The neuronal class 2 TSR proteins F-spondin and Mindin: a small family with divergent biological activities
Abstract
F-spondin and Mindin are members of a subgroup of the thrombospondin type 1 (TSR) class molecules, defined by two domains of homology, the FS1/FS2 and TSR domains. The TSRs of F-spondin proteins are typical of class 2 TSRs. F-spondin and Mindin are evolutionarily conserved proteins. The embryonic expression of the vertebrate genes is enriched in the nervous system, mainly at the floor plate and the hippocampus. Similar to thrombospondin, F-spondin and Mindin are extracellular matrix attached molecules that promote neurite outgrowth and inhibit angiogenesis. Analysis of gain and loss of function experiments reveal that F-spondin is required for accurate pathfinding of embryonic axons. F-spondin plays a dual role in patterning axonal trajectories: it promotes the outgrowth of commissural and inhibits the outgrowth of motor axons. Macrophages of Mindin-deficient mice exhibit defective responses to a broad spectrum of microbial stimuli. This may implicate Mindin and F-spondin in inflammatory processes in the nervous system.
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Spon2 is known to facilitate neurite outgrowth of hippocampal neurons.
“Spon2 is known to facilitate neurite outgrowth of hippocampal neurons39,40.”
From Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses (2019) · cites this paper as [40]
Cites
Reelin Is a Secreted Glycoprotein Recognized by the CR-50 Monoclonal Antibody
D’Arcangelo, G., Nakajima, K., Miyata, T., Ogawa, M., Mikoshiba, K., & Curran, T. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-01-00023.1997 · Cited by 515 · see citing works
Klar, A., Baldassare, M., & Jessell, T. M. (1992) · Cell · doi:10.1016/0092-8674(92)90121-r · Cited by 390 · see citing works
Self-citationCellular signaling by neural cell adhesion molecules of the immunoglobulin superfamily
Crossin, K. L., & Krushel, L. A. (2000) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(200006)218:2 · Cited by 283 · see citing works
Crystal structure of the TSP-1 type 1 repeats
Tan, K., Duquette, M. A., Liu, J., Dong, Y., Zhang, R., Joachimiak, A., Lawler, J., & Wang, J. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200206062 · Cited by 258 · see citing works
The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens
He, Y.-W., Li, H., Zhang, J., Hsu, C.-L., Lin, E., Zhang, N., Guo, J., Forbush, K. A., & Bevan, M. J. (2004) · Nature Immunology · doi:10.1038/ni1021 · Cited by 171 · see citing works
Heparin-binding proteins HB-GAM (pleiotrophin) and amphoterin in the regulation of cell motility
Rauvala, H., Huttunen, H. J., Fages, C., Kaksonen, M., Kinnunen, T. K., Imai, S., Raulo, E., & Kilpeläinen, I. (2000) · Matrix Biology · doi:10.1016/s0945-053x(00)00084-6 · Cited by 143 · see citing works
Mindin/F-spondin Family: Novel ECM Proteins Expressed in the Zebrafish Embryonic Axis
Higashijima, S., Nose, A., Eguchi, G., Hotta, Y., & Okamoto, H. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8760 · Cited by 134 · see citing works
Gobron, S., Monnerie, H., Meiniel, R., Creveaux, I., Lehmann, W., Lamalle, D., Dastugue, B., & Meiniel, A. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.5.1053 · Cited by 128 · see citing works
Debby-Brafman, A., Burstyn‐Cohen, T., Klar, A., & Kalcheim, C. (1999) · Neuron · doi:10.1016/s0896-6273(00)80703-5 · Cited by 126 · see citing works
Self-citationF-Spondin Is Required for Accurate Pathfinding of Commissural Axons at the Floor Plate
Burstyn‐Cohen, T., Tzarfaty, V., Frumkin, A., Feinstein, Y., Stoeckli, E. T., & Klar, A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80776-x · Cited by 124 · see citing works
Self-citationC-Mannosylation and O-Fucosylation of Thrombospondin Type 1 Repeats
de Peredo, A. G., Klein, D., Maček, B., Heß, D., Peter‐Katalinić, J., & Hofsteenge, J. (2002) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m100011-mcp200 · Cited by 116 · see citing works
Kilpeläinen, I., Kaksonen, M., Kinnunen, T. K., Avikainen, H., Fath, M. A., Linhardt, R. J., Raulo, E., & Rauvala, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.18.13564 · Cited by 111 · see citing works
Feinstein, Y., Borrell, V., Garcia, C., Burstyn-Cohen, T., Tzarfaty, V., Frumkin, A., Nose, A., Okamoto, H., Higashijima, S.-I., Soriano, E., et al. (1999) · Development · doi:10.1242/dev.126.16.3637 · Cited by 105 · see citing works
Self-citationMacrophage-mediated corpse engulfment is required for normalDrosophilaCNS morphogenesis
Sears, H. C., Kennedy, C. J., & Garrity, P. (2003) · Development · doi:10.1242/dev.00586 · Cited by 97 · see citing works
CD36 A critical anti angiogenic receptor
Simantov, R. (2003) · Frontiers in bioscience · doi:10.2741/1168 · Cited by 89 · see citing works
Altaba, A. R. I., Cox, C. M., Jessell, T. M., & Klar, A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.8268 · Cited by 87 · see citing works
Self-citationA green fluorescent protein enhancer trap screen in Drosophila photoreceptor cells
Mollereau, B., Wernet, M. F., Beaufils, P., et al. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00287-2 · Cited by 83 · see citing works
Accumulation ofF-Spondinin Injured Peripheral Nerve Promotes the Outgrowth of Sensory Axons
Burstyn‐Cohen, T., Frumkin, A., Xu, Y.-T., Scherer, S. S., & Klar, A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-21-08875.1998 · Cited by 67 · see citing works
Self-citationUmemiya, T., Takeichi, M., & Nose, A. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8591 · Cited by 62 · see citing works
Terai, Y., Abé, M., Miyamoto, K., et al. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1122 · Cited by 62 · see citing works
Savill, J., Hogg, N., & Haslett, C. (1991) · CHEST Journal · doi:10.1378/chest.99.3_supplement.6s-a · Cited by 60 · see citing works
F-spondin is a contact-repellent molecule for embryonic motor neurons
Tzarfati-Majar, V., Burstyn‐Cohen, T., & Klar, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081062398 · Cited by 57 · see citing works
Self-citationPlasmin-mediated Release of the Guidance Molecule F-spondin from the Extracellular Matrix
Tzarfaty, V., López‐Alemany, R., Feinstein, Y., Gombau, L., Goldshmidt, O., Soriano, E., Muñoz‐Cánoves, P., & Klar, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102585200 · Cited by 39 · see citing works
Self-citationEl-Bitar, F., Bamdad, M., Dastugue, B., et al. (2001) · Cell and Tissue Research · doi:10.1007/s004410100383 · Cited by 26 · see citing works
Bovine floor plate explants secrete SCO-spondin
Guinazu, M. F., Richter, H. G., & Rodríguez, E. M. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0511-5 · Cited by 18 · see citing works
Characterization of AmphiF-spondin reveals the modular evolution of chordate F-spondin genes
Shimeld, S. M. (1998) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a026029 · Cited by 11 · see citing works
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Gottschling, C., Wegrzyn, D., Denecke, B., & Faissner, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-50404-9 · Cited by 111 · see citing works
Functional Roles of the Interaction of APP and Lipoprotein Receptors
Pohlkamp, T., Wasser, C. R., & Herz, J. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00054 · Cited by 92 · see citing works
Extracellular Matrix Evolution: An Overview
Adams, J. C. (2013) · Biology of Extracellular Matrix · doi:10.1007/978-3-642-36002-2_1 · Cited by 16 · see citing works
- Authors
- Feinstein, Y., & Klar, A.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Klar, Avihu
- Venue
- The International Journal of Biochemistry & Cell Biology
- Publisher
- Elsevier BV
- Published
- 2004-06
- Volume
- 36
- Issue
- 6
- Pages
- 975-980
- ISSN
- 1357-2725 (ISSN-L)
- OpenAlex
- W1965622673
- Cited by
- 65
- References
- 26
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 3
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The International Journal of Biochemistry & Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- F-spondin, mindin, neuronal development, axon guidance, neurite outgrowth, floor plate, hippocampus, commissural axons, motor axons, extracellular matrix, angiogenesis inhibition, macrophage function, neuroinflammation, loss-of-function mutations
- MeSH terms
- Animals, Humans, Neurons, Peptides, Extracellular Matrix Proteins, Protein Structure, Tertiary, Thrombospondin 1
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