SPIO-conjugated, doxorubicin-loaded microbubbles for concurrent MRI and focused-ultrasound enhanced brain-tumor drug delivery

The 2007 WHO Classification of Tumours of the Central Nervous System

Louis, D. N., Ohgaki, H., Wiestler, O. D., Cavenee, W. K., Burger, P. C., Jouvet, A., Scheithauer, B. W., & Kleihues, P. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0243-4 · Cited by 15,675

Malignant Gliomas in Adults

Wen, P. Y., & Kesari, S. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0708126 · Cited by 3,511

Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging

Omid Veiseh, A., Gunn, J., & Zhang, M. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.002 · Cited by 1,854

Inorganic Nanoparticles for MRI Contrast Agents

Na, H. B., Song, I. C., & Hyeon, T. (2009) · Advanced Materials · doi:10.1002/adma.200802366 · Cited by 1,811

Recent advances in iron oxide nanocrystal technology for medical imaging☆

Corot, C., Robert, P., Idée, J., & Port, M. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.013 · Cited by 1,498

Noninvasive MR Imaging–guided Focal Opening of the Blood-Brain Barrier in Rabbits

Hynynen, K., McDannold, N. J., Vykhodtseva, N. I., & Jolesz, F. A. (2001) · Radiology · doi:10.1148/radiol.2202001804 · Cited by 1,463

Long-term survival with glioblastoma multiforme

Krex, D., Klink, B., Hartmann, C. J., von Deimling, A., Pietsch, T., Simon, M., Sabel, M., Steinbach, J. P., Heese, O., Reifenberger, G., et al. (2007) · Brain · doi:10.1093/brain/awm204 · Cited by 905

Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors

Chertok, B., Moffat, B. A., David, A. E., Yu, F., Bergemann, C., Ross, B. D., & Yang, V. C.-M. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.08.050 · Cited by 901

Local and reversible blood–brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications

Hynynen, K., McDannold, N., Sheikov, N. A., Jolesz, F. A., & Vykhodtseva, N. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.06.046 · Cited by 679

Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles

Sheikov, N. A., McDannold, N. J., Vykhodtseva, N. I., Jolesz, F. A., & Hynynen, K. (2004) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2004.04.010 · Cited by 619

Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI‐guided focused ultrasound

Treat, L. H., McDannold, N. J., Vykhodtseva, N. I., Zhang, Y., Tam, K., & Hynynen, K. (2007) · International Journal of Cancer · doi:10.1002/ijc.22732 · Cited by 543

Effect of Focused Ultrasound Applied With an Ultrasound Contrast Agent on the Tight Junctional Integrity of the Brain Microvascular Endothelium

Sheikov, N. A., McDannold, N. J., Sharma, S., & Hynynen, K. (2008) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2007.12.015 · Cited by 494

Chemotherapy Delivery Issues in Central Nervous System Malignancy: A Reality Check

Muldoon, L. L., Soussain, C., Jahnke, K., Johanson, C. E., Siegal, T., Smith, Q. R., Hall, W. A., Hynynen, K., Senter, P. D., Peereboom, D. M., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.09.9861 · Cited by 418

Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain

Liu, H.-L., Hua, M., Yang, H., Huang, C.-Y., Chu, P., Wu, J.-S., Tseng, I.-C., Wang, J., Yen, T., Chen, P., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003388107 · Cited by 396

The targeted delivery of cancer drugs across the blood–brain barrier: chemical modifications of drugs or drug-nanoparticles?

Juillerat‐Jeanneret, L. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2008.09.005 · Cited by 318

Design and Evaluation of Doxorubicin-containing Microbubbles for Ultrasound-triggered Doxorubicin Delivery: Cytotoxicity and Mechanisms Involved

Lentacker, I., Geers, B., Demeester, J., Smedt, S. C. D., & Sanders, N. N. (2009) · Molecular Therapy · doi:10.1038/mt.2009.160 · Cited by 312

Concurrent blood–brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment

Ting, C.-Y., Fan, C., Liu, H.-L., Huang, C.-Y., Hsieh, H.-Y., Yen, T., Wei, K., & Yeh, C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.09.096 · Cited by 283

Macrophage Imaging in Central Nervous System and in Carotid Atherosclerotic Plaque Using Ultrasmall Superparamagnetic Iron Oxide in Magnetic Resonance Imaging

Corot, C., Petry, K. G., Trivedi, R. A., Saleh, A., Jonkmanns, C., Bas, J. L., Blezer, E. L. A., Rausch, M., Brochet, B., Foster‐Gareau, P., et al. (2004) · Investigative Radiology · doi:10.1097/01.rli.0000135980.08491.33 · Cited by 229

The kinetics of blood brain barrier permeability and targeted doxorubicin delivery into brain induced by focused ultrasound

Park, J., Zhang, Y., Vykhodtseva, N. I., Jolesz, F. A., & McDannold, N. J. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.06.012 · Cited by 217

Intratumoral Chemotherapy

Walter, K. A., Tamargo, R. J., Olivi, A., Burger, P. C., & Brem, H. (1995) · Neurosurgery · doi:10.1227/00006123-199512000-00013 · Cited by 192

Multiphoton Imaging of Ultrasound/Optison Mediated Cerebrovascular Effects in vivo

Raymond, S. B., Skoch, J. M., Hynynen, K., & Bacskai, B. J. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600336 · Cited by 174

Iron oxide nanoparticle-containing microbubble composites as contrast agents for MR and ultrasound dual-modality imaging

Liu, Z., Lammers, T., Ehling, J., Fokong, S., Bornemann, J., Kiessling, F. M., & Gätjens, J. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.05.019 · Cited by 163

MRI‐based monitoring of inflammation and tissue damage in acute and chronic relapsing EAE

Rausch, M., HIESTAND, P. C., Kindler, D., Cannet, C., & Rudin, M. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10541 · Cited by 163

New doxorubicin-loaded phospholipid microbubbles for targeted tumor therapy: In-vivo characterization

Tinkov, S., Coester, C., Serba, S., Geis, N. A., Katus, H. A., Winter, G., & Bekeredjian, R. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.09.004 · Cited by 146

Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats

Jalali, S., Huang, Y., Dumont, D., & Hynynen, K. (2010) · BMC Neurology · doi:10.1186/1471-2377-10-114 · Cited by 97

Brain Metastasis: Opportunities in Basic and Translational Research

Maher, E. A., Mietz, J. A., Arteaga, C. L., DePinho, R. A., & Mohla, S. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4347 · Cited by 92

Glioma selectivity of magnetically targeted nanoparticles: A role of abnormal tumor hydrodynamics

Chertok, B., David, A. E., Huang, Y., & Yang, V. C.-M. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.05.030 · Cited by 89

Treating glioblastoma multiforme with selective high-dose liposomal doxorubicin chemotherapy induced by repeated focused ultrasound

Yang, F., Yang, F., & Wang (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s29229 · Cited by 84

Theranostic Gd(III)-lipid microbubbles for MRI-guided focused ultrasound surgery

Feshitan, J. A., Vlachos, F., Sirsi, S. R., Konofagou, E. E., & Borden, M. A. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.09.026 · Cited by 59

Magnetic resonance imaging enhanced by superparamagnetic iron oxide particles: Usefulness for distinguishing between focused ultrasound‐induced blood–brain barrier disruption and brain hemorrhage

Liu, H., Hsu, P., Chu, P., Wai, Y., Chen, J., Shen, C., Yen, T., & Wang, J. (2009) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21599 · Cited by 54

Management of glioblastoma

Aoki, T., Hashimoto, N., & Matsutani, M. (2007) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.8.18.3133 · Cited by 51

In vivo MR quantification of superparamagnetic iron oxide nanoparticle leakage during low‐frequency‐ultrasound‐induced blood–brain barrier opening in swine

Liu, H.-L., Chen, P.-Y., Yang, H.-W., Wu, J.-S., Tseng, I.-C., Ma, Y.-J., Huang, C.-Y., Tsai, H.-C., Chen, S.-M., Lu, Y.-J., et al. (2011) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.22697 · Cited by 32

Approximation of arterial input curve data in MRI estimation of cerebral blood-tumor-barrier leakage: Comparison between Gd-DTPA and 99mTc-DTPA input curves

Andersen, C., Taagehøj, J. F., Mühler, A., & Rehling, M. (1996) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(95)02082-5 · Cited by 23

Apparent water diffusion measurements in electrically stimulated neural tissue

Gulani, V., Iwamoto, G. A., & Lauterbur, P. C. (1999) · Magnetic Resonance in Medicine · doi:10.1002/(sici)1522-2594(199902)41:2 · Cited by 22

In vivo Assessment of Macrophage CNS Infiltration during Disruption of the Blood–Brain Barrier with Focused Ultrasound: A Magnetic Resonance Imaging Study

Liu, H.-L., Wai, Y., Hsu, P.-H., Lyu, L.-A., Wu, J.-S., Shen, C.-R., Chen, J.-C., Yen, T., & Wang, J.-J. (2010) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/jcbfm.2009.179 · Cited by 17

Challenges associated with penetration of nanoparticles across cell and tissue barriers: A review of current status and future prospects

Barua, S., & Mitragotri, S. (2014) · Nano Today · doi:10.1016/j.nantod.2014.04.008 · Cited by 1,288

Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications

Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

Qian, X., Zheng, Y., & Chen, Y. (2016) · Advanced Materials · doi:10.1002/adma.201602012 · Cited by 888

Metalloporphyrin-Encapsulated Biodegradable Nanosystems for Highly Efficient Magnetic Resonance Imaging-Guided Sonodynamic Cancer Therapy

Huang, P., Qian, X., Chen, Y., Yu, L., Lin, H., Wang, L., Zhu, Y., & Shi, J. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b11846 · Cited by 664

Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier

Upadhyay, R. K. (2014) · BioMed Research International · doi:10.1155/2014/869269 · Cited by 544

Superparamagnetic iron-oxide drug-loading microbubbles for concurrent magnetic resonance imaging monitoring and focused-ultrasound enhanced brain-tumor drug delivery

Fan, C., Lin, H.-J., Ting, C.-Y., Liu, H.-L., Yen, T., & Yeh, C. (2012) · IEEE International Ultrasonics Symposium · doi:10.1109/ultsym.2012.0568 · Cited by 1

SPIO-DOX-microbubble complex with ultrasound for MRI image-guided drug delivery in a rat glioma model

Fan, C., Cheng, Y., Ting, C.-Y., Ho, Y.-J., Hsu, P., Liu, H.-L., & Yeh, C. (2016) · IEEE International Ultrasonics Symposium · doi:10.1109/ultsym.2016.7728533

Ultrasound/Magnetic Targeting with SPIO-DOX-Microbubble Complex for Image-Guided Drug Delivery in Brain Tumors

Fan, C., CHENG, Y.-H., Ting, C.-Y., Ho, Y.-J., Hsu, P., Liu, H.-L., & Yeh, C. (2016) · Theranostics · doi:10.7150/thno.15297 · Cited by 140

Comparing the Delivery of Free and Liposomal Doxorubicin Across the Blood-Brain Barrier Following Microbubble-Mediated Focused Ultrasound

Fletcher, S.-M. P., Mashburn, M., Zhang, Y., Chisholm, A., Martinez, S., Power, C., & McDannold, N. J. (2026) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2026.01.010 · Cited by 1

Comparing the delivery of free and liposomal-encapsulated doxorubicin across the blood-brain barrier with microbubble-mediated focused ultrasound

Fletcher, S.-M. P., Zhang, Y., Mashburn, M., Martinez, S., Chisholm, A., & McDannold, N. J. (2024) · The Journal of the Acoustical Society of America · doi:10.1121/10.0035000