The DOI matches its Crossref record; 126 of the 127 references it cites were found in a registry or an index.
Challenges for successful implantation of biofuel cells
Open accessAbstract
There is a growing interest in the design and engineering of operational biofuel cells that can be implanted. This review highlights the recent progress in the electrochemistry of biofuel cell technologies, but with a particular emphasis on the medical and physiological aspects that impact the biocompatibility of biofuel cells operating inside a living body. We discuss the challenge of supplying power to implantable medical devices, with regard to the limitations of lithium battery technology and why implantable biofuel cells can be a promising alternative to provide the levels of power required for medical devices. In addition to the challenge of designing a biofuel cell that provides a stable level of sufficient power, the review highlights the biocompatibility and biofouling problems of implanting a biofuel cell that have a major impact on the availability of the substrates inside body that provide fuel for the biofuel cell. These physiological challenges and associated ethical considerations are essential to consider for biofuel cells that are designed to be implanted for long-term operation inside a living animal and eventually to human clinical applications.
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“Although Li/I2 batteries have been successfully used in cardiac pacemakers due to their high discharge voltages reaching up to 3.6 V and impressive energy densities of 210 and 810 W h/L, they are not directly applicable to brain implants (Zebda et al., 2018).”
From Comparative analysis of energy transfer mechanisms for neural implants (2024) · cites this paper as Zebda et al., 2018
In the citing paper
“Although Li/I2 batteries have been successfully used in cardiac pacemakers due to their high discharge voltages reaching up to 3.6 V and impressive energy densities of 210 and 810 W h/L, they are not directly applicable to brain implants (Zebda et al., 2018).”
From Comparative analysis of energy transfer mechanisms for neural implants (2024) · cites this paper as Zebda et al., 2018
Citations
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Self-citationWhere Does Biomimetic Membrane Technology Fit into Biological Engineering?
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Self-citationA Conductive Hydrogel-based Biofuel Cell Installed in Stent for Endoprothesis
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Metadata
- Authors
- Zebda, A., Alcaraz, J.-P., Vadgama, P., Shleev, S., Minteer, S. D., Boucher, F., Cinquin, P., & Martin, D. K.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Queen Mary University of London (GB)
- Malmö University (SE)
- University of Utah (US)
- Corresponding author
- Martin, Donald K.
- ORCID
- Venue
- Bioelectrochemistry
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 124
- Pages
- 57-72
- ISSN
- 1567-5394 (ISSN-L)
- OpenAlex
- W2808838311
- Cited by
- 224
- References
- 127
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 23 · 2023: 33 · 2022: 29 · 2021: 44 · 2020: 32 · 2019: 25 · 2018: 6
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Bioelectrochemistry (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc-nd)
- KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
- Malmö University Publications (Malmö University) (submittedVersion)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion, cc-by)
- Funders
- Vetenskapsrådet (621-2013-6006)
- Engineering and Physical Sciences Research Council (EP/H009744/1)
- Agence Nationale de la Recherche (ANR-15-CE05-0003-01)
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Electrochemical sensors and biosensors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Environmental Science › Environmental Engineering › Microbial Fuel Cells and Bioremediation
- Keywords
- implantable biofuel cells, biocompatibility, biofouling, biomedical implants, ethical considerations, long-term implantation
- MeSH terms
- Animals, Biocompatible Materials, Bioelectric Energy Sources, Electrodes, Electrochemical Techniques
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