Dynamics of neutral lipid storage and mobilization in yeast
Abstract
We make use of the yeast Saccharomyces cerevisiae as a flexible experimental system to investigate coordinate pathways of neutral lipid synthesis, storage and mobilization with special emphasis on the role of different organelles in these processes. Recently, a number of new gene products involved in triacylglycerol (TAG) and steryl ester (STE) metabolism were identified in our laboratory and by other groups. STE are synthesized by the two STE synthases Are1p and Are2p, whereas TAG are formed mainly through the action of the two TAG synthases Dga1p and Lro1p with minor contributions of Are1p and Are2p. Once formed, TAG and STE are stored in so-called lipid particles. A dga1Deltalro1Deltaare1Deltaare2Delta quadruple mutant which lacks neutral lipid synthesis and is consequently devoid of lipid particles turned out to be a valuable tool for studying the physiological role of storage lipids and lipid particles. Mobilization of neutral lipid depots occurs through catalysis of TAG lipases and STE hydrolases. Three TAG lipases named Tgl3p, Tgl4p and Tgl5p, and three STE hydrolases named Tgl1p, Yeh1p and Yeh2p were recently identified at the molecular level. Although these hydrolases exhibit overlapping function within the enzyme families, they are specific for TAG and STE, respectively. With the exception of Dga1p, whose activity is partially localized to lipid particles, TAG and STE forming enzymes are restricted to the endoplasmic reticulum. TAG lipases and STE hydrolases are components of lipid particles with the exception of Yeh2p, which is plasma membrane located. Thus, neutral lipid metabolism is not only regulated at the enzyme level but also by the distribution of the components to organelles. The fact that neutral lipid homeostasis is linked to a number of cell biological processes confirms the important role of this class of lipids as cellular modulators or effectors.
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In yeast, the major sterol is ergosterol, which is mainly synthesized in the endoplasmic reticulum and in lipid droplets.
“In yeast, the major sterol is ergosterol, which is mainly synthesized in the endoplasmic reticulum (ER) and in lipid droplets.”
From The synthesis, regulation, and functions of sterols in<i>Candida albicans</i>: Well-known but still lots to learn (2016) · cites this paper as [16]
Cites
Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase
Zimmermann, R., Bogner‐Strauß, J. G., Haemmerle, G., Schoiswohl, G., Birner‐Gruenberger, R., Riederer, M., Lass, A., Neuberger, G., Eisenhaber, F., Hermetter, A., et al. (2004) · Science · doi:10.1126/science.1100747 · Cited by 2,121 · see citing works
Dahlqvist, A., Ståhl, U., Lenman, M., Banaś, A., Lee, M. A., Sandager, L., Ronne, H., & Stymne, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.120067297 · Cited by 883 · see citing works
Cloning of DGAT2, a Second Mammalian Diacylglycerol Acyltransferase, and Related Family Members
Cases, S., Stone, S. J., Zhou, P., Yen, E., Tow, B., Lardizabal, K. D., Voelker, T., & Farese, R. V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106219200 · Cited by 818 · see citing works
Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila
Grönke, S., Mildner, A., Fellert, S., Tennagels, N., Petry, S., Müller, G. A., Jäckle, H., & Kühnlein, R. P. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.04.003 · Cited by 621 · see citing works
The Saccharomyces cerevisiae Lipin Homolog Is a Mg2+-dependent Phosphatidate Phosphatase Enzyme*
Han, G., Wu, W. I., & Carman, G. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600425200 · Cited by 559 · see citing works
Storage Lipid Synthesis Is Non-essential in Yeast
Sandager, L., Gustavsson, M. H., Ståhl, U., Dahlqvist, A., Wiberg, E., Banaś, A., Lenman, M., Ronne, H., & Stymne, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109109200 · Cited by 538 · see citing works
Eastmond, P. J. (2006) · The Plant Cell · doi:10.1105/tpc.105.040543 · Cited by 484 · see citing works
Walter de Gruyter Berlin‐New York
Neumann, W. P. (1982) · Nachrichten aus Chemie Technik und Laboratorium · doi:10.1002/nadc.19820300305 · Cited by 469 · see citing works
Phosphatidic acid, a key intermediate in lipid metabolism
Athenstaedt, K., & Daum, G. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00822.x · Cited by 403 · see citing works
Self-citationDGAT2 Is a New Diacylglycerol Acyltransferase Gene Family
Lardizabal, K. D., Mai, J. T., Wagner, N. W., Wyrick, A., Voelker, T., & Hawkins, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106168200 · Cited by 371 · see citing works
The DGA1 Gene Determines a Second Triglyceride Synthetic Pathway in Yeast
Oelkers, P. M., Cromley, D. A., Padamsee, M., Billheimer, J. T., & Sturley, S. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111646200 · Cited by 336 · see citing works
Intracellular lipid particles of eukaryotic cells
Zweytick, D., Athenstaedt, K., & Daum, G. (2000) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/s0005-2736(00)00294-7 · Cited by 334 · see citing works
Self-citationMcDermott, M. I., Wakelam, M. J. O., & Morris, A. J. (2004) · Biochemistry and Cell Biology · doi:10.1139/o03-079 · Cited by 333 · see citing works
Carman, G. M., & Henry, S. A. (1999) · Progress in Lipid Research · doi:10.1016/s0163-7827(99)00010-7 · Cited by 325 · see citing works
Obese Yeast: Triglyceride Lipolysis Is Functionally Conserved from Mammals to Yeast
Kurat, C. F., Natter, K., Petschnigg, J., Wolinski, H., Scheuringer, K., Scholz, H., Zimmermann, R., Leber, R., Zechner, R., & Kohlwein, S. D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508414200 · Cited by 323 · see citing works
Athenstaedt, K., Zweytick, D., Jandrositz, A., Kohlwein, S. D., & Daum, G. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.20.6441-6448.1999 · Cited by 316 · see citing works
Self-citationZinser, E., Paltauf, F., & Daum, G. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.10.2853-2858.1993 · Cited by 312 · see citing works
Self-citationSterol Esterification in Yeast: A Two-Gene Process
Yang, H., Bard, M., Bruner, D. A., Gleeson, A. M., Deckelbaum, R. J., Aljinovic, G., Pohl, T., Rothstein, R. J., & Sturley, S. L. (1996) · Science · doi:10.1126/science.272.5266.1353 · Cited by 275 · see citing works
A Lecithin Cholesterol Acyltransferase-like Gene Mediates Diacylglycerol Esterification in Yeast
Oelkers, P. M., Tinkelenberg, A. H., Erdeniz, N., Cromley, D. A., Billheimer, J. T., & Sturley, S. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000144200 · Cited by 269 · see citing works
Sorger, D., & Daum, G. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.2.519-524.2002 · Cited by 226 · see citing works
Self-citationAthenstaedt, K., & Daum, G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302577200 · Cited by 222 · see citing works
Self-citationAthenstaedt, K., & Daum, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507261200 · Cited by 212 · see citing works
Self-citationFlick, J. S., & Thorner, J. W. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5861 · Cited by 192 · see citing works
Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiae
Zweytick, D., Leitner, E., Kohlwein, S. D., Yu, C., Rothblatt, J. A., & Daum, G. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01103.x · Cited by 180 · see citing works
Self-citationRegulation of Phospholipid Biosynthesis in the Yeast Saccharomyces cerevisiae
Carman, G. M., & Zeimetz, G. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.23.13293 · Cited by 179 · see citing works
Triacylglycerol biosynthesis in yeast
Sorger, D., & Daum, G. (2003) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-002-1212-4 · Cited by 172 · see citing works
Self-citationThe Enzymes of Neutral Lipid Synthesis
Buhman, K. K., Chen, H. C., & Farese, R. V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100050200 · Cited by 172 · see citing works
Yu, C., Kennedy, N. J., Chang, C. C. Y., & Rothblatt, J. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.39.24157 · Cited by 141 · see citing works
Köffel, R., Tiwari, R., Falquet, L., & Schneiter, R. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.5.1655-1668.2005 · Cited by 136 · see citing works
Toke, D. A., Bennett, W. L., Oshiro, J., Wu, W., Voelker, D. R., & Carman, G. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14331 · Cited by 127 · see citing works
A Yeast Strain Lacking Lipid Particles Bears a Defect in Ergosterol Formation
Sorger, D., Athenstaedt, K., Hrastnik, C., & Daum, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403251200 · Cited by 124 · see citing works
Self-citationInterorganelle transport of aminoglycerophospholipids
Voelker, D. R. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00051-2 · Cited by 95 · see citing works
The lipase/acyltransferase from Candida parapsilosis
Neugnot, V., Moulin, G., Dubreucq, É., & Bigey, F. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2002.02828.x · Cited by 86 · see citing works
Jandrositz, A., Petschnigg, J., Zimmermann, R., Natter, K., Scholze, H., Hermetter, A., Kohlwein, S. D., & Leber, R. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.04.005 · Cited by 72 · see citing works
YEH2/YLR020c Encodes a Novel Steryl Ester Hydrolase of the Yeast Saccharomyces cerevisiae
Müllner, H., Deutsch, G., Leitner, E., Ingolić, E., & Daum, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409914200 · Cited by 66 · see citing works
Self-citationJensen-Pergakes, K., Guo, Z., Giattina, M., Sturley, S. L., & Bard, M. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.17.4950-4957.2001 · Cited by 64 · see citing works
Apoptosis and lipoapoptosis in the fission yeast
LOW, C., Liew, L. P., Pervaiz, S., & Yang, H. (2005) · FEMS Yeast Research · doi:10.1016/j.femsyr.2005.07.004 · Cited by 37 · see citing works
Diacylglycerol pyrophosphate phosphatase in Saccharomyces cerevisiae
Oshiro, J., Han, G., & Carman, G. M. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2003.10.002 · Cited by 30 · see citing works
Valachovič, M., Klobučnı́ková, V., Griač, P., & Hapala, I. (2002) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2002.tb10996.x · Cited by 25 · see citing works
Regulation of phosphatidic acid biosynthetic enzymes in Saccharomyces cerevisiae.
Minskoff, S. A., Racenis, P. V., Granger, J. M., Larkins, L. K., Hajra, A. K., & Greenberg, M. L. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39931-4 · Cited by 24 · see citing works
Biochemistry, cell biology and molecular biology of lipids ofSaccharomyces cerevisiae
Daum, G., Lees, N. D., Bard, M., & Dickson, R. (1998) · Yeast · doi:10.1002/(sici)1097-0061(199812)14:16
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Béopoulos, A., Cescut, J., Haddouche, R., Uribelarrea, J.-L., Molina‐Jouve, C., & Nicaud, J. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.08.005 · Cited by 756 · see citing works
Zhang, M., Fan, J., Taylor, D. C., & Ohlrogge, J. B. (2009) · The Plant Cell · doi:10.1105/tpc.109.071795 · Cited by 533 · see citing works
Metabolism and Regulation of Glycerolipids in the Yeast Saccharomyces cerevisiae
Henry, S. A., Kohlwein, S. D., & Carman, G. M. (2012) · Genetics · doi:10.1534/genetics.111.130286 · Cited by 518 · see citing works
Minireview: Lipid Droplets in Lipogenesis and Lipolysis
Ducharme, N. A., & Bickel, P. E. (2008) · Endocrinology · doi:10.1210/en.2007-1713 · Cited by 513 · see citing works
Walther, T. C., & Farese, R. V. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.10.009 · Cited by 478 · see citing works
Morant, M., Jørgensen, K., Schaller, H., Pinot, F., Møller, B. L., Werck‐Reichhart, D., & Bak, S. (2007) · The Plant Cell · doi:10.1105/tpc.106.045948 · Cited by 397 · see citing works
An overview of lipid metabolism in yeasts and its impact on biotechnological processes
Béopoulos, A., Nicaud, J., & Gaillardin, C. M. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3212-8 · Cited by 392 · see citing works
Acyl-CoA:diacylglycerol acyltransferase: Molecular biology, biochemistry and biotechnology
Liu, Q., Siloto, R. M. P., Lehner, R. S., Stone, S. J., & Weselake, R. J. (2012) · Progress in Lipid Research · doi:10.1016/j.plipres.2012.06.001 · Cited by 375 · see citing works
Béopoulos, A., Chardot, T., & Nicaud, J. (2009) · Biochimie · doi:10.1016/j.biochi.2009.02.004 · Cited by 321 · see citing works
Metabolism of acyl‐lipids in <i>Chlamydomonas reinhardtii</i>
Li‐Beisson, Y., Beisson, F., & Riekhof, W. (2015) · The Plant Journal · doi:10.1111/tpj.12787 · Cited by 310 · see citing works
Cell biology of lipid droplets
Thiele, C., & Spandl, J. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.05.009 · Cited by 307 · see citing works
Kohlwein, S. D., Marten Veenhuis, A., & van der Klei, I. J. (2012) · Genetics · doi:10.1534/genetics.112.143362 · Cited by 213 · see citing works
Lipids from heterotrophic microbes: advances in metabolism research
Kosa, M., & Ragauskas, A. J. (2010) · Trends in biotechnology · doi:10.1016/j.tibtech.2010.11.002 · Cited by 202 · see citing works
Béopoulos, A., Haddouche, R., Kabran, P., Dulermo, T., Chardot, T., & Nicaud, J. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3506-x · Cited by 156 · see citing works
Single cell oils of the cold-adapted oleaginous yeast Rhodotorula glacialis DBVPG 4785
Amaretti, A., Raimondi, S., Sala, M., Roncaglia, L., Lucia, M. D., Leonardi, A., & Rossi, M. (2010) · Microbial Cell Factories · doi:10.1186/1475-2859-9-73 · Cited by 154 · see citing works
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Kohlwein, S. D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.118356 · Cited by 140 · see citing works
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Self-citationLv, Q.-Z., Yan, L., & Jiang, Y.-Y. (2016) · Virulence · doi:10.1080/21505594.2016.1188236 · Cited by 133 · see citing works
A role for seipin in lipid droplet dynamics and inheritance in yeast
Wolinski, H., Kolb, D., Hermann, S., Koning, R. I., & Kohlwein, S. D. (2011) · Journal of Cell Science · doi:10.1242/jcs.091454 · Cited by 133 · see citing works
Kong, F., Liang, Y., Légeret, B., Beyly, A., Blangy, S., Haslam, R. P., Napier, J. A., Beisson, F., Peltier, G., & Li‐Beisson, Y. (2017) · The Plant Journal · doi:10.1111/tpj.13498 · Cited by 119 · see citing works
Vorapreeda, T., Thammarongtham, C., Cheevadhanarak, S., & Laoteng, K. (2011) · Microbiology · doi:10.1099/mic.0.051946-0 · Cited by 115 · see citing works
Monitoring Lipid Droplet Dynamics in Living Cells by Using Fluorescent Probes
Tatenaka, Y., Kato, H., Ishiyama, M., Sasamoto, K., Shiga, M., Nishitoh, H., & Ueno, Y. (2019) · Biochemistry · doi:10.1021/acs.biochem.8b01071 · Cited by 103 · see citing works
Rossi, M., Buzzini, P., Cordisco, L., Amaretti, A., Sala, M., Raimondi, S., Ponzoni, C., PAGNONI, U. M., & Matteuzzi, D. (2009) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2009.00727.x · Cited by 103 · see citing works
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Patkar, R., Ramos‐Pamplona, M., Gupta, A. P., Yang, F., & Naqvi, N. I. (2012) · Molecular Microbiology · doi:10.1111/mmi.12060 · Cited by 96 · see citing works
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Wang, C.-W. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1903-5 · Cited by 88 · see citing works
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Bouvier‐Navé, P., Berna, A., Noiriel, A., Compagnon, V., Carlsson, A. S., Banaś, A., Stymne, S., & Schaller, H. (2009) · PLANT PHYSIOLOGY · doi:10.1104/pp.109.145672 · Cited by 77 · see citing works
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Tronchoni, J., Rozés, N., Querol, A., & Guillamón, J. M. (2012) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2012.02.004 · Cited by 73 · see citing works
Gajdoš, P., Ledesma‐Amaro, R., Nicaud, J., Čertík, M., & Rossignol, T. (2016) · FEMS Yeast Research · doi:10.1093/femsyr/fow062 · Cited by 71 · see citing works
Najjar, A., Robert, S., Guérin, C., Asther, M., & Carrière, F. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-010-2993-5 · Cited by 69 · see citing works
Rajakumari, S., Rajasekharan, R., & Daum, G. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.08.004 · Cited by 64 · see citing works
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An Energy-Independent Pro-longevity Function of Triacylglycerol in Yeast
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Lipid Metabolism in Microalgae
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Enshaeieh, M., Nahvi, I., & Madani, M. (2013) · International Journal of Environmental Science and Technology · doi:10.1007/s13762-013-0373-2 · Cited by 43 · see citing works
Li, X., Pan, Y., & Hu, H. (2018) · Algal Research · doi:10.1016/j.algal.2018.06.023 · Cited by 41 · see citing works
Lige, B., Sampels, V., & Coppens, I. (2013) · Molecular Microbiology · doi:10.1111/mmi.12142 · Cited by 41 · see citing works
Ribeiro, T. D. P., Fonseca, F. L., de Carvalho, M. D. C., Godinho, R. M. D. C., de Almeida, F. P., Saint’Pierre, T. D., Rey, N. A., Fernandes, C., Horn, A., & Pereira, M. D. (2016) · Biochemical Journal · doi:10.1042/bcj20160480 · Cited by 38 · see citing works
Engineering of Saccharomyces cerevisiae for the accumulation of high amounts of triacylglycerol
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Filippucci, S., Tasselli, G., Scardua, A., Mauro, S. D., Cramarossa, M. R., Perini, D., Turchetti, B., Onofri, A., Forti, L., & Buzzini, P. (2016) · Biotechnology for Biofuels · doi:10.1186/s13068-016-0672-1 · Cited by 29 · see citing works
Niu, Y., Wang, C., Xiong, Q., Yang, X., Chi, D., Li, P., Liu, H., Li, J., & Huang, R. (2014) · Theriogenology · doi:10.1016/j.theriogenology.2014.09.002 · Cited by 24 · see citing works
Sineli, P. E., Maza, D. D., Aybar, M. J., de Figueroa, L. I. C., & Viñarta, S. C. (2022) · Energy Conversion and Management X · doi:10.1016/j.ecmx.2022.100331 · Cited by 23 · see citing works
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Kaliszewski, P., Szkopińska, A., Ferreira, T., Świeżewska, E., Bergès, T., & Żołądek, T. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.07.011 · Cited by 19 · see citing works
Jeennor, S., Anantayanon, J., Panchanawaporn, S., Khoomrung, S., Chutrakul, C., & Laoteng, K. (2019) · Gene · doi:10.1016/j.gene.2019.04.074 · Cited by 18 · see citing works
Viñarta, S. C., Angelicola, M. V., Nieuwenhove, C. P. V., Aybar, M. J., & de Figueroa, L. I. C. (2020) · Biotechnology Letters · doi:10.1007/s10529-020-02796-2 · Cited by 18 · see citing works
Genome mining of fungal lipid-degrading enzymes for industrial applications
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Liu, Z., Yu, K., Wu, S., Weng, X., Luo, S., Zeng, M., Wang, X., & Hu, X. (2022) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2022.110090 · Cited by 15 · see citing works
Lipid droplets alleviate cadmium induced cytotoxicity in Saccharomyces cerevisiae
Rajakumar, S., & Nachiappan, V. (2016) · Toxicology Research · doi:10.1039/c6tx00187d · Cited by 13 · see citing works
da Rosa, P. D., Mattanna, P., Carboni, D. D. S., Amorim, L. L., Richards, N. S. P. D. S., & Valente, P. (2014) · Folia Microbiologica · doi:10.1007/s12223-014-0325-3 · Cited by 13 · see citing works
Oleaginous Fungi in Biorefineries
Zhu, S., Bonito, G. M., Chen, Y., & Du, Z. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819990-9.00004-4 · Cited by 13 · see citing works
Zhang, T., Li, Y., Li, X., Gu, W., Moeketsi, E. K., Zhou, R., Zheng, X., Zhang, Z., & Zhang, H. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2021.811041 · Cited by 11 · see citing works
The role of lipids in the morphogenetic processes of mycelial fungi
Mysyakina, I. S., & Феофилова, Е. П. (2011) · Microbiology · doi:10.1134/s0026261711030155 · Cited by 10 · see citing works
Amaretti, A., Raimondi, S., Sala, M., Roncaglia, L., Lucia, M. D., Leonardi, A., & Rossi, M. (2010) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.3303/cet1020019 · Cited by 10 · see citing works
Haïli, N., Louap, J., Canonge, M., Jagic, F., Louis-Mondésir, C., Chardot, T., & Briozzo, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165431 · Cited by 10 · see citing works
Jiang, W., Peng, H., He, L., Lesma‐Amaro, R., & Haritos, V. S. (2024) · Biotechnology Journal · doi:10.1002/biot.202300694 · Cited by 8 · see citing works
The lipid droplet protein Pgc1 controls the subcellular distribution of phosphatidylglycerol
Kubalová, D., Káňovičová, P., Veselá, P., Awadová, T., Džugasová, V., Daum, G., Malínský, J., & Balážová, M. (2019) · FEMS Yeast Research · doi:10.1093/femsyr/foz045 · Cited by 8 · see citing works
Self-citationMolaeitabari, A., & Dahms, T. E. S. (2025) · Microbiology Spectrum · doi:10.1128/spectrum.02754-24 · Cited by 7 · see citing works
Kálmán, N., Gazdag, Z., Čertík, M., Belágyi, J., Selim, S., Pócsi, I., & Pesti, M. (2013) · Journal of Basic Microbiology · doi:10.1002/jobm.201200580 · Cited by 7 · see citing works
TOR and heat shock response pathways regulate peroxisome biogenesis during proteotoxic stress
Shukla, N., Neal, M. L., Farré, J., Mast, F. D., Sarkar, R., Truong, L., Simon, T., Miller, L. R., Aitchison, J. D., & Subramani, S. E. (2025) · Nature Communications · doi:10.1038/s41467-025-65776-y · Cited by 6 · see citing works
Deletion of ORM2 Causes Oleic Acid-Induced Growth Defects in Saccharomyces cerevisiae
Mathivanan, A., & Nachiappan, V. (2023) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-023-04359-3 · Cited by 5 · see citing works
Adipocyte heterogeneity regulated by the Bithorax Complex-Wnt signaling crosstalk in Drosophila
Hemba-Waduge, R.-U.-S., Liu, M., Li, X., Sun, J. L., Budslick, E. A., Bondos, S. E., & Ji, J. (2025) · EMBO Reports · doi:10.1038/s44319-025-00625-z · Cited by 5 · see citing works
Scott, J., & Amich, J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818731-9.00059-8 · Cited by 3 · see citing works
Deryabina, Y. I., Kokoreva, A. S., Klein, O. I., Gessler, N. N., & Isakova, E. P. (2022) · Journal of Fungi · doi:10.3390/jof8111233 · Cited by 3 · see citing works
Соколов, С. С., Zyrina, A. N., Akimov, S. A., & Severin, F. F. (2025) · Biochemistry (Moscow) · doi:10.1134/s0006297924604313 · Cited by 2 · see citing works
da Rosa, P. D., Mattanna, P., & Valente, P. (2015) · Revista Brasileira de Biociências · Cited by 1 · see citing works
31 Lipid Biotechnology and Biochemistry
Anankanbil, S., Suo, F., Jensen, P. R., & Guo, Z. (2017) · CRC Press eBooks · doi:10.1201/9781315151854-32 · Cited by 1 · see citing works
The main actors involved in extending the invertebrate life span
Ottaviani, E., Franchini, A., & Mandrioli, M. (2014) · Invertebrate survival journal · Cited by 1 · see citing works
Characterization of the genetic interactome of prohibitins in S. cerevisiae
Osman, C. (2009) · Kölner Universitäts PublikationsServer (Universität zu Köln) · Cited by 1 · see citing works
Oberländer, G. M. (2011) · doi:10.53846/goediss-3203 · Cited by 1 · see citing works
Engineering Saccharomyces ceresisiae for the Secretion of an Extracellular Lipase
Stewart, G. (2007) · ScholarWorks @ The University of New Orleans (The University of New Orleans)
Lipidomic analysis of S. cerevisiae cell during industrial bioethanol fermentation
Qiao, B., Tian, H., & Yuan, Y. (2008) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2008.07.093
Cytological, physiological and molecular characterisation of sparkling wine yeasts
Batista, J. M. S. F. (2010) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Mechanism of Lipid Droplet Formation
Fujimoto, T., Ohsaki, Y., & Suzuki, M. (2008) · MEMBRANE · doi:10.5360/membrane.33.17
CYTOLOGICAL, PHYSIOLOGICAL AND MOLECULAR CHARACTERISATION OF SPARKLING WINE YEASTS
Ciências, F. D., De, D., Vegetal, B., Yeasts, S. W., Miguel, J., Batista, S. F., Em, M., Aplicada, M., & de Lisboa, U. (2010)
(2007) · Yeast · doi:10.1002/yea.1452
Metabolites in fish and humans as a response to different food ingredients : a metabolomics approach
Brunel, M. (2023) · Acta universitatis agriculturae Sueciae · doi:10.54612/a.524khafcck
Mathivanan, A., & Nachiappan, V. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.03.621711
Arhar, S., Gogg‐Fassolter, G., Ogrizović, M., Pačnik, K., Schwaiger, K. N., Žganjar, M., Petrovič, U., & Natter, K. (2021) · Figshare · doi:10.6084/m9.figshare.15064015
- Authors
- Daum, G., Wagner, A., Czabany, T., & Athenstaedt, K.
- Affiliations
- Graz University of Technology (AT)
- Corresponding author
- Daum, G.
- Venue
- Biochimie
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 89
- Issue
- 2
- Pages
- 243-248
- ISSN
- 0037-9042 (ISSN-L)
- 0300-9084
- OpenAlex
- W2036510236
- Cited by
- 87
- References
- 41
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 1 · 2017: 3 · 2016: 9 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 7
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimie (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Austrian Science Fund
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- neutral lipid storage, lipid mobilization, triglycerides, sterol esters, lipid particles, triacylglycerol lipase, endoplasmic reticulum, organelle targeting, lipid homeostasis, Saccharomyces cerevisiae
- MeSH terms
- Enzymes, Esters, Hydrolysis, Saccharomyces cerevisiae, Sterols, Triglycerides, Saccharomyces cerevisiae Proteins, Lipid Metabolism
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