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Performance and biocompatibility of extremely tough alginate/polyacrylamide hydrogels
Open accessAbstract
Although hydrogels now see widespread use in a host of applications, low fracture toughness and brittleness have limited their more broad use. As a recently described interpenetrating network (IPN) of alginate and polyacrylamide demonstrated a fracture toughness of ∼9000 J/m2, we sought to explore the biocompatibility and maintenance of mechanical properties of these hydrogels in cell culture and in vivo conditions. These hydrogels can sustain a compressive strain of over 90% with minimal loss of Young's Modulus as well as minimal swelling for up to 50 days of soaking in culture conditions. Mouse mesenchymal stem cells exposed to the IPN gel-conditioned media maintain high viability, and although cells exposed to conditioned media demonstrate slight reductions in proliferation and metabolic activity (WST assay), these effects are abrogated in a dose-dependent manner. Implantation of these IPN hydrogels into subcutaneous tissue of rats for 8 weeks led to mild fibrotic encapsulation and minimal inflammatory response. These results suggest the further exploration of extremely tough alginate/PAAM IPN hydrogels as biomaterials.
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Strengthening Alginate/Polyacrylamide Hydrogels Using Various Multivalent Cations
Yang, C. H., Wang, M. X., Haider, H., Yang, J. H., Sun, J.-Y., Chen, Y. M., Zhou, J., & Suo, Z. (2013) · ACS Applied Materials & Interfaces · doi:10.1021/am403966x · Cited by 649
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Metadata
- Authors
- Darnell, M. C., Sun, J.-Y., Mehta, M., Johnson, C., Arany, P. R., Suo, Z., & Mooney, D. J.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 34
- Issue
- 33
- Pages
- 8042-8048
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2141362699
- Cited by
- 336
- References
- 1
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Darnell, M. C., Sun, J.-Y., Mehta, M., Johnson, C., Arany, P. R., Suo, Z., & Mooney, D. J. (2013). Performance and biocompatibility of extremely tough alginate/polyacrylamide hydrogels. Biomaterials. https://doi.org/10.1016/j.biomaterials.2013.06.061
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