The DOI matches its Crossref record; 183 of the 183 references it cites were found in a registry or an index.
An overview of substrate stiffness guided cellular response and its applications in tissue regeneration
Open accessAbstract
Cell-matrix interactions play a critical role in tissue repair and regeneration. With gradual uncovering of substrate mechanical characteristics that can affect cell-matrix interactions, much progress has been made to unravel substrate stiffness-mediated cellular response as well as its underlying mechanisms. Yet, as a part of cell-matrix interaction biology, this field remains in its infancy, and the detailed molecular mechanisms are still elusive regarding scaffold-modulated tissue regeneration. This review provides an overview of recent progress in the area of the substrate stiffness-mediated cellular responses, including 1) the physical determination of substrate stiffness on cell fate and tissue development; 2) the current exploited approaches to manipulate the stiffness of scaffolds; 3) the progress of recent researches to reveal the role of substrate stiffness in cellular responses in some representative tissue-engineered regeneration varying from stiff tissue to soft tissue. This article aims to provide an up-to-date overview of cell mechanobiology research in substrate stiffness mediated cellular response and tissue regeneration with insightful information to facilitate interdisciplinary knowledge transfer and enable the establishment of prognostic markers for the design of suitable biomaterials.
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Cites
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Cited by
Hakim Khalili, M., Zhang, R., Wilson, S., Goel, S., Impey, S. A., & Aria, A. I. (2023) · Polymers · doi:10.3390/polym15102341 · Cited by 114
Unraveling the Role of the Tumor Extracellular Matrix to Inform Nanoparticle Design for Nanomedicine
Cassani, M., Fernandes, S., Pagliari, S., Cavalieri, F., Caruso, F., & Forte, G. (2025) · Advanced Science · doi:10.1002/advs.202409898 · Cited by 48
Nawroth, J. C., Roth, D., van Schadewijk, A., Ravi, A., Maulana, T. I., Senger, C. N., van Riet, S., Ninaber, D. K., de Waal, A. M., Kraft, D., et al. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100713 · Cited by 46
Zhang, Y., Dai, J., Hang, R., Yao, X., Bai, L., Wang, H., Huang, D., & Hang, R. (2024) · Biomaterials Advances · doi:10.1016/j.bioadv.2024.214010 · Cited by 26
Metadata
- Authors
- Yi, B., Xu, Q., & Liu, W.
- Venue
- Bioactive Materials
- Publisher
- Elsevier BV
- Published
- 2022-09
- Volume
- 15
- Pages
- 82-102
- ISSN
- 2097-1192 (ISSN-L)
- 2452-199X
- OpenAlex
- W4200173546
- Cited by
- 304
- References
- 183
- FWCI
- 18.39
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yi, B., Xu, Q., & Liu, W. (2022). An overview of substrate stiffness guided cellular response and its applications in tissue regeneration. Bioactive Materials. https://doi.org/10.1016/j.bioactmat.2021.12.005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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