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Cited by 270Hemostasis and retained surgical itemsHydrogels: synthesis, properties, applicationsSurgical Sutures and Adhesives

A mussel-inspired supramolecular hydrogel with robust tissue anchor for rapid hemostasis of arterial and visceral bleedings

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Qiao, Ziwen, Lv, Xueli, He, Shaohua, Bai, Shumeng, Liu, Xiaochen, Hou, Linxi, He, Jingjing, Tong, Dongmei +4 more·2021·Bioactive Materials
DOI 10.1016/j.bioactmat.2021.01.039PMC PMC7905459
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Abstract

In recent years, the developed hemostatic technologies are still difficult to be applied to the hemostasis of massive arterial and visceral hemorrhage, owing to their weak hemostatic function, inferior wet tissue adhesion, and low mechanical properties. Herein, a mussel-inspired supramolecular interaction-cross-linked hydrogel with robust mechanical property (308.47 ± 29.20 kPa) and excellent hemostatic efficiency (96.5% ± 2.1%) was constructed as a hemostatic sealant. Typically, we combined chitosan (CS) with silk fibroin (SF) by cross-linking them through tannic acid (TA) to maintain the structural stability of the hydrogel, especially for wet tissue adhesion ability (shear adhesive strength = 29.66 ± 0.36 kPa). Compared with other materials reported previously, the obtained CS/TA/SF hydrogel yielded a lower amount of blood loss and shorter time to hemostasis in various arterial and visceral bleeding models, which could be ascribed to the synergistic effect of wound closure under wet state as well as intrinsic hemostatic activity of CS. As a superior hemostatic sealant, the unique hydrogel proposed in this work can be exploited to offer significant advantages in the acute wound and massive hemorrhage with the restrictive access of therapeutic moieties.

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  • These hydrogels are mainly designed as tissue adhesives, hemostatic sealants, nanocomposite gels, drug carriers, hydrogel bioelectrodes, and anti-adhesion gel coatings.

    “These hydrogels are mainly designed as tissue adhesives [61,87] (for wound closure and healing), hemostatic sealants [75,88] (for hemostasis), nanocomposite gels [41,89] (for bone repair), drug carriers [42,90] (for drug delivery), hydrogel bioelectrodes [44] (for smart sensors), and anti-adhesion gel coatings [45] (for biological coatings) (Figure 7).”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [88]

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Research works printed but not linked: 34

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Authors
Qiao, Z., Lv, X., He, S., Bai, S., Liu, X., Hou, L., He, J., Tong, D., Ruan, R., Zhang, J., Ding, J., & Yang, H.
Affiliations
  • Fuzhou University (CN)
  • Fujian Provincial Hospital (CN)
  • Chinese Academy of Sciences (CN)
Corresponding author
  • Zhang, Jin
  • Ding, Jianxun
  • Yang, Huanghao
ORCID
Venue
Bioactive Materials
Publisher
Elsevier BV
Published
2021-09
Volume
6
Issue
9
Pages
2829-2840
ISSN
  • 2097-1192 (ISSN-L)
  • 2452-199X
DOI
10.1016/j.bioactmat.2021.01.039
PMC
PMC7905459
OpenAlex
W3135565737
Cited by
270
References
50
Citations by year
2026: 14 · 2025: 49 · 2024: 57 · 2023: 53 · 2022: 70 · 2021: 27
FWCI
33.82
Type
journal article
Language
en
Open access
Licence
Locations
  • Bioactive Materials (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • First Hospital of Jilin University
  • National Natural Science Foundation of China (51903050)
  • Natural Science Foundation of Fujian Province (2019J01258)
  • Sichuan University (sklpme2019-4-34)
  • State Key Laboratory of Polymer Materials Engineering
Topics
  • Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
Keywords
hemostatic hydrogel, mussel-inspired materials, supramolecular cross-linking, chitosan, silk fibroin, tannic acid, arterial hemorrhage, tissue adhesion, hemostatic sealant, wound closure, massive hemorrhage

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