The role of NLRP3 inflammasome in type 2 inflammation related diseases
Open accessAbstract
Type 2 inflammation related diseases, such as atopic dermatitis, asthma, and allergic rhinitis, are diverse and affect multiple systems in the human body. It is common for individuals to have multiple co-existing type 2 inflammation related diseases, which can impose a significant financial and living burden on patients. However, the exact pathogenesis of these diseases is still unclear. The NLRP3 inflammasome is a protein complex composed of the NLRP3 protein, ASC, and Caspase-1, and is activated through various mechanisms, including the NF-κB pathway, ion channels, and lysosomal damage. The NLRP3 inflammasome plays a role in the immune response to pathogens and cellular damage. Recent studies have indicated a strong correlation between the abnormal activation of NLRP3 inflammasome and the onset of type 2 inflammation. Additionally, it has been demonstrated that suppressing NLRP3 expression effectively diminishes the inflammatory response, highlighting its promising therapeutic applications. Therefore, this article reviews the role of NLRP3 inflammasome in the development and therapy of multiple type 2 inflammation related diseases.
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NLRP3 is related to anxiety and depression behavior frequently found in AD through its action on the nervous system.
“Moreover, through its action on the nervous system, NLRP3 is also related to anxiety and depression behavior, frequently found in AD.69”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [69]
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Update on the pathogenesis of atopic dermatitis.
Criado, P. R., Miot, H. A., Bueno-Filho, R., Ianhez, M., Criado, R. F. J., & de Castro, C. C. S. (2024) · Anais brasileiros de dermatologia · doi:10.1016/j.abd.2024.06.001 · Cited by 66 · see citing works
- Authors
- Xu, S., Wang, D., Tan, L., & Lu, J.
- Affiliations
- Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
- Central South University (CN)
- Corresponding author
- Tan, Lina
- Lu, Jianyun
- Venue
- Autoimmunity
- Publisher
- Informa UK Limited
- Published
- 2024-02-08
- Volume
- 57
- Issue
- 1
- Pages
- 2310269-2310269
- ISSN
- 0891-6934 (ISSN-L)
- 1607-842X
- OpenAlex
- W4391691597
- Cited by
- 43
- References
- 5
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 18
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Autoimmunity (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- NLRP3 inflammasome, type 2 inflammation, atopic dermatitis, asthma, allergic rhinitis, caspase-1, ASC, NF-κB signaling, lysosomal damage, ion channel activation, inflammasome inhibition, anti-inflammatory therapy
- MeSH terms
- NLR Family, Pyrin Domain-Containing 3 Protein, Humans, Inflammation, NF-kappa B, Caspase 1, Inflammasomes
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