Mortality in craniopharyngiomas: data from the last two decades
Open accessAbstract
Craniopharyngiomas are rare epithelial tumours arising along the path of the craniopharyngeal duct. They are histologically benign but potentially clinically aggressive tumours due to their invasive behaviour and high recurrence rates. Patients with craniopharyngioma have a high burden of comorbidities which could affect their long-term survival. Studies published in the last 20 years and reporting on standardized mortality ratios (SMR) have demonstrated high mortality (SMRs ranging between 2.45 and 12.2), as also proposed in older reports. Cardiovascular, respiratory diseases and infections are main causes of death. Apart from older age at diagnosis, data on other predictors of mortality are not consistent requiring further elucidation.
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Childhood survivors of craniopharyngioma have elevated cardiovascular disease risk factors that portend future excess rates of premature mortality.
“Childhood survivors of craniopharyngioma (64), the prototypic tumor causing hypothalamic syndrome, have elevated cardiovascular disease risk factors that portend future excess rates of premature mortality (65).”
From Approach to the patient with acquired hypothalamic syndrome (2026) · cites this paper as [65]
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Approach to the patient with acquired hypothalamic syndrome
Grishman, E. K., & McCormack, S. E. (2026) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgag197
Rădulescu, A. M. (2026) · The Medical-Surgical Journal · doi:10.22551/msj.2026.02.17
- Authors
- Ntali, G., Shafi, A. M., & Karavitaki, N.
- Affiliations
- University Hospitals Birmingham NHS Foundation Trust (GB)
- Corresponding author
- Karavitaki, Niki
- Venue
- Best Practice & Research Clinical Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2025-09
- Volume
- 39
- Issue
- 5
- Pages
- 102049
- ISSN
- 1521-690X (ISSN-L)
- OpenAlex
- W4414920212
- Cited by
- 1
- References
- 28
- Citations by year
- 2026: 1
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (publishedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
- Health Sciences › Medicine › Surgery › Head and Neck Surgical Oncology
- Keywords
- craniopharyngioma, mortality, standardized mortality ratio, causes of death, cardiovascular disease, respiratory diseases, infection, comorbidities, age at diagnosis, mortality risk factors, long-term survival
- MeSH terms
- Craniopharyngioma, Humans, Pituitary Neoplasms
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