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Cited by 1143D Printing in Biomedical ResearchHydrogels: synthesis, properties, applicationsAdditive Manufacturing and 3D Printing Technologies

Additive Manufacturing and Physicomechanical Characteristics of PEGDA Hydrogels: Recent Advances and Perspective for Tissue Engineering

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Hakim Khalili, Mohammad, Zhang, Rujing, Wilson, Sandra, Goel, Saurav, Impey, Susan A., Aria, Adrianus Indrat·2023·Polymers
DOI 10.3390/polym15102341PMC PMC10221499
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Abstract

In this brief review, we discuss the recent advancements in using poly(ethylene glycol) diacrylate (PEGDA) hydrogels for tissue engineering applications. PEGDA hydrogels are highly attractive in biomedical and biotechnology fields due to their soft and hydrated properties that can replicate living tissues. These hydrogels can be manipulated using light, heat, and cross-linkers to achieve desirable functionalities. Unlike previous reviews that focused solely on material design and fabrication of bioactive hydrogels and their cell viability and interactions with the extracellular matrix (ECM), we compare the traditional bulk photo-crosslinking method with the latest three-dimensional (3D) printing of PEGDA hydrogels. We present detailed evidence combining the physical, chemical, bulk, and localized mechanical characteristics, including their composition, fabrication methods, experimental conditions, and reported mechanical properties of bulk and 3D printed PEGDA hydrogels. Furthermore, we highlight the current state of biomedical applications of 3D PEGDA hydrogels in tissue engineering and organ-on-chip devices over the last 20 years. Finally, we delve into the current obstacles and future possibilities in the field of engineering 3D layer-by-layer (LbL) PEGDA hydrogels for tissue engineering and organ-on-chip devices.

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  • PEG derivatives such as PEG-diacrylate or PEG-polyesters have been developed to enhance mechanical stability and control degradation rates for optimized anti-adhesion applications.

    “In response, PEG derivatives, such as PEG–diacrylate or PEG–polyesters, have been developed to enhance mechanical stability and control degradation rates for optimized anti-adhesion applications [220,221,222].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [222]

    Section 2.2 identifies PEGDA as a PEG derivative and says its mechanical properties and degradation rate can be modified. Section 3.1 also discusses the stability and degradation of PEGDA-based hydrogels. The cited paper does not establish that these derivatives were developed for anti-adhesion applications, and the passages do not substantiate the claim about PEG–polyesters. (LLM, conf=0.87)

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Cited by

Sorted by citations

Authors
Hakim Khalili, M., Zhang, R., Wilson, S., Goel, S., Impey, S. A., & Aria, A. I.
Affiliations
  • Surface Engineering and Precision Centre, School of Aerospace, Transport and Manufacturing, Cranfield University, Bedford MK43 0AL, UK
  • Sophion Bioscience A/S, Baltorpvej 154, 2750 Copenhagen, Denmark
  • London South Bank University (GB)
  • Cranfield University (GB)
Corresponding author
Aria, Adrianus Indrat
ORCID
Venue
Polymers
Publisher
MDPI AG
Published
2023-05-17
Volume
15
Issue
10
Pages
2341
ISSN
2073-4360 (ISSN-L)
DOI
10.3390/polym15102341
PMC
PMC10221499
OpenAlex
W4377104324
Cited by
114
References
4
Citations by year
2026: 45 · 2025: 44 · 2024: 19 · 2023: 6
FWCI
2.48
Type
journal article
Language
en
Open access
Licence
Locations
  • Polymers (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Open (London South Bank University) (acceptedVersion, cc-by)
  • CERES (Cranfield University) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • UKRI (EP/L016567/1, EP/S036180/1, EP/T024607/1, EP/V029746/1, TSP1332)
  • UKRI National Interdisciplinary Circular Economy Hub (EP/L016567/1, EP/S036180/1, EP/T024607/1, EP/V029746/1, TSP1332)
  • Royal Academy of Engineering (EP/L016567/1, EP/S036180/1, EP/T024607/1, EP/V029746/1, TSP1332)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Engineering › Automotive Engineering › Additive Manufacturing and 3D Printing Technologies
Keywords
PEGDA hydrogel, poly(ethylene glycol) diacrylate, 3D printing, additive manufacturing, tissue engineering, photocrosslinking, mechanical properties, physicochemical properties, extracellular matrix

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