Cited by 142Inflammasome and immune disordersImmune Response and Inflammationinterferon and immune responses

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Nlrp3: An immune sensor of cellular stress and infection

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Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi·2010·The International Journal of Biochemistry & Cell Biology

DOI 10.1016/j.biocel.2010.01.008PMC PMC2862759

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Abstract

Innate immune cells rely on pathogen recognition receptors such as the nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR) family to mount an appropriate immune response against microbial threats. The NLR protein Nlrp3 senses microbial ligands, endogenous danger signals and crystalline substances in the cytosol to trigger the assembly of a large caspase-1-activating protein complex termed the Nlrp3 inflammasome. Autoproteolytic maturation of caspase-1 zymogens in the Nlrp3 inflammasome leads to maturation and extracellular release of the pro-inflammatory cytokines interleukin (IL)-1beta and IL-18. Gain-of-function mutations in the NOD domain of Nlrp3 are associated with auto-inflammatory disorders characterized by skin rashes and prolonged episodes of fever. In addition, decreased Nlrp3 expression was recently linked with susceptibility to Crohn's disease in humans. In this review, we discuss recent developments on the role of the Nlrp3 inflammasome in innate immunity, its activation mechanisms and the auto-inflammatory disorders associated with deregulation of Nlrp3 inflammasome activity.

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Authors: Lamkanfi, M., & Kanneganti, T.-D.
Affiliations: Ghent University (BE)
St. Jude Children's Research Hospital (US)
Corresponding author: Kanneganti, Thirumala-Devi
ORCID: Lamkanfi, Mohamed
Kanneganti, Thirumala-Devi
Venue: The International Journal of Biochemistry & Cell Biology
Publisher: Elsevier BV
Published: 2010-06
Volume: 42
Issue: 6
Pages: 792-795
ISSN: 1357-2725 (ISSN-L)
DOI: 10.1016/j.biocel.2010.01.008
PMC: PMC2862759
OpenAlex: W2160038863
Cited by: 140
References: 32
Citations by year: 2026: 6 · 2025: 7 · 2024: 7 · 2023: 8 · 2022: 13 · 2021: 16 · 2020: 6 · 2019: 9 · 2018: 8 · 2017: 12 · 2016: 5 · 2015: 7 · 2014: 4 · 2013: 11 · 2012: 4
FWCI: 0.90
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: The International Journal of Biochemistry & Cell Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Funders: American Lebanese Syrian Associated Charities
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords: NLRP3, NLRP3 inflammasome, NOD-like receptors, innate immunity, caspase-1, IL-1β, IL-18, Crohn's disease, pathogen recognition, damage-associated molecular patterns, inflammasome activation
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Autoimmune Diseases, Carrier Proteins, Disease Susceptibility, Humans, Immunity, Innate, Infections, Inflammation, Polymorphism, Genetic, Stress, Physiological, Multiprotein Complexes, Host-Pathogen Interactions

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Nlrp3: An immune sensor of cellular stress and infection

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