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Cited by 445

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The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages

Open access
Xie, Jingwei, Willerth, Stephanie M., Li, Xiaoran, Macewan, Matthew R., Rader, Allison, Sakiyama-Elbert, Shelly E., Xia, Younan·2009·Biomaterials

Abstract

Due to advances in stem cell biology, embryonic stem (ES) cells can be induced to differentiate into a particular mature cell lineage when cultured as embryoid bodies. Although transplantation of ES cells-derived neural progenitor cells has been demonstrated with some success for either spinal cord injury repair in small animal model, control of ES cell differentiation into complex, viable, higher ordered tissues is still challenging. Mouse ES cells have been induced to become neural progenitors by adding retinoic acid to embryoid body cultures for 4 days. In this study, we examine the use of electrospun biodegradable polymers as scaffolds not only for enhancing the differentiation of mouse ES cells into neural lineages but also for promoting and guiding the neurite outgrowth. A combination of electrospun fiber scaffolds and ES cells-derived neural progenitor cells could lead to the development of a better strategy for nerve injury repair.

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Metadata

Authors
Xie, J., Willerth, S. M., Li, X., Macewan, M. R., Rader, A., Sakiyama-Elbert, S. E., & Xia, Y.
Venue
Biomaterials
Publisher
Elsevier BV
Published
2009-01
Volume
30
Issue
3
Pages
354-362
ISSN
0142-9612 (ISSN-L)
OpenAlex
W2093483666
Cited by
445
References
1
FWCI
10.77
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages. https://app.cochat.ai/papers/10.1016/j.biomaterials.2008.09.046
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Xie, J., Willerth, S. M., Li, X., Macewan, M. R., Rader, A., Sakiyama-Elbert, S. E., & Xia, Y. (2009). The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages. Biomaterials. https://doi.org/10.1016/j.biomaterials.2008.09.046

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