The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Scaffold Design for Bone Regeneration
Open accessAbstract
The use of bone grafts is the standard to treat skeletal fractures, or to replace and regenerate lost bone, as demonstrated by the large number of bone graft procedures performed worldwide. The most common of these is the autograft, however, its use can lead to complications such as pain, infection, scarring, blood loss, and donor-site morbidity. The alternative is allografts, but they lack the osteoactive capacity of autografts and carry the risk of carrying infectious agents or immune rejection. Other approaches, such as the bone graft substitutes, have focused on improving the efficacy of bone grafts or other scaffolds by incorporating bone progenitor cells and growth factors to stimulate cells. An ideal bone graft or scaffold should be made of biomaterials that imitate the structure and properties of natural bone ECM, include osteoprogenitor cells and provide all the necessary environmental cues found in natural bone. However, creating living tissue constructs that are structurally, functionally and mechanically comparable to the natural bone has been a challenge so far. This focus of this review is on the evolution of these scaffolds as bone graft substitutes in the process of recreating the bone tissue microenvironment, including biochemical and biophysical cues.
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Cites
Hydrogels for tissue engineering: scaffold design variables and applications
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On the mechanisms of biocompatibility
Williams, D. F. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.04.023 · Cited by 2,772
Normal Bone Anatomy and Physiology
Clarke, B. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.04151206 · Cited by 2,192
Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression
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Buried alive: How osteoblasts become osteocytes
Franz‐Odendaal, T. A., Hall, B. K., & Witten, P. E. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20603 · Cited by 795
Nucleation and growth of mineralized bone matrix on silk-hydroxyapatite composite scaffolds
Bhumiratana, S., Grayson, W. L., Castaneda, A., Rockwood, D. N., Gil, E. S., Kaplan, D. L., & Vunjak-Novakovic, G. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.12.058 · Cited by 265
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Cellulose and collagen derived micro-nano structured scaffolds for bone tissue engineering
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Cited by
Normal Bone Anatomy and Physiology
Clarke, B. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.04151206 · Cited by 2,192
A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds
Reddy, M. S. B., Ponnamma, D., Choudhary, R., & Sadasivuni, K. K. (2021) · Polymers · doi:10.3390/polym13071105 · Cited by 1,104
Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices
De Witte, T.-M., Fratila-Apachitei, L. E., Zadpoor, A. A., & Peppas, N. A. (2018) · Regenerative Biomaterials · doi:10.1093/rb/rby013 · Cited by 513
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Metadata
- Authors
- Polo-Corrales, L., Latorre-Esteves, M., & Ramirez-Vick, J. E.
- Venue
- Journal of Nanoscience and Nanotechnology
- Publisher
- American Scientific Publishers
- Published
- 2014-01-01
- Volume
- 14
- Issue
- 1
- Pages
- 15-56
- ISSN
- 1533-4880 (ISSN-L)
- 1533-4899
- OpenAlex
- W2005463566
- Cited by
- 945
- References
- 9
- FWCI
- 25.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Polo-Corrales, L., Latorre-Esteves, M., & Ramirez-Vick, J. E. (2014). Scaffold Design for Bone Regeneration. Journal of Nanoscience and Nanotechnology. https://doi.org/10.1166/jnn.2014.9127
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
