Poly(glycerol-dodecanoate), a biodegradable polyester for medical devices and tissue engineering scaffolds
Open accessAbstract
In this paper we describe the mechanical and biological features of a thermosetting polyester synthesized from glycerol and dodecanedioic acid named Poly-Glycerol-Dodecanoate (PGD). This polymer shows a glass transition temperature (T(g)) around 32 degrees C, and this accounts for its mechanical properties. At room temperature (21 degrees ) PGD behaves like a stiff elastic-plastic material, while at body temperature (37 degrees C), it shows a compliant non-linear elastic behavior. Together with biodegradability and biocompatibility PGD has distinct shape memory features. After the polymer is cured, no matter what the final configuration is, we can recover the original shape by heating PGD to temperatures of 32 degrees C and higher. The mechanical properties together with biocompatibility/biodegradability and shape memory features make PGD an attractive polymer for biomedical applications.
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Cites
Materials science and engineering: An introduction
Clayton, C. R. (1987) · Materials Science and Engineering · doi:10.1016/0025-5416(87)90343-0 · Cited by 5,963 · see citing works
Materials Science and Engineering: An Introduction
Callister, W. D. (1985) · Cited by 5,357 · see citing works
Introduction to Physical Polymer Science
Sperling, L. H. (2005) · doi:10.1002/0471757128 · Cited by 2,917 · see citing works
A tough biodegradable elastomer
Wang, Y., Ameer, G. A., Sheppard, B. J., & Langer, R. (2002) · Nature Biotechnology · doi:10.1038/nbt0602-602 · Cited by 1,314 · cited 3× · see citing works
“Notable work has been conducted on the fabrication [1], characterization [2] and use [3–5] of poly-glycerol sebacate (PGS), a thermoset elastomer derived from polycondensation of glycerol and sebacic acid.”
Introduction to physical polymer science
Sherrington, D. C. (1993) · Reactive Polymers · doi:10.1016/0923-1137(93)90096-x · Cited by 665 · see citing works
Biocompatibility analysis of poly(glycerol sebacate) as a nerve guide material
Sundback, C. A., Shyu, J. Y., Wang, Y., Faquin, W. C., Langer, R. S., Vacanti, J. P., & Hadlock, T. A. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.02.004 · Cited by 443 · see citing works
In vivo degradation characteristics of poly(glycerol sebacate)
Wang, Y., Kim, Y. M., & Langer, R. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.10534 · Cited by 389 · see citing works
Hemocompatibility evaluation of poly(glycerol-sebacate) in vitro for vascular tissue engineering
Motlagh, D., Yang, J. Y., Lui, K. Y., Webb, A. R., & Ameer, G. A. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.04.010 · Cited by 375 · see citing works
Thermomechanics of the shape memory effect in polymers for biomedical applications
Gall, K., Yakacki, C. M., Liu, Y., Shandas, R., Willett, N., & Anseth, K. S. (2005) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30296 · Cited by 351 · see citing works
Chemically Cross-Linked Polycyclooctene: Synthesis, Characterization, and Shape Memory Behavior
Liu, C., Chun, S. B., Mather, P. T., Zheng, L., Haley, E. H., & Coughlin, E. B. (2002) · Macromolecules · doi:10.1021/ma021141j · Cited by 282 · see citing works
Microfabrication of poly (glycerol–sebacate) for contact guidance applications
Bettinger, C. J., Orrick, B. K., Misra, A. C., et al. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.11.029 · Cited by 231 · see citing works
On the failure of ellipticity of the equations for finite elastostatic plane strain
Knowles, J. C., & Sternberg, E. (1976) · Archive for Rational Mechanics and Analysis · doi:10.1007/bf00279991 · Cited by 214 · see citing works
FTIR spectra and mechanical strength analysis of some selected rubber derivatives
Gunasekaran, S. G., Natarajan, R., & Kala, A. (2006) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2006.11.039 · Cited by 193 · see citing works
Shet, M. S., Fisher, C., Holmans, P. L., et al. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0243 · Cited by 40 · see citing works
Crosslinked Polymers and Rubber Elasticity
Sperling, L. H. (2005) · doi:10.1002/0471757128.ch9 · Cited by 20 · see citing works
Mingrone, G., Gaetano, A. D., Av, G., Capristo, E., Benedetti, G., Castagneto, M., & Gasbarrini, G. B. (1999) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719902300280 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Multifunctional Shape‐Memory Polymers
Behl, M., Razzaq, M. Y., & Lendlein, A. (2010) · Advanced Materials · doi:10.1002/adma.200904447 · Cited by 971 · see citing works
Shape-memory polymers as a technology platform for biomedical applications
Lendlein, A., Behl, M., Hiebl, B., & Wischke, C. (2010) · Expert Review of Medical Devices · doi:10.1586/erd.10.8 · Cited by 469 · see citing works
Review on the Functional Determinants and Durability of Shape Memory Polymers
Pretsch, T. (2010) · Polymers · doi:10.3390/polym2030120 · Cited by 138 · see citing works
- Authors
- Migneco, F., Huang, Y.-C., Birla, R. K., & Hollister, S. J.
- Affiliations
- University of Michigan (US)
- Florida International University (US)
- Corresponding author
- Hollister, Scott J.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 30
- Issue
- 33
- Pages
- 6479-6484
- ISSN
- 0142-9612 (ISSN-L)
- PMC
- PMC4372058
- OpenAlex
- W1998447474
- Cited by
- 136
- References
- 16
- Citations by year
- 2026: 10 · 2025: 6 · 2024: 8 · 2023: 12 · 2022: 8 · 2021: 3 · 2020: 8 · 2019: 6 · 2018: 6 · 2017: 8 · 2016: 14 · 2015: 8 · 2014: 10 · 2013: 8 · 2012: 7
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (T90 DK070071)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Materials Science › Polymers and Plastics › Polymer composites and self-healing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- biodegradable polyesters, thermosetting polymer, shape memory polymers, tissue engineering scaffolds, medical devices, glass transition temperature, biocompatibility, biodegradability, mechanical properties, dodecanedioic acid, glycerol
- MeSH terms
- Biocompatible Materials, Calorimetry, Differential Scanning, Decanoates, Equipment and Supplies, Fibroblasts, Humans, Materials Testing, Polyesters, Tensile Strength, Thermogravimetry, Spectroscopy, Fourier Transform Infrared, Tissue Engineering, Cell Proliferation, Tissue Scaffolds
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