lucidum polysaccharides F31 in db/db mice via RNA-seq and iTRAQ
Xiao, C., Wu, Q., Xie, Y., Tan, J., Ding, Y., & Bai, L. (2018) · Food & Function · doi:10.1039/c8fo01656a · Cited by 37 · see citing works
Cichoric acid regulates the hepatic glucose homeostasis via AMPK pathway and activates the antioxidant response in high glucose-induced hepatocyte injury
Zhu, D., Zhang, N., Zhou, X. J., Zhang, M., Liu, Z., & Liu, X. (2017) · RSC Advances · doi:10.1039/c6ra25901d · Cited by 35 · see citing works
Glucagon, cyclic AMP, and hepatic glucose mobilization: A half‐century of uncertainty
Rodgers, R. L. (2022) · Physiological Reports · doi:10.14814/phy2.15263 · Cited by 33 · see citing works
Disruption of the allosteric phosphorylase a regulation of the hepatic glycogen-targeted protein phosphatase 1 improves glucose tolerance in vivo
Kelsall, I. R., Rosenzweig, D., & Cohen, P. T. W. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.03.001 · Cited by 35 · see citing works
Hepatic Glucose Output Inhibition by Mexican Plants Used in the Treatment of Type 2 Diabetes
Mata-Torres, G., Adolfo Andrade-cetto, A., Espinoza-Hernández, F. A., & Cárdenas-Vázquez, R. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00215 · Cited by 34 · see citing works
Hepatic Overexpression of a Constitutively Active Form of Liver Glycogen Synthase Improves Glucose Homeostasis
R�os, S., Zafra, D., Valles-Ortega, J., Garcı́a-Rocha, M., Forrow, S., Domínguez, J. E., Calbó, J., & Guinovart, J. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.157396 · Cited by 33 · see citing works
Synthesis of Oleanolic Acid Dimers as Inhibitors of Glycogen Phosphorylase
Cheng, K., Liu, J., Sun, H., & Xie, J. (2010) · Chemistry & Biodiversity · doi:10.1002/cbdv.200900086 · Cited by 32 · see citing works
Mycosphere Essays 15. Ganoderma lucidum - are the beneficial medical properties substantiated?
Hapuarachchi, K. (2016) · Mycosphere · doi:10.5943/mycosphere/7/6/1 · Cited by 32 · see citing works
Novel design principle validated: Glucopyranosylidene-spiro-oxathiazole as new nanomolar inhibitor of glycogen phosphorylase, potential antidiabetic agent
Somsák, L., Nagy, V., Vidal, S., Czifrák, K., Berzsényi, E., & Praly, J. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.08.052 · Cited by 32 · see citing works
Probing multivalency for the inhibition of an enzyme: glycogen phosphorylase as a case study
Cecioni, S., Argintaru, O.-A., Docsa, T., Gergely, P., Praly, J., & Vidal, S. (2008) · New Journal of Chemistry · doi:10.1039/b812540f · Cited by 31 · see citing works
Establishment and characterization of a novel method for evaluating gluconeogenesis using hepatic cell lines, H4IIE and HepG2
Okamoto, T., Kanemoto, N., Ban, T., Sudo, T., Nagano, K., & Niki, I. (2009) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2009.09.015 · Cited by 30 · see citing works
Effects of chronic ingestion of catechin-rich green tea on hepatic gene expression of gluconeogenic enzymes in rats
Abe, K., Okada, N., Tanabe, H., Fukutomi, R., Yasui, K., Isemura, M., & Kinae, N. (2009) · Biomedical Research · doi:10.2220/biomedres.30.25 · Cited by 28 · see citing works
Bisphenol-A exposure in utero programs a sexually dimorphic estrogenic state of hepatic metabolic gene expression
Ilagan, Y., Mamillapalli, R., Goetz, T. G., Kayani, J., & Taylor, H. S. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2017.05.001 · Cited by 27 · see citing works
Synthesis of 4-amidomethyl-1-glucosyl-1,2,3-triazoles and evaluation as glycogen phosphorylase inhibitors
Goyard, D., Docsa, T., Gergely, P., Praly, J., & Vidal, S. (2014) · Carbohydrate Research · doi:10.1016/j.carres.2014.10.009 · Cited by 25 · see citing works
Structural Specificity of Flavonoids in the Inhibition of Human Fructose 1,6-Bisphosphatase
Proença, C., de Oliveira, A. L. N., Freitas, M., Ribeiro, D., Sousa, J. L. C., Ramos, M. J., Silva, A. M. S., Fernandes, P. A., & Fernandes, E. G. R. (2020) · Journal of Natural Products · doi:10.1021/acs.jnatprod.0c00014 · Cited by 25 · see citing works
3′‐Axial CH2OH Substitution on Glucopyranose does not Increase Glycogen Phosphorylase Inhibitory Potency. QM/MM‐PBSA Calculations Suggest Why
Manta, S., Xipnitou, A., Kiritsis, C., Kantsadi, A. L., Hayes, J. M., Skamnaki, V. T., Lamprakis, C., Kontou, M., Zoumpoulakis, P. G., Zographos, S. E., et al. (2012) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2012.01349.x · Cited by 25 · see citing works
An Active Part of Artemisia sacrorum Ledeb. Suppresses Gluconeogenesis through AMPK Mediated GSK3β and CREB Phosphorylation in Human HepG2 Cells
Yuan, H.-D., & Piao, G. (2011) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.100881 · Cited by 25 · see citing works
Structure based inhibitor design targeting glycogen phosphorylase b. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-d-glucopyranosylamines
Parmenopoulou, V., Kantsadi, A. L., Tsirkone, V. G., Chatzileontiadou, D. S. M., Manta, S., Zographos, S. E., Molfeta, C., Archontis, G., Agius, L., Hayes, J. M., et al. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2014.06.058 · Cited by 24 · see citing works
Self-citation
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Goyard, D., Praly, J., & Vidal, S. (2012) · Carbohydrate Research · doi:10.1016/j.carres.2012.08.014 · Cited by 23 · see citing works
Tethered derivatives of d-glucose and pentacyclic triterpenes for homo/heterobivalent inhibition of glycogen phosphorylase
Cheng, K., Liu, J., Sun, H., Bokor, É., Czifrák, K., Kónya, B., Tóth, M., Docsa, T., Gergely, P., & Somsák, L. (2010) · New Journal of Chemistry · doi:10.1039/b9nj00602h · Cited by 23 · see citing works
The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: Synthesis, biochemical and biological assessment
Kantsadi, A. L., Manta, S., Psarra, A. G., Dimopoulou, A., Kiritsis, C., Parmenopoulou, V., Skamnaki, V. T., Zoumpoulakis, P. G., Zographos, S. E., Leonidas, D. D., et al. (2012) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2012.06.029 · Cited by 22 · see citing works
Mice expressing reduced levels of hepatic glucose-6-phosphatase-α activity do not develop age-related insulin resistance or obesity
Kim, G.-Y., Lee, Y., Cho, J., Pan, C., Jun, H. S., Springer, D., Mansfield, B. C., & CHOU, J. Y. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv230 · Cited by 21 · see citing works
Plasma Glucose Lowering Effect of the Wild Satureja khuzestanica Jamzad Essential Oil in Diabetic Rats: Role of Decreased Gluconeogenesis
Shahsavari, R., Ehsani-Zonouz, A., Houshmand, M., Salehnia, A., Ahangari, G., & Firoozrai, M. (2009) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2009.140.145 · Cited by 20 · see citing works
Synthesis, enzyme kinetics and computational evaluation of N-(β-d-glucopyranosyl) oxadiazolecarboxamides as glycogen phosphorylase inhibitors
Polyák, M., Varga, G., Szilágyi, B., Juhász, L., Docsa, T., Gergely, P., Begum, J., Hayes, J. M., & Somsák, L. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.07.024 · Cited by 20 · see citing works
Evolutionary history of glucose-6-phosphatase encoding genes in vertebrate lineages: towards a better understanding of the functions of multiple duplicates
Marandel, L., Panserat, S., Plagnes‐Juan, E., Arbenoits, E., Soengas, J. L., & Bobe, J. (2017) · BMC Genomics · doi:10.1186/s12864-017-3727-1 · Cited by 20 · see citing works
A new level of regulation in gluconeogenesis: metabolic state modulates the intracellular localization of aldolase B and its interaction with liver fructose-1,6-bisphosphatase
Droppelmann, C. A., Sáez, D. E., Asenjo, J. L., Yáñez, A. J., Garcı́a-Rocha, M., Concha, I. I., Grez, M., Guinovart, J. J., & Slebe, J. C. (2015) · Biochemical Journal · doi:10.1042/bj20150269 · Cited by 18 · see citing works
Synthesis of substituted 2-(β-d-glucopyranosyl)-benzimidazoles and their evaluation as inhibitors of glycogen phosphorylase
Bokor, É., Szilágyi, E., Docsa, T., Gergely, P., & Somsák, L. (2013) · Carbohydrate Research · doi:10.1016/j.carres.2013.01.011 · Cited by 19 · see citing works
Polysaccharide from Momordica charantia L. Alleviates Type 2 Diabetes Mellitus in Mice by Activating the IRS1/PI3K/Akt and AMPK Signaling Pathways and Regulating the Gut Microbiota
Zhang, Y., Cao, Y., Wang, F., Wang, L., Xiong, L., Shen, X., & Song, H. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c12660 · Cited by 17 · see citing works
Nuclear accumulation of fructose 1,6‐bisphosphatase is impaired in diabetic rat liver
Bertinat, R., Pontigo, J. P., Pérez, M. E. M., Concha, I. I., Martín, R. S., Guinovart, J. J., Slebe, J. C., & Yáñez, A. J. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23413 · Cited by 17 · see citing works
New therapies for diabesity
Bailey, C. J. (2009) · Current Diabetes Reports · doi:10.1007/s11892-009-0057-y · Cited by 17 · see citing works

Authors: Agius, L.
Affiliations: Newcastle University (GB)
Corresponding author: Agius, Loranne
ORCID: Agius, Loranne
Venue: Best Practice & Research Clinical Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2007-12
Volume: 21
Issue: 4
Pages: 587-605
ISSN: 1521-690X (ISSN-L)
DOI: 10.1016/j.beem.2007.09.001
OpenAlex: W2132179056
Cited by: 155
References: 107
Citations by year: 2026: 3 · 2025: 5 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 11 · 2019: 2 · 2018: 10 · 2017: 10 · 2016: 10 · 2015: 13 · 2014: 10 · 2013: 12 · 2012: 16
FWCI: 1.91
Type: journal article
Language: en
Open access: green
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Newcastle University ePrints (Newcastle Univesity)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Keywords: type 2 diabetes, hepatic glucose metabolism, antidiabetic drugs, glucokinase, glucagon receptor, gluconeogenesis, glycogenolysis, glucose-6-phosphatase, fructose-1,6-bisphosphatase, glycogen phosphorylase, tachyphylaxis, adverse drug reactions
MeSH terms: Animals, Binding Sites, Blood Glucose, Diabetes Mellitus, Type 2, Enzyme Inhibitors, Glucagon, Glucokinase, Gluconeogenesis, Glucose-6-Phosphatase, Fructose-Bisphosphatase, Humans, Hypoglycemic Agents, Liver, Glycogen Phosphorylase

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New hepatic targets for glycaemic control in diabetes

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