The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Development of functionalized superparamagnetic iron oxide nanoparticles for interaction with human cancer cells
Open accessAbstract
Our goal is to develop, characterize and optimize functionalized super paramagnetic iron oxide nanoparticles (SPION) demonstrating the capacity to be internalized by human cancer cells. SPION (mean diameter 9nm) were coated with various ratios to iron oxide of either polyvinyl alcohol (PVA), carboxylate-functionalized PVA, thiol-functionalized PVA and amino-functionalized PVA (amino-PVA). The interaction with cells and cytotoxicity of the SPION preparations were determined using human melanoma cells. From the four functionalized SPION preparations, only the amino-PVA SPION demonstrated the capacity to interact with, and were not cytotoxic to, human melanoma cells. This interaction with melanoma cells was dependent on the amino-PVA to iron oxide ratio, was an active and saturable mechanism displayed by all cells in a culture. These functionalized SPION were characterized by transmission electron microscopy and electrophoretic mobility. The physical comportment of SPION changed at specific PVAs to iron oxide ratios, and this ratio corresponded to the ratio of optimal interaction with cells. In conclusion, the successful development of functionalized SPION displaying potential cellular uptake by human cancer cells depends both on the presence of amino groups on the coating shell of the nanoparticles and of its ratio to the amount of iron oxide.
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Marchal, G., Van Hecke, P., Demaerel, P., Decrop, E., Kennis, C., Baert, A., & van der Schueren, E. (1989) · American Journal of Roentgenology · doi:10.2214/ajr.152.4.771 · Cited by 122
Cited by
Laurent, S., Forge, D., Port, M., Roch, A., Robic, C., Vander Elst, L., & Muller, R. N. (2008) · Chemical Reviews · doi:10.1021/cr068445e · Cited by 6,852
Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers
Wahajuddin, & Arora (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s30320 · Cited by 1,117
Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine
Sousa de Almeida, M., Susnik, E., Drasler, B., Taladriz-Blanco, P., Petri-Fink, A., & Rothen-Rutishauser, B. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01127d · Cited by 1,079
Self-citationDuan, X., & Li, Y. (2013) · Small · doi:10.1002/smll.201201390 · Cited by 926
Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging
Thorek, D. L. J., Chen, A. K., Czupryna, J., & Tsourkas, A. (2006) · Annals of Biomedical Engineering · doi:10.1007/s10439-005-9002-7 · Cited by 772
Metadata
- Authors
- Petri-Fink, A., Chastellain, M., Juillerat-Jeanneret, L., Ferrari, A., & Hofmann, H.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 26
- Issue
- 15
- Pages
- 2685-2694
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2068371378
- Cited by
- 343
- References
- 1
- FWCI
- 10.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Petri-Fink, A., Chastellain, M., Juillerat-Jeanneret, L., Ferrari, A., & Hofmann, H. (2005). Development of functionalized superparamagnetic iron oxide nanoparticles for interaction with human cancer cells. Biomaterials. https://doi.org/10.1016/j.biomaterials.2004.07.023
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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