CoChat
Sign Up
Cited by 907Bone Tissue Engineering Materials3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

Recent advances in biomaterials for 3D scaffolds: A review

Open access
Nikolova, Maria P., Chavali, Murthy S.·2019·Bioactive Materials
DOI 10.1016/j.bioactmat.2019.10.005PMC PMC6829098
Open this paper in CoChat — free accountOpen PDF

Abstract

Considering the advantages and disadvantages of biomaterials used for the production of 3D scaffolds for tissue engineering, new strategies for designing advanced functional biomimetic structures have been reviewed. We offer a comprehensive summary of recent trends in development of single- (metal, ceramics and polymers), composite-type and cell-laden scaffolds that in addition to mechanical support, promote simultaneous tissue growth, and deliver different molecules (growth factors, cytokines, bioactive ions, genes, drugs, antibiotics, etc.) or cells with therapeutic or facilitating regeneration effect. The paper briefly focuses on divers 3D bioprinting constructs and the challenges they face. Based on their application in hard and soft tissue engineering, in vitro and in vivo effects triggered by the structural and biological functionalized biomaterials are underlined. The authors discuss the future outlook for the development of bioactive scaffolds that could pave the way for their successful imposing in clinical therapy.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.bioactmat.2019.10.005

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Polymers have successfully found applications in the regeneration of muscles, tendons, heart valves, arteries, bladder, and pancreas.

    “Furthermore, they have successfully found applications in the regeneration of muscles, tendons, heart valves, arteries, bladder, and pancreas [10].”

    From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [10]

  • Hydroxyapatite (HAp), β-tricalcium phosphate (β-TCP), and bioactive glasses are among the most commonly used biomaterials for 3D scaffolds in bone regeneration.

    “Hydroxyapatite (HAp, Ca10(PO4)6(OH)2) (Figure 7a,b), β-tricalcium phosphate (β-TCP, Ca3(PO4)2), and bioactive glasses are among the most commonly used biomaterials for 3D scaffolds in bone regeneration [10].”

    From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [10]

  • Ceramic biomaterials often consist of inorganic calcium or phosphate salts that possess osteoconductive and osteoinductive properties.

    “Ceramic biomaterials often consist of inorganic calcium or phosphate salts that possess osteoconductive (promoting new bone ingrowth) and osteoinductive (promoting osteoblastic differentiation) properties.”

    From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [10]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 215

  1. [1]Chia H.N. Wu B.M. Recent advances in 3D printing of biomaterials J. Biol. Eng. 9 2015 4 25866560 PMC4392469
  2. [2]Jammalamadaka U. Tappa K. Recent advances in biomaterials for 3D printing and tissue engineering J. Funct. Biomater. 9 1 2018 22 PMC5872108 29494503
  3. [4]Saiz E. Zimmermann E.A. Lee J.S. Wegst U.G. Tomsia A.P. Perspectives on the role of nanotechnology in bone tissue engineering Dent. Mater. 29 2013 103 115 22901861 PMC3638810
  4. [5]Feng L. Lingling E. Liu H. The effects of separating inferior alveolar neurovascular bundles on osteogenesis of tissue-engineered bone and vascularization Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub. 159 4 2015 637 641 25363725
  5. [6]Marrella A. Lee T.Y. Lee D.H. Karuthedom S. Syla D. Chawla A. Khademhosseini A. Jang H.L. Engineering vascularized and innervated bone biomaterials for improved skeletal tissue regeneration Mater. Today 21 4 2018 362 376 PMC6082025 30100812
  6. [7]Shruti S. Salinas A.J. Lusvardi G. Malavasi G. Menabue L. Vallet-Regi M. Mesoporous bioactive scaffolds prepared with cerium-, gallium- and zinc-containing glasses Acta Biomater. 9 1 2013 4836 4844 23026489
  7. [8]Wei G. Ma P.X. Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering Biomaterials 25 19 2004 4749 4757 15120521
  8. [9]Boyan B.D. Hummert T.W. Dean D.D. Schwartz Z. Role of material surfaces in regulating bone and cartilage cell response Biomaterials 17 2 1996 137 146 8624390
  9. [10]Lee M. Wu B.M. Dunn J.C. Effect of scaffold architecture and pore size on smooth muscle cell growth J. Biomed. Mater. Res. A 87 4 2008 1010 1016 18257081
  10. [11]Hulbert S.F. Young F.A. Mathews R.S. Klawitter J.J. Talbert C.D. Stelling F.H. Potential of ceramic materials as permanently implantable skeletal prostheses J. Biomed. Mater. Res. 4 3 1970 433 456 5469185
  11. [12]Mouriño V. Boccaccini A.R. Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds J. R. Soc. Interface 7 2012 209 227 PMC2842615 19864265
  12. [13]Bencherif S.A. Braschler T.M. Renaud P. Advances in the design of macroporous polymer scaffolds for potential applications in dentistry J. Periodontal Implant Sci. 43 2013 251 261 24455437 PMC3891856
  13. [14]Rampichová M. Buzgo M. Chvojka J. Prosecká E. Kofroňová O. Amler E. Cell penetration to nanofibrous scaffolds Cell Adhes. Migrat. 8 2014 36 41 PMC3974791 24429388
  14. [15]Ren L. Pandit V. Elkin J. Denman T. Cooper J.A. Kotha S.P. Large-scale and highly efficient synthesis of micro- and nano-fibres with controlled fiber morphology by centrifugal jet spinning for tissue regeneration Nanoscale 5 2013 2337 2345 23392606
  15. [17]Loordhuswamy A. Krishnaswamy V. Korrapati P. Thinakaran S. Rengaswami G. Fabrication of highly aligned fibrous scaffolds for tissue regeneration by centrifugal spinning technology Mater. Sci. Eng. C 42 2014 799 807 25063182
  16. [19]Melke J. Midha S. Ghosh S. Ito K. Hofmann S. Silk fibroin as a biomaterial for bone tissue engineering Acta Biomater. 31 2016 1 16 26360593
  17. [20]Vasita R. Katti D.S. Nanofibers and their applications in tissue engineering Int. J. Nanomed. 1 1 2006 15–30. PMC2426767 PMC2426767 17722259
  18. [21]Xia H. Chen Q. Fang Y. Liu D. Zhong D. Wu H. Xia Y. Yan Y. Tang W. Sun X. Directed neurite growth of rat dorsal root ganglion neurons and increased colocalization with Schwann cells on aligned poly(methyl methacrylate) electrospun nanofibers Brain Res. Elsevier 1565 2014 18 27 24721525
  19. [22]Hejazian L.B. Esmaeilzade B. Ghoroghi F.M. Moradi F. Hejazian M.B. Aslani A. The role of biodegradable engineered nanofiber scaffolds seeded with hair follicle stem cells for tissue engineering, Iran Biomed. J. 16 2012 193 201 PMC3600961 23183618
  20. [24]Christopherson G.T. Song H. Mao H.-Q. The influence of fibre diameter of electrospun substrates on neural stem cell differentiation and proliferation Biomaterials 30 2009 556 564 18977025
  21. [26]Yao Q. Cosme J.G.L. Xu T. Miszuk J.M. Picciani P.H.S. Fong H. Sun H. Three dimensional electrospun PCL/PLA blend nanofibrous scaffolds with significantly improved stem cells osteogenic differentiation and cranial bone formation Biomaterials 115 2017 115 127 27886552 PMC5181114
  22. [27]Corey J.M. Lin D.Y. Mycek K.B. Chen Q. Samuel S. Feldman E.L. Aligned electrospun nanofibers specify the direction of dorsal root ganglia neurite growth J. Biomed. Mater. Res. A 83A 2007 636 645 17508416
  23. [28]Frohbergh M.E. Katsman A. Botta G.P. Lazarovici P. Schauer C.L. Wegst U.G. Electrospun hydroxyapatite-containing chitosan nanofibers crosslinked with genipin for bone tissue engineering Biomaterials 33 2012 9167 9178 23022346 PMC3488354
  24. [29]Yin Z. Chen X. Song H.X. Hu J.-j. Tang Q.-m. Zhu T. Shen W.-l. Chen J.-l. Liu H. Heng B.C. Ouyang H.-W. Electrospun scaffolds for multiple tissues regeneration in vivo through topography dependent induction of lineage-specific differentiation Biomaterials 44 2015 173 185 25617136
  25. [30]Cai J. Wang J. Ye K. Li D. Ai C. Sheng D. Jin W. Liu X. Zhi Y. Jiang J. Chen J. Mo X. Chen S. Dual-layer aligned-random nanofibrous scaffolds for improving gradient microstructure of tendon-to the -bone healing in a rabbit extra-articular model Int. J. Nanomed. 13 2018 3481 3492 PMC6014388 29950830
  26. [32]Stephens D. Li L. Robinson D. Chen S. Chang H. Liu R.M. Tian Y. Ginsburg E.J. Gao X. Stultz T. Investigation of the in vitro release of gentamicin from a polyanhydride matrix J. Control. Release 63 3 2000 305 317 10601726
  27. [35]Ravivarapu H.B. Burton K. DeLuca P.P. Polymer and microsphere blending to alter the release of a peptide from PLGA microspheres Eur. J. Pharm. Biopharm. 50 2 2000 263 270 10962237
  28. [36]Hu Y. Hollinger J. Marra K. Controlled release from coated polymer microparticles embedded in tissue-engineered scaffolds J. Drug Target. 9 2001 431 438 11822815
  29. [37]Dhandayuthapani B. Yoshida Y. Maekawa T. Kumar D.S. Polymeric scaffolds in tissue engineering application: a review Int. J. Polymer Sci. Art. ID 290602 2011 1 19
  30. [38]Borden M. Attawia M. Laurencin C.T. The sintered microsphere matrix for bone tissue engineering: in vitro osteoconductivity studies J. Biomed. Mater. Res. 61 3 2002 421 429 12115467
  31. [39]Yoshii T. Hafeman A.E. Esparza J.M. Okawa A. Gutierrez G. Guelcher S.A. Local injection of lovastatin in biodegradable polyurethane scaffolds enhances bone regeneration in a critical-sized segmental defect in rat femora J. Tissue Eng. Regenerat. Med. 8 2014 589 595 22718577
  32. [40]Radisic M. Yang L. Boublik J. Cohen R.J. Langer R. Freed L.E. Vunjak-Novakovic G. Medium perfusion enables engineering of compact and contractile cardiac tissue Am. J. Physiol. Heart Circ. Physiol. 286 2 2004 H507 H516 14551059
  33. [41]Fan W. Crawford R. Xiao Y. Enhancing in vivo vascularized bone formation by cobalt chloride-treated bone marrow stromal cells in a tissue-engineered periosteum model Biomaterials 31 13 2010 3580 3589 20153522
  34. [42]Kempen D.H. Lu L. Heijink A. Hefferan T.E. Creemers L.B. Maran A. Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration Biomaterials 30 2009 2816 2825 19232714
  35. [43]Turnbull G. Clarke J. Picard F. Riches P. Jia L. Han F. Li B. Shu W. 3D bioactive composite scaffolds for bone tissue engineering Bioact. Mater. 3 2018 278 314 29744467 PMC5935790
  36. [44]Shor L. Güçeri S. Wen X. Gandhi M. Sun W. Fabrication of three-dimensional polycaprolactone/hydroxyapatite tissue scaffolds and osteoblast-scaffold interactions in vitro Biomaterials 28 35 2007 5291 5297 17884162
  37. [45]Deng C. Chang J. Wu C. Bioactive scaffolds for osteochondral regeneration J. Orthop. Transl. 17 2019 15 25 PMC6551354 31194079
  38. [46]Datta P. Dhawan A. Yu Y. Hayes D. Gudapati H. Ozbolat I.T. Bioprinting of osteochondral tissues: a perspective on current gaps and future trends Int. J. Bioprint. 3 2 2017 109 120 PMC7575632 33094191
  39. [48]Yang Y. Wang G. Liang H. Gao C. Peng S. Shen L. Shuai C. Additive manufacturing of bone scaffolds Int. J. Bioprint. 5 1 2019 148 173 PMC7294697 32596528
  40. [49]Murphy S.V. Atala A. 3D bioprinting of tissues and organs Nat. Biotechnol. 32 2014 773 785 25093879
  41. [50]Markstedt K. Mantas A. Tournier I. Martínez Ávila H. Hägg D. Gatenholm P. 3D bioprinting human chondrocytes with nanocellulose–alginate bioink for cartilage tissue engineering applications Biomacromolecules 16 2015 1489 1496 25806996
  42. [51]Zhang Y. Wang C. Fu L. Ye S. Wang M. Zhou Y. Fabrication and application of novel porous scaffold in situ-loaded graphene oxide and osteogenic peptide by cryogenic 3D printing for repairing critical-sized bone defect Molecules 24 2019 1669 PMC6539066 31035401
  43. [53]Hoffman A.S. Hydrogels for biomedical applications Adv. Drug Deliv. Rev. 64 2012 18 23 11755703
  44. [54]El-Sherbiny I.M. Yacoub M.H. Hydrogel scaffolds for tissue engineering, progress and challenges Global Cardiol. Sci. Practice 38 2013 1 27 PMC3963751 24689032
  45. [55]Schmedlen R.H. Masters K.S. West J.L. Photocrosslinkable polyvinyl alcohol hydrogels that can be modified with cell adhesion peptides for use in tissue engineering Biomaterials 23 2002 4325 4332 12219822
  46. [57]Aizman I. Tate C.C. McGrogan M. Case C.C. Extracellular matrix produced by bone marrow stromal cells and by their derivative, SB623 cells, supports neural cell growth J. Neurosci. Res. 87 2009 3198 3206 19530164
  47. [58]Zia S. Mozafari M. Natasha G. Tan A. Cui Z. Seifalian A.M. Hearts beating through decellularized scaffolds: whole-organ engineering for cardiac regeneration and transplantation Crit. Rev. Biotechnol. 36 2016 705 715 25739987
  48. [59]Crabbé A. Liu Y. Sarker S.F. Bonenfant N.R. Barrila J. Borg Z.D. Recellularization of Decellularized Lung Scaffolds Is Enhanced by Dynamic Suspension Culture vol. 10 2015 e0126846 PMC4427280 25962111
  49. [60]Chen F. Yoo J.J. Atala A. Acellular collagen matrix as a possible 'off the shelf' biomaterial for urethral repair Urology 54 3 1999 407 410 10475343
  50. [63]Lai Y. Sun Y. Skinner C.M. Son E.L. Lu Z. Tuan R.S. Jilka R.L. Ling J. Chen X.-D. Reconstitution of marrow-derived extracellular matrix ex vivo: a robust culture system for expanding large-scale highly functional human mesenchymal stem cells Stem Cells Dev. 19 2010 1095 1107 19737070 PMC3128312
  51. [64]Chan B. Leong K. Scaffolding in tissue engineering: general approaches and tissue-specific considerations Eur. Spine J. 17 2008 467 479 19005702 PMC2587658
  52. [65]Hang L. Yang G. Jian T. Tuan R.S. Influence of decellularized matrix derived from human mesenchymal stem cells on their proliferation, migration and multi-lineage differentiation potential Biomaterials 33 18 2012 4480 4489 22459197
  53. [67]Pacelli S. Basu S. Whitlow J. Chakravarti A. Acosta F. Varshney A. Modaresi S. Berkland C. Paul A. Strategies to develop endogenous stem cell-recruiting bioactive materials for tissue repair and regeneration Adv. Drug Deliv. Rev. 120 2017 50 70 28734899 PMC5705585
  54. [68]Li J. Hansen K.C. Zhang Y. Dong C. Dinu C.Z. Dzieciatkowska M. Pei M. Rejuvenation of chondrogenic potential in a young stem cell microenvironment Biomaterials 35 2 2014 642 653 24148243
  55. [69]Chocholata P. Kulda V. Babuska V. Fabrication of scaffolds for bone-tissue regeneration Materials 12 2019 568 PMC6416573 30769821
  56. [70]Yoo D. New paradigms in hierarchical porous scaffold design for tissue engineering Mater. Sci. Eng. C 33 2013 1759 1772 23827634
  57. [71]Yang F. Chen C. Zhou Q. Gong Y. Li R. Li C. Klämpfl F. Freund S. Wu X. Sun Y. Li X. Schmidt M. Ma D. Yu Y.C. Laser beam melting 3D printing of Ti6Al4V based porous structured dental implants: fabrication, biocompatibility analysis and photoelastic study Sci. Rep. 7 2017 45360 28350007 PMC5368973
  58. [72]Zhao B. Wang H. Qiao N. Wang C. Hu M. Corrosion resistance characteristics of a Ti–6Al–4V alloy scaffold that is fabricated by electron beam melting and selective laser melting for implantation in vivo Mater. Sci. Eng. C 70 2016 832 841 27770961
  59. [74]Shah F.A. Omar O. Suska F. Snis A. Matic A. Emanuelsson L. Norlindh B. Lausmaa J. Thomsen P. Palmquist A. Long–term osseointegration of 3D printed CoCr constructs with an interconnected open-pore architecture prepared by electron beam melting Acta Biomater. 36 2016 296 309 27000553
  60. [75]Fousová M. Kubásek J. Vojtěch D. Fort J. Čapek J. 3D printed porous stainless steel for potential use in medicine IOP Conf. Ser. Mater. Sci. Eng. 179 2017 012025
  61. [76]van den Dolder J. Farber E. Spauwen P.H.M. Jansen J.A. Bone tissue reconstruction using titanium fibre mesh combined with rat bone marrow stromal cells Biomaterials 24 10 2003 1745 1750 12593956
  62. [77]Bobe K. Willbold E. Morgenthal I. Andersen O. Studnitzky T. Nellesen J. Tillmann W. Vogt C. Vano K. Witte F. In vitro and in vivo evaluation of biodegradable, open-porous scaffolds made of sintered magnesium W4 short fibres Acta Biomater. 9 2013 8611 8623 23542554
  63. [78]Witte F. Ulrich H. Rudert M. Willbold E. Biodegradable magnesium scaffolds: Part 1: appropriate inflammatory response J. Biomed. Mater. Res. A 81 2007 748 756 17390368
  64. [79]Cheng M.-Q. Wahafu T. Jiang G.-F. Liu W. Qiao Y.-Q. Peng X.-C. Cheng T. Zhang X.-L. He G. Liu X.-Y. A novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration Sci. Rep. 6 2016 24134 27071777 PMC4829853
  65. [80]Witte F. Ulrich H. Palm C. Willbold E. Biodegradable magnesium scaffolds: Part II: peri-implant bone remodelling J. Biomed. Mater. Res. A 81A 2007 757 765 17390322
  66. [81]Han P. Cheng P. Zhang S. Zhao C. Ni J. Zhang Y. Zhong W. Hou P. Zhang X. Zheng Y. Chai Y. In vitro and in vivo studies on the degradation of high-purity Mg (99.99wt.%) screw with femoral intracondylar fractured rabbit model Biomaterials 64 2015 57 69 26117658
  67. [82]Staiger M.P. Pietak A.M. Huadmai J. Dias G. Magnesium and its alloys as orthopaedic biomaterials: a review Biomaterials 27 9 2006 1728 1734 16246414
  68. [85]Komlev V.S. Popov V.K. Mironov A.V. Yu A. Fedotov Teterina A. Yu Smirnov I.V. Bozo I.Y. Rybko V.A. Deev R.V. 3D printing of octacalcium phosphate bone substitutes Front. Bioeng. Biotechnol. 3 2015 81 26106596 PMC4459096
  69. [88]Fielding G.A. Bandyopadhyay A. Bose S. Effects of silica and zinc oxide doping on mechanical and biological properties of 3D printed tricalcium phosphate tissue engineering scaffolds Dent. Mater. 28 2 2012 113 122 22047943 PMC3259206
  70. [89]Pietak A.M. Reid J.W. Stott M.J. Sayer M. Silicon substitution in the calcium phosphate bioceramics Biomaterials 28 2007 4023 4032 17544500
  71. [90]Chang C.H. Lin C.Y. Liu F.H. Chen M.H.C. Lin C.P. Ho H.N. Liao Y.S. 3D printing bioceramic porous scaffolds with good mechanical property and cell affinity PLoS One 10 2015 e0143713 PMC4664392 26618362
  72. [91]Qi X. Pei P. Zhu M. Du X. Xin C. Zhao S. Li X. Zhu Y. Three-dimensional printing of calcium sulfate and mesoporous bioactive glass scaffolds for improving bone regeneration in vitro and in vivo Sci. Rep. 7 2017 2 13 28211911 PMC5304193
  73. [92]Li C. Jiang C. Deng Y. Li T. Li N. Peng M. Wang J. RhBMP-2 loaded 3D-printed mesoporous silica/calcium phosphate cement porous scaffolds with enhanced vascularization and osteogenesis properties Sci. Rep. 7 2017 41331 28128363 PMC5269721
  74. [93]Wu C. Zhou Y. Lin C. Chang J. Xiao Y. Strontium-containing mesoporous bioactive glass scaffolds with improved osteogenic/cementogenic differentiation of periodontal ligament cells for periodontal tissue engineering Acta Biomater. 8 2012 3805 3815 22750735
  75. [95]Wang X. Li X. Ito A. Sogo Y. Synthesis and characterization of hierarchically macroporous and mesoporous CaO–MO–SiO2–P2O5 (M = Mg, Zn, Sr) bioactive glass scaffolds Acta Biomater. 7 2011 3638 3644 21742065
  76. [97]Valappil S.P. Ready D. Abou Neel E.A. Pickup D.M. Ó’Dell L.A. Chrzanoweki W. Pratten J. Newport R.J. Smith M.E. Wilson M. Knowles J.C. Controlled delivery of antimicrobial gallium ions from phosphate-based glasses Acta Biomater. 5 2009 1198 1210 18974026
  77. [98]Wu C. Miron R. Sculean A. Kaskel S. Doert T. Schulze R. Zhang Y. Proliferation, differentiation and gene expression of osteoblasts in boron-containing associated with dexamethasone deliver from mesoporous bioactive glass scaffolds Biomaterials 32 29 2011 7068 7078 21704367
  78. [99]Wu C. Fan W. Zhu Y. Gelinsky M. Chang J. Cuniberti G. Albrecht V. Friis T. Xiao Y. Multifunctional magnetic mesoporous bioactive glass scaffolds with a hierarchical pore structure Acta Biomater. 7 10 2011 3563 3572 21745610
  79. [100]Zhang J. Zhao S. Zhu Y. Huang Y. Zhu M. Tao C. Zhang C. Three-dimensional printing of strontium-containing mesoporous bioactive glass scaffolds for bone regeneration Acta Biomater. 10 5 2014 2269 2281 24412143
  80. [101]Wu C. Zhou Y. Xu M. Han P. Chen L. Chang J. Xiao Y. Copper-containing mesoporous bioactive glass scaffolds with multifunctional properties of angiogenesis capacity, osteostimulation and antibacterial activity Biomaterials 34 2013 422 433 23083929
  81. [102]Kokubo T. Kim H.M. Kawashita M. Novel bioactive materials with different mechanical properties Biomaterials 24 13 2003 2161 2175 12699652
  82. [103]Yang G.Y. Liu J. Li F. Pan Z. Ni X. Shen Y. Xu H. Huang Q. Bioactive calcium sulfate/magnesium phosphate cement for bone substitute applications Mater. Sci. Eng. C 35 2014 70 76 24411353
  83. [105]Portici V. Amendola J. Laurin J. Gigmes D. Madaschi L. Carelli S. Marquette T. Gorio A. Decherchi P. The use of poly(N-[2-hydroxypropyl]-methacrylamide) hydrogel to repair a T10 spinal cord hemisection in rat: a behavioural, electrophysiological and anatomical examination ASN Neuro 5 2 2013 149 166 23614684 PMC3667642
  84. [106]Valdes-Sanchez T. Rodriguez-Jimenez F.J. Garcia-Cruz D.M. Escobar-Ivirico J.L. Alastrue-Agudo A. Erceg S. Monleon M. Moreno-Manzano V. Methacrylate-endcapped caprolactone and FM19G11 provide a proper niche for spinal cord-derived neural cells J. Tissue Eng. Regenerat. Med. 9 6 2015 734 739 23533014
  85. [107]Xie M. Wang L. Ge J. Guo B. Ma P.X. Strong electroactive biodegradable shape memory polymer networks based on star-shaped polylactide and aniline trimer for bone tissue engineering ACS Appl. Mater. Interfaces 7 12 2015 6772 6781 25742188
  86. [108]Wang W. Yeung K.W.K. Bone grafts and biomaterials substitutes for bone defect repair: a review Bioactive Materials 2 4 2017 224 247 29744432 PMC5935655
  87. [109]Bertoldi C. Zaffe D. Consolo U. Polylactide/polyglycolide copolymer in bone defect healing in humans Biomaterials 29 12 2008 1817 1823 18234328
  88. [110]Bhattarai D.P. Aguilar L.E. Park C.H. Kim C.S. A review on properties of natural and synthetic based electrospun fibrous materials for bone tissue engineering Membranes 8 2018 62 PMC6160934 30110968
  89. [111]Rifkin D.B. Mazzieri R. Munger J.S. Noguera I. Sung J. Proteolytic control of growth factor availability Apmis 107 1999 80 85 10190283
  90. [112]Reyes R. Delgado A. Sánchez E. Fernández A. Hernández A. Evora C. Repair of an osteochondral defect by sustained delivery of BMP-2 or TGFβ1 from a bilayered alginate-PLGA scaffold J. Tissue Eng. Regen. Me ofd. 8 7 2012 521 533 22733683
  91. [113]Ker E.D.F. Nain A.S. Weiss L.E. Wang J. Suhan J. Amon C.H. Campbell P.G. Bioprinting of growth factors onto aligned sub-micron fibrous scaffolds for simultaneous control of cell differentiation and alignment Biomaterials 32 2011 8097 8107 21820736
  92. [114]Kim H.W. Lee E.J. Jun I.K. Kim H.E. Knowles J.C. Degradation and drug release of phosphate glass/polycaprolactone biological composites for hard-tissue regeneration J. Biomed. Mater. Res. B 75 1 2005 34 41 16001393
  93. [116]Tyagi P. Catledge S.A. Stanishevsky A. Thomas V. Vohra Y.K. Nanomechanical properties of electrospun composite scaffolds based on polycaprolactone and hydroxyapatite J. Nanosci. Nanotechnol. 9 2009 4839 4845 19928159
  94. [119]Zhang R. Ma P.X. Porous poly(L-lactic acid)/apatite composites created by the biomimetic process J. Biomed. Mater. Res. 45 4 1999 285 293 10321700
  95. [120]Wu C. Ramaswamy Y. Zhu Y. Zheng R. Appleyard R. Howard A. Zreiqat H. The effect of mesoporous bioactive glass on the physiochemical, biological and drug-release properties of poly(dl-lactide-co-glycolide) films Biomaterials 30 12 2009 2199 2208 19203787
  96. [121]Gorodzha S.N. Muslimov A.R. Syromotina D.S. Timin A.S. Tcvetkov N.Y. Lepik K.V. Petrova A.V. Surmeneva M.A. Gorin D.A. Sukhorukov G.B. Surmeneva R.A. A comparison study between electrospun polycaprolactone andpiezoelectric poly(3-hydroxybutyrate-co-3-hydroxyvalerate)scaffolds for bone tissue engineering Colloids Surf., B 160 2017 48 59 28917149
  97. [122]TheinHan W. Weir M.D. Simon C.G. Xu H.H. Non‐rigid calcium phosphate cement containing hydrogel microbeads and absorbable fibres seeded with umbilical cord stem cells for bone engineering J. Tissue Eng. Regenerat. Med. 7 10 2012 777 787 PMC3641181 22451091
  98. [124]Crowder S.W. Prasai D. Rath R. Balikov D.A. Bae H. Bolotin K.I. Sung H.J. Three-dimensional graphene foams promote osteogenic differentiation of human mesenchymal stem cells Nanoscale 5 2013 4171 4176 23592029 PMC3672224
  99. [126]Wu C. Zhang Y. Zhu Y. Friis T. Xiao Y. Structure-property relationships of silk-modified mesoporous bioglass scaffolds Biomaterials 31 13 2010 3429 3438 20122721
  100. [127]Chen J. Chen H. Li P. Diao H. Zhu S. Dong L. Wang R. Guo T. Zhao J. Zhang J. Simultaneous regeneration of articular cartilage and subchondral bone in vivo using MSCs induced by a spatially controlled gene delivery system in bilayered integrated scaffolds Biomaterials 32 21 2011 4793 4805 21489619
  101. [128]Torres A.L. Gaspar V.M. Serra I.R. Diogo G.S. Fradique R. Silva A.P. Correia I.J. Bioactive polymeric–ceramic hybrid 3D scaffold for application in bone tissue regeneration Mater. Sci. Eng. C 33 7 2013 4460 4469 23910366
  102. [129]Liu X. Ding C. Chu P.K. Mechanism of apatite formation on wollastonite coatings in simulated body fluids Biomaterials 25 10 2004 1755 1761 14738838
  103. [130]Tache A. Gan L. Deporter D. Pilliar R.M. Effect of surface chemistry on the rate of osseointegration of sintered porous-surfaced Ti-6Al-4V implants Int. J. Oral Maxillofac. Implant. 19 1 2004 19 29 14982351
  104. [131]Li P. Biomimetic nano-apatite coating capable of promoting bone ingrowth J. Biomed. Mater. Res. A 66 1 2003 79 85 12833433
  105. [132]Rifai A. Tran N. Lau D.W. Elbourne A. Zhan H. Stacey A.D. Mayes E.L.H. Sarker A. Ivanova E.P. Crawford R.J. Tran P.A. Gibson B.C. Greentree A.D. Pirogova E. Fox K. Polycrystalline diamond coating of additively manufactured titanium for biomedical applications ACS Appl. Mater. Interfaces 10 10 2018 8474 8484 29470044
  106. [134]Wust S. Godla M.E. Muller R. Hofmann S. Tunable hydrogel composite with two-step processing in combination with innovative hardware upgrade for cell-based three-dimensional bioprinting Acta Biomater. 10 2 2014 630 640 24157694
  107. [135]Chang C. Peng N. He M. Teramoto Y. Nishio Y. Zhang L. Fabrication and properties of chitin/hydroxyapatite hybrid hydrogels as scaffold nano-materials Carbohydr. Polym. 1 1 2013 7 13 23044099
  108. [136]Maji S. Agarwal T. Tapas J.D. Maiti K. Development of gelatin/carboxymethyl chitosan/nano-hydroxyapatite composite 3D macroporous scaffold for bone tissue engineering applications, Carbohydr Polymers 189 2018 115 125 29580388
  109. [138]Saravanan S. Chawla Anjali Vairamani M. Sastry T.P. Subramanian K.S. Selvamurugan N. Scaffolds containing chitosan, gelatin and graphene oxide for bone tissue regeneration in vitro and in vivo Int. J. Biol. Macromol. 104 2017 1975 1985 28089930
  110. [139]Tripathi A. Saravanan S. Pattnaik S. Moorthi A. Partridge N.C. Selvamurugan N. Bio-composite scaffolds containing chitosan/nano-hydroxyapatite/nano-copper-zinc for bone tissue engineering Int. J. Biol. Macromol. 50 2012 294 299 22123094
  111. [140]Gao Y. Shao W. Qian W. He J. Zhou Y. Qi K. Wang L. Cui S. Wang R. Biomineralized poly (l-lactic-co-glycolic acid)-tussah silk fibroin nanofiber fabric with hierarchical architecture as a scaffold for bone tissue engineering Mater. Sci. Eng. C 84 1 2018 195 207 29519429
  112. [141]Kwak S. Haider A. Gupta K.C. Kim S. Kang I.-K. Micro/nano multilayered scaffolds of PLGA and collagen by alternately electrospinning for bone tissue engineering Nanoscale Res. Lett. 11 2016 323 27376895 PMC4932007
  113. [142]Bendtsen S.T. Quinnell S.P. Wei M. Development of a novel alginate-polyvinyl alcohol-hydroxyapatite hydrogel for 3D bioprinting bone tissue-engineered scaffolds J. Biomed. Mater. Res. A 105 5 2017 1457 1468 28187519
  114. [144]Chen Z. Song Y. Zhang J. Liu W. Cui J. Li H. Chen F. Laminated electrospun nHA/PHB-composite scaffolds mimicking bone extracellular matrix for bone tissue engineering Mater. Sci. Eng. C 72 2017 341 351 28024596
  115. [145]Kaur K. Singh K.J. Anand V. Bhatia G. Kaur R. Kaur M. Nim L. Arora D.S. Scaffolds of hydroxyl apatite nanoparticles disseminated in 1,6-diisocyanatohexane-extended poly(1,4-butylene succinate)/poly(methyl methacrylate) for bone tissue engineering Mater. Sci. Eng. C 71 2017 780 790 27987773
  116. [146]Eslami H. Azimi Lisar H. Jafarzadeh Kashi T.S. Tahriri M. Ansari M. Rafiei T. Bastami F. Shahin-Shamsabadi A. Mashhadi Abbas F. Tayebi L. Poly(lactic-co-glycolic acid)(PLGA)/TiO2 nanotube bioactive composite as a novel scaffold for bone tissue engineering: in vitro and in vivo studies Biologicals 53 2018 51 62 29503205
  117. [150]Fu Y. Liu L. Cheng R. Cui W. ECM decorated electrospun nanofiber for improving bone tissue regeneration Polymers 10 3 2018 272 PMC6414933 30966307
  118. [152]Lee P. Tran K. Zhou G. Bedi A. Shelke N.B. Yu X. Kumbar S.G. Guided differentiation of bone marrow stromal cells on co-cultured cartilage and bone scaffolds Soft Matter 11 2015 7648 7655 26292727
  119. [153]Mayer J.E. Shinoka T. Shum-Tim D. Tissue engineering of cardiovascular structures Curr. Opin. Cardiol. 12 6 1997 528 532 9429823
  120. [154]Oberpenning F. Meng J. Yoo J.J. Atala A. De novo reconstitution of a functional mammalian urinary bladder by tissue engineering Nat. Biotechnol. 17 2 1999 149 155 10052350
  121. [155]Tziampazis E. Sambanis A. Tissue engineering of a bioartificial pancreas: modelling the cell environment and device function Biotechnol. Prog. 11 2 1995 115 126 7766095
  122. [156]Santhosh K.T. Alizadeh A. Karimi-Abdolrezaee S. Design and optimization of PLGA microparticles for controlled and local delivery of neuregulin-1 in traumatic spinal cord injury J. Control. Release 261 2017 147 162 28668379
  123. [157]Pieretti S. Ranjan A.P. Di Giannuario A. Mukerjee A. Marzoli F. Di Giovannandrea R. Vishwanatha J.K. Curcumin-loaded poly(D, L-lactide-co-glycolide) nanovesicles induce antinociceptive effects and reduce pronociceptive cytokine and BDNF release in the spinal cord after acute administration in mice Colloids Surf., B 158 2017 379 386 28719859
  124. [159]Du B.L. Zeng C.G. Zhang W. Quan D.P. Ling E.A. Zeng Y.S. A comparative study of gelatin sponge scaffolds and PLGA scaffolds transplanted to the completely transected spinal cord of rat J. Biomed. Mater. Res. A 102 6 2014 1715 1725 23776140
  125. [160]Murua A. Herran E. Orive G. Igartua M. Blanco F.J. Pedraz J.L. M Hernández R. Design of a composite drug delivery system to prolong the functionality of cell-based scaffolds Int. J. Pharmaceutics 407 1–2 2011 142 150 21094235
  126. [161]Janoušková O. Synthetic polymer scaffolds for soft tissue engineering Physiol. Res. 67 2 2018 S335 S348 30379554
  127. [162]Aviss K.J. Gough J.E. Downes S. Aligned electrospun polymer fibres for skeletal muscle regeneration Eur. Cells Mater. 19 2010 193 204 20467965
  128. [163]Chen M.C. Sun Y.C. Chen Y.H. Electrically conductive nanofibers with highly oriented structures and their potential application in skeletal muscle tissue engineering Acta Biomater. 9 2013 5562 5572 23099301
  129. [164]Li T. Tian L. Liao S. Ding X. Irvine S.A. Ramakrishna S. Fabrication, mechanical property and in vitro evaluation of poly (L-lactic acid-co-ε-caprolactone) core-shell nanofiber scaffold for tissue engineering J. Mech. Behav. Biomed. Mater. 98 2019 48 57 31195187
  130. [165]Islam M.S. Ang B.C. Andriyana A. Afifi A.M. A review on fabrication of nanofibers via electrospinning and their applications SN Appl. Sci. 1 2019 1248
  131. [166]Li X. Yang C. Li L. Xiong J. Xie L. Yang B. Yu M. Feng L. Jiang Z. Guo W. Tian W. A therapeutic strategy for spinal cord defect: human dental follicle cells combined with aligned PCL/PLGA electrospun material BioMed Res. Int. 2015 2015 197183 25695050 PMC4324737
  132. [167]Wang C.Y. Liu J.J. Fan C.Y. Mo X.M. Ruan H.J. Li F.F. The effect of aligned core-shell nanofibres delivering NGF on the promotion of sciatic nerve regeneration J. Biomater. Sci. Polym. Ed. 23 1–4 2012 167 184 21192836
  133. [168]Laurilliard E.J. Lee K.L. Cooper J.A. Characterization and Evaluation of Fabricated poly(L-Lactic) Acid Core Fibres for Ligament Fascicle Development, 41st Annual Northeast Biomedical Engineering Conference (NEBEC) 2015 1 2
  134. [169]Sánchez-Téllez D.A. Téllez-Jurado L. Rodríguez-Lorenzo L.M. Hydrogels for cartilage regeneration, from polysaccharides to hybrids Polymers 9 2017 671 PMC6418920 30965974
  135. [170]Kim H.D. Lee Y. Kim Y. Hwang Y. Hwang N.S. Biomimetically reinforced polyvinyl alcohol-based hybrid scaffolds for cartilage tissue engineering Polymers 9 12 2017 655 PMC6418829 30965950
  136. [171]Sridhar B.V. Doyle N.R. Randolph M.A. Anseth K.S. Covalently tethered TGF-β1 with encapsulated chondrocytes in a PEG hydrogel system enhances extracellular matrix production J. Biomed. Mater. Res. A 102 12 2014 4464 4472 24616326 PMC4145048
  137. [172]Guo T. Lim C.G. Noshin M. Ringel J.P. Fisher J.P. 3D printing bioactive PLGA scaffolds using DMSO as a removable solvent Bioprinting 10 2018 e00038 PMC6660168 31355352
  138. [173]Jing X. Mi H.-Y. Huang H.-X. Turning L.-S. Shape memory thermoplastic polyurethane (TPU)/poly(ε-caprolactone) (PCL) blends as self-knotting sutures J. Mech. Behav. Biomed. Mater. 64 2016 94 103 27490212
  139. [174]Lee J.W. Kim J.Y. Cho D.-W. Solid free-form fabrication technology and its application to bone tissue engineering Int. J. Stem Cells 3 2 2010 85 95 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021802/ 24855546 PMC4021802
  140. [175]Putnam D. The heart of the matter Nat. Mater. 7 2008 836 837 18955993
  141. [176]Rufaihah A.J. Yasa C. Vaibavi Ramanujam S. Arularasu S.C. Kofidis T. Guler M.O. Tekinay A.B. Angiogenic peptide nanofibers repair cardiac tissue defect after myocardial infarction Acta Biomater. 58 2017 102 112 28600129
  142. [177]Uzunalli G. Tomas Y. Delibasi T. Yasa O. Mercan S. Guler M.O. Tekinay A.B. Improving pancreatic islet in vitro functionality and transplantation efficiency by using heparin mimetic peptide nanofiber gels Acta Biomater. 22 2015 8 18 25931015
  143. [178]Fernández-Muiños T. Recha-Sancho L. López-Chicón P. Castells-Sala C. Mata A. Semino C.E. Bimolecular based heparin and self-assembling hydrogel for tissue engineering applications Acta Biomater. 16 1 2015 35 48 25595471
  144. [179]Li Y. Wang F. Cui H. Peptide‐based supramolecular hydrogels for delivery of biologics Bioeng. Transl. Med. 1 3 2016 306 322 28989975 PMC5629974
  145. [180]Vickers S.M. Squitieri L.S. Spector M. Effects of cross-linking type II collagen-GAG scaffolds on chondrogenesis in vitro: dynamic pore reduction promotes cartilage formation Tissue Eng. 12 2006 1345 1355 16771647
  146. [181]Pang Y. Greisler H.P. Using a type I collagen-based system to understand cell-scaffold interactions and to deliver chimeric collagen-binding growth factors for vascular tissue engineering J. Investig. Med. Off. Publ. Am. Fed. Clin. Res. 58 2010 845 848 10.231/JIM.0b013e3181ee81f7 PMC2950018 20683346
  147. [182]Han S. Wang B. Jin W. Xiao Z. Li X. Ding W. Kapur M. Chen B. Yuan B. Zhu T. Wang H. Wang J. Dong Q. Liang W. Dai J. The linear-ordered collagen scaffold-BDNF complex significantly promotes functional recovery after completely transected spinal cord injury in canine Biomaterials 41 2015 89 96 25522968
  148. [183]Chen X. Fan Y. Xiao Z. Li X. Yang B. Zhao Y. Hou X. Han S. Dai J. Promotion of transplanted collagen scaffolds combined with brain-derived neurotrophic factor for axonal regeneration and motor function recovery in rats after transected spinal cord injury Chin. J. Reparative Reconstr. Surg. 32 6 2018 650 659 PMC8413998 29905040
  149. [184]Serena E. Flaibani M. Carnio S. Boldrin L. Vitiello L. De Coppi P. Elvassore N. Electrophysiologic stimulation improves myogenic potential of muscle precursor cells grown in a 3D collagen scaffold Neurol. Res. 30 2008 207 214 18397614
  150. [185]Bhattarai D.P. Aguilar L.E. Park C.H. Kim C.S. A review on properties of natural and synthetic based electrospun fibrous materials for bone tissue engineering Membranes 8 2018 62 PMC6160934 30110968
  151. [186]Onuma-Ukegawa M. Bhatt K. Hirai T. Kaburagi H. Saotome S. Wakabayashi Y. Ichinose S. Shinomiya K. Okawa A. Enomoto M. Bone marrow stromal cells combined with a honeycomb collagen sponge facilitate neurite elongation in bitro and neural restoration in the hemisected rat spinal cord Cell Transplant. 24 7 2015 1283 1297 24911956
  152. [187]Tseng T.C. Tao L. Hsieh F.Y. Wei Y. Chiu I.M. Hsu S.H. An injectable, self-healing hydrogel to repair the central nervous system Adv. Mater. 27 2015 3518 3524 25953204
  153. [188]Mackova H. Plichta Z. Proks V. Kotelnikov I. Kucka J. Hlidkova H. Horak D. Kubinova S. Jirakova K. RGDS- and SIKVAVS-modifiedsuperporous poly(2-hydroxyethyl methacrylate) scaffolds for tis-sue engineering applications Macromol. Biosci. 16 2016 1621 1631 27460202
  154. [189]Zaviskova K. Tukmachev D. Dubisova J. Vackova I. Hejcl A. Bystronova J. Pravda M. Scigalkova I. Sulakova R. Velebny V. Wolfova L. Kubinova S. Injectable hydroxyphenyl derivative of hyaluronic acid hydrogel modifiedwith RGD as scaffold for spinal cord injury repair J. Biomed. Mater. Res. A 106 4 2017 1129 1140 29266693
  155. [190]Almeida R. Vasconcelos D.P. Goncalves R.M. Barbosa M.A. Enhanced mesenchymal stromal cell recruitment via natural killer cells by incorporation of inflammatory signals in biomaterials J. R. Soc. Interface 9 2012 261 271 21752807 PMC3243397
  156. [191]Mata M. Milian L. Oliver M. Zurriaga J. Sancho-Tello M. de Llano J.J.M. Carda C. In vivo articular cartilage regeneration using human dental pulp stem cells cultured in an alginate scaffold: a preliminary study Stem Cell. Int. 2017 e8309256 2017 PMC5603743 28951745
  157. [192]Wang Y. Blasioli D.J. Kim H.-J. Kim H.S. Kaplan D.L. Cartilage tissue engineering with silk scaffolds and human articular chondrocytes Biomaterials 27 2006 4434 4442 16677707
  158. [193]Kardestuncer T. McCarthy M. Karageorgiou V. Kaplan D. Gronowicz G. RGD-tethered silk substrate stimulates the differentiation of human tendon cells Clin. Orthop. Relat. Res. 448 2006 234 239 16826121
  159. [194]Cai Z.-X. Mo X.-M. Zhang K.-H. Fan L.-P. Yin A.-l. He C.-l. Fabrication of chitosan/silk fibroin composite nanofibers for wound dressing applications Int. J. Mol. Sci. 11 2010 3529 3539 20957110 PMC2956110
  160. [196]Monteiro I.P. Shukla A. Marques A.P. Reis R.L. Hammond P.T. Spray-assisted layer-by-layer assembly on hyaluronic acid scaffolds for skin tissue engineering J. Biomed. Mater. Res. A. 103 2015 330 340 24659574
  161. [197]Lin C.‐W. Chen Y.‐K. Tang K.‐C. Yang K.‐C. Cheng N.‐C. Yu J. Keratin scaffolds with human adipose stem cells: physical and biological effects toward wound healing J. Tissue Eng. Regenerat. Med. 13 6 2019 1044 1058 30938939
  162. [199]Elsayed Y. Lekakou C. Labelled F. Tomlins P. Smooth muscle tissue engineering in crosslinked electrospun gelatin scaffolds J. Biomed. Mater. Res. A 2015 313 321 26378902
  163. [200]Hsu F.Y. Hung Y.S. Liou H.M. Shen C.H. Electrospun hyaluronate-collagen nanofibrous matrix and the effects of varying the concentration of hyaluronate on the characteristics of foreskin fibroblast cells Acta Biomater. 6 6 2010 2140 2147 20035907
  164. [201]Zhang Q. Shi B. Ding J. Yan L. Thawani J.P. Fu C. Chen X. Polymer scaffolds facilitate spinal cord injury repair Acta Biomater. 88 2019 57 77 30710714
  165. [202]Stratton S. Shelke N.B. Hoshino K. Rudraiah S. Kumbar S.G. Bioactive polymeric scaffolds for tissue engineering Bioact. Mater. 1 2 2016 93 108 28653043 PMC5482547
  166. [204]Neves S.C. Teixeira L.S.M. Moroni L. Reis R.L. Van Blitterswijk C.A. Alves N.M. Karperien M. Mano J.F. Chitosan/Poly (ϵ-caprolactone) blend scaffolds for cartilage repair Biomaterials 32 2011 1068 1079 20980050
  167. [205]Kenar H. Ozdogan C.Y. Dumlu C. Doger E. Kose G.T. Hasirci V. Microfibrous scaffolds from poly(l-lactide-co-ε-caprolactone) blended with xeno-free collagen/hyaluronic acid for improvement of vascularization in tissue engineering applications Mater. Sci. Eng. C 97 2019 31 44 30678916
  168. [206]Yao C.-H. Lee C.-Y. Huang C.-H. Chen Y.-S. Chen K.-Y. Novel bilayer wound dressing based on electrospun gelatin/keratin nanofibrous mats for skin wound repair Mater. Sci. Eng. C Mater. Biol. Appl. 79 2017 533 540 28629050
  169. [207]Wen Y.J. Yu S.K. Wu Y.H. Ju R.K. Wang H. Liu Y.J. Wang Y. Xu Q.Y. Spinal cord injury repair by implantation of the structured hyaluronic acid scaffold with PLGA microspheres in the rat Cell Tissue Res. 364 1 2016 17 28 26463048
  170. [208]Xu T. Binder K.W. Albanna M.Z. Dice D. Zhao W. Yoo J.J. Atala A. Hybrid printing of mechanically and biologically improved constructs for cartilage tissue engineering applications Biofabrication 5 1 2013 015001 23172542
  171. [209]Kolesky D.B. Homan K.A. Skylar-Scott M.A. Lewis J.A. Three-dimensional bioprinting of thick vascularized tissues Proc. Natl. Acad. Sci. U.S.A. 113 12 2016 3179 3184 26951646 PMC4812707
  172. [210]Colosi C. Shin S.R. Manoharan V. Massa S. Costantini M. Barbetta A. Dokmeci M.R. Dentini M. Khademhosseini A. Microfluidic bioprinting of heterogeneous 3D tissue constructs using low-viscosity bioink Adv. Mater. 28 4 2016 677 684 26606883 PMC4804470
  173. [211]Duan B. Kapetanovic E. Hockaday L.A. Butcher J.T. Three-dimensional printed trileaflet valve conduits using biological hydrogels and human valve interstitial cells Acta Biomater. 10 5 2014 1836 1846 24334142 PMC3976766
  174. [212]Skardal A. Devarasetty M. Kang H.W. Mead I. Bishop C. Shupe T. Lee S.J. Jackson J. Yoo J. Soker S. Atala A. A hydrogel bioink toolkit for mimicking native tissue biochemical and mechanical properties in bioprinted tissue constructs Acta Biomater. 25 2015 24 34 26210285
  175. [213]Huang S. Yao B. Xie J. Fu X. 3D bioprinted extracellular matrix mimics facilitate directed differentiation of epithelial progenitors for sweat gland regeneration Acta Biomater. 32 2016 170 177 26747979
  176. [215]Yeo M. Lee J.S. Chun W. Kim G.H. An innovative collagen-based cell-printing method for obtaining human adipose stem cell-laden structures consisting of core-sheath structures for tissue engineering Biomacromolecules 17 4 2016 1365 1375 26998966
  177. [216]Severa M. Turkyilmaz M. Sevinc C. Cakir A. Ocalan B. Cansev M. Guler M.O. Tekinay A.B. Regenerative effects of peptide nanofibers in an experimental model of Parkinson's disease Acta Biomater. 46 2016 79 90 27619838
  178. [217]Patient J.D. Hajiali H. Harris K. Abrahamsson B. Tannergren C. White L.J. Ghaemmaghami A.M. Williams P.M. Roberts C.J. Rose F.R.A.J. Nanofibrous scaffolds support a 3D in vitro permeability model of the human intestinal epithelium Front. Pharmacol. 10 2019 456 31133850 PMC6524416
  179. [218]Tiwari A.P. Hwang T.I. Oh J.M. Maharjan B. Chun S. Kim B.S. Joshi M.K. Park C.H. Kim C.S. pH/nir-responsive polypyrrole-functionalized fibrous localized drug-delivery platform for synergistic cancer therapy ACS Appl. Mater. Interfaces 10 24 2018 20256 20270 29808986
  180. [219]Kim J.I. Kim J.Y. Park C.H. Fabrication of transparent hemispherical 3D nanofibrous scaffolds with radially aligned patterns via a novel electrospinning method Sci. Rep. 8 2018 3424 29467436 PMC5821851
  181. [220]Byoung Soo K. Jung-Seob L. Ge G. Dong-Woo C. Direct 3D cell-printing of human skin with functional transwell system Biofabrication 9 2 2017 025034 28586316
  182. [221]Albright V. Xu M. Palanisamy A. Cheng J. Stack M. Zhang B. Jayaraman A. Sukhishvili S.A. Wang H. Micelle‐coated, hierarchically structured nanofibers with dual‐release capability for accelerated wound healing and infection control Adv. Healthc. Mater. 7 11 2018 e1800132 PMC6347427 29683273
  183. [222]Garrigues N.W. Little D. Sanchez-Adams J. Ruch D.S. Guilak F. Electrospun cartilage-derived matrix scaffolds for cartilage tissue engineering J. Biomed. Mater. Res. A 102 11 2014 3998 4008 24375991 PMC4063882
  184. [223]Hackelberg S. Tuck S.J. He L. Rastogi A. White C. Liu L. Prieskorn D.M. Miller R.J. Chan C. Loomis B.R. Corey J.M. Miller J.M. Duncan R.K. Nanofibrous scaffolds for the guidance of stem cell-derived neurons for auditory nerve regeneration PLoS One 12 7 2017 e0180427 PMC5495534 28672008
  185. [224]Gong Y.H. He L.J. Li J. Zhou Q.L. Ma Z.W. Gao C.Y. Shen J.C. Hydrogel-filled polylactide porous scaffolds for cartilage tissue engineering J. Biomed. Mater. Res. B. 82 2007 192 204 17106896
  186. [226]Pei B. Wang W. Fan Y. Wang X. Watari F. Li X. Fiber-reinforced scaffolds in soft tissue engineering Regen. Biomater. 4 4 2017 257 268 28798872 PMC5544910
  187. [227]Zhou J. Xu C. Wu G. Cao X. Zhang L. Zhai Z. Zheng Z. Chen X. Wang Y. In vitro generation of osteochondral differentiation of human marrow mesenchymal stem cells in novel collagen-hydroxyapatite layered scaffolds Acta Biomater. 7 11 2011 3999 4006 21757035
  188. [228]Xue D. Zheng Q. Zong C. Li Q. Li H. Qian S. Zhang B. Yu L. Pan Z. Osteochondral repair using porous poly(lactide-co-glycolide)/nano-hydroxyapatite hybrid scaffolds with undifferentiated mesenchymal stem cells in a rat model J. Biomed. Mater. Res. 94A 1 2010 259 270 20166224
  189. [230]Hong S.M. Kim J.W. Knowles J.C. Gong M.S. Facile preparation of antibacterial, highly elastic silvered polyurethane nanofiber fabrics using silver carbamate and their dermal wound healing properties J. Biomater. Appl. 31 7 2017 1026 1038 28077051
  190. [231]Amna T. Hassan M.S. Yang J. Khil M.S. Song K.D. Oh J.D. Hwang I. Virgin olive oil blended polyurethane micro/nanofibers ornamented with copper oxide nanocrystals for biomedical applications Int. J. Nanomed. 9 2014 891 898 PMC3928461 24611006
  191. [232]Yu K. Zhu T. Wu Y. Zhou X. Yang X. Wang J. Fang J. El-Hamshary H. Al-Deyab S.S. Mo X. Incorporation of amoxicillin-loaded organic montmorillonite into poly(ester-urethane) urea nanofibers as a functional tissue engineering scaffold Colloids Surfaces B Biointerfaces 151 2017 314 323 28040663
  192. [233]Altinbasak I. Jijie R. Barras A. Golba B. Sanyal R. Bouckaert J. Drider D. Bilyy R. Dumych T. Paryzhak S. Vovk V. Boukherroub R. Sanyal A. Sanyal A. Sabine Szunerits Reduced graphene-oxide-embedded polymeric nanofiber mats: an “on-demand” photothermally triggered antibiotic release platform ACS Appl. Mater. Interfaces 10 48 2018 41098 41106 30376295
  193. [234]Jiang W. Li M. Chen Z. Leong K.W. Cell-laden microfluidic microgels for tissue regeneration Lab Chip 16 23 2016 4482 4506 27797383 PMC5110393
  194. [235]Kolesky D.B. Truby R.L. Gladman A.S. Busbee T.A. Homan K.A. Lewis J.A. 3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs Adv. Mater. 26 2014 3124 3130 24550124
  195. [236]Tasoglu S. Demirci U. Bioprinting for stem cell research Trends Biotechnol. 31 2013 10 19 23260439 PMC3534918
  196. [237]Guillotin B. Souquet A. Catros S. Duocastella M. Pippenger B. Bellance S. Bareille R. Rémy M. Bordenave L. Amédée J. Guillemot F. Laser-assisted bioprinting of engineered tissue with high cell density and microscale organization Biomaterials 31 2010 7250 7256 20580082
  197. [238]Mironov V. Visconti R.P. Kasyanov V. Forgacs G. Drake C.J. Markwald R.R. Organ printing: tissue spheroids building blocks Biomaterials 30 2009 2164 2174 19176247 PMC3773699
  198. [239]Bishop E.S. Mostafa S. Pakvasa M. Luu H.H. Lee M.J. Wolf J.M. Ameer G.A. He T.-C. Reid R.R. 3-D bioprinting technologies in tissue engineering and regenerative medicine: current and future trends Genes Dis 4 4 2017 185 195 29911158 PMC6003668
  199. [241]Kang H.-W. Lee S.J. Ko I.K. Kengla C. Yoo J.J. Atala A. A 3D bioprinting system to produce human-scale tissue constructs with structural integrity Nat. Biotechnol. 34 2016 312 319 26878319
  200. [242]Gu Q. Tomaskoviccrook E. Lozano R. Chen Y. Kapsa R.M. Zhou Q. Wallace G.G. Crook J.M. Functional 3D neural mini-tissues from printed gel-based bioink and human neural stem cells Adv. Healthc. Mater. 5 12 2016 1429 1438 27028356

200 of 215 shown

Cited by

Sorted by citations

Authors
Nikolova, M. P., & Chavali, M. S.
Affiliations
Angel Kanchev University of Ruse (BG)
Corresponding author
Nikolova, Maria P.
ORCID
Venue
Bioactive Materials
Publisher
Elsevier BV
Published
2019-12
Volume
4
Pages
271-292
ISSN
  • 2097-1192 (ISSN-L)
  • 2452-199X
DOI
10.1016/j.bioactmat.2019.10.005
PMC
PMC6829098
OpenAlex
W2981661151
Cited by
907
References
3
Citations by year
2026: 51 · 2025: 129 · 2024: 158 · 2023: 167 · 2022: 174 · 2021: 165 · 2020: 61 · 2019: 2
FWCI
34.56
Type
journal article
Language
en
Open access
Licence
Locations
  • Bioactive Materials (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Bulgarian National Science Fund (DN 07/3 (2016)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
3D scaffolds, biomaterials, tissue engineering, 3D bioprinting, cell-laden scaffolds, composite scaffolds, ceramic biomaterials, polymer scaffolds, growth factor delivery, drug delivery, gene delivery, bioactive ions, hard tissue engineering, soft tissue engineering, biomimetic structures, tissue regeneration

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review