Characterization and Comparison of ATF and TFF in Stirred Bioreactors for Continuous Mammalian Cell Culture Processes
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Published bioreactor experiments report only the target levels of environmental parameters.
“The apparent under appreciation of reporting measured environmental parameters is exemplified by published bioreactor experiments that report only the target levels of environmental parameters (e.g., Karst et al., 2016; Abecasis et al., 2017).”
From Toward Best Practices for Controlling Mammalian Cell Culture Environments (2022) · cites this paper as Karst et al., 2016
Cites
Review of Measuring Methods and Results in Nonviscous Gas-Liquid Mass Transfer in Stirred Vessels
Riet, K. V. (1979) · Industrial & Engineering Chemistry Process Design and Development · doi:10.1021/i260071a001 · Cited by 770 · see citing works
Optimal and consistent protein glycosylation in mammalian cell culture
Hossler, P., Khattak, S. F., & Li, Z. J. (2009) · Glycobiology · doi:10.1093/glycob/cwp079 · Cited by 669 · see citing works
Integrated continuous production of recombinant therapeutic proteins
Warikoo, V., Godawat, R., Brower, K., Jain, S., Cummings, D., Simons, E., Johnson, T., Walther, J. L., Yu, M., Wright, B., et al. (2012) · Biotechnology and Bioengineering · doi:10.1002/bit.24584 · Cited by 423 · see citing works
On impeller circulation and mixing effectiveness in the turbulent flow regime
Nienow, A. W. (1997) · Chemical Engineering Science · doi:10.1016/s0009-2509(97)00072-9 · Cited by 329 · see citing works
Pollock, J., Ho, S. V., & Farid, S. S. (2012) · Biotechnology and Bioengineering · doi:10.1002/bit.24608 · Cited by 297 · see citing works
Acién, F. G., García-Camacho, F., Pérez, J. A. S., Fernández-Sevilla, J. M., & Grima, E. M. (1997) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(19970905)55:5 · Cited by 248 · see citing works
Clincke, M., Mölleryd, C., Zhang, Y., Lindskog, E. K., Walsh, K., & Chotteau, V. (2013) · Biotechnology Progress · doi:10.1002/btpr.1704 · Cited by 242 · see citing works
Engineering challenges in high density cell culture systems
Ozturk, S. S. (1996) · Cytotechnology · doi:10.1007/bf00353919 · Cited by 201 · see citing works
Pacis, E., Yu, M., Autsen, J., Bayer, R. J., & Li, F. (2011) · Biotechnology and Bioengineering · doi:10.1002/bit.23200 · Cited by 173 · see citing works
Gawlitzek, M., Ryll, T., Lofgren, J., & Sliwkowski, M. B. (2000) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(20000620)68:6 · Cited by 158 · see citing works
The potential of hydrodynamic damage to animal cells of industrial relevance: current understanding
Hu, W., Berdugo, C., & Chalmers, J. J. (2011) · Cytotechnology · doi:10.1007/s10616-011-9368-3 · Cited by 150 · see citing works
Clincke, M., Mölleryd, C., Samani, P. K., Lindskog, E. K., Fäldt, E., Walsh, K., & Chotteau, V. (2013) · Biotechnology Progress · doi:10.1002/btpr.1703 · Cited by 149 · see citing works
Perfusion seed cultures improve biopharmaceutical fed‐batch production capacity and product quality
Yang, W. C., Lü, J., Kwiatkowski, C., Yuan, H., Kshirsagar, R., Ryll, T., & Huang, Y. (2014) · Biotechnology Progress · doi:10.1002/btpr.1884 · Cited by 143 · see citing works
Microelectrode measurements of local mass transport rates in heterogeneous biofilms
Rasmussen, K., & Lewandowski, Z. (1998) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(19980805)59:3 · Cited by 130 · see citing works
Bailey, L., Hatton, D., Field, R. P., & Dickson, A. J. (2012) · Biotechnology and Bioengineering · doi:10.1002/bit.24485 · Cited by 127 · see citing works
Evaluating the impact of cell culture process parameters on monoclonal antibody N-glycosylation
Ivarsson, M., Villiger, T. K., Morbidelli, M., & Šoóš, M. (2014) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2014.08.026 · Cited by 124 · see citing works
Self-citationIndustrial scale harvest of proteins from mammalian cell culture by tangential flow filtration
van Reis, R., Leonard, L. C., Hsu, C. C., & Builder, S. E. (1991) · Biotechnology and Bioengineering · doi:10.1002/bit.260380411 · Cited by 121 · see citing works
The “Push-to-Low” Approach for Optimization of High-Density Perfusion Cultures of Animal Cells
Konstantinov, K., Goudar, C. T., Ng, M. R. A. V., Meneses, R., Thrift, J., Chuppa, S., Matanguihan, C., Michaels, J., & Naveh, D. (2006) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_016 · Cited by 120 · see citing works
Batt, B. C., Davis, R. H., & Kompala, D. S. (1990) · Biotechnology Progress · doi:10.1021/bp00006a600 · Cited by 111 · see citing works
Sieck, J. B., Cordes, T., Budach, W. E., Rhiel, M. H., Suemeghy, Z., Leist, C., Villiger, T. K., Morbidelli, M., & Šoóš, M. (2012) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2012.11.012 · Cited by 106 · see citing works
Self-citationCrossflow microfiltration of animal cells
Maiorella, B. L., Dorin, G., Carion, A., & Harano, D. (1991) · Biotechnology and Bioengineering · doi:10.1002/bit.260370205 · Cited by 100 · see citing works
Physiological responses of CHO cells to repetitive hydrodynamic stress
Godoy‐Silva, R. D., Chalmers, J. J., Casnocha, S. A., Bass, L. A., & Ma, N. (2009) · Biotechnology and Bioengineering · doi:10.1002/bit.22339 · Cited by 96 · see citing works
Optimizing capacity utilization by large scale 3000 L perfusion in seed train bioreactors
Pohlscheidt, M., Jacobs, M., Wolf, S., Thiele, J., Jockwer, A., Gabelsberger, J., Jenzsch, M., Tebbe, H., & Burg, J. (2012) · Biotechnology Progress · doi:10.1002/btpr.1672 · Cited by 95 · see citing works
Understanding and modeling alternating tangential flow filtration for perfusion cell culture
Kelly, W. J., Scully, J. E. C., Zhang, D., Feng, G., Lavengood, M., Condon, J., Knighton, J., & Bhatia, R. (2014) · Biotechnology Progress · doi:10.1002/btpr.1953 · Cited by 81 · see citing works
Determination of the maximum operating range of hydrodynamic stress in mammalian cell culture
Neunstoecklin, B., Stettler, M., Solacroup, T., Broly, H., Morbidelli, M., & Šoóš, M. (2014) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2014.12.003 · Cited by 78 · see citing works
Self-citationTailoring recombinant protein quality by rational media design
Brühlmann, D., Jordan, M., Hemberger, J., Sauer, M., Stettler, M., & Broly, H. (2015) · Biotechnology progress (Print) · doi:10.1002/btpr.2089 · Cited by 77 · see citing works
Goudar, C. T., Piret, J. M., & Konstantinov, K. B. (2011) · Biotechnology Progress · doi:10.1002/btpr.646 · Cited by 75 · see citing works
Scale‐up and optimization of an acoustic filter for 200 L/day perfusion of a CHO cell culture
Gorenflo, V. M., Smith, L., Dedinsky, B., Persson, B., & Piret, J. M. (2002) · Biotechnology and Bioengineering · doi:10.1002/bit.10386 · Cited by 71 · see citing works
Searles, J. A., Todd, P. W., & Kompala, D. S. (1994) · Biotechnology Progress · doi:10.1021/bp00026a600 · Cited by 68 · see citing works
Development and implementation of a perfusion‐based high cell density cell banking process
Tao, Y., Shih, J., Sinacore, M., Ryll, T., & Yusuf‐Makagiansar, H. (2011) · Biotechnology Progress · doi:10.1002/btpr.599 · Cited by 66 · see citing works
Mapping and partial characterization of proteases expressed by a CHO production cell line
Sandberg, H., Lütkemeyer, D., Kuprin, S., Wrangel, M., Almstedt, A., Persson, P., Ek, V., & Mikaelsson, M. (2006) · Biotechnology and Bioengineering · doi:10.1002/bit.21057 · Cited by 65 · see citing works
Acoustic cell filter: a proven cell retention technology for perfusion of animal cell cultures
Shirgaonkar, I. Z., Lanthier, S., & Kamen, A. (2004) · Biotechnology Advances · doi:10.1016/j.biotechadv.2004.03.003 · Cited by 64 · see citing works
Use of the Centritech Lab Centrifuge for Perfusion Culture of Hybridoma Cells in Protein‐Free Medium
Johnson, M., Lanthier, S., Bernard Massie, B., Lefèbvre, G., & Kamen, A. (1996) · Biotechnology Progress · doi:10.1021/bp960072n · Cited by 64 · see citing works
Shi, H. H., & Goudar, C. (2014) · Biotechnology and Bioengineering · doi:10.1002/bit.25318 · Cited by 55 · see citing works
Padawer, I., Ling, W. L. W., & Bai, Y. (2013) · Biotechnology Progress · doi:10.1002/btpr.1719 · Cited by 53 · see citing works
A comparison of oxygenation methods fro high‐density perfusion culture of animal cells
Zhang, S., Handa-Corrigan, A., & Spier, R. E. (1993) · Biotechnology and Bioengineering · doi:10.1002/bit.260410702 · Cited by 52 · see citing works
Sieck, J. B., Budach, W. E., Suemeghy, Z., Leist, C., Villiger, T. K., Morbidelli, M., & Šoóš, M. (2014) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2014.08.042 · Cited by 51 · see citing works
Self-citationVilliger, T. K., Morbidelli, M., & Šoóš, M. (2015) · AIChE Journal · doi:10.1002/aic.14753 · Cited by 48 · see citing works
Self-citationAn Innovative Microwave Process for Nanocatalyst Synthesis
Antonetti, C., Galletti, A. M. R., & Longo, I. (2010) · International Journal of Chemical Reactor Engineering · doi:10.2202/1542-6580.2132 · Cited by 47 · see citing works
Seth, G., Hamilton, R. W., Stapp, T. R., Zheng, L., Meier, A., Petty, K., Leung, S., & Chary, S. (2012) · Biotechnology and Bioengineering · doi:10.1002/bit.24808 · Cited by 47 · see citing works
Efficiency improvement of an antibody production process by increasing the inoculum density
Hecht, V., Duvar, S., Ziehr, H., Burg, J., & Jockwer, A. (2014) · Biotechnology Progress · doi:10.1002/btpr.1887 · Cited by 34 · see citing works
Shi, Y. C., Ryu, D. D. Y., & Park, S. H. (1993) · Biotechnology and Bioengineering · doi:10.1002/bit.260420405 · Cited by 33 · see citing works
Pinelli, D., Liu, Z., & Magelli, F. (2010) · International Journal of Chemical Reactor Engineering · doi:10.2202/1542-6580.1915 · Cited by 32 · see citing works
Production of a Secreted Glycoprotein from an Inducible Promoter System in a Perfusion Bioreactor
Lipscomb, M. L., Mowry, M. C., & Kompala, D. S. (2004) · Biotechnology Progress · doi:10.1021/bp049973j · Cited by 28 · see citing works
Stressmann, M., & Moresoli, C. (2008) · Biotechnology Progress · doi:10.1002/btpr.4 · Cited by 28 · see citing works
Investigations on Mechanical Stress Caused to CHO Suspension Cells by Standard and Single‐Use Pumps
Blaschczok, K., Kaiser, S. C., Löffelholz, C., Imseng, N., Burkart, J., Bösch, P., Dornfeld, W., Eibl, R., & Eibl, D. (2012) · Chemie Ingenieur Technik · doi:10.1002/cite.201200135 · Cited by 27 · see citing works
Experience in scale-up of homogeneous perfusion culture for hybridomas
Greenfield, P. F., Guillaume, J. M., Randerson, D. H., & Smith, C. G. (1991) · Bioprocess and Biosystems Engineering · doi:10.1007/bf00369714 · Cited by 25 · see citing works
Carlsen, M., Jokumsen, K. V., Emborg, C., & Nielsen, J. (1997) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(19970720)55:2 · Cited by 24 · see citing works
Kim, B. J., Oh, D. J., & Chang, H. N. (2008) · Biotechnology Progress · doi:10.1021/bp070235f · Cited by 22 · see citing works
Choo, C. Y., Tian, Y., Kim, W., Blatter, E. E., Conary, J. T., & Brady, C. P. (2006) · Biotechnology Progress · doi:10.1021/bp060231v · Cited by 21 · see citing works
Structured Modelling of Bioreactors
Reuss, M., Schmalzriedt, S., & Jenne, M. (1994) · Springer eBooks · doi:10.1007/978-94-017-0641-4_29 · Cited by 18 · see citing works
Flagged first, then by citations
1 of the 52 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Tripathi, N. K., & Shrivastava, A. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00420 · Cited by 470 · see citing works
Perfusion mammalian cell culture for recombinant protein manufacturing – A critical review
Bielser, J., Wolf, M., Souquet, J., Broly, H., & Morbidelli, M. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.04.011 · Cited by 264 · see citing works
Self-citationO’Flaherty, R., Bergin, A., Flampouri, E., Mota, L. M., Obaidi, I., Quigley, A., Xie, Y., & Butler, M. (2020) · Biotechnology Advances · doi:10.1016/j.biotechadv.2020.107552 · Cited by 232 · see citing works
Boodhoo, K. V. K., Flickinger, M. C., Woodley, J. M., & Emanuelsson, E. A. C. (2022) · Chemical Engineering and Processing - Process Intensification · doi:10.1016/j.cep.2022.108793 · Cited by 170 · see citing works
The behavior of suspensions and macromolecular solutions in crossflow microfiltration: An update
Chew, J. W., Kilduff, J. E., & Belfort, G. (2020) · Journal of Membrane Science · doi:10.1016/j.memsci.2020.117865 · Cited by 146 · see citing works
Process performance and product quality in an integrated continuous antibody production process
Karst, D. J., Steinebach, F., Šoóš, M., & Morbidelli, M. (2016) · Biotechnology and Bioengineering · doi:10.1002/bit.26069 · Cited by 142 · see citing works
Self-citationDesign and operation of a continuous integrated monoclonal antibody production process
Steinebach, F., Ulmer, N., Wolf, M., Decker, L., Schneider, V., Wälchli, R., Karst, D. J., Souquet, J., & Morbidelli, M. (2017) · Biotechnology Progress · doi:10.1002/btpr.2522 · Cited by 129 · see citing works
Self-citationWang, S., Godfrey, S., Ravikrishnan, J., Lin, H. C., Vogel, J. H., & Coffman, J. (2017) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2017.01.020 · Cited by 127 · see citing works
New developments in membranes for bioprocessing – A review
Zydney, A. L. (2020) · Journal of Membrane Science · doi:10.1016/j.memsci.2020.118804 · Cited by 110 · see citing works
Economic Analysis of Batch and Continuous Biopharmaceutical Antibody Production: a Review
Yang, O., Qadan, M., & Ierapetritou, M. (2019) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-018-09370-4 · Cited by 108 · see citing works
Comparison between Batch and Continuous Monoclonal Antibody Production and Economic Analysis
Yang, O., Prabhu, S., & Ierapetritou, M. (2019) · Industrial & Engineering Chemistry Research · doi:10.1021/acs.iecr.8b04717 · Cited by 105 · see citing works
Upstream process intensification and continuous manufacturing
Chen, C., Wong, H. E., & Goudar, C. T. (2018) · Current Opinion in Chemical Engineering · doi:10.1016/j.coche.2018.10.006 · Cited by 103 · see citing works
Feidl, F., Vogg, S., Wolf, M., Podobnik, M., Ruggeri, C., Ulmer, N., Wälchli, R., Souquet, J., Broly, H., Butté, A., et al. (2020) · Biotechnology and Bioengineering · doi:10.1002/bit.27296 · Cited by 99 · see citing works
Self-citationKarst, D. J., Scibona, E., Serra, E., Bielser, J., Souquet, J., Stettler, M., Broly, H., Šoóš, M., Morbidelli, M., & Villiger, T. K. (2017) · Biotechnology and Bioengineering · doi:10.1002/bit.26315 · Cited by 95 · see citing works
Self-citationMicrofluidic Cell Retention Device for Perfusion of Mammalian Suspension Culture
Kwon, T., Prentice, H. L., Oliveira, J. D., Madziva, N., Warkiani, M. E., Hamel, J. P., & Han, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-06949-8 · Cited by 92 · see citing works
Chopda, V., Gyorgypal, A., Yang, O., Singh, R., Ramachnadran, R., Zhang, H., Tsilomelekis, G., Chundawat, S. P. S., & Ierapetritou, M. (2021) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.6765 · Cited by 73 · see citing works
Schwarz, H., Zhang, Y., Zhan, C., Malm, M., Field, R., Turner, R., Sellick, C., Varley, P., Rockberg, J., & Chotteau, V. (2020) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2019.12.017 · Cited by 62 · see citing works
Integration and digitalization in the manufacturing of therapeutic proteins
Narayanan, H., Sponchioni, M., & Morbidelli, M. (2022) · Chemical Engineering and Science · doi:10.1016/j.ces.2021.117159 · Cited by 53 · see citing works
Self-citationKarst, D. J., Steinhoff, R., Kopp, M. R. G., Serra, E., Šoóš, M., Zenobi, R., & Morbidelli, M. (2016) · Biotechnology Progress · doi:10.1002/btpr.2421 · Cited by 58 · see citing works
Self-citationPerfusion culture of Chinese Hamster Ovary cells for bioprocessing applications
MacDonald, M. A., Nöbel, M., Roche Recinos, D., Martínez, V. S., Schulz, B. L., Howard, C. B., Baker, K., Shave, E., Lee, Y. Y., Marcellin, E., et al. (2022) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2021.1998821 · Cited by 55 · see citing works
Janoschek, S., Schulze, M., Zijlstra, G., Greller, G., & Matuszczyk, J. (2018) · Biotechnology Progress · doi:10.1002/btpr.2757 · Cited by 54 · see citing works
Improved Performance in Mammalian Cell Perfusion Cultures by Growth Inhibition
Wolf, M., Closet, A., Bzowska, M., Bielser, J., Souquet, J., Broly, H., & Morbidelli, M. (2018) · Biotechnology Journal · doi:10.1002/biot.201700722 · Cited by 50 · see citing works
Self-citationDevelopment of a shake tube‐based scale‐down model for perfusion cultures
Wolf, M., Lorenz, V., Karst, D. J., Souquet, J., Broly, H., & Morbidelli, M. (2018) · Biotechnology and Bioengineering · doi:10.1002/bit.26804 · Cited by 50 · see citing works
Self-citationAAV process intensification by perfusion bioreaction and integrated clarification
Mendes, J. P., Fernandes, B., Pineda, E., Kudugunti, S. K., Bransby, M., Gantier, R., Peixoto, C., Alves, P. M., Roldão, A., & Silva, R. J. S. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1020174 · Cited by 48 · see citing works
Intensified Downstream Processing of Monoclonal Antibodies Using Membrane Technology
Nadar, S., Shooter, G. K., Somasundaram, B., Shave, E., Baker, K., & Lua, L. (2020) · Biotechnology Journal · doi:10.1002/biot.202000309 · Cited by 43 · see citing works
Walther, J. L., McLarty, J., & Johnson, T. (2018) · Biotechnology and Bioengineering · doi:10.1002/bit.26811 · Cited by 46 · see citing works
Process analytical technology as key‐enabler for digital twins in continuous biomanufacturing
Schmidt, A., Helgers, H., Lohmann, L. J., Vetter, F. L., Juckers, A., Mouellef, M., Zobel‐Roos, S., & Strube, J. (2021) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.7008 · Cited by 45 · see citing works
Radoniqi, F., Zhang, H., Bardliving, C. L., Shamlou, P. A., & Coffman, J. (2018) · Biotechnology and Bioengineering · doi:10.1002/bit.26813 · Cited by 44 · see citing works
Process intensification in biologics manufacturing
Strube, J., Ditz, R., Kornecki, M., Huter, M. J., Schmidt, A., Thiess, H., & Zobel‐Roos, S. (2018) · Chemical Engineering and Processing - Process Intensification · doi:10.1016/j.cep.2018.09.022 · Cited by 42 · see citing works
Continuous Manufacturing of Recombinant Therapeutic Proteins: Upstream and Downstream Technologies
Patil, R., & Walther, J. L. (2017) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2016_58 · Cited by 40 · see citing works
Wolf, M., Müller, A., Souquet, J., Broly, H., & Morbidelli, M. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.26999 · Cited by 40 · see citing works
Self-citationChen, G., Hu, J., Qin, Y., & Zhou, W. (2021) · Biochemical Engineering Journal · doi:10.1016/j.bej.2021.108063 · Cited by 38 · see citing works
Continuous Biopharmaceutical Processes
Pfister, D., Nicoud, L., & Morbidelli, M. (2018) · Cambridge University Press eBooks · doi:10.1017/9781108332897 · Cited by 38 · see citing works
Self-citationCoronel, J., Behrendt, I., Bürgin, T., Anderlei, T., Sandig, V., Reichl, U., & Genzel, Y. (2019) · Vaccine · doi:10.1016/j.vaccine.2019.06.005 · Cited by 37 · see citing works
Virus harvesting in perfusion culture: Choosing the right type of hollow fiber membrane
Nikolay, A., de Grooth, J., Genzel, Y., Wood, J. A., & Reichl, U. (2020) · Biotechnology and Bioengineering · doi:10.1002/bit.27470 · Cited by 35 · see citing works
Liu, Z., Zhang, Z., Qin, Y., Chen, G., Hu, J., Wang, Q., & Zhou, W. (2021) · Biochemical Engineering Journal · doi:10.1016/j.bej.2021.108064 · Cited by 35 · see citing works
Schulze, M., Lemke, J., Pollard, D., Wijffels, R. H., Matuszczyk, J., & Martens, D. E. (2021) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2021.06.011 · Cited by 34 · see citing works
Pinto, N. D. S., Napoli, W. N., & Brower, M. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.27192 · Cited by 33 · see citing works
Liang, K., Luo, H., & Li, Q. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1112349 · Cited by 32 · see citing works
“Generally, scaling of the fed-batch process needs larger and more rigid layouts which limits its application (Karst et al., 2016; MacDonald et al., 2021).”
BackgroundA two-step procedure for the design of perfusion bioreactors
Wolf, M. K. F., Pechlaner, A., Lorenz, V., Karst, D. J., Souquet, J., Broly, H., & Morbidelli, M. (2019) · Biochemical Engineering Journal · doi:10.1016/j.bej.2019.107295 · Cited by 32 · see citing works
Self-citationImpact of Pluronic® F68 on hollow fiber filter-based perfusion culture performance
Xu, S., Jiang, R., Chen, Y., Wang, F., & Chen, H. H. (2017) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-017-1790-2 · Cited by 32 · see citing works
Kornecki, M., Schmidt, A., Lohmann, L. J., Huter, M. J., Mestmäcker, F., Klepzig, L., Mouellef, M., Zobel‐Roos, S., & Strube, J. (2019) · Processes · doi:10.3390/pr7080495 · Cited by 32 · see citing works
Shirahata, H., Diab, S., Sugiyama, H., & Gerogiorgis, D. I. (2019) · Process Safety and Environmental Protection · doi:10.1016/j.cherd.2019.07.016 · Cited by 32 · see citing works
Karst, D. J., Steinhoff, R., Kopp, M. R. G., Šoóš, M., Zenobi, R., & Morbidelli, M. (2017) · Biotechnology Progress · doi:10.1002/btpr.2539 · Cited by 30 · see citing works
Self-citationHydrocyclones as cell retention device for CHO perfusion processes in single-use bioreactors
Bettinardi, I. W., Castan, A., Medronho, R. A., & Castilho, L. R. (2020) · Biotechnology and Bioengineering · doi:10.1002/bit.27335 · Cited by 29 · see citing works
ATF for cell culture harvest clarification: mechanistic modelling and comparison with TFF
Hadpe, S. R., Sharma, A. K., Mohite, V. V., & Rathore, A. S. (2016) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.5165 · Cited by 29 · see citing works
Kreye, S., Stahn, R., Nawrath, K., Goralczyk, V., Zoro, B., & Goletz, S. (2019) · Biotechnology Progress · doi:10.1002/btpr.2832 · Cited by 29 · see citing works
Transformation of biomanufacturing by single-use systems and technology
Frank, G. (2018) · Current Opinion in Chemical Engineering · doi:10.1016/j.coche.2018.09.006 · Cited by 26 · see citing works
Pinto, N. D. S., & Brower, M. (2020) · Biotechnology and Bioengineering · doi:10.1002/bit.27504 · Cited by 26 · see citing works
Enablers of continuous processing of biotherapeutic products
Rathore, A. S., Zydney, A. L., Anupa, A., Nikita, S., & Gangwar, N. (2022) · Trends in biotechnology · doi:10.1016/j.tibtech.2021.12.003 · Cited by 26 · see citing works
Purification of New Biologicals Using Membrane-Based Processes
Hoffmann, D. E., Leber, J., Loewe, D., Lothert, K., Oppermann, T., Zitzmann, J., Weidner, T., Salzig, D., Wolff, M. W., & Czermak, P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813606-5.00005-1 · Cited by 26 · see citing works
From chemostats to high‐density perfusion: the progression of continuous mammalian cell cultivation
Wong, H. E., Chen, C., Le, H., & Goudar, C. T. (2021) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.6841 · Cited by 25 · see citing works
Transcriptome and proteome analysis of steady‐state in a perfusion CHO cell culture process
Bertrand, V., Karst, D. J., Bachmann, A., Cantalupo, K., Šoóš, M., & Morbidelli, M. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.26996 · Cited by 24 · see citing works
Self-citationMayrhofer, P., Reinhart, D., Castan, A., & Kunert, R. (2019) · Biotechnology Progress · doi:10.1002/btpr.2933 · Cited by 24 · see citing works
Miniature auto‐perfusion bioreactor system with spiral microfluidic cell retention device
Yin, L., Au, W. Y., Yu, C. C., Kwon, T., Lai, Z., Shang, M., Warkiani, M. E., Rosche, R., Lim, C. T., & Han, J. (2021) · Biotechnology and Bioengineering · doi:10.1002/bit.27709 · Cited by 24 · see citing works
Toward Best Practices for Controlling Mammalian Cell Culture Environments
Klein, S. G., Steckbauer, A., Alsolami, S. M., Arossa, S., Parry, A. J., Li, M., & Duarte, C. M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.788808 · Cited by 23 · see citing works
Impact of Bioreactor Geometry on Mesenchymal Stem Cell Production in Stirred‐Tank Bioreactors
Petry, F., & Salzig, D. (2021) · Chemie Ingenieur Technik · doi:10.1002/cite.202100041 · Cited by 23 · see citing works
Process intensification for lentiviral vector manufacturing using tangential flow depth filtration
Tona, R. M., Shah, R., Middaugh, K., Steve, J., Marques, J., Roszell, B. R., & Jung, C. (2023) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2023.02.017 · Cited by 23 · see citing works
Maria, S., Bonneau, L., Fould, B., Ferry, G., Boutin, J. A., Cabanne, C., Santarelli, X., & Joucla, G. (2022) · Biochemical Engineering Journal · doi:10.1016/j.bej.2022.108779 · Cited by 22 · see citing works
Novel, linked bioreactor system for continuous production of biologics
Gagnon, M., Nagre, S., Wang, W., Coffman, J., & Hiller, G. W. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.26985 · Cited by 21 · see citing works
Glycosylation Flux Analysis of Immunoglobulin G in Chinese Hamster Ovary Perfusion Cell Culture
Hutter, S., Wolf, M. K. F., Gao, N. P., Lepori, D., Schweigler, T., Morbidelli, M., & Gunawan, R. (2018) · Processes · doi:10.3390/pr6100176 · Cited by 19 · see citing works
Self-citationKateja, N., Tiwari, A., Thakur, G., & Rathore, A. S. (2021) · Biotechnology Journal · doi:10.1002/biot.202000524 · Cited by 18 · see citing works
Recent advances in harvest clarification for antibodies and related products
Gupta, A., Amara, J. P., Gousseinov, E., & Cacace, B. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-103019-6.00006-0 · Cited by 17 · see citing works
Becker, M., Junghans, L., Teleki, A., Bechmann, J., & Takors, R. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.26926 · Cited by 17 · see citing works
Silva, C. A. T., Kamen, A., & Henry, O. (2021) · The Canadian Journal of Chemical Engineering · doi:10.1002/cjce.24197 · Cited by 16 · see citing works
Expansion and differentiation of ex vivo cultured erythroblasts in scalable stirred bioreactors
Gallego‐Murillo, J. S., Iacono, G., van der Wielen, L. A. M., van den Akker, E., Lindern, M. V., & Wahl, A. (2022) · Biotechnology and Bioengineering · doi:10.1002/bit.28193 · Cited by 14 · see citing works
Gas‐Liquid Mixing in a Grid‐Disc Impeller Stirred Tank
Yang, F., Sun, H., & Zhang, C. (2020) · Chemical Engineering & Technology · doi:10.1002/ceat.201900651 · Cited by 16 · see citing works
Bubble column and airlift bioreactor systems for animal cell culture applications
Mutaf, T., & Öncel, S. Ş. (2022) · Asia-Pacific Journal of Chemical Engineering · doi:10.1002/apj.2872 · Cited by 15 · see citing works
Perfusion Cell Culture Processes for Biopharmaceuticals
Wolf, M., Bielser, J., & Morbidelli, M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108847209 · Cited by 15 · see citing works
Self-citationZhang, D., Patel, P., Strauss, D., Qian, X., & Wickramasinghe, S. R. (2020) · Biotechnology Progress · doi:10.1002/btpr.3115 · Cited by 14 · see citing works
Romann, P., Giller, P., Sibilia, A., Herwig, C., Zydney, A. L., Périlleux, A., Souquet, J., Bielser, J., & Villiger, T. K. (2023) · Biotechnology and Bioengineering · doi:10.1002/bit.28589 · Cited by 14 · see citing works
Self-citationContinuous biomanufacturing in upstream and downstream processing
Schmidt, A., Hengelbrock, A., & Strube, J. (2023) · Physical Sciences Reviews · doi:10.1515/psr-2022-0106 · Cited by 13 · see citing works
Su, Y., Wei, Z., Miao, Y., Sun, L., Shen, Y., Tang, Z., Li, L., Quan, Y., Yu, H., Wang, W., et al. (2021) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-021-11662-8 · Cited by 13 · see citing works
Continuous Biopharmaceutical Processes: Chromatography, Bioconjugation, and Protein Stability
Pfister, D., Nicoud, L., & Morbidelli, M. (2018) · Cited by 13 · see citing works
Self-citationBielser, J., Aeby, M., Caso, S., Roulet, A., Broly, H., & Souquet, J. (2021) · Biochemical Engineering Journal · doi:10.1016/j.bej.2021.107966 · Cited by 13 · see citing works
Romann, P., Kolar, J., Chappuis, L., Herwig, C., Villiger, T. K., & Bielser, J. (2023) · Biochemical Engineering Journal · doi:10.1016/j.bej.2023.108873 · Cited by 12 · see citing works
Self-citationClaessen, M. J. A. G., Yağcı, N., Fu, K., Brandsma, E. T., Kersten, M. J., Lindern, M. V., & van den Akker, E. (2024) · Scientific Reports · doi:10.1038/s41598-024-66440-z · Cited by 12 · see citing works
Flow Patterns of Multiple Axial‐Radial Impellers for Potential Use in Aerated Stirred Tanks
Posadas-Navarro, D. I., Palacios, C., Blancas‐Cabrera, A., Trujillo‐Roldán, M. A., Salinas-Vázquez, M., & Ascanio, G. (2022) · Chemical Engineering & Technology · doi:10.1002/ceat.202100521 · Cited by 11 · see citing works
Weinberger, M. E., Schoch, L., & Kulozik, U. (2022) · Biotechnology Progress · doi:10.1002/btpr.3309 · Cited by 11 · see citing works
On the effect of flow reversal during crossflow microfiltration of a cell and protein mixture
Weinberger, M. E., & Kulozik, U. (2021) · Food and Bioproducts Processing · doi:10.1016/j.fbp.2021.07.001 · Cited by 10 · see citing works
Thakur, G., Ghumade, P., & Rathore, A. S. (2021) · Journal of Chromatography A · doi:10.1016/j.chroma.2021.462614 · Cited by 10 · see citing works
Chen, P.-H., Cheng, Y.-T., Ni, B.-S., & Huang, J. (2020) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-020-03288-9 · Cited by 10 · see citing works
Fernandes, B., Correia, R., Alves, P. M., & Roldão, A. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.917746 · Cited by 10 · see citing works
Perfusion Formats and Their Specific Medium Requirements
Sieck, J. B., Schild, C., & von Hagen, J. (2017) · doi:10.1002/9783527699902.ch7 · Cited by 10 · see citing works
Schaub, J., Ankenbauer, A., Habicher, T., Löffler, M., Maguire, N., Monteil, D. T., Püngel, S., Stepper, L., Stiefel, F., Thoma, J., et al. (2023) · Physical Sciences Reviews · doi:10.1515/psr-2022-0113 · Cited by 10 · see citing works
WuDunn, D., Squeri, A., Vu, J., Dhingra, A., Coffman, J., & Lee, K. C. L. (2024) · Biotechnology Progress · doi:10.1002/btpr.3440 · Cited by 9 · see citing works
Iacono, G., Abay, A., Gallego‐Murillo, J. S., Aglialoro, F., Yağcı, N., Varga, E., Bijlsma, T., Sohler, J., Fu, K., Reisz, J. A., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-81746-8 · Cited by 9 · see citing works
Intensified and Continuous mAb Production with Single-Use Systems
Müller, J., Teale, M., Steiner, S., Junne, S., Neubauer, P., Eibl, D., & Eibl, R. (2021) · Cell Engineering · doi:10.1007/978-3-030-79871-0_13 · Cited by 4 · see citing works
Monitoring of antibody glycosylation pattern based on microarray MALDI-TOF mass spectrometry.
Hajduk, J., Wolf, M. K. F., Steinhoff, R., Karst, D., Souquet, J., Broly, H., Morbidelli, M., & Zenobi, R. (2019) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2019.06.306 · Cited by 7 · see citing works
Self-citationVeje, M. H., Quirós, M., Kristensen, P. K., & Jørgensen, M. K. (2024) · Journal of Membrane Science · doi:10.1016/j.memsci.2024.122764 · Cited by 8 · see citing works
CFD supported scale up of perfusion bioreactors in biopharma
Kuschel, M., Wutz, J., Salli, M., Monteil, D. T., & Wucherpfennig, T. (2023) · Frontiers in Chemical Engineering · doi:10.3389/fceng.2023.1076509 · Cited by 8 · see citing works
Ultra- and Microfiltration in Dairy Technology
Kulozik, U. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813606-5.00001-4 · Cited by 8 · see citing works
Continuous and Integrated Expression and Purification of Recombinant Antibodies
Vogg, S., Wolf, M., & Morbidelli, M. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8730-6_11 · Cited by 8 · see citing works
Self-citationRaza, H., Tang, T., Gao, B., Phuangthong, C., Chen, C. B., & Pinto, N. D. S. (2024) · Biotechnology and Bioengineering · doi:10.1002/bit.28722 · Cited by 7 · see citing works
Zhang, W., Ran, Q., Zhao, L., Ye, Q., & Tan, W. (2024) · Biotechnology Journal · doi:10.1002/biot.202400063 · Cited by 7 · see citing works
Carvalho, R. J., & Castilho, L. R. (2017) · doi:10.1002/9783527699902.ch2 · Cited by 7 · see citing works
Zhang, W., Ran, Q., Zhao, L., Wan, Y., Ye, Q., & Tan, W. (2024) · Biochemical Engineering Journal · doi:10.1016/j.bej.2024.109309 · Cited by 6 · see citing works
Modeling tangential flow filtration using reverse asymmetric membranes for bioreactor harvesting
Zhang, D., Patel, P., Strauss, D., Qian, X., & Wickramasinghe, S. R. (2020) · Biotechnology Progress · doi:10.1002/btpr.3084 · Cited by 6 · see citing works
Weinberger, M. E., & Kulozik, U. (2021) · Food and Bioproducts Processing · doi:10.1016/j.fbp.2021.11.003 · Cited by 6 · see citing works
Nie, J., Sun, Y., Feng, K., Huang, L., Li, Y., & Bai, Z. (2022) · Vaccine · doi:10.1016/j.vaccine.2022.02.024 · Cited by 6 · see citing works
- Authors
- Karst, D. J., Serra, E., Villiger, T. K., Soos, M., & Morbidelli, M.
- Affiliations
- ETH Zurich (CH)
- Corresponding author
- Morbidelli, Massimo
- Venue
- Biochemical Engineering Journal
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 110
- Pages
- 17-26
- ISSN
- 1369-703X (ISSN-L)
- OpenAlex
- W2258522366
- Cited by
- 151
- References
- 52
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 14 · 2023: 11 · 2022: 13 · 2021: 20 · 2020: 22 · 2019: 19 · 2018: 25 · 2017: 10 · 2016: 3 · 2015: 1
- FWCI
- 9.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Engineering Journal (publishedVersion)
- Virtual Community of Pathological Anatomy (University of Castilla La Mancha) (submittedVersion)
- Funders
- SNF (206021_150744/1)
- University Research grant of UCT
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
- Physical Sciences › Engineering › Biomedical Engineering › Fluid Dynamics and Mixing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein purification and stability
- Keywords
- cross-flow filtration, cell retention, stirred tank reactor, mammalian cell culture, CHO cells, bioreactor hydrodynamics, oxygen transfer, scale-up
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
