CD36 gene polymorphism is associated with Alzheimer's disease
Abstract
CD36 gene encodes a membrane glycoprotein (type B scavenger receptor) present on the surface of many types of cells and having multiple cellular functions ranging from angiogenesis to gustatory perception of fatty acids. Using a case control genetic association approach we have analyzed selected single nucleotide polymorphisms (SNP's) in a total of 859 patients with Alzheimer's disease (AD) and controls and have identified the allele A in rs3211892 polymorphism of CD36 gene as significantly increasing the risk of AD. Additionally we have investigated, in the same sample of control subjects and patients, SNP's in ApoE gene and confirmed that the previously identified AD-associated SNP's indeed increased the risk and decreased the age of onset of AD as reported by others earlier. Based on the current knowledge of CD36 biochemistry we propose that the AD risk-imparting variants of CD36 alter cholesterol homeostasis, oxidation stress or induce pathological inflammatory cascades. The SNP rs3211892 has previously been associated with heart disease and other conditions but the present study is the first to identify a significant association between variations in CD36 gene and the risk of Alzheimer's disease.
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The rs3211892 polymorphism, which raises CD36 levels, is linked to higher AD risk.
“Polymorphism (rs3211892) that increases CD36 levels is associated with increased AD risk137.”
From Microglia in neurodegeneration (2018) · cites this paper as [137]
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Bednářová, A., Jarčušková, D., Dóci, I., Dubinská, S., & Petruňová, H. (2025) · Springer eBooks · doi:10.1007/978-3-031-32035-4_147-2
Selected Genetic Polymorphisms in Psychiatry
Bednářová, A., Jarčušková, D., Dóci, I., Dubinská, S., & Petruňová, H. (2025) · Springer eBooks · doi:10.1007/978-3-031-73368-0_147
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Vastrad, B. M., Pattanashetti, S., Sadashivanavar, V., Pai, K. S. R., & Vastrad, C. M. (2026) · Molecular Diversity · doi:10.1007/s11030-025-11453-7
- Authors
- Šerý, O., Janoutová, J., Ewerlingová, L., Hálová, A., Lochman, J., Janout, V., Khan, N. A., & Balcar, V. J.
- Affiliations
- Czech Academy of Sciences (CZ)
- University of Ostrava (CZ)
- Masaryk University (CZ)
- Inserm (FR)
- Corresponding author
- Šerý, Omar
- Venue
- Biochimie
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 135
- Pages
- 46-53
- ISSN
- 0037-9042 (ISSN-L)
- 0300-9084
- OpenAlex
- W2572155340
- Cited by
- 44
- References
- 54
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 10 · 2019: 4 · 2018: 5 · 2017: 3
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimie (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- ASEP (submittedVersion, public-domain)
- Funders
- Ministry of Health of the Czech Republic (NT/11152–6)
- Agency for Healthcare Research, Czech Republic (16-31207A)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- CD36, Alzheimer's disease, genetic association, single nucleotide polymorphisms, apolipoprotein E, disease risk, age of onset, cholesterol homeostasis, oxidative stress, inflammation
- MeSH terms
- Aged, Alzheimer Disease, Cholesterol, Female, Genotype, Humans, Male, Polymorphism, Genetic, Oxidative Stress, CD36 Antigens, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide
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