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Cited by 257

The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.

Self-assemble peptide biomaterials and their biomedical applications

Open access
Chen, Jun, Zou, Xuenong·2019·Bioactive Materials

Abstract

Inspired by self-assembling peptides found in native proteins, deliberately designed engineered peptides have shown outstanding biocompatibility, biodegradability, and extracellular matrix-mimicking microenvironments. Assembly of the peptides can be triggered by external stimuli, such as electrolytes, temperature, and pH. The formation of nanostructures and subsequent nanocomposite materials often occur under physiological conditions. The respective properties of side chains in each amino acids provide numerous sites for chemical modification and conjugation choices of the peptides, enabling various resulting supramolecular nanostructures and hydrogels with adjustable mechanical and physicochemical properties. Moreover, additional functionalities can be easily induced into the hydrogels, including shear-thinning, bioactivity, self-healing, and shape memory. It further broaden the scope of application of self-assemble peptide materials. This review outlines designs of self-assembly peptide (β-sheet, α-helix, collagen-like peptides, elastin-like polypeptides, and peptide amphiphiles) with potential additional functionalities and their biomedical applications in bioprinting, tissue engineering, and drug delivery.

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Crossref · 10.1016/j.bioactmat.2019.01.002

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Metadata

Authors
Chen, J., & Zou, X.
Venue
Bioactive Materials
Publisher
Elsevier BV
Published
2019-12
Volume
4
Pages
120-131
ISSN
  • 2097-1192 (ISSN-L)
  • 2452-199X
OpenAlex
W2911251639
Cited by
257
References
109
FWCI
7.96
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Self-assemble peptide biomaterials and their biomedical applications. https://app.cochat.ai/papers/10.1016/j.bioactmat.2019.01.002
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Chen, J., & Zou, X. (2019). Self-assemble peptide biomaterials and their biomedical applications. Bioactive Materials. https://doi.org/10.1016/j.bioactmat.2019.01.002

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.