CoChat
Sign Up
Cited by 17Diet, Metabolism, and DiseaseAdipose Tissue and MetabolismRegulation of Appetite and Obesity

Early differences in metabolic flexibility between obesity-resistant and obesity-prone mice

Open access
Bardova, Kristina, Horakova, Olga, Janovska, Petra, Hansikova, Jana, Kus, Vladimir, van Schothorst, Evert M., Hoevenaars, Femke P.M., Uil, Melissa +3 more·2016·Biochimie
DOI 10.1016/j.biochi.2015.11.014
Open this paper in CoChat — free account

Abstract

Decreased metabolic flexibility, i.e. a compromised ability to adjust fuel oxidation to fuel availability supports development of adverse consequences of obesity. The aims of this study were (i) to learn whether obesity-resistant A/J and obesity-prone C57BL/6J mice differ in their metabolic flexibility right after weaning; and (ii) to characterize possible differences in control of glucose homeostasis in these animals using glucose tolerance tests (GTT). A/J and C57BL/6J mice of both genders were maintained at 20 °C and weaned to standard low-fat diet at 30 days of age. During the first day after weaning, using several separate animal cohorts, (i) GTT was performed using 1 or 3 mg glucose/g body weight (BW), while glucose was administered either orally (OGTT) or intraperitoneally (IPGTT) at 20 °C; and (ii) indirect calorimetry (INCA) was performed, either in a combination with oral gavage of 1 or 7.5 mg glucose/g BW, or during a fasting/re-feeding transition. INCA was conducted either at 20 °C or 34 °C. Results of both OGTT and IPGTT using 1 mg glucose/g BW at 20 °C, and INCA using 7.5 mg glucose/g BW at 34 °C, indicated higher glucose tolerance and higher metabolic flexibility to glucose, respectively, and lower fasting glycemia in A/J mice as compared with C57BL/6J mice. Thus, control of whole body glucose metabolism between A/J and C57BL/6J mice represents a phenotypic feature differentiating between the strains right after weaning.

Integrity signals

Registry

Crossref · 10.1016/j.biochi.2015.11.014

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Bardova, K., Horakova, O., Janovska, P., Hansikova, J., Kus, V., van Schothorst, E. M., Hoevenaars, F. P. M., Uil, M., Hensler, M., Keijer, J., & Kopecky, J.
Affiliations
  • Czech Academy of Sciences (CZ)
  • Wageningen University & Research (NL)
ORCID
Venue
Biochimie
Publisher
Elsevier BV
Published
2016-05
Volume
124
Pages
163-170
ISSN
  • 0037-9042 (ISSN-L)
  • 0300-9084
DOI
10.1016/j.biochi.2015.11.014
OpenAlex
W2176927896
Cited by
17
References
31
Citations by year
2025: 2 · 2024: 1 · 2021: 3 · 2020: 3 · 2018: 3 · 2017: 2 · 2016: 2 · 2013: 1
FWCI
2.02
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biochimie (publishedVersion)
  • PubMed (publishedVersion)
  • ASEP (submittedVersion, public-domain)
  • Socio-Environmental Systems Modeling (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
  • European Union's Seventh Framework Program (244995)
  • Czech Science Foundation (14-36804G)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
metabolic flexibility, obesity resistance, A/J mice, C57BL/6J mice, glucose tolerance, glucose homeostasis, fuel oxidation, fasting blood glucose, weaning, strain differences, indirect calorimetry, glucose tolerance test
MeSH terms
Animals, Female, Glucose, Glucose Tolerance Test, Male, Obesity, Species Specificity, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review